Detailed information for compound 1797232

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.73 | Formula: C18H20Cl3N3O
  • H donors: 1 H acceptors: 2 LogP: 5.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1ccc(c2c1nc1ccccc1c2)Cl)C.Cl.Cl
  • InChi: 1S/C18H18ClN3O.2ClH/c1-22(2)10-9-20-18(23)13-7-8-15(19)14-11-12-5-3-4-6-16(12)21-17(13)14;;/h3-8,11H,9-10H2,1-2H3,(H,20,23);2*1H
  • InChiKey: WZQUAPXKIQVNOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0133 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0336 0.0452
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus multilocularis geminin 0.0205 0.2429 0.2429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0133 0.0179
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0336 0.1088
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0273 0.428
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0171 0.0326
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0062 0.0091
Echinococcus multilocularis acetylcholinesterase 0.0142 0.1644 0.1644
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0058 0.0058
Echinococcus multilocularis neurogenic locus notch protein 0.0196 0.2322 0.2322
Toxoplasma gondii EGF family domain-containing protein 0.0196 0.2322 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0111 0.0149
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0103 0.1164 0.1565
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0133 0.0133
Echinococcus multilocularis dnaJ subfamily B 0.041 0.4985 0.4985
Brugia malayi Importin beta-1 subunit 0.0029 0.0242 0.0325
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0497 0.8833
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0173 0.2747
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0569 0.0569
Onchocerca volvulus Peroxidasin homolog 0.0607 0.7437 1
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2278 0.3063
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0003 0.0003
Brugia malayi hypothetical protein 0.0012 0.0029 0.0039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0133 0.0179
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0133 0.0179
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Schistosoma mansoni topbp1 0.0012 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0341 0.0459
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0336 0.0452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0439
Loa Loa (eye worm) hypothetical protein 0.0029 0.0242 0.0325
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0083
Schistosoma mansoni ap endonuclease 0.0019 0.0113 0.0152
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0336 0.585
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0273 0.7927
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0133 0.0179
Onchocerca volvulus Chorion peroxidase homolog 0.0607 0.7437 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0336 0.0452
Brugia malayi beta-lactamase family protein 0.0037 0.0336 0.0452
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0081 0.0992
Brugia malayi hypothetical protein 0.0011 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0004
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0111 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0497 1
Echinococcus granulosus protein jagged 2 0.0196 0.2322 0.3122
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0179 0.024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0111 0.0149
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0062 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0316 0.1015
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0062 0.07
Loa Loa (eye worm) hypothetical protein 0.0037 0.0341 0.0459
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0113 0.1602
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0497 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0497 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0062 0.0083
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0273 0.4637
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0113 0.0278
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0133 0.0133
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0341 0.1106
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0003 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0171 0.0489
Loa Loa (eye worm) animal heme peroxidase 0.0607 0.7437 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1393 0.1873
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Echinococcus multilocularis fat cadherin tumor suppressor 0.0196 0.2322 0.2322
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0062 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0196 0.2322 0.3122
Onchocerca volvulus 0.0015 0.0062 0.0083
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Echinococcus granulosus insulin growth factor binding 0.0577 0.7064 0.9498
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0497 0.1671
Onchocerca volvulus Slit protein homolog 0.0196 0.2322 0.3122
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2596 0.349
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0111 0.0149
Brugia malayi nuclear receptor NHR-88 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0019
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0179 0.024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0111 0.0149
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0196 0.2322 0.3122
Schistosoma mansoni importin beta-1 0.0029 0.0242 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0039
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0015 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0113 0.0113
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0273 0.1118
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.279 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0113 0.0152
Brugia malayi Animal haem peroxidase family protein 0.0607 0.7437 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Echinococcus multilocularis nibrin 0.0012 0.0029 0.0029
Echinococcus granulosus acetylcholinesterase 0.0142 0.1644 0.221
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0171 0.0171
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0111 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0003 0.0004
Brugia malayi MH2 domain containing protein 0.0144 0.1676 0.2254
Entamoeba histolytica hypothetical protein 0.0043 0.0422 0.0817
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0062 0.0205
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0171 0.023
Onchocerca volvulus 0.0015 0.0062 0.0083
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0111 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0341 0.6672
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Brugia malayi CXXC zinc finger family protein 0.0057 0.0594 0.0799
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0111 0.0111
Schistosoma mansoni notch 0.0196 0.2322 0.3122
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0113 0.0166
Brugia malayi Cadherin domain containing protein 0.0196 0.2322 0.3122
Schistosoma mansoni cpg binding protein 0.0061 0.0635 0.0853
Onchocerca volvulus 0.0024 0.0179 0.024
Entamoeba histolytica hypothetical protein 0.0043 0.0422 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0081 0.0992
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0062 0.07
Loa Loa (eye worm) notch protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) Notch2 0.0196 0.2322 0.3122
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0062 0.0624
Brugia malayi topoisomerase 0.0012 0.0029 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0133 0.0179
Echinococcus granulosus protein jagged 2 0.0196 0.2322 0.3122
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0171 0.0171
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0354 0.1471
Schistosoma mansoni septate junction protein 0.0196 0.2322 0.3122
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0133 0.0133
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0436 0.5307 0.7136
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0111 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2278 0.3063
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0173 0.4696
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0062 0.0083
Brugia malayi Carboxylesterase family protein 0.0024 0.0179 0.024
Schistosoma mansoni thyroid hormone receptor 0.002 0.0133 0.0179
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0273 0.7804
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0171 0.2707
Schistosoma mansoni coup transcription factor 0.002 0.0133 0.0179
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0179 0.024
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0133 0.0179
Brugia malayi GCC2 and GCC3 family protein 0.0196 0.2322 0.3122
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.1369 0.2672
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0111 0.0149
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0111 0.0149
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.026 0.7402
Echinococcus granulosus snurportin 1 0.0309 0.373 0.5015
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0436 0.5307 0.7136
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0015 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0014 0.0014
Giardia lamblia High cysteine protein 0.0196 0.2322 0.4514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0316 0.1015
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0111 0.0149
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0015 0.0015
Loa Loa (eye worm) animal heme peroxidase 0.0607 0.7437 1
Leishmania major hypothetical protein, conserved 0.003 0.026 0.4025
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0062 0.1066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0316 0.1015
Echinococcus granulosus smad 0.001 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0133 0.0179
Brugia malayi Carboxylesterase family protein 0.0024 0.0179 0.024
Echinococcus multilocularis smad 0.001 0.0003 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0113 0.0152
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0062 0.0091
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0113 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0111 0.0149
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0015 0.002
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0336 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0569 0.0765
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0015 0.002
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0081 0.0992
Brugia malayi Carboxylesterase family protein 0.0024 0.0179 0.024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0133 0.0179
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0062 0.0624
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0142 0.1644 0.221
Schistosoma mansoni topbp1 0.0012 0.0029 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Schistosoma mansoni peroxidasin 0.0607 0.7437 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0133 0.0179
Mycobacterium ulcerans beta-lactamase 0.0037 0.0336 0.6568
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0179 0.024
Brugia malayi N-terminal motif family protein 0.0218 0.2596 0.349
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2278 0.3063
Brugia malayi hypothetical protein 0.0607 0.7437 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0497 0.0668
Schistosoma mansoni flap endonuclease-1 0.0028 0.0235 0.0316
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0133 0.0133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0048 0.0475 0.0638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0569 0.0765
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.2278 0.3063
Onchocerca volvulus 0.0607 0.7437 1
Giardia lamblia DINP protein human, muc B family 0.0023 0.0171 0.028
Echinococcus granulosus neurogenic locus notch protein 0.0196 0.2322 0.3122
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0133 0.0133
Brugia malayi Cation transporter family protein 0.0018 0.0111 0.0149
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0051 0.0069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0111 0.0149
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.026 0.4398
Schistosoma mansoni hypothetical protein 0.0205 0.2429 0.3266
Brugia malayi Carboxylesterase family protein 0.0024 0.0179 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0111 0.0149
Mycobacterium ulcerans lipase LipD 0.0037 0.0336 0.6568
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0102 0.0137
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0111 0.0111
Onchocerca volvulus 0.0012 0.0029 0.0039
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Brugia malayi Delta serrate ligand family protein 0.0196 0.2322 0.3122
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0015 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0133 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0171 0.2707
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Brugia malayi DIX domain containing protein 0.0011 0.0015 0.002
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0336 0.9845
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0015 0.0015
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0005 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0497 0.0668
Echinococcus multilocularis fibropellin Ia 0.0196 0.2322 0.2322
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0497 0.8833
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0062 0.105
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0336 0.0336
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0058 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1757 0.2363
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0336 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0062 0.0091
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0354 0.619
Onchocerca volvulus 0.0018 0.0111 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0497 0.0668
Loa Loa (eye worm) hypothetical protein 0.0037 0.0336 0.0452
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.1644 0.221
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.0668
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0336 0.1088
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0113 0.2739
Loa Loa (eye worm) carboxylesterase 0.0024 0.0179 0.024
Echinococcus granulosus neural cadherin 0.0196 0.2322 0.3122
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0062 0.0083
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Loa Loa (eye worm) animal heme peroxidase 0.0607 0.7437 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0015 0.002
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0015 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0133 0.0179
Brugia malayi Peroxidasin 0.0607 0.7437 1
Onchocerca volvulus 0.0196 0.2322 0.3122
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0133 0.0179
Echinococcus granulosus carboxylesterase 5A 0.0142 0.1644 0.221
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0439
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0039
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Echinococcus granulosus geminin 0.0205 0.2429 0.3266
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0436 0.5307 0.7136
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0062 0.0205
Loa Loa (eye worm) blistered cuticle protein 3 0.0607 0.7437 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1676 0.2254
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0171 0.4627
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.0062 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Echinococcus granulosus neurogenic locus protein delta 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0015 0.0062 0.0083
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0171 0.2221
Onchocerca volvulus Putative cubilin 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0005 0.0006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0111 0.0149
Schistosoma mansoni ap endonuclease 0.0019 0.0113 0.0152
Schistosoma mansoni gliotactin 0.0024 0.0179 0.024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0594 0.0799
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0019
Brugia malayi Smad1 0.001 0.0003 0.0004
Echinococcus multilocularis neurogenic locus notch protein 4 0.0196 0.2322 0.2322
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0062 0.0091
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0004
Schistosoma mansoni notch 0.0196 0.2322 0.3122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0475 0.0638
Echinococcus granulosus dnaJ subfamily B 0.041 0.4985 0.6703
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0133 0.0179
Brugia malayi RNA binding protein 0.0192 0.2278 0.3063
Leishmania major DNA polymerase eta, putative 0.0038 0.0354 0.5936
Brugia malayi hypothetical protein 0.0024 0.0179 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0133 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0133 0.0179
Schistosoma mansoni DNA ligase IV 0.0012 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2278 0.3063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0336 0.1088
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Schistosoma mansoni acetylcholinesterase 0.0024 0.0179 0.024
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0111 0.0111
Brugia malayi Calcium binding EGF domain containing protein 0.0196 0.2322 0.3122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0475 0.0638
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0005 0.0006
Schistosoma mansoni notch 0.0196 0.2322 0.3122
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.373 0.5015
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.026 0.4398
Schistosoma mansoni insulin-like growth factor binding protein-related 0.0577 0.7064 0.9498
Schistosoma mansoni dep domain containing protein 0.0011 0.0015 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0058 0.0058
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0005 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0497 0.0964
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0062 0.0083
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0029 0.0063
Echinococcus multilocularis cpg binding protein 0.0061 0.0635 0.0635
Trichomonas vaginalis esterase, putative 0.0037 0.0336 1
Echinococcus granulosus protein jagged 1 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0054 0.0554 0.0745
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0111 0.0111
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0024 0.0179 0.4875
Onchocerca volvulus 0.0024 0.0179 0.024
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0179 0.024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0336 0.0452
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0273 0.0479
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0336 0.0452
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Echinococcus granulosus nAChR subunit 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0018 0.0111 0.0149
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0014 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0133 0.0179
Onchocerca volvulus 0.0018 0.0111 0.0149
Mycobacterium ulcerans hypothetical protein 0.0049 0.0497 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0242 0.4046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0133 0.0179
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Schistosoma mansoni hypothetical protein 0.0309 0.373 0.5015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0341 0.0459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0133 0.0179
Schistosoma mansoni hypothetical protein 0.0043 0.0422 0.0567
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0133 0.0179
Echinococcus granulosus fibropellin Ia 0.0196 0.2322 0.3122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0336 0.6568
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0058 0.0078
Trichomonas vaginalis spcc417.12 protein, putative 0.0024 0.0179 0.4875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0569 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0133 0.0179
Brugia malayi Cation transporter family protein 0.0018 0.0111 0.0149
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0003 0.0004
Loa Loa (eye worm) acetylcholinesterase 1 0.0142 0.1644 0.221
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus granulosus delta-like protein 1 0.0196 0.2322 0.3122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0173 0.4696
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0475 0.0638
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0111 0.0111
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0111 0.0149
Entamoeba histolytica hypothetical protein 0.0012 0.0029 0.0048
Echinococcus multilocularis protein jagged 1 0.0196 0.2322 0.2322
Onchocerca volvulus 0.0436 0.5307 0.7136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0422 0.0422
Echinococcus granulosus slit 2 protein 0.0196 0.2322 0.3122
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0111 0.0149
Entamoeba histolytica hypothetical protein 0.0119 0.1369 0.2672
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0196 0.2322 0.3122
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0171 0.3039
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Schistosoma mansoni laminin gamma-3 chain 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0111 0.0149
Brugia malayi hypothetical protein 0.003 0.026 0.035
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Echinococcus multilocularis GPCR, family 2 0.0048 0.0475 0.0475
Mycobacterium tuberculosis Carboxylesterase LipT 0.0024 0.0179 0.0516
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0019
Schistosoma mansoni hypothetical protein 0.0103 0.1164 0.1565
Onchocerca volvulus Peroxidase homolog 0.0607 0.7437 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0062 0.07
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0336 0.1088
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0062 0.0112
Loa Loa (eye worm) hypothetical protein 0.0436 0.5307 0.7136
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0497 0.8833
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1232 0.5274
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0057 0.0594 0.0799
Echinococcus granulosus Smad4 0.001 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0113 0.2739
Echinococcus granulosus neurogenic locus notch protein 0.0196 0.2322 0.3122
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0336 0.585
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0113 0.1602
Echinococcus granulosus tar DNA binding protein 0.0192 0.2278 0.3063
Schistosoma mansoni hypothetical protein 0.0205 0.2429 0.3266
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0014 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0111 0.0149
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1164 0.1565
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0554 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0005 0.0006
Brugia malayi notch-like transmembrane receptor 0.0196 0.2322 0.3122
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0111 0.0149
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0062 0.0083
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0336 0.1088
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0336 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0336 0.585
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0102 0.0137
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0029 0.0048
Onchocerca volvulus 0.0018 0.0111 0.0149
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0336 0.0452
Schistosoma mansoni Smad4 0.001 0.0003 0.0004
Plasmodium vivax importin-beta 2, putative 0.0029 0.0242 0.6808
Schistosoma mansoni DNA polymerase eta 0.0054 0.0554 0.0745
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0273 0.0273
Onchocerca volvulus Neurogenic locus notch homolog 0.0196 0.2322 0.3122
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0171 0.4627
Schistosoma mansoni cell polarity protein 0.0196 0.2322 0.3122
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0062 0.07
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0111 0.0149
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0336 0.0452
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0062 0.0624
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0111 0.0111
Echinococcus multilocularis neural cadherin 0.0196 0.2322 0.2322
Loa Loa (eye worm) hypothetical protein 0.0048 0.0475 0.0638
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0133 0.0179
Brugia malayi nuclear receptor RXR 0.0011 0.0014 0.0019
Onchocerca volvulus 0.0024 0.0179 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0554 0.0745
Loa Loa (eye worm) hypothetical protein 0.0436 0.5307 0.7136
Echinococcus multilocularis nAChR subunit 0.0018 0.0111 0.0111
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0014 0.0019
Echinococcus granulosus dna polymerase eta 0.0054 0.0554 0.0745
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0039
Echinococcus granulosus nibrin 0.0012 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0113 0.1602
Echinococcus granulosus flap endonuclease 1 0.0031 0.0273 0.0367
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0005 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Loa Loa (eye worm) carboxylesterase 0.0142 0.1644 0.221
Onchocerca volvulus 0.0607 0.7437 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0273 0.4637
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0062 0.07
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0436 0.5307 0.7136
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.0061 0.0635 0.0853
Toxoplasma gondii exonuclease III APE 0.0019 0.0113 0.0427
Echinococcus multilocularis neurogenic locus protein delta 0.0196 0.2322 0.2322
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Schistosoma mansoni hypothetical protein 0.0048 0.0475 0.0638
Brugia malayi beta-lactamase family protein 0.0037 0.0336 0.0452
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0015 0.002
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0111 0.0149
Brugia malayi Animal haem peroxidase family protein 0.0607 0.7437 1
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0015 0.002
Echinococcus multilocularis carboxylesterase 5A 0.0142 0.1644 0.1644
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1676 0.2254
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0039
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0015 0.002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0113 0.0152
Onchocerca volvulus 0.0037 0.0336 0.0452
Schistosoma mansoni cpg binding protein 0.0057 0.0594 0.0799
Loa Loa (eye worm) Smad1 0.001 0.0003 0.0004
Plasmodium falciparum importin beta, putative 0.0029 0.0242 0.6808
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0111 0.0149
Echinococcus multilocularis insulin growth factor binding 0.0577 0.7064 0.7064
Brugia malayi Carboxylesterase family protein 0.0142 0.1644 0.221
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus multilocularis peroxidasin 0.0607 0.7437 0.7437
Brugia malayi hypothetical protein 0.002 0.0126 0.0169
Echinococcus granulosus FTZ F1 alpha 0.002 0.0133 0.0179
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Echinococcus multilocularis neurogenic locus notch protein 0.0196 0.2322 0.2322
Onchocerca volvulus 0.0011 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0048 0.0475 0.0638
Giardia lamblia DNA repair protein RAD52 0.042 0.5109 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0003 0.0004
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Entamoeba histolytica hypothetical protein 0.0043 0.0422 0.0817
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0111 0.0149
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0111 0.0149
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0422 0.0567
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0113 0.2696
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0111 0.0149
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0062 0.07
Mycobacterium tuberculosis Conserved protein 0.0037 0.0336 0.1088
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0051 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0111 0.0149
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0062 0.0091
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0062 0.0205
Brugia malayi Flap endonuclease-1 0.0031 0.0273 0.0367
Onchocerca volvulus 0.0436 0.5307 0.7136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0497 0.1671
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0569 0.0569
Schistosoma mansoni notch 0.0196 0.2322 0.3122
Echinococcus granulosus notch 0.0196 0.2322 0.3122
Plasmodium falciparum flap endonuclease 1 0.0031 0.0273 0.7804
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0569 0.0765
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0436 0.5307 0.7136
Loa Loa (eye worm) hypothetical protein 0.0436 0.5307 0.7136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Schistosoma mansoni dishevelled 0.0011 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0048 0.0475 0.0638
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0475 0.0475
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0133 0.0179
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0171 0.023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0341 0.0459
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0029 0.0039
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0341 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0133 0.0179
Schistosoma mansoni peroxidasin 0.0607 0.7437 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Leishmania major hypothetical protein, conserved 0.0037 0.0336 0.5574
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Onchocerca volvulus 0.0196 0.2322 0.3122
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0029 0.0029
Echinococcus multilocularis slit 2 protein 0.0196 0.2322 0.2322
Echinococcus multilocularis neuroligin 0.0024 0.0179 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2278 0.3063
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0341 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0439
Brugia malayi hypothetical protein 0.0011 0.0015 0.002
Schistosoma mansoni notch 0.0196 0.2322 0.3122
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0111 0.0149
Brugia malayi Cadherin domain containing protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0341 0.0459
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0242 0.4046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0113 0.1044
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0111 0.0111
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0273 0.0367
Onchocerca volvulus 0.0024 0.0179 0.024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0497 1
Loa Loa (eye worm) oxidoreductase 0.0015 0.0062 0.0083
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0179 0.024
Echinococcus granulosus neuroligin 0.0024 0.0179 0.024
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0436 0.5307 0.7136
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0133 0.0179
Brugia malayi steroid hormone receptor 0.002 0.0133 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0133 0.0179
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0014 0.0019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0171 0.023
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.026 0.1064
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0111 0.0149
Brugia malayi hypothetical protein 0.0011 0.0014 0.0019
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.5109 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0569 0.0765
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0015 0.002
Brugia malayi hypothetical protein 0.0011 0.0014 0.0019
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0003 0.0004
Onchocerca volvulus 0.0024 0.0179 0.024
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Brugia malayi Carboxylesterase family protein 0.0142 0.1644 0.221
Echinococcus multilocularis protein jagged 1 0.0196 0.2322 0.2322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1757 0.2363
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0113 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0062 0.07
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0336 0.6568
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0439
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0004
Leishmania major DNA polymerase eta, putative 0.0054 0.0554 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0133 0.0179
Onchocerca volvulus Dual oxidase homolog 0.0607 0.7437 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0242 0.0983
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0341 1
Brugia malayi DKFZp564C0469 protein 0.0012 0.0029 0.0039
Brugia malayi RNA, U transporter 1 0.0082 0.0906 0.1219
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0005 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0336 0.6568
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0497 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0475 0.0638
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0179 0.0179
Onchocerca volvulus 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0037 0.0336 0.0452
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Schistosoma mansoni nAChR subunit 0.0018 0.0111 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Mycobacterium ulcerans hypothetical protein 0.0037 0.0336 0.6568
Onchocerca volvulus 0.0018 0.0111 0.0149
Trichomonas vaginalis helicase, putative 0.0013 0.0043 0.0439
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0062 0.07
Brugia malayi Animal haem peroxidase family protein 0.0607 0.7437 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0171 0.023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0336 0.0452
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0111 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1757 0.2363
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0336 1
Brugia malayi nuclear hormone receptor 0.002 0.0133 0.0179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0439
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0029 0.0063
Leishmania major importin beta-1 subunit, putative 0.0023 0.0173 0.2265
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0336 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Onchocerca volvulus 0.0196 0.2322 0.3122
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0062 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Schistosoma mansoni dishevelled 0.0011 0.0015 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0497 1
Echinococcus multilocularis snurportin 1 0.0309 0.373 0.373
Onchocerca volvulus 0.0037 0.0336 0.0452
Trypanosoma brucei unspecified product 0.0016 0.0081 0.0992
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0062 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Echinococcus multilocularis nAChR subunit 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Mycobacterium ulcerans carboxylesterase, LipT 0.0024 0.0179 0.3202
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0171 0.023
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0179 0.0516
Loa Loa (eye worm) animal heme peroxidase 0.0607 0.7437 1
Echinococcus granulosus acetylcholinesterase 0.0142 0.1644 0.221
Onchocerca volvulus 0.0018 0.0111 0.0149
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0099 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0133 0.0179
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0062 0.0083
Onchocerca volvulus 0.002 0.0133 0.0179
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0062 0.0083
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0113 1
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0029 0.0039
Brugia malayi hypothetical protein 0.0043 0.0422 0.0567
Onchocerca volvulus 0.001 0.0005 0.0006
Echinococcus granulosus cpg binding protein 0.0061 0.0635 0.0853
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Schistosoma mansoni smad 0.001 0.0003 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0133 0.0179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0171 0.0489
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0171 0.2707
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0062 0.0091
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0111 0.0149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0043 0.0439
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0029 0.0039
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0497 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0113 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.026 0.7402
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.1644 0.221
Brugia malayi Cation transporter family protein 0.0018 0.0111 0.0149
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0607 0.7437 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0569 0.0765
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0062 0.0091
Loa Loa (eye worm) carboxylesterase 0.0024 0.0179 0.024
Echinococcus multilocularis neurogenic locus protein delta 0.0196 0.2322 0.2322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0569 0.0765
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0019
Echinococcus multilocularis acetylcholinesterase 0.0142 0.1644 0.1644
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0058 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0336 0.0452
Echinococcus multilocularis Smad4 0.001 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0336 1
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0179 0.024
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0111 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0171 0.023
Entamoeba histolytica hypothetical protein 0.0043 0.0422 0.0817
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0173 0.4696
Echinococcus granulosus neurogenic locus notch protein 4 0.0196 0.2322 0.3122
Brugia malayi EGF-like domain containing protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0336 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Brugia malayi hypothetical protein 0.0012 0.0029 0.0039
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0497 0.0964
Schistosoma mansoni notch 0.0196 0.2322 0.3122
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0336 0.1088
Brugia malayi beta-lactamase 0.0037 0.0336 0.0452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0475 0.0638
Onchocerca volvulus Peroxidasin homolog 0.0607 0.7437 1
Echinococcus multilocularis notch 0.0196 0.2322 0.2322
Onchocerca volvulus Peroxidase homolog 0.0607 0.7437 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.0554 0.0554
Brugia malayi Calcium binding EGF domain containing protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0043 0.0439
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0336 0.1088
Toxoplasma gondii ABC1 family protein 0.0037 0.0336 0.1394
Brugia malayi Calcium binding EGF domain containing protein 0.0196 0.2322 0.3122
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0111 0.0149
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0111 0.0149
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Echinococcus granulosus GPCR family 2 0.0048 0.0475 0.0638
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.2278 0.3063
Loa Loa (eye worm) hypothetical protein 0.0151 0.1757 0.2363
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.035
Brugia malayi TAR-binding protein 0.0192 0.2278 0.3063
Loa Loa (eye worm) hypothetical protein 0.0218 0.2596 0.349
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0062 0.0091
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0196 0.2322 0.3122
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.0062 0.07
Leishmania major DNA polymerase kappa, putative 0.0023 0.0171 0.2221
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0133 0.0179
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0111 0.0149
Brugia malayi Animal haem peroxidase family protein 0.0607 0.7437 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0242 0.0325
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0133 0.0179
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0062 0.0624
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0111 0.0149
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0422 0.0567
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0062 0.0091
Onchocerca volvulus 0.0436 0.5307 0.7136
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0171 0.3039
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0062 0.07
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Onchocerca volvulus 0.0015 0.0062 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Onchocerca volvulus Putative nachr subunit 0.0018 0.0111 0.0149
Schistosoma mansoni hypothetical protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0062 0.105
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0133 0.0179
Loa Loa (eye worm) RNA binding protein 0.0192 0.2278 0.3063
Loa Loa (eye worm) TAR-binding protein 0.0192 0.2278 0.3063
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0062 0.1066
Entamoeba histolytica hypothetical protein 0.0023 0.0173 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0171 0.2707
Echinococcus granulosus protein jagged 1 0.0196 0.2322 0.3122
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0111 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0133 0.0179
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0111 0.0149
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0242 0.0242
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0015 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0497 1
Echinococcus granulosus peroxidasin 0.0607 0.7437 1
Brugia malayi Blistered cuticle protein 3 0.0607 0.7437 1
Echinococcus multilocularis protein jagged 2 0.0196 0.2322 0.2322
Onchocerca volvulus 0.0049 0.0497 0.0668
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.026 0.4398
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0043 0.0439
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0497 1
Trypanosoma brucei unspecified product 0.0023 0.0171 0.2707
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0003 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0133 0.0179
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0179 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Mycobacterium leprae Probable lipase LipE 0.0037 0.0336 0.6568
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0006
Schistosoma mansoni nuclear hormone receptor 0.002 0.0133 0.0179
Loa Loa (eye worm) hypothetical protein 0.0607 0.7437 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0133 0.0179
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0133 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0133 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0113 0.2696
Brugia malayi secreted modular calcium-binding protein 1 0.0436 0.5307 0.7136
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0133 0.0179
Mycobacterium tuberculosis Conserved protein 0.0037 0.0336 0.1088
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0069
Echinococcus multilocularis tar DNA binding protein 0.0192 0.2278 0.2278
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0102 0.0102
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0149
Trypanosoma brucei unspecified product 0.0016 0.0081 0.0992
Schistosoma mansoni slit 0.0196 0.2322 0.3122
Echinococcus granulosus nAChR subunit 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0497 0.0668
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.026 0.7402
Brugia malayi ecdysteroid receptor 0.002 0.0133 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0133 0.0179
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0111 0.0149
Brugia malayi Muscle positioning protein 4 0.0196 0.2322 0.3122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0316 0.1015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0475 0.0475
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0062 0.07
Loa Loa (eye worm) hypothetical protein 0.0196 0.2322 0.3122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0133 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0133 0.0179
Onchocerca volvulus 0.001 0.0005 0.0006
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0004
Mycobacterium tuberculosis Conserved protein 0.0037 0.0336 0.1088
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0111 0.0149
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0062 0.0083
Onchocerca volvulus 0.0436 0.5307 0.7136
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0273 0.0525
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0111 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0083
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0179 0.0516
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0133 0.0179
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0062 0.0624
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0497 0.0964
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0062 0.07
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0062 0.0624
Brugia malayi Animal haem peroxidase family protein 0.0607 0.7437 1
Schistosoma mansoni hypothetical protein 0.041 0.4985 0.6703
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0179 0.0179

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 33 nM Inhibition murine leukemia L1210 cell growth in culture ChEMBL. 3560161
IC50 (functional) = 370 nM Inhibition of human colon tumor (HCT-8) cell growth in culture ChEMBL. 3560161
ILS (functional) = 110 % Percentage increase in life span of tumor bearing animals compared to non treated, tumor-bearing controls when treated at the optimal dose of 100 mg/kg/day intraperitoneally ChEMBL. 3560161

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 3560161
Homo sapiens ChEMBL23 3560161

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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