Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.218 | 1 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0368 | 0.1291 | 0.1291 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.07 | 0.289 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.0927 | 0.0764 |
Onchocerca volvulus | 0.0292 | 0.0927 | 0.0594 | |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0173 | 0.0355 | 0.0747 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.0927 | 0.2259 |
Brugia malayi | nuclear hormone receptor | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0177 | 0.0177 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.0927 | 0.2744 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0927 | 0.0927 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0173 | 0.0355 | 0.0747 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0173 | 0.0355 | 0.0355 |
Schistosoma mansoni | integrin alpha | 0.0179 | 0.0387 | 0.0126 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.0927 | 0.3275 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Echinococcus multilocularis | integrin beta 2 | 0.0272 | 0.0833 | 0.2858 |
Brugia malayi | steroid hormone receptor | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0368 | 0.1291 | 0.1134 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0173 | 0.0355 | 0.0747 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0173 | 0.0355 | 0.0747 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0173 | 0.0355 | 0.0181 |
Onchocerca volvulus | Bile acid receptor homolog | 0.218 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0179 | 0.0387 | 0.0214 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0277 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.0927 | 0.0927 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0173 | 0.0355 | 0.0181 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.0927 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.07 | 0.289 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0173 | 0.0355 | 0.0626 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0173 | 0.0355 | 0.0626 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0173 | 0.0355 | 0.0355 |
Echinococcus granulosus | integrin beta 2 | 0.0272 | 0.0833 | 0.2394 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0173 | 0.0355 | 0.0747 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | nuclear receptor NHR-88 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus granulosus | FTZ F1 alpha | 0.0173 | 0.0355 | 0.0626 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0747 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0626 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.0927 | 0.0927 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0173 | 0.0355 | 0.0626 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0927 | 0.0927 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.0927 | 0.2259 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0173 | 0.0355 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0173 | 0.0355 | 0.0355 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0609 | 0.2451 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0173 | 0.0355 | 0.0747 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0173 | 0.0355 | 0.0181 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.0927 | 0.0927 |
Schistosoma mansoni | integrin beta subunit | 0.0216 | 0.0565 | 0.0828 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0355 | 0.0355 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0173 | 0.0355 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0201 | 0.0201 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0173 | 0.0355 | 0.0181 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0173 | 0.0355 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0927 | 0.0927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.