Detailed information for compound 1796304

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 499.366 | Formula: C24H16Cl2N2O4S
  • H donors: 1 H acceptors: 3 LogP: 6.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)COc1ccc(cc1)/C=C\1/S/C(=N\c2cccc(c2)Cl)/N(C1=O)c1cccc(c1)Cl
  • InChi: 1S/C24H16Cl2N2O4S/c25-16-3-1-5-18(12-16)27-24-28(19-6-2-4-17(26)13-19)23(31)21(33-24)11-15-7-9-20(10-8-15)32-14-22(29)30/h1-13H,14H2,(H,29,30)/b21-11+,27-24-
  • InChiKey: PSCJIWSVYZZYSV-JJUHIMRNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei proteasome beta 6 subunit 0.0143 0.2301 0.3738
Toxoplasma gondii proteasome subunit alpha1, putative 0.0135 0.2153 0.3498
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0145 0.0235
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0135 0.2153 0.3498
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0354 0.6156 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0031 0.0264 0.0429
Leishmania major proteasome alpha 3 subunit, putative 0.0124 0.1959 0.3183
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0128 0.2038 0.331
Echinococcus granulosus adhesion regulating molecule 1 0.0081 0.1177 0.1911
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0096 0.1451 0.2357
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0169 0.0274
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0128 0.2038 0.331
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.0544
Brugia malayi proteasome subunit alpha type 6 0.0135 0.2153 0.2153
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0169 0.0274
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0017 0.0000024804 0.0000024804
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0143 0.2301 0.3738
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0257 0.0418
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0189 0.0189
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0114 0.1782 0.2895
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0189 0.0307
Onchocerca volvulus 0.0032 0.0285 0.1434
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0264 0.0429
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0372 0.0605
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0685 0.0684
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0196 0.0196
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0169 0.0274
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0307 0.0499
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0017 0.0009 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0189 0.0307
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0119 0.1868 0.3035
Loa Loa (eye worm) PAS-3 protein 0.011 0.1704 0.1704
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.1842 0.2992
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0189 0.0189
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0166 0.2733 0.4441
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0135 0.2153 0.3498
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0146 0.2364 0.384
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0335 0.0544
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0118 0.1842 0.2992
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0124 0.1966 0.3194
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.0257
Onchocerca volvulus 0.0032 0.0285 0.1434
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0189 0.0951
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0026 0.0169 0.0274
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0166 0.027
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0134 0.2138 0.3473
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0017 0.0009 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0189 0.0307
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.012 0.1883 0.3058
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.1842 0.2992
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0685 0.1112
Brugia malayi PCI domain containing protein 0.0028 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.0185 0.3066 0.498
Leishmania major proteasome beta 7 subunit, putative 0.0118 0.1842 0.2992
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0372 0.0605
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0119 0.1868 0.3035
Loa Loa (eye worm) proteasome Regulatory Particle 0.0028 0.0209 0.0209
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0143 0.2301 0.3738
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.0307 0.0499
Schistosoma mansoni hypothetical protein 0.0165 0.2717 0.4413
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0032 0.0285 0.0462
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0143 0.2301 0.3738
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0146 0.2364 0.384
Onchocerca volvulus Notchless protein homolog 0.0125 0.1985 1
Plasmodium vivax proteasome subunit beta type-4, putative 0.0118 0.1842 0.2992
Onchocerca volvulus 0.0027 0.0189 0.0951
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Onchocerca volvulus 0.0017 0.0009 0.0045
Plasmodium vivax proteasome subunit beta type-2, putative 0.0119 0.1868 0.3035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0189 0.0307
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0685 0.0684
Leishmania major proteasome alpha 2 subunit, putative 0.0128 0.2038 0.331
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0264 0.0429
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0189 0.0189
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0211 0.0343
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0185 0.3066 0.3066
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.0307 0.0499
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0007 0.0012
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0096 0.1451 0.2357
Echinococcus multilocularis adhesion regulating molecule 1 0.0081 0.1177 0.1911
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0017 0.0009 0.0014
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0124 0.1951 0.317
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0118 0.1842 0.2992
Echinococcus multilocularis transmembrane protease serine 3 0.0032 0.0285 0.0462
Echinococcus multilocularis proteasome subunit beta type 6 0.0124 0.1966 0.3194
Brugia malayi proteasome subunit beta type 1 0.0143 0.2301 0.2301
Echinococcus multilocularis Mastin 0.0032 0.0285 0.0462
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.1842 0.2992
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0028 0.0045
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0166 0.2733 0.4441
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0145 0.0235
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0119 0.1868 0.3035
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0124 0.1951 0.317
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0031 0.0264 0.0429
Brugia malayi Trypsin family protein 0.0032 0.0285 0.0285
Brugia malayi Proteasome A-type and B-type family protein 0.0118 0.1842 0.1842
Echinococcus granulosus nuclear factor of activated T cells 5 0.0302 0.5212 0.8467
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0189 0.0307
Echinococcus multilocularis enteropeptidase 0.0032 0.0285 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0007 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Toxoplasma gondii peptidase, T1 family protein 0.0125 0.1985 0.3224
Entamoeba histolytica hypothetical protein 0.0033 0.0298 0.0484
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0125 0.1985 0.1985
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0189 0.0307
Echinococcus multilocularis proteasome (prosome, macropain) 0.0354 0.6156 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0189 0.0189
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Echinococcus granulosus carbonic anhydrase 0.0054 0.0685 0.1112
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0118 0.1842 0.2992
Mycobacterium ulcerans proteasome PrcB 0.0354 0.6156 1
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0026 0.0169 0.0274
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0114 0.1782 0.1782
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0135 0.2153 0.3498
Echinococcus granulosus Proteasome subunit alpha beta 0.0125 0.1985 0.3224
Loa Loa (eye worm) hypothetical protein 0.0054 0.0685 0.0685
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0169 0.0169
Brugia malayi Kringle domain containing protein 0.0017 0.0007 0.0007
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0124 0.1951 0.317
Loa Loa (eye worm) proteasome subunit beta type 2 0.0119 0.1868 0.1868
Brugia malayi Ubiquitin interaction motif family protein 0.0018 0.0027 0.0027
Echinococcus multilocularis proteasome subunit alpha type 2 0.0128 0.2038 0.331
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0018 0.0028 0.0045
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Brugia malayi nuclear receptor NHR-88 0.0027 0.0189 0.0189
Giardia lamblia 20S proteasome alpha subunit 2 0.0128 0.2038 0.331
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0134 0.2138 0.3473
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0028 0.0209 0.034
Echinococcus granulosus proteasome subunit alpha type 2 0.0128 0.2038 0.331
Echinococcus granulosus Ankyrin 0.0031 0.0259 0.0421
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0124 0.1959 0.3183
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0145 0.0145
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0118 0.1842 0.2992
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0017 0.0009 0.0014
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0032 0.0285 0.0462
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0119 0.1868 0.3035
Plasmodium falciparum carbonic anhydrase 0.0054 0.0685 0.1112
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0119 0.1868 0.3035
Trypanosoma brucei proteasome alpha 7 subunit 0.0125 0.1985 0.3224
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0169 0.0274
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0037 0.0372 0.0605
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0354 0.6156 1
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0018 0.003
Loa Loa (eye worm) proteasome subunit beta type 3 0.0119 0.1868 0.1868
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0189 0.0307
Brugia malayi Protein kinase domain containing protein 0.0031 0.0257 0.0257
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0257 0.0257
Brugia malayi 26S protease regulatory subunit 6A 0.0018 0.0028 0.0028
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0033 0.0298 0.0484
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0372 0.0605
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0017 0.0009 0.0014
Giardia lamblia 20S proteasome alpha subunit 5 0.0134 0.2138 0.3473
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0134 0.2138 0.3473
Schistosoma mansoni 26S proteasome subunit S9 0.0031 0.0264 0.0429
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0042 0.0466 0.0756
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0125 0.1985 0.3224
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0189 0.0951
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0169 0.0274
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0166 0.2733 0.4441
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0028 0.0045
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0019 0.0047 0.0076
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0017 0.0009 0.0014
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0169 0.0274
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0143 0.2301 0.3738
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0166 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Echinococcus multilocularis glycoprotein Antigen 5 0.0032 0.0285 0.0462
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0031 0.0264 0.0429
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0124 0.1951 0.317
Trypanosoma brucei proteasome beta 7 subunit 0.0118 0.1842 0.2992
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0196 0.0196
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0124 0.1959 0.3183
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0118 0.1842 0.1842
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0146 0.2364 0.2364
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0134 0.2138 0.3473
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0354 0.6156 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0124 0.1959 0.3183
Toxoplasma gondii proteasome subunit beta type, putative 0.0354 0.6156 1
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0017 0.0009 0.0014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0169 0.0274
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0209 0.034
Giardia lamblia 20S proteasome alpha subunit 6 0.0124 0.1951 0.317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0189 0.0307
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0096 0.1451 0.2357
Mycobacterium ulcerans proteasome PrcA 0.0096 0.1451 0.1987
Echinococcus granulosus subfamily T1A non peptidase ue 0.0134 0.2138 0.3473
Giardia lamblia 20S proteasome alpha subunit 4 0.0166 0.2733 0.4441
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0096 0.1451 0.2357
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0124 0.1966 0.3194
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0124 0.1959 0.3183
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0037 0.0372 0.0605
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0026 0.0169 0.0274
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0119 0.1868 0.3035
Loa Loa (eye worm) proteasome 26S subunit 0.0017 0.0000024804 0.0000024804
Brugia malayi Proteasome A-type and B-type family protein 0.0354 0.6156 0.6156
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0685 0.1112
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0189 0.0307
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0119 0.1868 0.3035
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0124 0.1959 0.3183
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0125 0.1985 0.3224
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0124 0.1951 0.317
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0128 0.2038 0.331
Echinococcus granulosus proteasome subunit beta type 6 0.0124 0.1966 0.3194
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0259 0.0421
Brugia malayi Trypsin family protein 0.0032 0.0285 0.0285
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0114 0.1782 0.2895
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0372 0.0605
Loa Loa (eye worm) hypothetical protein 0.0054 0.0685 0.0685
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0209 0.0209
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.011 0.1707 0.2772
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0012
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0166 0.2733 0.2733
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0037 0.0372 0.0605
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0143 0.2301 0.3738
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0135 0.2153 0.3498
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0134 0.2138 0.3473
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0135 0.2153 0.3498
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0209 0.034
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0189 0.0307
Brugia malayi hypothetical protein 0.0032 0.0285 0.0285
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0037 0.0372 0.0605
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0189 0.0307
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0028 0.0209 0.034
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0146 0.2364 0.2364
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0118 0.1842 0.2992
Brugia malayi Uncoordinated protein 44 0.0031 0.0257 0.0257
Onchocerca volvulus 0.0017 0.0007 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0189 0.0189
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0354 0.6156 1
Giardia lamblia Proteasome subunit beta type 1 0.0143 0.2301 0.3738
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0119 0.1868 0.3035
Brugia malayi Death domain containing protein 0.0031 0.0257 0.0257
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0017 0.0009 0.0014
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0169 0.0274
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0125 0.1985 0.3224
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0685 0.1112
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0257 0.0418
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0166 0.2733 0.4441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0189 0.0189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0189 0.0307
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0166 0.027
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0169 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0189 0.0189
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0257 0.0418
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0196 0.0196
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0081 0.1177 0.1176
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0166 0.2733 0.4441
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0189 0.0189
Schistosoma mansoni carbonic anhydrase 0.0054 0.0685 0.1112
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0189 0.0307
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0124 0.1966 0.1966
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0017 0.0009 0.0014
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0027 0.0044
Giardia lamblia 20S proteasome alpha subunit 7 0.0125 0.1985 0.3224
Toxoplasma gondii proteasome subunit alpha type, putative 0.007 0.0975 0.1584
Toxoplasma gondii heat shock protein hslv, putative 0.0096 0.1451 0.2357
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0017 0.0009 0.0014
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0017 0.0009 0.0014
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0134 0.2138 0.3473
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0028 0.0209 0.034
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0124 0.1951 0.317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0189 0.0189
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0028 0.0211 0.0343
Loa Loa (eye worm) trypsin family protein 0.0032 0.0285 0.0285
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0125 0.1985 0.3224
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0134 0.2138 0.3473
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0017 0.0009 0.0014
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0114 0.1782 0.2895
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0037 0.0372 0.0372
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0114 0.1782 0.2895
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0075 0.1067 0.1733
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0052 0.0635 0.3198
Entamoeba histolytica proteasome regulatory subunit, putative 0.0018 0.0027 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0189 0.0307
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0017 0.0009 0.0014
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0125 0.1985 0.3224
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0257 0.0257
Brugia malayi proteasome subunit alpha type 1 0.0124 0.1951 0.1951
Loa Loa (eye worm) hypothetical protein 0.0054 0.0685 0.0685
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.0307 0.0499
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0028 0.0045
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0145 0.0235
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0335 0.0544
Schistosoma mansoni hypothetical protein 0.0054 0.0685 0.1112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0189 0.0189
Brugia malayi ecdysteroid receptor 0.0027 0.0189 0.0189
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0096 0.1451 0.2357
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0031 0.0264 0.0264
Plasmodium falciparum proteasome subunit beta type-4 0.0118 0.1842 0.2992
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0189 0.0307
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0119 0.1868 0.3035
Toxoplasma gondii proteasome subunit alpha type, putative 0.0124 0.1959 0.3183
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0135 0.2153 0.3498
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0166 0.027
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0134 0.2138 0.3473
Leishmania major proteasome alpha 1 subunit, putative 0.0135 0.2153 0.3498
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0031 0.0264 0.0429
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0125 0.1985 0.3224
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0134 0.2138 0.2138
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0166 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0189 0.0307
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0145 0.0235
Loa Loa (eye worm) proteasome subunit beta type 1 0.0143 0.2301 0.2301
Echinococcus granulosus Mastin 0.0032 0.0285 0.0462
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0298 0.0484
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0017 0.0009 0.0014
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0032 0.0285 0.0285
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0166 0.027
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0685 0.0685
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0028 0.0045
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0124 0.1959 0.3183
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0145 0.0145
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0037 0.0372 0.0605
Brugia malayi nuclear hormone receptor 0.0027 0.0189 0.0189
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0134 0.2138 0.3473
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0124 0.1951 0.317
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0257 0.1296
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0145 0.0235
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0125 0.1985 0.3224
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0354 0.6156 1
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0119 0.1868 0.3035
Brugia malayi steroid hormone receptor 0.0027 0.0189 0.0189
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0257 0.0418
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0124 0.1951 0.1951
Brugia malayi hypothetical protein 0.0035 0.0335 0.0335
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0189 0.0307
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0026 0.0169 0.0169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0096 0.1451 0.2357
Giardia lamblia 26S protease regulatory subunit 6A 0.0018 0.0028 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0189 0.0189
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0028 0.0211 0.0343
Echinococcus granulosus proteasome prosome macropain 0.0354 0.6156 1
Toxoplasma gondii PCI domain-containing protein 0.0034 0.0307 0.0499
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0189 0.0307
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0007 0.0012
Onchocerca volvulus 0.0032 0.0285 0.1434
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0028 0.0211 0.0343
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0028 0.0211 0.0343
Brugia malayi Proteasome subunit alpha type 7-1 0.0166 0.2733 0.2733
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0209 0.034
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0307 0.0499
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0189 0.0307
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0189 0.0189
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0033 0.0298 0.0484
Leishmania major proteasome alpha 7 subunit, putative 0.0166 0.2733 0.4441
Plasmodium vivax proteasome subunit beta type-6, putative 0.0124 0.1966 0.3194
Plasmodium vivax proteasome subunit beta type-5, putative 0.0354 0.6156 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0028 0.0211 0.0343
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0026 0.0169 0.0274
Echinococcus granulosus carbonic anhydrase 0.0054 0.0685 0.1112
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0018 0.0028 0.0028
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0354 0.6156 0.6156
Brugia malayi Proteasome A-type and B-type family protein 0.0317 0.549 0.549
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0166 0.027
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0135 0.2153 0.3498
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0032 0.0285 0.0462
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0009 0.0014
Onchocerca volvulus 0.0032 0.0285 0.1434
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0189 0.0189
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0146 0.2364 0.2364
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0033 0.0298 0.0484
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0146 0.2364 0.384
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0189 0.0951
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0075 0.1067 0.1733
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0302 0.5212 0.8467
Giardia lamblia 20S proteasome alpha subunit 1 0.0135 0.2153 0.3498
Leishmania major proteasome alpha 1 subunit, putative 0.0124 0.1951 0.317
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0189 0.0307
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0166 0.027
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0354 0.6156 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0189 0.0189
Giardia lamblia 26S protease regulatory subunit 6B 0.0017 0.0009 0.0014
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0124 0.1959 0.3183
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0134 0.2138 0.3473
Schistosoma mansoni hypothetical protein 0.0032 0.0285 0.0462
Loa Loa (eye worm) hypothetical protein 0.0025 0.0145 0.0145
Echinococcus granulosus proteasome subunit beta type 7 0.0317 0.549 0.8919
Brugia malayi Probable 26S protease regulatory subunit 4 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0145 0.0145
Giardia lamblia Proteasome subunit beta type 2 0.0119 0.1868 0.3035
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0124 0.1959 0.3183
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0166 0.0166
Brugia malayi proteasome subunit alpha type 2 0.0128 0.2038 0.2037
Echinococcus granulosus proteasome subunit beta t family 0.0119 0.1868 0.3035
Giardia lamblia Proteasome subunit beta type 3 0.0119 0.1868 0.3035
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0096 0.1451 0.2357
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0119 0.1868 0.3035
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0354 0.6156 1
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0017 0.0009 0.0014
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0145 0.0235
Loa Loa (eye worm) PCI domain-containing protein 0.0028 0.0211 0.0211
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0018 0.0027 0.0044
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0114 0.1782 0.2895
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0135 0.2153 0.3498
Echinococcus granulosus geminin 0.0165 0.2717 0.4413
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0166 0.2733 0.4441
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0027 0.0044
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0298 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0189 0.0189
Schistosoma mansoni coup transcription factor 0.0027 0.0189 0.0307
Schistosoma mansoni 26S protease regulatory subunit 0.0017 0.0009 0.0014
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0018 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0189 0.0307
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0335 0.0544
Loa Loa (eye worm) RPN-3 protein 0.0034 0.0307 0.0307
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.1842 0.2992
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0209 0.034
Echinococcus granulosus carbonic anhydrase II 0.0146 0.2364 0.384
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0124 0.1966 0.3194
Plasmodium vivax proteasome subunit beta type-7, putative 0.0114 0.1782 0.2895
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0189 0.0307
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.0544
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0118 0.1842 0.2992
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0007 0.0012
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0685 0.0684
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0017 0.0007 0.0007
Echinococcus granulosus proteasome subunit alpha type 6 0.0135 0.2153 0.3498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0189 0.0189
Brugia malayi proteasome subunit beta type 2 0.0119 0.1868 0.1868
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0143 0.2301 0.3738
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0166 0.2733 0.4441
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0017 0.0009 0.0014
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0685 0.1112
Echinococcus multilocularis proteasome subunit beta type 7 0.0317 0.549 0.8919
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.1966 0.3194
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0018 0.0028 0.0045
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0026 0.0169 0.0274
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0018 0.0028 0.0045
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0128 0.2038 0.331
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0166 0.027
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0166 0.027
Leishmania major carbonic anhydrase-like protein 0.0146 0.2364 0.384
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0145 0.0235
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0017 0.0009 0.0014
Plasmodium vivax proteasome subunit beta type-1, putative 0.0143 0.2301 0.3738
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0354 0.6156 1
Echinococcus granulosus glycoprotein Antigen 5 0.0032 0.0285 0.0462
Plasmodium vivax proteasome subunit beta type-3, putative 0.0119 0.1868 0.3035
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0018 0.0027 0.0044
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0354 0.6156 1
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0119 0.1868 0.3035
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0166 0.027
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0145 0.0235
Brugia malayi 20S proteasome alpha5 subunit 0.0134 0.2138 0.2138
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0685 0.1112
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0028 0.0211 0.0343
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0128 0.2038 0.331
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0189 0.0307
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0026 0.0169 0.0274
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0037 0.0372 0.0605
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0189 0.0307
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0134 0.2138 0.3473
Toxoplasma gondii hypothetical protein 0.0023 0.011 0.0179
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0007 0.0007
Echinococcus granulosus enteropeptidase 0.0032 0.0285 0.0462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0259 0.0259
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.0307 0.0499
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0096 0.1451 0.5
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.0307 0.0499
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0114 0.1782 0.2895
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0124 0.1959 0.3183
Leishmania major hypothetical protein, conserved 0.0017 0.0007 0.0012
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0143 0.2301 0.3738
Brugia malayi proteasome subunit beta type 3 0.0119 0.1868 0.1868
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0189 0.0189
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0119 0.1868 0.3035
Loa Loa (eye worm) RPT-2 protein 0.0017 0.0009 0.0009
Plasmodium falciparum proteasome subunit beta type-5 0.0354 0.6156 1
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0119 0.1868 0.3035
Schistosoma mansoni netrin receptor unc5 0.0031 0.0257 0.0418
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0209 0.034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0189 0.0307
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0017 0.0009 0.0014
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0143 0.2301 0.3738
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0317 0.549 0.8919
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0081 0.1177 0.1911
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.0307 0.0499
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0166 0.2733 0.4441
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0124 0.1951 0.317
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0166 0.2733 0.4441
Giardia lamblia Hypothetical protein 0.0031 0.0264 0.0429
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.1842 0.2992
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0134 0.2138 0.3473
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0189 0.0189
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0017 0.0009 0.0014
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0017 0.0009 0.0014
Brugia malayi Proteasome A-type and B-type family protein 0.0124 0.1966 0.1966
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.1868 0.3035
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0372 0.0605
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0124 0.1951 0.317
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0145 0.0235
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0018 0.0028 0.0045
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0143 0.2301 0.3738
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0026 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0031 0.0257 0.0418
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0028 0.0211 0.0343
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0189 0.0307
Schistosoma mansoni hypothetical protein 0.0032 0.0285 0.0462
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0027 0.0044
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0032 0.0285 0.0462
Brugia malayi Trypsin family protein 0.0032 0.0285 0.0285
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0096 0.1451 0.2357
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0028 0.0209 0.034
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0033 0.0298 0.0484
Brugia malayi 26S proteasome subunit P45 family protein 0.0017 0.0009 0.0009
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0166 0.2733 0.4441
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0189 0.0189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0189 0.0307
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0169 0.0274
Schistosoma mansoni proteasome regulatory subunit-related 0.0028 0.0211 0.0343
Toxoplasma gondii hypothetical protein 0.0054 0.0685 0.1112
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0119 0.1868 0.3035
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0209 0.034
Giardia lamblia 20S proteasome alpha subunit 3 0.0124 0.1959 0.3183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0189 0.0189
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0017 0.0009 0.0014
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0145 0.0235
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0128 0.2038 0.2038
Echinococcus granulosus carbonic anhydrase 0.0054 0.0685 0.1112
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0026 0.0169 0.0169
Leishmania major proteasome alpha 7 subunit, putative 0.0125 0.1985 0.3224
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Schistosoma mansoni multiubiquitin binding protein S5a 0.0018 0.0027 0.0044
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0009 0.0014
Onchocerca volvulus 0.0032 0.0285 0.1434
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0372 0.0605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0189 0.0189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0189 0.0189
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0685 0.0684
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0114 0.1782 0.2895
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0118 0.1842 0.2992
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0027 0.0044
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0028 0.0045
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0145 0.0235
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0124 0.1959 0.3183
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.0264 0.0429
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0028 0.0211 0.0343
Loa Loa (eye worm) hypothetical protein 0.0564 1 1
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0025 0.0153 0.0248
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0209 0.034
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.0264 0.0429
Schistosoma mansoni hypothetical protein 0.0075 0.1067 0.1733
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0124 0.1966 0.3194
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.0307 0.0307
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0169 0.0274
Leishmania major proteasome beta 2 subunit, putative 0.0114 0.1782 0.2895
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0028 0.0045
Echinococcus multilocularis geminin 0.0165 0.2717 0.4413
Leishmania major proteasome beta 3 subunit, putative 0.0119 0.1868 0.3035
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0685 0.0684
Echinococcus granulosus death domain containing protein 0.0031 0.0257 0.0418
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0028 0.0211 0.0343
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0031 0.0264 0.0429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0189 0.0307
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0026 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0081 0.1177 0.1177
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Onchocerca volvulus 0.0017 0.0009 0.0045
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0124 0.1951 0.317
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0114 0.1782 0.2895
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0257 0.0418
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0128 0.2038 0.331
Echinococcus multilocularis carbonic anhydrase II 0.0146 0.2364 0.384
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Brugia malayi Trypsin family protein 0.0032 0.0285 0.0285
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0125 0.1985 0.3224
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0128 0.2038 0.331
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0145 0.0235
Echinococcus granulosus transmembrane protease serine 3 0.0032 0.0285 0.0462
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0685 0.1112
Loa Loa (eye worm) hypothetical protein 0.0185 0.3066 0.3066
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0145 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0189 0.0189
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0285 0.0462
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0033 0.0298 0.0484
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0124 0.1966 0.3194
Brugia malayi proteasome subunit alpha type 3 0.0125 0.1985 0.1985
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0037 0.0372 0.0372
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0124 0.1959 0.3183
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0019 0.0047 0.0076
Schistosoma mansoni hypothetical protein 0.0026 0.0166 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0017 0.0009 0.0014
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.1868 0.3035
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0143 0.2301 0.3738
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0114 0.1782 0.2895
Toxoplasma gondii proteasome beta subunit 0.0119 0.1868 0.3035
Toxoplasma gondii proteasome regulatory subunit 0.0026 0.0169 0.0274
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0007 0.0012
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0124 0.1966 0.3194
Loa Loa (eye worm) proteasome regulatory particle 0.0031 0.0264 0.0264
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0124 0.1966 0.3194
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0285 0.0462
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.0544
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0119 0.1868 0.3035
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0018 0.0028 0.0045
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0189 0.0307
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0018 0.0028 0.0045
Leishmania major proteasome beta 2 subunit, putative 0.0119 0.1868 0.3035
Trypanosoma cruzi 20S proteasome subunit 0.0119 0.1868 0.3035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0285
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0018 0.0027 0.0044
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0031 0.0264 0.0429
Brugia malayi Proteasome subunit alpha type 1 0.011 0.1696 0.1696
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0028 0.0209 0.034
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0169 0.0274
Brugia malayi PCI domain containing protein 0.0026 0.0166 0.0166
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0146 0.2364 0.384
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0196 0.0319
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0119 0.1868 0.3035
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0134 0.2138 0.3473
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.1868 0.3035
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0118 0.1842 0.2992
Trypanosoma brucei carbonic anhydrase-like protein 0.0146 0.2364 0.384
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0189 0.0189
Leishmania major proteasome beta-1 subunit, putative 0.0124 0.1966 0.3194
Echinococcus multilocularis proteasome subunit alpha type 6 0.0135 0.2153 0.3498
Echinococcus granulosus Proteasome subunit alpha type 7 0.0166 0.2733 0.4441
Loa Loa (eye worm) carbonic anhydrase 3 0.0146 0.2364 0.2364
Leishmania major hypothetical protein, conserved 0.0042 0.0466 0.0756
Schistosoma mansoni hypothetical protein 0.0165 0.2717 0.4413
Brugia malayi Trypsin-like protease protein 5 0.0032 0.0285 0.0285
Onchocerca volvulus 0.0032 0.0285 0.1434
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0081 0.1177 0.1911
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0189 0.0307
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0125 0.1985 0.3224
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0189
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.0307 0.0499
Schistosoma mansoni hypothetical protein 0.0035 0.0335 0.0544
Leishmania major proteasome beta 5 subunit, putative 0.0354 0.6156 1
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0166 0.2733 0.4441
Brugia malayi proteasome subunit alpha type 4 0.011 0.1704 0.1704
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0166 0.2733 0.4441
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0135 0.2153 0.2153
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0118 0.1842 0.2992
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0018 0.003
Schistosoma mansoni hypothetical protein 0.005 0.0616 0.1
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0018 0.0028 0.0045
Echinococcus multilocularis Ankyrin 0.0031 0.0259 0.0421
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.0544
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0017 0.0009 0.0014
Toxoplasma gondii proteasome subunit 0.0124 0.1966 0.3194

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 200 uM Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 12 hr by CLSI broth microdilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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