Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.2156 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0824 | 0.3531 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2156 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2156 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0824 | 0.3531 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0824 | 0.3531 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2156 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2156 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0824 | 0.3531 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2156 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0278 | 0.0875 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2156 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2156 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2156 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0824 | 0.3531 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0824 | 0.3531 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0278 | 0.0875 | 0.0215 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | Antimicrobial activity against Escherichia coli ATCC 35218 assessed as growth inhibition after 18-24 hr by broth double microdilution method | ChEMBL. | No reference | |
MIC (functional) | = 500 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae RSKK 251 assessed as growth inhibition after 18-24 hr by broth double microdilution method | ChEMBL. | No reference |
MIC (functional) | = 500 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 60193 assessed as growth inhibition after 18-24 hr by broth double microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.