Detailed information for compound 1798300

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.372 | Formula: C19H18N4O2
  • H donors: 1 H acceptors: 4 LogP: 3.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c2nnc(n2c2c(c1=O)cccc2)c1cccc(c1)O
  • InChi: 1S/C19H18N4O2/c1-2-3-11-22-18(25)15-9-4-5-10-16(15)23-17(20-21-19(22)23)13-7-6-8-14(24)12-13/h4-10,12,24H,2-3,11H2,1H3
  • InChiKey: LCDHFLNWGPDARW-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0001
Brugia malayi phosphoglycerate mutase family protein 0.005 0.0156 0.0985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0111 0.0366 0.0366
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0056 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0032 0.1873
Plasmodium vivax histone acetyltransferase GCN5, putative 0.003 0.0089 0.5548
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0032 0.1786
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0005 0.0003 0.0016
Mycobacterium tuberculosis Conserved protein 0.005 0.0156 1
Mycobacterium ulcerans hypothetical protein 0.005 0.0156 0.0212
Mycobacterium tuberculosis Conserved protein 0.005 0.0156 1
Schistosoma mansoni ap endonuclease 0.0013 0.0032 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0005 0.0003 0.0002
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0013 0.0012
Leishmania major hypothetical protein, conserved 0.005 0.0156 0.0151
Toxoplasma gondii phosphoglycerate mutase 0.005 0.0156 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.003 0.0089 0.5595
Schistosoma mansoni importin-beta 2 0.0005 0.0005 0.0005
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.005 0.0156 0.0155
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0081 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0013 0.0013
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0005 0.0003 0.0016
Echinococcus granulosus importin 5 0.0005 0.0005 0.0004
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.005 0.0156 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0018 0.005 0.3039
Entamoeba histolytica hypothetical protein 0.007 0.0224 0.0379
Giardia lamblia Histone acetyltransferase GCN5 0.0027 0.008 0.0115
Leishmania major phosphoglycerate mutase protein, putative 0.005 0.0156 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0224 0.0223
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0013 0.0013
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0029 0.0086 0.5513
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0008 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.005 0.0156 0.0156
Giardia lamblia Hypothetical protein 0.1734 0.5896 1
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.005 0.0156 1
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.005 0.0156 1
Entamoeba histolytica recQ family helicase, putative 0.001 0.002 0.0034
Echinococcus granulosus muscleblind protein 0.0466 0.1576 0.1576
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0013 0.0078
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0013 0.0012
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0005 0.0003 0.0002
Leishmania major phosphoglycerate mutase, putative 0.005 0.0156 0.0151
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0008 0.0013 0.0012
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0156
Echinococcus multilocularis phosphoglycerate mutase 0.005 0.0156 0.0155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0111 0.0366 0.2317
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0005 0.0003 0.0003
Mycobacterium ulcerans lipoprotein LpqD 0.005 0.0156 0.0212
Schistosoma mansoni DNA helicase recq5 0.0008 0.0013 0.0013
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0005 0.0003 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0013 0.0012
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0013 0.0078
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0008 0.0013 0.0012
Brugia malayi RNA, U transporter 1 0.0079 0.0256 0.1621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0005 0.0003 0.0002
Loa Loa (eye worm) acetyltransferase 0.0102 0.0333 0.0333
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0032 0.0197
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.005 0.0156 0.0155
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0013 0.0032 0.0027
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1734 0.5896 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0013 0.0012
Schistosoma mansoni ap endonuclease 0.0013 0.0032 0.0032
Echinococcus granulosus snurportin 1 0.0297 0.0998 0.0997
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0047 0.3014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0013 0.0078
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0026 0.0076 0.353
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.0056 0.3426
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0005 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0111 0.0366 0.0365
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.005 0.0156 0.5
Mycobacterium ulcerans phosphoglycerate mutase 0.005 0.0156 0.0212
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0086 0.5422
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Echinococcus granulosus phosphoglycerate mutase 0.005 0.0156 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0013 0.0078
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0005 0.0003 0.0016
Onchocerca volvulus 0.005 0.0156 0.0153
Mycobacterium leprae conserved hypothetical protein 0.005 0.0156 1
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0005 0.0003 0.0003
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.005 0.0156 0.0156
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0005 0.0003 0.0002
Onchocerca volvulus Protein UBASH3A homolog 0.005 0.0156 0.0153
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.005 0.0156 1
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0005 0.0303
Loa Loa (eye worm) RecQ helicase 0.0018 0.005 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0013 0.0078
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.0056 0.0074
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.005 0.3039
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0005 0.0003 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Brugia malayi G-protein alpha subunit 0.0005 0.0003 0.0016
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.005 0.0156 0.0151
Loa Loa (eye worm) G protein alpha subunit 3 0.0005 0.0003 0.0003
Echinococcus multilocularis inositol monophosphatase 1 0.0029 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0001
Toxoplasma gondii phosphoglycerate mutase family protein 0.005 0.0156 1
Onchocerca volvulus 0.005 0.0156 0.0153
Trichomonas vaginalis bromodomain-containing protein, putative 0.003 0.0089 0.5595
Brugia malayi acetyltransferase, GNAT family protein 0.0102 0.0333 0.2108
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.0056 0.3426
Entamoeba histolytica hypothetical protein 0.007 0.0224 0.0379
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0013 0.0814
Schistosoma mansoni hypothetical protein 0.0297 0.0998 0.0998
Brugia malayi nuclear hormone receptor 0.0008 0.0013 0.0078
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.005 0.0156 0.0155
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0156
Entamoeba histolytica G protein alpha subunit, putative 0.0005 0.0003 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0013 0.0078
Mycobacterium ulcerans hypothetical protein 0.005 0.0156 0.0212
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0036 0.0036
Echinococcus multilocularis geminin 0.0131 0.0435 0.0434
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0016 0.0042 0.246
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0047 0.2796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0111 0.0366 0.0366
Trichomonas vaginalis phosphoglycerate mutase, putative 0.005 0.0156 1
Onchocerca volvulus Protein UBASH3A homolog 0.005 0.0156 0.0153
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.005 0.0156 0.0212
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.002 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0013 0.0078
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Brugia malayi UBASH3A protein homolog 0.005 0.0156 0.0985
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0004 0.0001 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0081 0.0077
Trypanosoma cruzi phosphoglycerate mutase, putative 0.005 0.0156 0.0156
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0151
Echinococcus granulosus geminin 0.0131 0.0435 0.0434
Echinococcus granulosus expressed protein 0.0005 0.0003 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0111 0.0366 0.0365
Echinococcus multilocularis expressed protein 0.0005 0.0003 0.0002
Mycobacterium leprae probable isochorismate synthase EntC 0.005 0.0156 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.396
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0013 0.0013
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.005 0.0156 0.0156
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0013 0.0013
Toxoplasma gondii phosphoglycerate mutase family protein 0.005 0.0156 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0013 0.0077
Onchocerca volvulus Protein UBASH3A homolog 0.005 0.0156 0.0153
Mycobacterium ulcerans hydrolase MutT1 0.005 0.0156 0.0212
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0005 0.0005
Echinococcus granulosus inositol monophosphatase 1 0.0029 0.0086 0.0085
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0064 0.396
Trypanosoma brucei glycerolphosphate mutase, putative 0.005 0.0156 0.0151
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0156
Brugia malayi kap beta 3 protein 0.0005 0.0005 0.0026
Loa Loa (eye worm) hypothetical protein 0.2938 1 1
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0013 0.0012
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0156
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0093 0.0302 0.0302
Toxoplasma gondii phosphoglycerate mutase family protein 0.005 0.0156 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Echinococcus granulosus bloom syndrome protein 0.0018 0.005 0.0049
Schistosoma mansoni DNA helicase recq1 0.0008 0.0013 0.0013
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.2938 1 1
Brugia malayi Bloom's syndrome protein homolog 0.0018 0.005 0.031
Schistosoma mansoni hypothetical protein 0.0131 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0001
Echinococcus multilocularis transportin 1 0.0005 0.0005 0.0004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0008 0.0013 0.0013
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.005 0.0156 0.0156
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0032 0.1786
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0005 0.0003 0.0016
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.005 0.0156 0.0264
Onchocerca volvulus Bile acid receptor homolog 0.0008 0.0013 0.001
Schistosoma mansoni 6-phosphofructokinase 0.2938 1 1
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.005 0.0156 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0047 0.0047
Trichomonas vaginalis phosphoglycerate mutase, putative 0.005 0.0156 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.005 0.0156 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0013 0.0078
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0005 0.0003 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.001 0.002 0.1127
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0102 0.0333 0.0332
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0081
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0005 0.0003 0.0016
Schistosoma mansoni GTP-binding protein alpha subunit 0.0005 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0001
Mycobacterium leprae conserved hypothetical protein 0.005 0.0156 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0005 0.0003 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0013 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0013 0.0013
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2888 0.9831 0.9831
Toxoplasma gondii exonuclease III APE 0.0013 0.0032 0.2034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0032 0.0032
Schistosoma mansoni phosphoglycerate mutase 0.005 0.0156 0.0156
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.003 0.0089 0.5682
Leishmania major hypothetical protein, conserved 0.005 0.0156 0.0151
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.005 0.0156 1
Echinococcus multilocularis phosphoglycerate mutase 0.005 0.0156 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0013 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0013 0.0013
Echinococcus multilocularis phosphoglycerate mutase 0.005 0.0156 0.0155
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0151
Brugia malayi steroid hormone receptor 0.0008 0.0013 0.0078
Echinococcus multilocularis bloom syndrome protein 0.0018 0.005 0.0049
Plasmodium falciparum histone acetyltransferase GCN5 0.0027 0.008 0.4987
Echinococcus multilocularis phosphoglycerate mutase 0.005 0.0156 0.0155
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0003
Echinococcus granulosus transportin 1 0.0005 0.0005 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0013 0.0012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.0056 0.3625
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0111 0.0366 0.0365
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0005 0.0003 0.0003
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0005 0.0003 0.0003
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0156
Leishmania major phosphoglycerate mutase family member 5, putative 0.005 0.0156 0.0151
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1254 0.4259 0.4259
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0032 0.1873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.005 0.0156 0.0151
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.005 0.0156 0.0151
Giardia lamblia Hypothetical protein 0.1734 0.5896 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0224 0.0223
Onchocerca volvulus 0.2938 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0027 0.008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0032 0.0031
Trichomonas vaginalis ran, putative 0.002 0.0056 0.3496
Loa Loa (eye worm) hypothetical protein 0.2888 0.9831 0.9831
Mycobacterium leprae conserved hypothetical protein 0.005 0.0156 1
Plasmodium falciparum phosphoglucomutase-2 0.005 0.0156 1
Echinococcus granulosus phosphoglycerate mutase 0.005 0.0156 0.0155
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0029 0.1842
Mycobacterium ulcerans phosphoglycerate mutase 0.005 0.0156 0.0212
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.0056 0.0056
Mycobacterium leprae Possible phosphoglycerate mutase 0.005 0.0156 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0013 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0008 0.0013 0.001
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0108
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0013 0.0013
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0131 0.0435 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0013 0.0078
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.0056 0.0355
Echinococcus multilocularis phosphoglycerate mutase 0.005 0.0156 0.0155
Loa Loa (eye worm) inositol-1 0.0029 0.0086 0.0086
Entamoeba histolytica hypothetical protein 0.007 0.0224 0.0379
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.005 0.0156 0.0212
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0003
Brugia malayi ecdysteroid receptor 0.0008 0.0013 0.0078
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0005 0.0003 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0013 0.0013
Schistosoma mansoni ran 0.002 0.0056 0.0056
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0064 0.0064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0704 0.2386 0.2385
Treponema pallidum phosphoglyceromutase 0.005 0.0156 1
Brugia malayi hypothetical protein 0.0011 0.0026 0.0159
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0086 0.0081
Schistosoma mansoni coup transcription factor 0.0008 0.0013 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.1684 0.5727 0.5727
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0047 0.0042
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.005 0.0156 0.0151
Schistosoma mansoni ran 0.002 0.0056 0.0056
Onchocerca volvulus Protein UBASH3A homolog 0.005 0.0156 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0013 0.0078
Brugia malayi Importin beta-1 subunit 0.0028 0.0081 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0013 0.0078
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0005 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.007 0.0224 0.0224
Entamoeba histolytica HEAT repeat domain containing protein 0.0005 0.0005 0.0008
Echinococcus granulosus translational activator gcn1 0.0005 0.0005 0.0004
Plasmodium falciparum importin beta, putative 0.0028 0.0081 0.508
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0013 0.0012
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0029 0.0086 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0013 0.0078
Trichomonas vaginalis hypothetical protein 0.0005 0.0005 0.0107
Schistosoma mansoni importin beta-1 0.0028 0.0081 0.0081
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1734 0.5896 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0156 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1254 0.4259 0.4259
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0005 0.0003 0.0003
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.005 0.0156 0.0264
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0005 0.0005
Onchocerca volvulus 0.005 0.0156 0.0153
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0013 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0013 0.0078
Echinococcus multilocularis muscleblind protein 1 0.0466 0.1576 0.1576
Treponema pallidum exodeoxyribonuclease (exoA) 0.0013 0.0032 0.2034
Echinococcus granulosus histone acetyltransferase KAT2B 0.003 0.0089 0.0088
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0005 0.0003 0.0002
Mycobacterium ulcerans acid phosphatase 0.005 0.0156 0.0212
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0013 0.0012
Plasmodium vivax importin-beta 2, putative 0.0028 0.0081 0.508
Brugia malayi Inositol-1 0.0029 0.0086 0.0541
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.005 0.0156 0.0156
Echinococcus multilocularis importin 5 0.0005 0.0005 0.0004
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2888 0.9831 0.9831
Schistosoma mansoni phosphoglycerate mutase 0.005 0.0156 0.0156
Trypanosoma brucei phosphoglycerate mutase, putative 0.005 0.0156 0.0151
Trichomonas vaginalis phosphoglycerate mutase, putative 0.005 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0003
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.005 0.0156 1
Toxoplasma gondii phosphoglycerate mutase PGMII 0.005 0.0156 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0013 0.0078
Leishmania major importin beta-1 subunit, putative 0.0023 0.0064 0.0059
Plasmodium vivax phosphoglucomutase-2, putative 0.005 0.0156 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0005 0.0003 0.0002
Echinococcus granulosus importin subunit beta 1 0.0028 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.003 0.0089 0.5682
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.005 0.0156 0.0155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0013 0.0012
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0013 0.0013
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0005 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0008 0.0013 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0008 0.0014 0.0014
Entamoeba histolytica Ran family GTPase 0.002 0.0056 0.0096
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0008 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0111 0.0366 0.0366
Onchocerca volvulus Protein ultraspiracle homolog 0.0008 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0005 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0013 0.0078
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2938 1 1
Echinococcus multilocularis snurportin 1 0.0297 0.0998 0.0997
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0013 0.0013
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.005 0.0156 0.0151
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0086 0.0081
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0029 0.162
Brugia malayi hypothetical protein 0.0018 0.0047 0.0294
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0081 0.5229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0013 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0224 0.0224
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2888 0.9831 0.9831
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0008 0.0013 0.0528
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0156
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.0998 0.0998
Leishmania major GTP-binding protein, putative 0.002 0.0056 0.0052
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1254 0.4259 0.4257
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0005 0.0003 0.0016
Trypanosoma cruzi phosphoglycerate mutase, putative 0.005 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Loa Loa (eye worm) phosphoglycerate mutase 0.005 0.0156 0.0156
Trichomonas vaginalis phosphoglycerate mutase, putative 0.005 0.0156 1
Brugia malayi hypothetical protein 0.0005 0.0003 0.0016
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2938 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0013 0.0013
Echinococcus granulosus phosphoglycerate mutase 0.005 0.0156 0.0155
Schistosoma mansoni GTP-binding protein alpha subunit 0.0005 0.0003 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0013 0.0013
Echinococcus granulosus phosphoglycerate mutase 0.005 0.0156 0.0155
Plasmodium vivax phosphoglycerate mutase, putative 0.005 0.0156 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.002 0.0016
Mycobacterium tuberculosis Possible hydrolase MutT1 0.005 0.0156 1
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.005 0.0156 0.0151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0013 0.0012
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0008 0.0014 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0013 0.0032 0.0027
Trichomonas vaginalis phosphoglycerate mutase, putative 0.005 0.0156 1
Echinococcus multilocularis phosphoglycerate mutase 0.005 0.0156 0.0155
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0047 0.2796
Echinococcus granulosus phosphoglycerate mutase 0.005 0.0156 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0156 1
Trypanosoma cruzi glycerolphosphate mutase, putative 0.005 0.0156 0.0156
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0005 0.0003 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0008 0.0013 0.0012
Mycobacterium ulcerans hypothetical protein 0.1734 0.5896 1
Schistosoma mansoni inositol monophosphatase 0.0029 0.0086 0.0086
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0013 0.0013
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0005 0.0003 0.0003
Plasmodium falciparum phosphoglycerate mutase, putative 0.005 0.0156 1
Onchocerca volvulus 0.0008 0.0013 0.001
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0005 0.0003 0.0003
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2938 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0047 0.2796
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0156
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0005 0.0003 0.0016
Brugia malayi hypothetical protein 0.007 0.0224 0.1416
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.005 0.0156 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0111 0.0366 0.0365
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0013 0.0012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0086 0.0086
Leishmania major hypothetical protein, unknown function 0.005 0.0156 0.0151
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0102 0.0333 0.0333
Trichomonas vaginalis inositol monophosphatase, putative 0.0029 0.0086 0.5422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0013 0.0013
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.005 0.0156 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.0056 0.0056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0032 0.0054
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0029 0.0086 0.0146
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.005 0.0156 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0086 0.5422
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2938 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0005 0.0303
Echinococcus multilocularis translational activator gcn1 0.0005 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0005 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0466 0.1576 0.1576
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0111 0.0366 0.0366
Schistosoma mansoni inositol monophosphatase 0.0029 0.0086 0.0086
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0013 0.0077
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0005 0.0003 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0013 0.0012
Leishmania major glycerolphosphate mutase, putative 0.005 0.0156 0.0151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0013 0.0012
Leishmania major hypothetical protein, conserved 0.0018 0.0047 0.0042
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0032 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.0466 0.1576 0.1576
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0005 0.0003 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0013 0.0012
Entamoeba histolytica hypothetical protein 0.007 0.0224 0.0379
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0013 0.0814
Echinococcus granulosus histone acetyltransferase KAT2B 0.0099 0.0323 0.0323
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Brugia malayi Muscleblind-like protein 0.0466 0.1576 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0032 0.0032
Brugia malayi phosphoglycerate mutase family protein 0.005 0.0156 0.0985
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.005 0.0156 0.0264
Trypanosoma cruzi glycerolphosphate mutase, putative 0.005 0.0156 0.0156
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.002 0.002
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.0056 0.0052
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0013 0.0012
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.2888 0.9831 0.9831
Loa Loa (eye worm) hypothetical protein 0.0466 0.1576 0.1576
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0029 0.0086 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.005 0.0156 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0004 0.0001 0.0001
Mycobacterium ulcerans phosphoglyceromutase 0.005 0.0156 0.0212
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1254 0.4259 0.4257
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0005 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 44 % Inhibition of PDE4B2 (unknown origin) using FAM-cAMP as substrate at 10 uM after 60 min by fluorescence polarization assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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