Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9606 | 0.9606 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0024 | 0.7795 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.1458 | 0.1458 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.8593 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 1 | 1 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0024 | 0.7795 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.8593 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 1 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.7795 | 0.7795 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8593 | 1 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0024 | 0.7795 | 0.7795 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.7795 | 0.7795 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.8593 | 0.8593 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0024 | 0.7795 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.8593 | 0.8593 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.8593 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0027 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8593 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.8593 | 1 |
Trichomonas vaginalis | chaperonin, putative | 0.0024 | 0.7795 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 61 % | Mean percent inhibition of Estrogen receptor beta in rat | ChEMBL. | 2258907 |
Inhibition (binding) | = 61 % | Mean percent inhibition of Estrogen receptor beta in rat | ChEMBL. | 2258907 |
Mean weight (functional) | = 19.3 mg | Estrogenic activity as mean uterine weight in rats on 10 ug dose | ChEMBL. | 2258907 |
Mean weight (functional) | = 19.3 mg | Estrogenic activity as mean uterine weight in rats on 10 ug dose | ChEMBL. | 2258907 |
Mean weight (functional) | = 23.1 mg | Antiestrogenic activity in presence of unlabeled estradiol as mean uterine weight in rats after 0.3 ug dose | ChEMBL. | 2258907 |
Mean weight (functional) | = 23.1 mg | Antiestrogenic activity in presence of unlabeled estradiol as mean uterine weight in rats after 0.3 ug dose | ChEMBL. | 2258907 |
RBA (functional) | = 153 | Relative binding affinity against Antiestrogen binding site(AEBS) | ChEMBL. | 2258907 |
RBA (binding) | = 0.24 | Relative binding affinity against estrogen receptor(ER) | ChEMBL. | 2258907 |
RBA (functional) | = 153 | Relative binding affinity against Antiestrogen binding site(AEBS) | ChEMBL. | 2258907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.