Detailed information for compound 1798062

Basic information

Technical information
  • TDR Targets ID: 1798062
  • Name: 3-(1H-indol-3-yl)propan-1-amine
  • MW: 174.242 | Formula: C11H14N2
  • H donors: 2 H acceptors: 0 LogP: 1.73 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCc1c[nH]c2c1cccc2
  • InChi: 1S/C11H14N2/c12-7-3-4-9-8-13-11-6-2-1-5-10(9)11/h1-2,5-6,8,13H,3-4,7,12H2
  • InChiKey: OOIAXMPVZJKJHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1H-indol-3-yl)propylamine
  • 6245-89-2
  • 1H-Indole-3-propanamine
  • Homotryptamine
  • 1H-Indole-3-propylamine
  • EINECS 228-361-1
  • Oprea1_526363

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ecdysteroid receptor 0.002 0.0029 0.0294
Echinococcus multilocularis lamin dm0 0.0025 0.0049 0.0045
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0025 0.0051 0.4697
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0098 0.7883
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0029 0.0294
Echinococcus granulosus smad 0.0016 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor 0.002 0.0029 0.0039
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0098 1
Schistosoma mansoni ap endonuclease 0.0036 0.0098 0.015
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0115
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0025 0.0051 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0036 0.0098 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0029 0.0294
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0036 0.0098 0.015
Brugia malayi hypothetical protein 0.0015 0.0008 0.0085
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0025 0.0051 0.5
Leishmania major phosphoglycerate mutase family member 5, putative 0.0025 0.0051 0.0074
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0012 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0049 0.0078
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0025 0.0051 0.5
Brugia malayi isocitrate dehydrogenase 0.0015 0.0009 0.009
Loa Loa (eye worm) hypothetical protein 0.1458 0.6165 0.983
Brugia malayi hypothetical protein 0.0035 0.0092 0.0948
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0633 0.2644 0.4212
Brugia malayi Latrophilin receptor protein 2 0.006 0.0201 0.2063
Schistosoma mansoni ap endonuclease 0.0036 0.0098 0.015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0029 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.0936 0.1493
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0029 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3066
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0029 0.0025
Toxoplasma gondii phosphoglycerate mutase 0.0025 0.0051 0.4697
Giardia lamblia Hypothetical protein 0.0875 0.3678 1
Schistosoma mansoni intermediate filament proteins 0.0025 0.0049 0.0071
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0036 0.0098 0.015
Brugia malayi MH1 domain containing protein 0.0016 0.0012 0.0118
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0201 0.0321
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0029 0.0294
Plasmodium vivax phosphoglycerate mutase, putative 0.0025 0.0051 0.4697
Leishmania major glycerolphosphate mutase, putative 0.0025 0.0051 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0029 0.0294
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0875 0.3678 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0025 0.0051 0.0074
Onchocerca volvulus 0.0025 0.0051 0.0035
Toxoplasma gondii phosphoglycerate mutase family protein 0.0025 0.0051 0.4697
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0029 0.0039
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0042 0.0123 0.019
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0633 0.2644 0.4212
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0044 0.0063
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0051 0.5
Brugia malayi nuclear receptor NHR-88 0.002 0.0029 0.0294
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0029 0.0039
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0009 0.0008
Trypanosoma brucei glycerolphosphate mutase, putative 0.0025 0.0051 0.0074
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0025 0.0051 0.0074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0029 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0219 0.088 0.1398
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0025 0.0051 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0029 0.0294
Echinococcus granulosus phosphoglycerate mutase 0.0025 0.0051 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0051 0.3913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.3945
Onchocerca volvulus Huntingtin homolog 0.0111 0.042 0.0626
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0025 0.0051 0.3913
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0029 0.0039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0201 0.0197
Leishmania major phosphoglycerate mutase, putative 0.0025 0.0051 0.0074
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0017 0.0018 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0029 0.0046
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0025 0.0051 0.3913
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0025 0.0051 0.0074
Schistosoma mansoni hypothetical protein 0.0025 0.0051 0.0074
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1458 0.6165 0.983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0064 0.5047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3066
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0042 0.0123 0.0119
Loa Loa (eye worm) hypothetical protein 0.006 0.0201 0.0321
Schistosoma mansoni hypothetical protein 0.013 0.05 0.0791
Giardia lamblia Hypothetical protein 0.0875 0.3678 1
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0025 0.0051 0.0074
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1483 0.6272 1
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0044 0.3899
Loa Loa (eye worm) Smad1 0.0016 0.0012 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0029 0.0046
Trypanosoma cruzi target of rapamycin kinase 3 0.0033 0.0087 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0092 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.0757 0.7762
Schistosoma mansoni hypothetical protein 0.006 0.0201 0.0314
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0009 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0004 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.6922
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3066
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0633 0.2644 0.4212
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0036 0.0098 0.013
Toxoplasma gondii phosphoglycerate mutase family protein 0.0025 0.0051 0.4697
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0025 0.0051 0.3913
Loa Loa (eye worm) hypothetical protein 0.085 0.3572 0.5695
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0008
Brugia malayi phosphoglycerate mutase family protein 0.0025 0.0051 0.052
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0029 0.0039
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.1483 0.6272 1
Brugia malayi MH2 domain containing protein 0.0233 0.0936 0.9602
Brugia malayi follicle stimulating hormone receptor 0.0242 0.0975 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0036 0.0098 0.013
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0044 0.3899
Onchocerca volvulus 0.0025 0.0049 0.0032
Leishmania major hypothetical protein, conserved 0.0023 0.0044 0.0063
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0025 0.0051 0.0047
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0025 0.0051 0.0074
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0042 0.0123 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0029 0.0294
Echinococcus granulosus Smad4 0.0016 0.0012 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0004 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0029 0.0039
Onchocerca volvulus Huntingtin homolog 0.0111 0.042 0.0626
Loa Loa (eye worm) hypothetical protein 0.0155 0.0605 0.0965
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0115
Schistosoma mansoni coup transcription factor 0.002 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0074
Plasmodium falciparum phosphoglucomutase-2 0.0025 0.0051 0.4697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0029 0.0046
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.0936 0.1493
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0012 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0042 0.0123 0.019
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0008
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0025 0.0051 0.4697
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0219 0.088 0.1398
Echinococcus granulosus geminin 0.0177 0.0698 0.1108
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0029 0.0025
Schistosoma mansoni hypothetical protein 0.0025 0.0051 0.0074
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0025 0.0051 0.5
Leishmania major hypothetical protein, conserved 0.0025 0.0051 0.0074
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0025 0.0051 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0051 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1483 0.6272 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0029 0.0294
Onchocerca volvulus Protein UBASH3A homolog 0.0025 0.0051 0.0035
Echinococcus multilocularis muscleblind protein 0.0155 0.0605 0.0602
Toxoplasma gondii phosphoglycerate mutase family protein 0.0025 0.0051 0.4697
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0201 0.2063
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0155 0.0605 0.0965
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0092 0.0141
Schistosoma mansoni hypothetical protein 0.006 0.0201 0.0314
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0012 0.0012
Brugia malayi MH1 domain containing protein 0.0016 0.0012 0.0118
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0029 0.0039
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0025 0.0051 0.0074
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1483 0.6272 0.627
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Schistosoma mansoni hypothetical protein 0.006 0.0201 0.0314
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0036 0.0098 0.015
Schistosoma mansoni phosphoglycerate mutase 0.0025 0.0051 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0123 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0051 0.3913
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0029 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.6922
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1458 0.6165 0.983
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0036 0.0098 0.015
Toxoplasma gondii exonuclease III APE 0.0036 0.0098 1
Onchocerca volvulus 0.0025 0.0051 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.005 0.3855
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.007
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0012 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0029 0.0039
Leishmania major hypothetical protein, unknown function 0.0025 0.0051 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0201 0.0314
Giardia lamblia GTOR 0.0042 0.0123 0.0071
Brugia malayi nuclear hormone receptor 0.002 0.0029 0.0294
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1483 0.6272 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0042 0.0123 0.019
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0009 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0042 0.0123 0.02
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0633 0.2644 0.4212
Brugia malayi intermediate filament protein 0.0025 0.0049 0.0499
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0123 0.1264
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1458 0.6165 0.983
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0219 0.088 0.1398
Loa Loa (eye worm) hypothetical protein 0.0111 0.042 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0029 0.0294
Echinococcus multilocularis musashi 0.0025 0.0049 0.0045
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0042 0.0123 0.019
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1483 0.6272 1
Echinococcus multilocularis phosphoglycerate mutase 0.0025 0.0051 0.0047
Schistosoma mansoni hypothetical protein 0.0025 0.0051 0.0074
Schistosoma mansoni thyroid hormone receptor 0.002 0.0029 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0219 0.088 0.0876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3078
Brugia malayi MH2 domain containing protein 0.0016 0.0012 0.0118
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0025 0.0051 0.0074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0029 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.0757 0.7762
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0029 0.0294
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0029 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0029 0.0039
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0025 0.0051 0.4697
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0029 0.0025
Brugia malayi hypothetical protein 0.0111 0.042 0.4304
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0219 0.088 0.1398
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0025 0.0051 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0123 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0029 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.6922
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0098 1
Echinococcus multilocularis phosphoglycerate mutase 0.0025 0.0051 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.006 0.4722
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0025 0.0051 0.5
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0605 0.0602
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Brugia malayi hypothetical protein 0.0023 0.0044 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0005
Echinococcus granulosus lamin dm0 0.0025 0.0049 0.0071
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0025 0.0051 0.0074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0029 0.0039
Mycobacterium tuberculosis Conserved protein 0.0025 0.0051 0.4697
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0098 0.7883
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0029 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0097 0.78
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.0098 0.1006
Echinococcus granulosus phosphoglycerate mutase 0.0025 0.0051 0.0074
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0033 0.0087 0.0132
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0042 0.0123 0.019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0081
Mycobacterium leprae probable isochorismate synthase EntC 0.0025 0.0051 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0042 0.0123 0.019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0029 0.0025
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0025 0.0051 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0219 0.088 0.1403
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0025 0.0051 0.0074
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0875 0.3678 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0029 0.0294
Schistosoma mansoni thyroid hormone receptor 0.002 0.0029 0.0039
Brugia malayi phosphoglycerate mutase family protein 0.0025 0.0051 0.052
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0025 0.0051 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.019 0.0757 0.1207
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0029 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0029 0.0046
Brugia malayi Muscleblind-like protein 0.0155 0.0605 0.621
Loa Loa (eye worm) hypothetical protein 0.013 0.05 0.0797
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3078
Schistosoma mansoni lamin 0.0025 0.0049 0.0071
Schistosoma mansoni smad1 5 8 and 0.0016 0.0012 0.0012
Plasmodium vivax phosphoglucomutase-2, putative 0.0025 0.0051 0.4697
Brugia malayi MH2 domain containing protein 0.0016 0.0012 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0029 0.0294
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0009 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0029 0.0046
Schistosoma mansoni hypothetical protein 0.0177 0.0698 0.1108
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0025 0.0051 0.4697
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0033 0.0087 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0029 0.0294
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0081
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0025 0.0051 0.3913
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0029 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0092 0.0141
Schistosoma mansoni hypothetical protein 0.006 0.0201 0.0314
Mycobacterium ulcerans hypothetical protein 0.0875 0.3678 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.6922
Schistosoma mansoni smad 0.0016 0.0012 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.0975 0.1555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0029 0.0046
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0025 0.0051 0.4697
Onchocerca volvulus 0.0025 0.0049 0.0032
Schistosoma mansoni smad1 5 8 and 0.0016 0.0012 0.0012
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0025 0.0051 0.0074
Echinococcus multilocularis GPCR, family 2 0.006 0.0201 0.0197
Echinococcus multilocularis smad 0.0016 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0111 0.042 0.0669
Schistosoma mansoni hypothetical protein 0.0035 0.0092 0.0141
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.0098 1
Echinococcus multilocularis phosphoglycerate mutase 0.0025 0.0051 0.0047
Brugia malayi Smad1 0.0016 0.0012 0.0118
Leishmania major hypothetical protein, conserved 0.0025 0.0051 0.0074
Echinococcus multilocularis phosphoglycerate mutase 0.0025 0.0051 0.0047
Plasmodium falciparum phosphoglycerate mutase, putative 0.0025 0.0051 0.4697
Schistosoma mansoni phosphoglycerate mutase 0.0025 0.0051 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0044 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0029 0.0294
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0044 0.0063
Onchocerca volvulus Protein UBASH3A homolog 0.0025 0.0051 0.0035
Loa Loa (eye worm) phosphoglycerate mutase 0.0025 0.0051 0.0081
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0042 0.0123 0.019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.0757 0.1207
Echinococcus multilocularis phosphoglycerate mutase 0.0025 0.0051 0.0047
Schistosoma mansoni hypothetical protein 0.0025 0.0051 0.0074
Trypanosoma brucei phosphoglycerate mutase, putative 0.0025 0.0051 0.0074
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0029 0.0046
Schistosoma mansoni hypothetical protein 0.0025 0.0051 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0051 0.4697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0029 0.0025
Onchocerca volvulus 0.0025 0.0051 0.0035
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Echinococcus granulosus lamin 0.0025 0.0049 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.6922
Toxoplasma gondii target of rapamycin (TOR), putative 0.0031 0.0077 0.7678
Brugia malayi steroid hormone receptor 0.002 0.0029 0.0294
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0115
Echinococcus granulosus FTZ F1 alpha 0.002 0.0029 0.0039
Onchocerca volvulus Protein UBASH3A homolog 0.0025 0.0051 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0044 0.3899
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0044 0.3899
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1458 0.6165 0.983
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0115
Echinococcus multilocularis phosphoglycerate mutase 0.0025 0.0051 0.0047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0009 0.0014
Schistosoma mansoni lamin 0.0025 0.0049 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0029 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0005
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0042 0.0123 0.019
Mycobacterium tuberculosis Conserved protein 0.0025 0.0051 0.4697
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0029 0.0294
Echinococcus granulosus phosphoglycerate mutase 0.0025 0.0051 0.0074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0036 0.0098 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3078
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0049 0.0499
Echinococcus granulosus muscleblind protein 0.0155 0.0605 0.096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0219 0.088 0.9025
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0025 0.0051 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0029 0.0025
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0025 0.0051 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0123 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.3078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0201 0.0314
Schistosoma mansoni 6-phosphofructokinase 0.1483 0.6272 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0029 0.0039
Schistosoma mansoni Smad4 0.0016 0.0012 0.0012
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0049 0.0078
Loa Loa (eye worm) hypothetical protein 0.1483 0.6272 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0036 0.0098 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.05 0.5124
Leishmania major hypothetical protein, conserved 0.0025 0.0051 0.0074
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0025 0.0051 0.4697
Echinococcus multilocularis Smad4 0.0016 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Onchocerca volvulus 0.1483 0.6272 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0012 0.0012
Brugia malayi UBASH3A protein homolog 0.0025 0.0051 0.052
Echinococcus granulosus GPCR family 2 0.006 0.0201 0.0314
Echinococcus granulosus intermediate filament protein 0.0025 0.0049 0.0071
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0012 0.0018
Echinococcus multilocularis lamin 0.0025 0.0049 0.0045
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0012 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0036 0.0098 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0029 0.0025
Echinococcus granulosus phosphoglycerate mutase 0.0025 0.0051 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.3945
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0025 0.0051 0.3913
Echinococcus multilocularis geminin 0.0177 0.0698 0.0695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0219 0.088 0.0876
Echinococcus granulosus phosphoglycerate mutase 0.0025 0.0051 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0077 0.6145
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0025 0.0051 0.0074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0201 0.0197
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0009 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0012 0.0007
Mycobacterium leprae Possible phosphoglycerate mutase 0.0025 0.0051 0.5
Toxoplasma gondii phosphoglycerate mutase family protein 0.0025 0.0051 0.4697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.005 0.3855
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0081
Onchocerca volvulus Protein UBASH3A homolog 0.0025 0.0051 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0046
Leishmania major phosphoglycerate mutase protein, putative 0.0025 0.0051 0.0074
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0025 0.0051 0.4697
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0219 0.088 0.1398
Schistosoma mansoni hypothetical protein 0.0025 0.0051 0.0074
Schistosoma mansoni hypothetical protein 0.0177 0.0698 0.1108
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.0098 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0029 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.3945

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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