Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Onchocerca volvulus | 0.042 | 0.7626 | 0.5 | |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0248 | 0.2175 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Mycobacterium ulcerans | hypothetical protein | 0.0248 | 0.2175 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.7626 | 0.7051 |
Giardia lamblia | Hypothetical protein | 0.0248 | 0.2175 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0467 | 0.9128 | 0.6327 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0495 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0413 | 0.7401 | 0.7401 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0413 | 0.7401 | 0.7401 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0248 | 0.2175 | 0.5 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0495 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0248 | 0.2175 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.7401 | 0.6772 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0413 | 0.7401 | 0.7401 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0413 | 0.7401 | 0.7401 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0495 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.02 | 0.0676 | 0.5 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0495 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0495 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0495 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0495 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0467 | 0.9128 | 0.6327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.