Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0047 | 0.1475 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.0981 | 0.3589 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0274 | 0.1361 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.4367 | 0.4367 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0017 | 0.0027 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0905 | 0.9231 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0905 | 0.1411 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0905 | 0.6138 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1454 | 0.2267 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.0981 | 0.3831 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.0981 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0905 | 0.6138 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0905 | 0.3313 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.3531 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.1475 | 0.5796 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0981 | 0.6649 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.1475 | 0.5397 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0981 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.1475 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0905 | 0.9231 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0017 | 0.0085 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0905 | 0.0905 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.4942 | 0.4942 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0905 | 0.9231 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0385 | 0.141 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0905 | 0.0905 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0905 | 0.6138 |
Onchocerca volvulus | 0.0035 | 0.0905 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0905 | 0.6138 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0905 | 0.3313 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0905 | 0.9231 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0905 | 0.9231 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.3531 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0905 | 0.9231 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.4942 | 0.4942 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0905 | 0.6138 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0017 | 0.0027 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0905 | 0.0905 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0981 | 0.6649 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0037 | 0.0981 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0905 | 0.0905 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.1475 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0905 | 0.9231 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1016 | 0.3972 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1013 | 0.3706 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0905 | 0.9231 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0905 | 0.0905 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0905 | 0.6138 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.1475 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0135 | 0.0671 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0981 | 0.6649 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.0981 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.1475 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0905 | 0.3313 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0017 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0185 | 0.0288 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.0981 | 0.6649 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2016 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1454 | 0.7214 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1454 | 0.7214 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0981 | 0.6649 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1454 | 0.7214 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0017 | 0.0027 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.1475 | 0.7316 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0905 | 0.0905 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0046 | 0.0114 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0905 | 0.9231 |
Onchocerca volvulus | 0.0035 | 0.0905 | 0.5 | |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0905 | 0.0905 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.4367 | 0.4367 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.4367 | 0.4367 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.4942 | 0.4942 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.4367 | 0.4367 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0902 | 0.4474 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0905 | 0.3313 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.4367 | 0.4367 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.0981 | 0.6649 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0905 | 0.4491 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0905 | 0.9231 |
Onchocerca volvulus | 0.0035 | 0.0905 | 0.5 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0905 | 0.0905 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0037 | 0.0981 | 0.4865 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.1475 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.1475 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.1475 | 0.7316 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0135 | 0.0211 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0135 | 0.0671 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1454 | 0.5714 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1454 | 0.7214 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0905 | 0.9231 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0902 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.3531 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.0981 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0185 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1217 | 0.4769 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.4367 | 0.4367 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.0981 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.1475 | 0.1475 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.0981 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.2733 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0017 | 0.0085 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0274 | 0.1361 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2184 | 0.3404 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0017 | 0.0085 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0905 | 0.4491 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.3531 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0981 | 0.1529 |
Brugia malayi | glutathione reductase | 0.0047 | 0.1475 | 0.5397 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0108 | 0.4367 | 0.8576 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0905 | 0.3531 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1454 | 0.2267 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.4942 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0981 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.3531 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0905 | 0.3531 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0905 | 0.0905 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1454 | 0.2267 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.0981 | 0.6649 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1454 | 0.5321 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0905 | 0.0905 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0274 | 0.0428 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.1475 | 0.5796 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.1475 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0037 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2533 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0017 | 0.0027 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0905 | 0.3531 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0905 | 0.1411 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1127 | 0.4413 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0037 | 0.0981 | 0.4865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.