Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0426 | 0.9826 | 0.9824 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0041 | 0.0041 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0111 | 0.0111 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0041 | 0.0041 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0111 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0185 | 0.4081 | 0.4015 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0111 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0256 | 0.5769 | 1 |
Giardia lamblia | Hypothetical protein | 0.0256 | 0.5769 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0426 | 0.9826 | 0.9824 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0111 | 0.0111 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0111 | 0.0193 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0111 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0426 | 0.9826 | 0.9824 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0111 | 0.0111 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0041 | 0.0041 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0111 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0111 | 0.0111 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0185 | 0.4081 | 0.4015 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0041 | 0.0041 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0433 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0256 | 0.5769 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0433 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0433 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0433 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0111 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.083 | 0.083 |
Giardia lamblia | Hypothetical protein | 0.0256 | 0.5769 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0185 | 0.4081 | 0.4015 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0465 | 0.5601 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.0433 | 1 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.083 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0041 | 0.0041 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0185 | 0.4081 | 0.4015 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0111 | 0.1343 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0111 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.9826 | 0.9826 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0426 | 0.9826 | 0.9824 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0111 | 0.0111 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0041 | 0.0041 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0041 | 0.0041 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0041 | 0.0497 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0256 | 0.5769 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0111 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.083 | 0.083 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0041 | 0.0041 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0111 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.5595 | 0.5595 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0041 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0465 | 0.0465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.