Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0589 | 0.109 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0479 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.1337 | 0.1337 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0407 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1337 | 0.1337 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0304 | 0.0304 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.001 | 0.0052 | 0.0052 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.001 | 0.0052 | 0.0052 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.001 | 0.0052 | 0.0052 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0589 | 0.109 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0026 | 0.0589 | 0.0589 |
Onchocerca volvulus | 0.0026 | 0.0589 | 1 | |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.001 | 0.0052 | 0.0052 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.1337 | 0.1337 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.001 | 0.0052 | 0.0052 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0661 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0224 | 0.0224 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0356 | 0.0356 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0067 | 0.1997 | 0.1997 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0224 | 0.0224 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.0356 | 0.0617 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0589 | 0.109 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0304 | 0.0304 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.001 | 0.0052 | 0.0052 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0837 | 0.1593 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.1997 | 0.1997 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1589 | 0.1589 |
Schistosoma mansoni | serine/threonine kinase | 0.001 | 0.0052 | 0.0052 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.1745 | 0.1745 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1365 | 0.2665 |
Echinococcus granulosus | carboxylesterase 5A | 0.0153 | 0.4979 | 0.4979 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0052 | 0.0052 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.4979 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.001 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Schistosoma mansoni | gliotactin | 0.0026 | 0.0589 | 0.0589 |
Onchocerca volvulus | 0.0026 | 0.0589 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.4979 | 0.4979 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0407 | 0.5818 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0479 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.001 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1365 | 0.1365 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0837 | 0.0837 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.4979 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 0.1997 | 0.1997 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.001 | 0.0052 | 0.0052 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0153 | 0.4979 | 0.4979 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0661 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1365 | 0.2665 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0224 | 0.035 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0026 | 0.0589 | 0.0589 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0026 | 0.0589 | 0.0589 |
Onchocerca volvulus | 0.0026 | 0.0589 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0026 | 0.0589 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.001 | 0.0052 | 0.0052 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0052 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0224 | 0.0224 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1365 | 0.1365 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0661 | 0.0661 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.4979 | 0.4979 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0407 | 0.0407 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0407 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0026 | 0.0589 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0661 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0407 | 0.8307 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0026 | 0.0589 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0661 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0026 | 0.0589 | 0.5 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0407 | 0.0407 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0479 | 0.7981 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.4979 | 0.4979 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0661 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0153 | 0.4979 | 0.4979 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0224 | 0.0224 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.001 | 0.0052 | 0.0052 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.001 | 0.0052 | 0.0052 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.1337 | 0.1337 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.4979 | 0.4979 |
Loa Loa (eye worm) | carboxylesterase | 0.0026 | 0.0589 | 0.0589 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.001 | 0.0052 | 0.0052 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0407 | 0.6654 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0224 | 0.0224 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0026 | 0.0589 | 0.0589 |
Schistosoma mansoni | ran | 0.0021 | 0.0407 | 0.0407 |
Schistosoma mansoni | serine/threonine protein kinase | 0.001 | 0.0052 | 0.0052 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0224 | 0.0224 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Onchocerca volvulus | 0.0026 | 0.0589 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0661 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0224 | 0.0224 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0407 | 0.0407 |
Schistosoma mansoni | ran | 0.0021 | 0.0407 | 0.0407 |
Schistosoma mansoni | acetylcholinesterase | 0.0026 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.001 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | carboxylesterase | 0.0026 | 0.0589 | 0.0589 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0589 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.1997 | 0.1997 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.4979 | 0.4979 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0026 | 0.0589 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0479 | 0.7981 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.001 | 0.0052 | 0.0052 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0661 | 0.0661 |
Echinococcus multilocularis | neuroligin | 0.0026 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.001 | 0.0052 | 0.0052 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.4979 | 0.4979 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0407 | 0.5818 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.2441 | 0.4849 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.0589 | 0.0589 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0479 | 0.7981 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.1649 | 0.3241 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.1397 | 0.1397 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.001 | 0.0052 | 0.0052 |
Onchocerca volvulus | 0.0026 | 0.0589 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0224 | 0.0224 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0661 | 0.1237 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.0356 | 0.0356 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.1745 | 0.1745 |
Echinococcus granulosus | neuroligin | 0.0026 | 0.0589 | 0.0589 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0224 | 0.035 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.001 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.4979 | 0.4979 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0052 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0661 | 0.0661 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.0589 | 0.109 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0026 | 0.0589 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.4979 | 0.4979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.