Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0042 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0042 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0042 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0042 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0042 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0042 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0042 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0042 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0042 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 85.01047149 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (ADMET) | = 94.20047154 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.