Detailed information for compound 1796546

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.713 | Formula: C27H52N2O3
  • H donors: 1 H acceptors: 2 LogP: 9.76 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCC/C=C/N(C(=O)CCCCCCCCC)NC(=O)COC
  • InChi: 1S/C27H52N2O3/c1-4-6-8-10-12-13-14-15-16-18-20-22-24-29(28-26(30)25-32-3)27(31)23-21-19-17-11-9-7-5-2/h22,24H,4-21,23,25H2,1-3H3,(H,28,30)/b24-22+
  • InChiKey: HZOWHYHEDAUGGZ-ZNTNEXAZSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0085 0.0908 0.0908
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.0216 0.0216
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0133 0.1552 0.1768
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0157 0.1876 0.2153
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0107 0.0107
Giardia lamblia 20S proteasome alpha subunit 6 0.0162 0.194 0.2226
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0015 0.0018
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0164 0.1966 0.2256
Trypanosoma brucei proteasome beta 7 subunit 0.0155 0.1855 0.2129
Onchocerca volvulus 0.0034 0.0216 0.1096
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0019 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Leishmania major DNA polymerase eta, putative 0.005 0.0438 0.0503
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0107 0.0123
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0016 0.0019
Brugia malayi Death domain containing protein 0.0032 0.0194 0.0201
Trypanosoma brucei unspecified product 0.0022 0.005 0.0056
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0141 0.0146
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Mycobacterium ulcerans proteasome PrcA 0.0133 0.1552 0.1734
Schistosoma mansoni 26S proteasome subunit S9 0.0033 0.0199 0.0199
Echinococcus granulosus geminin 0.0174 0.2104 0.2104
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0141 0.0141
Schistosoma mansoni sodium/calcium exchanger 0.0758 1 1
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0019 0.0014 0.0015
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0016 0.0016
Echinococcus multilocularis carbonic anhydrase 0.0057 0.0526 0.0526
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2234
Leishmania major proteasome alpha 7 subunit, putative 0.0164 0.1966 0.2257
Brugia malayi proteasome subunit beta type 3 0.0157 0.1876 0.1946
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0157 0.1876 0.2153
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0133 0.1552 0.1552
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0162 0.194 0.194
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0126 0.0144
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0182 0.2212 0.2212
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0235 0.027
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0126 0.013
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0035 0.0226 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus granulosus carbonic anhydrase II 0.0153 0.183 0.183
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0126 0.0143
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0157 0.1876 0.2153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0196 0.0196
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0015 0.0016
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0126 0.0143
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0019 0.0014 0.0014
Schistosoma mansoni proteasome regulatory subunit-related 0.003 0.0159 0.0159
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0141 0.0141
Echinococcus granulosus proteasome prosome macropain 0.0663 0.871 0.871
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.005 0.0057
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0155 0.1855 0.2129
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0194 0.0194
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0141 0.0141
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0085 0.0908 0.0942
Echinococcus multilocularis proteasome subunit beta type 6 0.0162 0.1951 0.1951
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Onchocerca volvulus 0.0034 0.0216 0.1096
Schistosoma mansoni na/ca exchanger 0.0019 0.0014 0.0014
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0207 0.2547 0.2925
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0226 0.0259
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2924
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0141 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0141 0.0146
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0035 0.0226 0.0258
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0663 0.871 1
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0141 0.0141
Echinococcus granulosus proteasome subunit beta type 7 0.0731 0.9637 0.9637
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0035 0.0233 0.0266
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0157 0.1876 0.2152
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0141 0.0141
Toxoplasma gondii heat shock protein hslv, putative 0.0133 0.1552 0.1782
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0141 0.0146
Leishmania major DNA polymerase eta, putative 0.0035 0.0235 0.027
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0133 0.1552 0.1782
Brugia malayi Sodium/calcium exchanger protein 0.0303 0.3854 0.3999
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0254 0.0254
Onchocerca volvulus 0.0034 0.0216 0.1096
Brugia malayi PCI domain containing protein 0.003 0.0159 0.0164
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0663 0.871 1
Loa Loa (eye worm) proteasome subunit beta type 2 0.0157 0.1876 0.1876
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0155 0.1855 0.2129
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0182 0.2212 0.2538
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0133 0.1552 0.1782
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0157 0.1876 0.1876
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.008
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0016 0.0016
Toxoplasma gondii proteasome subunit beta type, putative 0.0663 0.871 1
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0164 0.1966 0.1966
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0033 0.0199 0.0229
Brugia malayi Proteasome subunit alpha type 1 0.0147 0.1742 0.1807
Loa Loa (eye worm) carbonic anhydrase 3 0.0153 0.183 0.183
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0155 0.1855 0.1855
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0016 0.0017
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0207 0.2547 0.2547
Leishmania major proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2234
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0107 0.0121
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0016 0.0017
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Plasmodium vivax proteasome subunit beta type-7, putative 0.0207 0.2558 0.2937
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0162 0.194 0.2226
Giardia lamblia 20S proteasome alpha subunit 7 0.0164 0.1966 0.2256
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0126 0.0143
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0016 0.0016
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0016 0.0016
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.1951 0.2239
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0126 0.0144
Echinococcus granulosus dna polymerase kappa 0.0022 0.005 0.005
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0107 0.0123
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.2212 0.2538
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.005 0.0056
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0019 0.0014 0.0015
Giardia lamblia Hypothetical protein 0.0033 0.0199 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.003 0.0159 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0141 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0016 0.0019
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0172 0.2085 0.2085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0141 0.0141
Echinococcus multilocularis proteasome (prosome, macropain) 0.0663 0.871 0.871
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1876 0.2152
Trypanosoma brucei proteasome alpha 7 subunit 0.0164 0.1966 0.2256
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0162 0.194 0.2226
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0016 0.0019
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0172 0.2085 0.2085
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0033 0.0199 0.0229
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0172 0.2085 0.2393
Schistosoma mansoni hypothetical protein 0.0079 0.0823 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0015
Echinococcus multilocularis dna polymerase eta 0.005 0.0438 0.0438
Toxoplasma gondii hypothetical protein 0.0024 0.008 0.0092
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0133 0.1552 0.178
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0157 0.0163
Toxoplasma gondii proteasome subunit alpha1, putative 0.0173 0.2097 0.2407
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0164 0.1966 0.2257
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0199 0.0229
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.0526 0.0546
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0207 0.2547 0.2924
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0035 0.0233 0.0268
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Schistosoma mansoni netrin receptor unc5 0.0032 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.0124 0.0124
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0173 0.2097 0.2097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.003 0.0159 0.0182
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Echinococcus granulosus nuclear factor of activated T cells 5 0.0317 0.4041 0.4041
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0124 0.0142
Loa Loa (eye worm) proteasome subunit beta type 3 0.0157 0.1876 0.1876
Loa Loa (eye worm) proteasome regulatory particle 0.0033 0.0199 0.0199
Brugia malayi Proteasome A-type and B-type family protein 0.0663 0.871 0.9038
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0126 0.0143
Giardia lamblia 20S proteasome alpha subunit 3 0.0162 0.1946 0.2233
Brugia malayi proteasome subunit beta type 2 0.0157 0.1876 0.1946
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0167 0.2007 0.2304
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0141 0.0141
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.0526 0.0526
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0162 0.1951 0.2239
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0039 0.0284 0.0326
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0164 0.1966 0.2256
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0207 0.2547 0.2924
Loa Loa (eye worm) hypothetical protein 0.0303 0.3854 0.3854
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0126 0.0126
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0001 0.0002
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0159 0.018
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0016 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0592 0.7759 0.7759
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0153 0.183 0.183
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0019 0.0014 0.0014
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0001 0.0002
Onchocerca volvulus 0.0018 0.0001 0.0007
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0164 0.1966 0.1966
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0001 0.0002
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.0124 0.0142
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0663 0.871 0.871
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0207 0.2558 0.2936
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0141 0.0141
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0162 0.1946 0.2233
Loa Loa (eye worm) proteasome Regulatory Particle 0.003 0.0157 0.0157
Onchocerca volvulus 0.0028 0.0141 0.0717
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0173 0.2097 0.2407
Leishmania major DNA polymerase kappa, putative 0.0022 0.005 0.0057
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0157 0.1876 0.2153
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2234
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0182 0.2212 0.2539
Toxoplasma gondii 26s proteasome subunit p55, putative 0.003 0.0159 0.0182
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.0216 0.0216
Leishmania major proteasome beta 3 subunit, putative 0.0157 0.1876 0.2153
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.003 0.0159 0.0182
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0001 0.0002
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.0216 0.0216
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0015 0.0016
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0107 0.0111
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0164 0.1966 0.2257
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.003 0.0157 0.018
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0663 0.871 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.0663 0.871 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0157 0.1876 0.2152
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0173 0.2097 0.2406
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0019 0.0009 0.0008
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0152 0.1809 0.2076
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0158 0.1887 0.1887
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0035 0.0226 0.0226
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0162 0.1951 0.224
Trichomonas vaginalis proteasome regulatory subunits, putative 0.003 0.0159 0.018
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0035 0.0233 0.0268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0085 0.0908 0.0908
Echinococcus granulosus Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0016 0.0019
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0162 0.194 0.194
Plasmodium vivax proteasome subunit beta type-3, putative 0.0157 0.1876 0.2153
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0194 0.2375 0.2464
Brugia malayi Uncoordinated protein 44 0.0032 0.0194 0.0201
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0019 0.0009 0.001
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.0159 0.0159
Brugia malayi PCI domain containing protein 0.0027 0.0124 0.0128
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0173 0.2097 0.2406
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0207 0.2558 0.2937
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0172 0.2085 0.2085
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0133 0.1552 0.1782
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0284 0.0326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0039 0.0284 0.0324
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0079 0.0823 0.0823
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.0526 0.0546
Trypanosoma brucei carbonic anhydrase-like protein 0.0153 0.183 0.2099
Treponema pallidum hypothetical protein 0.0019 0.0014 0.5
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0153 0.183 0.2101
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0162 0.1946 0.1946
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.0216 0.0216
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0157 0.018
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0157 0.0157
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0731 0.9637 0.9637
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.0216 0.0224
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0141 0.0141
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0035 0.0226 0.0259
Brugia malayi proteasome subunit alpha type 2 0.0167 0.2007 0.2083
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0155 0.1855 0.213
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.003 0.0157 0.0157
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0147 0.0152
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0035 0.0233 0.0242
Echinococcus granulosus Proteasome subunit alpha beta 0.0164 0.1966 0.1966
Schistosoma mansoni hypothetical protein 0.0027 0.0124 0.0124
Plasmodium falciparum carbonic anhydrase 0.0057 0.0526 0.0604
Leishmania major proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2407
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0153 0.183 0.1899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0141 0.0141
Loa Loa (eye worm) proteasome subunit beta type 1 0.0182 0.2212 0.2212
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0141 0.0146
Echinococcus granulosus Ankyrin 0.0033 0.0196 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Toxoplasma gondii PCI domain-containing protein 0.0033 0.0199 0.0229
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0141 0.0141
Giardia lamblia 20S proteasome alpha subunit 5 0.0172 0.2085 0.2393
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0033 0.0199 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0016 0.0016
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0147 0.0152
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0155 0.1855 0.1855
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2233
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.005 0.0041
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0107 0.0111
Echinococcus granulosus carbonic anhydrase 0.0057 0.0526 0.0526
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0157 0.1876 0.1876
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0031 0.0034
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0162 0.1951 0.2239
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0126 0.013
Brugia malayi proteasome subunit alpha type 6 0.0173 0.2097 0.2176
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0162 0.1946 0.2234
Leishmania major proteasome alpha 2 subunit, putative 0.0167 0.2007 0.2304
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Brugia malayi proteasome subunit alpha type 4 0.0147 0.1748 0.1814
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0194 0.0194
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0167 0.2007 0.2304
Leishmania major carbonic anhydrase-like protein 0.0153 0.183 0.2101
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0194 0.2375 0.2375
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0182 0.2212 0.2539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0141 0.0141
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0001 0.0002
Brugia malayi steroid hormone receptor 0.0028 0.0141 0.0146
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0124 0.0142
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0039 0.0284 0.0324
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0199 0.0227
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0141 0.0141
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0164 0.1966 0.1966
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1876 0.2152
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Toxoplasma gondii proteasome subunit 0.0162 0.1951 0.224
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0107 0.0121
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0182 0.2212 0.2539
Echinococcus granulosus dna polymerase eta 0.005 0.0438 0.0438
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0172 0.2085 0.2393
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0153 0.183 0.1899
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0141 0.0141
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.0124 0.0124
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0167 0.2007 0.2304
Brugia malayi Proteasome subunit alpha type 7-1 0.0207 0.2547 0.2643
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0026 0.0107 0.0121
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0035 0.0226 0.0226
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0019 0.0014 0.0074
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0001 0.0001
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0173 0.2097 0.2407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0001 0.0001
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.0526 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2393
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0162 0.194 0.2227
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.0216 0.0216
Echinococcus granulosus proteasome subunit alpha type 6 0.0173 0.2097 0.2097
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0317 0.4041 0.4041
Plasmodium vivax cation/H+ antiporter, putative 0.0019 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0194
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0182 0.2212 0.2212
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.003 0.0157 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Onchocerca volvulus 0.0034 0.0216 0.1096
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0162 0.194 0.194
Echinococcus granulosus death domain containing protein 0.0032 0.0194 0.0194
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0153 0.183 0.183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0019 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0001 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0141 0.0141
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0124 0.0142
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0199 0.0199
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0162 0.1946 0.1946
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0173 0.2097 0.2097
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0134 0.1563 0.1793
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0015
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0133 0.1552 0.178
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0126 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0107
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0157 0.1876 0.1876
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0141 0.0146
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0167 0.2007 0.2007
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0167 0.2007 0.2304
Toxoplasma gondii PCI domain-containing protein 0.0035 0.0233 0.0268
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0141 0.0141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0141 0.0141
Toxoplasma gondii proteasome subunit alpha type, putative 0.0162 0.1946 0.2234
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Leishmania major proteasome beta 5 subunit, putative 0.0663 0.871 1
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0033 0.0199 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0056
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0016 0.0017
Schistosoma mansoni hypothetical protein 0.0174 0.2104 0.2104
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0001 0.0002
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0126 0.0143
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0141 0.0141
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0126 0.0144
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.005 0.005
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2925
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0039 0.0284 0.0324
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0107 0.0123
Trypanosoma cruzi 20S proteasome subunit 0.0157 0.1876 0.2153
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.003 0.0159 0.018
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0157 0.1876 0.2153
Brugia malayi nuclear hormone receptor 0.0028 0.0141 0.0146
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0107 0.0121
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0057 0.0526 0.0526
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0663 0.871 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0141 0.0141
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Plasmodium vivax proteasome subunit beta type-1, putative 0.0182 0.2212 0.2539
Brugia malayi small heat shock protein 0.0592 0.7759 0.8051
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0162 0.1946 0.2234
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.0526 0.0546
Leishmania major proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2925
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0226 0.0259
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0057 0.0526 0.0526
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0113 0.013
Echinococcus multilocularis proteasome subunit beta type 7 0.0731 0.9637 0.9637
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.003 0.0157 0.0179
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0001 0.0002
Leishmania major hypothetical protein, conserved 0.0044 0.0356 0.0409
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0126 0.0144
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0207 0.2558 0.2558
Brugia malayi 20S proteasome alpha5 subunit 0.0172 0.2085 0.2164
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0133 0.1552 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0216 0.0216
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.003 0.0159 0.0182
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Echinococcus granulosus carbonic anhydrase 0.0057 0.0526 0.0526
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.0526 0.0526
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Schistosoma mansoni carbonic anhydrase 0.0057 0.0526 0.0526
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.0526 0.0546
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0526 0.0526
Toxoplasma gondii manganese resistance 1 protein, putative 0.0019 0.0014 0.0017
Brugia malayi Proteasome A-type and B-type family protein 0.0155 0.1855 0.1925
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0207 0.2547 0.2547
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0126 0.0144
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0016 0.0016
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0157 0.1876 0.1876
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0056
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0001 0.0001
Echinococcus granulosus carbonic anhydrase 0.0057 0.0526 0.0526
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0016 0.0017
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0134 0.1563 0.1793
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.0124 0.014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0141 0.0146
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0162 0.194 0.194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0162 0.194 0.2226
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0182 0.2212 0.2212
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0157 0.1876 0.2152
Brugia malayi ecdysteroid receptor 0.0028 0.0141 0.0146
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0172 0.2085 0.2394
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.005 0.005
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1876 0.2152
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0663 0.871 1
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0141 0.0146
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0141 0.0141
Brugia malayi Trypsin-like protease protein 5 0.0034 0.0216 0.0224
Echinococcus granulosus enteropeptidase 0.0034 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0107
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0039 0.0284 0.0294
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0167 0.2007 0.2007
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0172 0.2085 0.2393
Leishmania major proteasome alpha 1 subunit, putative 0.0162 0.194 0.2227
Echinococcus multilocularis geminin 0.0174 0.2104 0.2104
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0172 0.2085 0.2394
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0141 0.0146
Plasmodium falciparum proteasome subunit beta type-5 0.0663 0.871 1
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.003 0.0157 0.018
Onchocerca volvulus 0.0018 0.0001 0.0007
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0029 0.0147 0.0147
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0079 0.0823 0.0823
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0194 0.0201
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0207 0.2558 0.2936
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0015 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.005 0.0052
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0199 0.0229
Loa Loa (eye worm) solute carrier family 8 0.0758 1 1
Schistosoma mansoni hypothetical protein 0.0053 0.0472 0.0472
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0016 0.0019
Giardia lamblia 20S proteasome alpha subunit 1 0.0173 0.2097 0.2406
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0157 0.1876 0.1876
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0107 0.0123
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0001 0.0002
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0126 0.0144
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0019 0.0014 0.0014
Echinococcus multilocularis adhesion regulating molecule 1 0.0085 0.0908 0.0908
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0167 0.2007 0.2303
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0207 0.2547 0.2924
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0019 0.0014 0.0015
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0133 0.1552 0.1782
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0194 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0141 0.0146
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0157 0.0179
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Leishmania major proteasome beta 7 subunit, putative 0.0155 0.1855 0.213
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0015 0.0015
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0162 0.194 0.2227
Echinococcus multilocularis proteasome subunit alpha type 2 0.0167 0.2007 0.2007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0057 0.0526 0.0526
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0126 0.0144
Brugia malayi Proteasome A-type and B-type family protein 0.0162 0.1951 0.2025
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0141 0.0717
Onchocerca volvulus Notchless protein homolog 0.0164 0.1966 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0141 0.0141
Loa Loa (eye worm) PAS-3 protein 0.0147 0.1748 0.1748
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0157 0.0179
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0153 0.183 0.2101
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0167 0.2007 0.2303
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.0124 0.014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.003 0.0157 0.018
Echinococcus multilocularis Ankyrin 0.0033 0.0196 0.0196
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0044 0.0356 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0141 0.0146
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0162 0.1951 0.224
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Toxoplasma gondii proteasome 26S regulatory subunit 0.0019 0.0009 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0438 0.0454
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0141 0.0141
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.003 0.0159 0.0182
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Echinococcus multilocularis Mastin 0.0034 0.0216 0.0216
Echinococcus multilocularis carbonic anhydrase II 0.0153 0.183 0.183
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.003 0.0157 0.0179
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0182 0.2212 0.2539
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0153 0.183 0.183
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0162 0.1951 0.1951
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0126 0.0126
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0157 0.1876 0.1876
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0284 0.0326
Schistosoma mansoni hypothetical protein 0.0037 0.0254 0.0254
Entamoeba histolytica hypothetical protein 0.0035 0.0226 0.0258
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0148 0.175 0.2008
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0162 0.1951 0.224
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0001 0.0001
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0207 0.2547 0.2925
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0085 0.0908 0.1042
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.0124 0.014
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0001 0.0002
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0019 0.0014 0.0014
Echinococcus granulosus Mastin 0.0034 0.0216 0.0216
Loa Loa (eye worm) RPN-3 protein 0.0035 0.0233 0.0233
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2925
Giardia lamblia Proteasome subunit beta type 1 0.0182 0.2212 0.2538
Onchocerca volvulus 0.0034 0.0216 0.1096
Echinococcus granulosus proteasome subunit alpha type 2 0.0167 0.2007 0.2007
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.0216 0.0216
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0039 0.0284 0.0284
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.0438 0.0501
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0141 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0141 0.0141
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0031 0.0034
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0001 0.0002
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0155 0.1855 0.213
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0015 0.0015
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0107 0.0121
Mycobacterium ulcerans hypothetical protein 0.0034 0.0216 0.0191
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Onchocerca volvulus 0.0034 0.0216 0.1096
Echinococcus multilocularis proteasome subunit alpha type 6 0.0173 0.2097 0.2097
Toxoplasma gondii proteasome beta subunit 0.0157 0.1876 0.2153
Schistosoma mansoni hypothetical protein 0.0032 0.0194 0.0194
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0141 0.0141
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.005 0.0041
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0035 0.0233 0.0268
Brugia malayi Proteasome A-type and B-type family protein 0.0731 0.9637 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Brugia malayi hypothetical protein 0.0037 0.0254 0.0264
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0162 0.1946 0.2233
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Giardia lamblia Proteasome subunit beta type 2 0.0157 0.1876 0.2152
Mycobacterium ulcerans proteasome PrcB 0.0663 0.871 1
Schistosoma mansoni DNA polymerase eta 0.005 0.0438 0.0438
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0172 0.2085 0.2085
Schistosoma mansoni hypothetical protein 0.0194 0.2375 0.2375
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0014
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0016 0.0019
Plasmodium vivax proteasome subunit beta type-2, putative 0.0157 0.1876 0.2153
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0039 0.0284 0.0326
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.005 0.0056
Plasmodium falciparum cation/H+ antiporter 0.0019 0.0014 0.0017
Giardia lamblia Proteasome subunit beta type 3 0.0157 0.1876 0.2152
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0141 0.0717
Brugia malayi proteasome subunit alpha type 3 0.0164 0.1966 0.204
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0663 0.871 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0157 0.1876 0.1876
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0157 0.1876 0.2152
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0162 0.194 0.2227
Echinococcus multilocularis carbonic anhydrase 0.0057 0.0526 0.0526
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0155 0.1855 0.1855
Giardia lamblia 20S proteasome alpha subunit 4 0.0207 0.2547 0.2924
Toxoplasma gondii SAC3/GANP family protein 0.0026 0.0107 0.0123
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0141 0.0146
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0164 0.1966 0.2257
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0207 0.2558 0.2936
Loa Loa (eye worm) trypsin family protein 0.0034 0.0216 0.0216
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0001 0.0001
Echinococcus granulosus proteasome subunit beta t family 0.0157 0.1876 0.1876
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0162 0.1951 0.2239
Brugia malayi proteasome subunit alpha type 1 0.0162 0.194 0.2013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0164 0.1966 0.2256
Echinococcus multilocularis enteropeptidase 0.0034 0.0216 0.0216
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.003 0.0159 0.0159
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.0124 0.0124
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0164 0.1966 0.2257
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0141 0.0146
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0157 0.1876 0.2153
Giardia lamblia 20S proteasome alpha subunit 2 0.0167 0.2007 0.2303
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0207 0.2558 0.2937
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0194 0.0194
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0029 0.0147 0.0167
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Plasmodium vivax proteasome subunit beta type-6, putative 0.0162 0.1951 0.224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0141 0.0146
Schistosoma mansoni hypothetical protein 0.0174 0.2104 0.2104
Toxoplasma gondii proteasome subunit alpha type, putative 0.0074 0.0752 0.0863
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.0028 0.0141 0.0146
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0001 0.0002
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0194 0.0194
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Brugia malayi hypothetical protein 0.0034 0.0216 0.0224
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.003 0.0157 0.018
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0155 0.1855 0.2129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.0216 0.0216
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2407
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0054 0.0487 0.2478
Plasmodium vivax proteasome subunit beta type-4, putative 0.0155 0.1855 0.213
Echinococcus multilocularis carbonic anhydrase 0.0057 0.0526 0.0526
Toxoplasma gondii hypothetical protein 0.0057 0.0526 0.0604
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0155 0.1855 0.1855
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.0526 0.0546
Echinococcus granulosus adhesion regulating molecule 1 0.0085 0.0908 0.0908
Leishmania major proteasome beta-1 subunit, putative 0.0162 0.1951 0.224
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0235 0.027
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0233 0.0266
Giardia lamblia DINP protein human, muc B family 0.0022 0.005 0.0056
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2407
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0141 0.0717
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0015 0.0015
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0663 0.871 0.871
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0207 0.2558 0.2936
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0254 0.0254
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0126 0.0144
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0162 0.1951 0.1951
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0199 0.0199
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0663 0.871 1
Echinococcus multilocularis dna polymerase kappa 0.0022 0.005 0.005
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.005 0.005
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0133 0.1552 0.1768
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0152 0.1809 0.2075
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0033 0.0199 0.0227
Echinococcus multilocularis sodium calcium exchanger 0.0758 1 1
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0182 0.2212 0.2539
Plasmodium falciparum proteasome subunit beta type-4 0.0155 0.1855 0.213
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0016 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0438 0.0503
Leishmania major proteasome beta 2 subunit, putative 0.0207 0.2558 0.2937
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0001 0.0001
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0107 0.0107
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0133 0.1552 0.1782
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0207 0.2558 0.2937
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0141 0.0146
Schistosoma mansoni coup transcription factor 0.0028 0.0141 0.0141
Toxoplasma gondii PCI domain-containing protein 0.0027 0.0124 0.0142
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0141 0.0141
Toxoplasma gondii peptidase, T1 family protein 0.0164 0.1966 0.2257
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0194 0.0987
Loa Loa (eye worm) hypothetical protein 0.005 0.0438 0.0438
Trypanosoma brucei proteasome beta 6 subunit 0.0182 0.2212 0.2538
Echinococcus granulosus proteasome subunit beta type 6 0.0162 0.1951 0.1951
Leishmania major proteasome beta 2 subunit, putative 0.0157 0.1876 0.2153
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0663 0.871 1
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0194 0.0194
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2406
Brugia malayi Protein kinase domain containing protein 0.0032 0.0194 0.0201
Brugia malayi proteasome subunit beta type 1 0.0182 0.2212 0.2295
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0162 0.194 0.2227
Loa Loa (eye worm) hypothetical protein 0.0057 0.0526 0.0526
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0026 0.0107 0.0107
Echinococcus granulosus subfamily T1A non peptidase ue 0.0172 0.2085 0.2085
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0162 0.1946 0.1946
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0124 0.014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0126 0.0144
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0162 0.1946 0.2233
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 110.4 uM Cytotoxicity against human HeLa cells after 72 hrs by methylene blue staining ChEMBL. 24113061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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