Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3361 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3361 | 1 |
Brugia malayi | glutathione reductase | 0.0053 | 0.2299 | 0.684 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3361 | 0.3361 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0135 | 0.7701 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0135 | 0.7701 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.6806 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3361 | 0.3361 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.2299 | 0.684 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3361 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.6806 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.2299 | 0.684 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.2299 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3361 | 0.3361 |
Treponema pallidum | NADH oxidase | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.2299 | 1 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3361 | 1 |
Leishmania major | trypanothione reductase | 0.0053 | 0.2299 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.2299 | 0.2985 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.2299 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.6806 | 0.8837 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3361 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3361 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.2299 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.2299 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3361 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.2299 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.2299 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3361 | 0.3361 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3361 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.6806 | 0.8837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3361 | 0.3361 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0135 | 0.7701 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.2299 | 0.684 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.6806 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0135 | 0.7701 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 11 mm | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition at 1.56 to 25 ug/mL | ChEMBL. | No reference |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition by serial plate dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.