Detailed information for compound 1798212

Basic information

Technical information
  • TDR Targets ID: 1798212
  • Name: 3466-09-9
  • MW: 392.401 | Formula: C23H20O6
  • H donors: 0 H acceptors: 1 LogP: 3.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1OC)OCc1c2c(=O)c2c(o1)c1CC(Oc1cc2)C(=C)C
  • InChi: 1S/C23H20O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16H,1,8,10H2,2-4H3
  • InChiKey: GFERNZCCTZEIET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SpecPlus_000107
  • KBio2_003735
  • KBio1_001147
  • DivK1c_006203
  • KBioSS_001167
  • Spectrum_000687
  • Spectrum3_000686
  • NCGC00095794-01
  • KBioGR_002219
  • SPBio_001939
  • Spectrum5_000319
  • KBio2_006303
  • Spectrum2_001930
  • KBio3_001631
  • BSPBio_002411
  • Spectrum4_001520
  • SPECTRUM201154
  • Dehydrorotenone
  • NSC194812
  • KBio2_001167

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0483 0.3732 1
Trypanosoma brucei trypanothione reductase 0.0094 0.0493 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0228 0.1607 0.4305
Plasmodium falciparum glutathione reductase 0.0094 0.0493 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0236 0.0633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Brugia malayi hypothetical protein 0.0255 0.1834 0.4915
Brugia malayi putative neuropeptide receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis somatostatin receptor 0.0063 0.0236 0.0633
Brugia malayi follicle stimulating hormone receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0236 0.0633
Echinococcus granulosus GPCR family 2 0.0047 0.0097 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0483 0.3732 1
Entamoeba histolytica hypothetical protein 0.007 0.0296 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0147 0.0937 0.2511
Schistosoma mansoni neuropeptide receptor 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi GnHR receptor homolog 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni hypothetical protein 0.0063 0.0236 0.0236
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0483 0.3732 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0228 0.1607 0.4305
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0703 0.1882
Echinococcus granulosus neuropeptide receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis serotonin receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis serotonin receptor 0.0063 0.0236 0.0633
Schistosoma mansoni hypothetical protein 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0215 0.1497 0.8342
Schistosoma mansoni biogenic amine receptor 0.0063 0.0236 0.0236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Schistosoma mansoni retinoic acid receptor RXR 0.0483 0.3732 0.3732
Loa Loa (eye worm) hypothetical protein 0.0101 0.0548 0.1469
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0236 0.0633
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus neuropeptide receptor A26 0.0063 0.0236 0.0633
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0228 0.1607 0.4305
Schistosoma mansoni hypothetical protein 0.0047 0.0097 0.0097
Brugia malayi nuclear receptor RXR 0.0228 0.1607 0.4305
Brugia malayi G-protein coupled receptor 0.0063 0.0236 0.0633
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 0.0236 0.0633
Brugia malayi ecdysone receptor 0.0228 0.1607 0.4305
Brugia malayi nuclear receptor NHR-88 0.0228 0.1607 0.4305
Echinococcus multilocularis orexin receptor type 2 0.0063 0.0236 0.0633
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0548 0.1469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0236 0.0633
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0236 0.0236
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 0.0236 0.0236
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0483 0.3732 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0236 0.0633
Brugia malayi putative neuropeptide receptor NPR1 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0483 0.3732 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0296 0.0792
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0483 0.3732 0.3732
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 0.0236 0.0633
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0215 0.1497 0.8342
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0236 0.0633
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 0.0236 0.0633
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0483 0.3732 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0483 0.3732 0.3732
Schistosoma mansoni nuclear hormone receptor 0.0228 0.1607 0.1607
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0097 0.0261
Brugia malayi Dopamine receptor protein 2 0.0063 0.0236 0.0633
Loa Loa (eye worm) TYRA-2 protein 0.0063 0.0236 0.0633
Echinococcus multilocularis ecdysone induced protein 78C 0.0483 0.3732 1
Plasmodium vivax glutathione reductase, putative 0.0094 0.0493 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) nuclear hormone receptor 0.0228 0.1607 0.4305
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0236 0.0633
Echinococcus granulosus Nuclear hormone receptor HR96 0.0228 0.1607 0.4305
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Schistosoma mansoni nuclear receptor nhr-48 0.0228 0.1607 0.1607
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 0.0236 0.0633
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0493 0.5
Brugia malayi nuclear hormone receptor 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0483 0.3732 0.3732
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Schistosoma mansoni nuclear hormone receptor 0.0228 0.1607 0.1607
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0239 0.1696 1
Schistosoma mansoni hypothetical protein 0.0047 0.0097 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0483 0.3732 0.3732
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0483 0.3732 1
Echinococcus granulosus neuropeptide s receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi G-protein coupled receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi nuclear receptor NHR-88 0.0483 0.3732 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 0.0236 0.0633
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0483 0.3732 1
Schistosoma mansoni opsin-like receptor 0.0063 0.0236 0.0236
Echinococcus granulosus Nuclear hormone receptor HR96 0.0228 0.1607 0.4305
Brugia malayi ORL1-like opioid receptor 0.0063 0.0236 0.0633
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor E75 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0255 0.1834 0.4915
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0228 0.1607 0.392
Echinococcus multilocularis nuclear receptor nhr 48 0.0228 0.1607 0.4305
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0483 0.3732 1
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0483 0.3732 0.3732
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0236 0.0633
Echinococcus granulosus somatostatin receptor 0.0063 0.0236 0.0633
Echinococcus granulosus serotonin receptor 0.0063 0.0236 0.0633
Brugia malayi hypothetical protein 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 0.0236 0.0633
Schistosoma mansoni histamine h1 receptor 0.0063 0.0236 0.0236
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0236 0.0633
Schistosoma mansoni amine GPCR 0.0063 0.0236 0.0236
Echinococcus multilocularis allatostatin A receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi Serotonin receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0255 0.1834 0.4915
Brugia malayi MH2 domain containing protein 0.0119 0.0703 0.1882
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0937 0.2511
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0236 0.0633
Entamoeba histolytica hypothetical protein 0.007 0.0296 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0097 0.0261
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni amine GPCR 0.0063 0.0236 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0483 0.3732 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 0.0236 0.0236
Brugia malayi nuclear hormone receptor family member odr-7 0.0228 0.1607 0.4305
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0236 0.0633
Schistosoma mansoni steroid hormone receptor ad4bp 0.0483 0.3732 0.3732
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0215 0.1497 0.8342
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0483 0.3732 1
Echinococcus multilocularis g-protein coupled receptor 0.0063 0.0236 0.0633
Brugia malayi tailless protein 0.0228 0.1607 0.4305
Schistosoma mansoni neuropeptide receptor 0.0063 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0483 0.3732 1
Brugia malayi Dopamine receptor 0.0063 0.0236 0.0633
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 0.0236 0.0633
Mycobacterium tuberculosis Probable dehydrogenase 0.0215 0.1497 0.8342
Echinococcus granulosus sex peptide receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi ecdysteroid receptor 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0497 0.1331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0483 0.3732 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0228 0.1607 0.4305
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0483 0.3732 1
Brugia malayi Nuclear hormone receptor-like 1 0.0255 0.1834 0.4915
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 0.0236 0.0633
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 0.0236 0.0633
Brugia malayi jmjC domain containing protein 0.0095 0.0497 0.1331
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Echinococcus granulosus thyroid hormone receptor alpha 0.0228 0.1607 0.4305
Schistosoma mansoni RAR-like nuclear receptor 0.0483 0.3732 0.3732
Brugia malayi Thioredoxin reductase 0.0094 0.0493 0.132
Onchocerca volvulus 0.0228 0.1607 0.392
Brugia malayi Steroid receptor seven-up type 2 0.0483 0.3732 1
Schistosoma mansoni thyroid hormone receptor 0.0483 0.3732 0.3732
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0483 0.3732 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0228 0.1607 0.1607
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis G protein coupled receptor 139 0.0063 0.0236 0.0633
Schistosoma mansoni nuclear hormone receptor 0.0483 0.3732 0.3732
Echinococcus granulosus G protein coupled receptor 139 0.0063 0.0236 0.0633
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0239 0.1696 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0228 0.1607 0.4305
Brugia malayi neuropeptide F receptor 0.0063 0.0236 0.0633
Brugia malayi nuclear receptor NHR-67 0.0228 0.1607 0.4305
Echinococcus granulosus hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0236 0.0633
Loa Loa (eye worm) glutathione reductase 0.0094 0.0493 0.132
Loa Loa (eye worm) steroid hormone receptor 0.0483 0.3732 1
Echinococcus granulosus fmrfamide receptor 0.0063 0.0236 0.0633
Entamoeba histolytica hypothetical protein 0.007 0.0296 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0236 0.0236
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0236 0.0633
Brugia malayi Serotonin receptor 0.0063 0.0236 0.0633
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0483 0.3732 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0483 0.3732 1
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi larval opioid receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) nuclear receptor NHR-67 0.0228 0.1607 0.4305
Brugia malayi nuclear hormone receptor family member nhr-6 0.0228 0.1607 0.4305
Echinococcus granulosus orexin receptor type 2 0.0063 0.0236 0.0633
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0236 0.0236
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0236 0.0633
Echinococcus granulosus nuclear receptor nhr 48 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0255 0.1834 0.4915
Plasmodium falciparum thioredoxin reductase 0.0094 0.0493 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0483 0.3732 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0483 0.3732 1
Schistosoma mansoni amine GPCR 0.0063 0.0236 0.0236
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0335 0.0335
Schistosoma mansoni neuropeptide receptor 0.0063 0.0236 0.0236
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0097 0.0261
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 0.0236 0.0633
Schistosoma mansoni biogenic amine receptor 0.0063 0.0236 0.0236
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi hypothetical protein 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0255 0.1834 0.4915
Entamoeba histolytica hypothetical protein 0.007 0.0296 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0483 0.3732 1
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0236 0.0633
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 0.0236 0.0236
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0255 0.1834 0.4915
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0255 0.1834 0.1834
Schistosoma mansoni adenoreceptor 0.0063 0.0236 0.0236
Schistosoma mansoni zinc finger protein 0.0228 0.1607 0.1607
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0483 0.3732 0.3732
Echinococcus multilocularis thyroid hormone receptor alpha 0.0483 0.3732 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Schistosoma mansoni hypothetical protein 0.0047 0.0097 0.0097
Onchocerca volvulus 0.0483 0.3732 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0236 0.0236
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 0.0236 0.0633
Brugia malayi Dopamine receptor protein 1 0.0063 0.0236 0.0633
Onchocerca volvulus Protein ultraspiracle homolog 0.0483 0.3732 1
Brugia malayi glutathione reductase 0.0094 0.0493 0.132
Echinococcus multilocularis neuropeptide receptor A26 0.0063 0.0236 0.0633
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Mycobacterium tuberculosis Probable reductase 0.0215 0.1497 0.8342
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Brugia malayi hypothetical protein 0.007 0.0296 0.0792
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 0.0236 0.0236
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 0.0236 0.0633
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0483 0.3732 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 0.0236 0.0236
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0236 0.0633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0483 0.3732 1
Echinococcus granulosus g protein coupled receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 0.0236 0.0633
Brugia malayi nuclear receptor RXR 0.0255 0.1834 0.4915
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0097 0.0261
Brugia malayi orphan nuclear receptor NR2E1 0.0228 0.1607 0.4305
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0483 0.3732 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Echinococcus multilocularis GPCR, family 2 0.0047 0.0097 0.0261
Schistosoma mansoni nuclear receptor 0.0228 0.1607 0.1607
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0493 0.132
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0497 0.1331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus jumonji domain containing protein 0.004 0.0044 0.0117
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0228 0.1607 0.392
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0483 0.3732 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0236 0.0633
Schistosoma mansoni hypothetical protein 0.0047 0.0097 0.0097
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Schistosoma mansoni opsin-like receptor 0.0063 0.0236 0.0236
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0483 0.3732 1
Schistosoma mansoni amine GPCR 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.005 0.0121 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0483 0.3732 1
Schistosoma mansoni biogenic amine receptor 0.0063 0.0236 0.0236
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 0.0236 0.0236
Echinococcus granulosus allatostatin A receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 0.0236 0.0633
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0236 0.0633
Schistosoma mansoni hypothetical protein 0.0101 0.0548 0.0548
Brugia malayi Nuclear hormone receptor-like 1 0.0255 0.1834 0.4915
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0097 0.0261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0236 0.0236
Brugia malayi Nuclear hormone receptor E75 0.0228 0.1607 0.4305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Schistosoma mansoni coup transcription factor 0.0483 0.3732 0.3732
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0206 0.0551
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 0.0236 0.0633
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0228 0.1607 0.4305
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0236 0.0633
Echinococcus multilocularis sex peptide receptor 0.0063 0.0236 0.0633
Echinococcus granulosus g protein coupled receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0483 0.3732 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0937 0.2511
Brugia malayi photoreceptor-specific nuclear receptor 0.0483 0.3732 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0255 0.1834 0.4915
Mycobacterium tuberculosis Probable oxidoreductase 0.0239 0.1696 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 0.0236 0.0236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0296 0.0792
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis neuropeptide s receptor 0.0063 0.0236 0.0633
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0228 0.1607 0.4305
Schistosoma mansoni opsin-like receptor 0.0063 0.0236 0.0236
Schistosoma mansoni thyroid hormone receptor 0.0483 0.3732 0.3732
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0236 0.0236
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0493 0.132
Schistosoma mansoni nuclear receptor 0.0228 0.1607 0.1607
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0215 0.1497 0.8342
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0097 0.0261
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi conserved hypotetical protein 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 0.0236 0.0633
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 0.0236 0.0236
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0097 0.0261
Echinococcus granulosus neuropeptide receptor 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0483 0.3732 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0255 0.1834 0.1834
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0044 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0937 0.2511
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0296 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Brugia malayi hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus FTZ F1 alpha 0.0483 0.3732 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0255 0.1834 0.4915
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 0.0236 0.0633
Schistosoma mansoni hypothetical protein 0.007 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0063 0.0236 0.0236
Brugia malayi steroid hormone receptor 0.0483 0.3732 1
Brugia malayi AKH receptor 0.0063 0.0236 0.0633
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0255 0.1834 0.4915
Leishmania major trypanothione reductase 0.0094 0.0493 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0483 0.3732 1
Schistosoma mansoni myosin xvIII 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0493 0.132
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0236 0.0633
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 0.0236 0.0236
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0236 0.0633
Onchocerca volvulus Bile acid receptor homolog 0.0483 0.3732 1
Brugia malayi nuclear hormone receptor 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus g protein coupled receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 0.0236 0.0633
Schistosoma mansoni hypothetical protein 0.0063 0.0236 0.0236
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 0.0236 0.0633
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0483 0.3732 1
Brugia malayi neuropeptide F receptor 0.0063 0.0236 0.0633
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0493 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 0.0236 0.0633
Schistosoma mansoni neuropeptide receptor 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0236 0.0236
Toxoplasma gondii thioredoxin reductase 0.0094 0.0493 0.5
Brugia malayi hypothetical protein 0.0255 0.1834 0.4915
Brugia malayi RE15519p 0.0063 0.0236 0.0633
Echinococcus granulosus dro:myosuppressin receptor 0.0063 0.0236 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0483 0.3732 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Brugia malayi sulfakinin receptor protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.0097 0.0261
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0239 0.1696 1
Echinococcus multilocularis FTZ F1 alpha 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Onchocerca volvulus 0.0228 0.1607 0.392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0483 0.3732 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0236 0.0633
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0228 0.1607 0.4305
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 0.0236 0.0633
Brugia malayi Melatonin receptor type 1A 0.0063 0.0236 0.0633
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0236 0.0633
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 0.0236 0.0633
Schistosoma mansoni amine GPCR 0.0063 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0703 0.1882
Brugia malayi G protein-coupled receptor 0.0063 0.0236 0.0633
Loa Loa (eye worm) hypothetical protein 0.0483 0.3732 1
Echinococcus granulosus g-protein coupled receptor 0.0063 0.0236 0.0633
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 0.0236 0.0236
Loa Loa (eye worm) DR-78 0.0228 0.1607 0.4305
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0228 0.1607 0.4305
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0236 0.0236
Brugia malayi Nuclear hormone receptor-like 1 0.0483 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.1607 0.4305
Loa Loa (eye worm) hypothetical protein 0.0063 0.0236 0.0633

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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