Detailed information for compound 1797605

Basic information

Technical information
  • TDR Targets ID: 1797605
  • Name: 1-[3-[4-(3-aminophenyl)butyl]phenyl]-6,6-dime thyl-1,3,5-triazine-2,4-diamine
  • MW: 364.487 | Formula: C21H28N6
  • H donors: 3 H acceptors: 0 LogP: 2.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc(c1)CCCCc1cccc(c1)N1C(=NC(=NC1(C)C)N)N
  • InChi: 1S/C21H28N6/c1-21(2)26-19(23)25-20(24)27(21)18-12-6-10-16(14-18)8-4-3-7-15-9-5-11-17(22)13-15/h5-6,9-14H,3-4,7-8,22H2,1-2H3,(H4,23,24,25,26)
  • InChiKey: WNZMAGKIGDUEIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-amino-1-[3-[4-(3-aminophenyl)butyl]phenyl]-6,6-dimethyl-s-triazin-2-yl]amine
  • 151648-38-3
  • 1,3,5-Triazine-2,4-diamine der.
  • 1,3,5-Triazine-2,4-diamine, 1-[3-[4-(3-aminophenyl)butyl]phenyl]-1,6-dihydro-6,6-dimethyl-
  • AIDS-007035
  • AIDS007035
  • 1,3,5-Triazine-2,4-diamine, 1-(3-(4-(3-aminophenyl)butyl)phenyl)-1,6-dihydro-6,6-dimethyl-
  • NSC 109835

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0123 0.126 0.1191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0369 0.0369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0382 0.035
Schistosoma mansoni 6-phosphofructokinase 0.0234 0.253 0.2505
Schistosoma mansoni DNA polymerase eta 0.0019 0.0083 0.005
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0234 0.253 0.2505
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.123
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0123 0.126 1
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0123 0.126 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0295 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0166 0.0166
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0123 0.126 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0138 0.1438 0.1371
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0083 0.005
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0123 0.126 0.123
Schistosoma mansoni ap endonuclease 0.0019 0.0078 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0137 0.0137
Brugia malayi dihydrofolate reductase family protein 0.0079 0.0767 0.0736
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0123 0.126 0.123
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0078 0.0078
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0123 0.126 0.123
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0369 0.0336
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0369 0.0336
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.024 0.137
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0079 0.0767 0.5836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0163 0.0163
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.123
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0123 0.126 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0891 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0079 0.0767 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0266
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0266 0.0233
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0891 1 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0123 0.126 1
Giardia lamblia Hypothetical protein 0.0138 0.1438 0.1371
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0078 0.0044
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0103 0.0088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0078 0.0062
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0369 0.0293
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.023 0.2485 0.246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0123 0.126 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0123 0.126 0.1191
Trichomonas vaginalis fk506-binding protein, putative 0.0123 0.126 0.126
Trypanosoma brucei hypothetical protein, conserved 0.0123 0.126 0.1246
Trichomonas vaginalis fk506 binding protein, putative 0.0123 0.126 0.126
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0234 0.253 0.2519
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0078 0.0044
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0034 0.0018
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0123 0.126 0.123
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0123 0.126 0.1246
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0083 0.0068
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.023 0.2485 0.246
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0891 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Trichomonas vaginalis fk506-binding protein, putative 0.0891 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1216 0.1186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0034 0.0034
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0123 0.126 0.1191
Schistosoma mansoni dihydrofolate reductase 0.0079 0.0767 0.0736
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0891 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0266
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0369 0.0336
Trichomonas vaginalis immunophilin, putative 0.0891 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0083 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Loa Loa (eye worm) hypothetical protein 0.0123 0.126 0.123
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.1191
Loa Loa (eye worm) hypothetical protein 0.0234 0.253 0.2505
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0891 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.126 0.126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0891 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0083 0.005
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0891 1 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0083 0.005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0083 0.0083
Giardia lamblia Hypothetical protein 0.0138 0.1438 0.1371
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0266 0.0251
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0078 0.0044
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.023 0.2485 0.246
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0079 0.0767 0.0736
Echinococcus multilocularis dna polymerase eta 0.0019 0.0083 0.005
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0074 0.0059
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0078 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0369 0.0369
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0083 0.0006
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0369 0.0293
Trichomonas vaginalis fk506-binding protein, putative 0.0123 0.126 0.126
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.023 0.2485 0.2474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0369 0.0369
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.1191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.0136
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0891 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0891 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0083 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.0068
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0123 0.126 0.1191
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.123
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0123 0.126 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0891 1 1
Echinococcus multilocularis fk506 binding protein 0.0891 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Schistosoma mansoni fk506 binding protein 0.0123 0.126 0.123
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0891 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0083 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0369 0.0354
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0078 0.0044
Mycobacterium ulcerans hypothetical protein 0.0138 0.1438 0.1371
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.1246
Loa Loa (eye worm) dihydrofolate reductase 0.0079 0.0767 0.0736
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0382 0.035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0078 0.0044
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.01 0.1002 0.0972
Loa Loa (eye worm) hypothetical protein 0.023 0.2485 0.246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0034 0.0034
Echinococcus granulosus dihydrofolate reductase 0.0079 0.0767 0.0736
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0369 0.0354
Echinococcus granulosus dna polymerase kappa 0.0019 0.0083 0.005
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0891 1 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0079 0.0767 0.0753
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0079 0.0767 0.5836
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0034 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0034 0.0034
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0234 0.253 0.2505
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0891 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0234 0.253 0.2505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0137 0.0137
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0769 0.8605 0.86
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0382 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0266
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.01 0.1002 0.0972
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0079 0.0767 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0891 1 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0083 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.0068
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0083 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.01 0.1002 0.0988
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0369 0.0336
Echinococcus multilocularis dihydrofolate reductase 0.0079 0.0767 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0166 0.0166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0078 0.0044
Giardia lamblia GTOR 0.0044 0.0369 0.0293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0382 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0034 0.0034
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0369 0.0336
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0123 0.126 0.123
Mycobacterium ulcerans hypothetical protein 0.0123 0.126 0.1191
Echinococcus granulosus FK506 binding protein 2 0.0123 0.126 0.123
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0083 0.005
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0123 0.126 0.1246
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0123 0.126 0.123
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0083 0.005
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0891 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0083 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0123 0.126 0.123
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0079 0.0767 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0166 0.0166
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0769 0.8605 0.86
Onchocerca volvulus 0.0234 0.253 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0083 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0203 0.0203
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0891 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0123 0.126 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1216 0.1186
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0123 0.126 0.123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0382 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0163 0.0163
Schistosoma mansoni immunophilin 0.0891 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0123 0.126 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0192 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0137 0.0137
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0123 0.126 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0266
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0083 0.0047
Trypanosoma brucei unspecified product 0.0019 0.0083 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.005
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.01 0.1002 0.0972
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0382 0.035
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0234 0.253 0.2505
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0266 0.0233
Loa Loa (eye worm) hypothetical protein 0.0769 0.8605 0.86
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0891 1 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0891 1 1
Loa Loa (eye worm) FKBP5 protein 0.0891 1 1
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0234 0.253 0.2505
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0083 0.0083
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.1191
Giardia lamblia Hypothetical protein 0.0123 0.126 0.1191
Schistosoma mansoni hypothetical protein 0.0123 0.126 0.123
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0123 0.126 0.1191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0382 0.035
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0123 0.126 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0382 0.035
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0369 0.0336
Brugia malayi Dihydrofolate reductase 0.0079 0.0767 0.0736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0382 0.035
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0891 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0123 0.126 0.123
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0079 0.0767 0.0695
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.126 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0083 0.005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0369 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Schistosoma mansoni immunophilin 0.0769 0.8605 0.86
Schistosoma mansoni ap endonuclease 0.0019 0.0078 0.0044
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0891 1 1
Leishmania major fk506-binding protein 1-like protein 0.0891 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0266
Leishmania major peptidylprolyl isomerase-like protein 0.0891 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0891 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.126 0.126
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.024 0.024
Brugia malayi MH2 domain containing protein 0.0119 0.1216 0.1186
Giardia lamblia DINP protein human, muc B family 0.0019 0.0083 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0083 0.005
Schistosoma mansoni immunophilin 0.0891 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0369 0.0336
Echinococcus granulosus dna polymerase eta 0.0019 0.0083 0.005
Loa Loa (eye worm) hypothetical protein 0.0134 0.1393 0.1364
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0138 0.1438 0.1371
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0078 0.0078
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0369 0.0336
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0083 0.005
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0891 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.0068
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0123 0.126 1
Echinococcus multilocularis 0.0123 0.126 0.123

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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