Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0047 | 0.003 | 0.5 |
Leishmania major | fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein | 0.0047 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.2771 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0053 | 0.0053 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1183 | 0.4186 | 0.4186 |
Trypanosoma brucei | Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative | 0.0047 | 0.003 | 0.003 |
Mycobacterium leprae | conserved hypothetical protein | 0.0047 | 0.003 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1183 | 0.4186 | 0.4186 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0047 | 0.003 | 0.0051 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0047 | 0.003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1589 | 0.5673 | 0.5673 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0047 | 0.003 | 0.003 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0047 | 0.003 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0047 | 0.003 | 0.003 |
Brugia malayi | Protein kinase domain containing protein | 0.1679 | 0.6004 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1679 | 0.6004 | 0.6004 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0174 | 0.0496 | 0.0826 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0047 | 0.003 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0.003 | 0.5 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 0.003 |
Leishmania major | phosphoglycerate mutase protein, putative | 0.0047 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Conserved protein | 0.0047 | 0.003 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0053 | 0.0053 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.003 | 0.003 |
Mycobacterium leprae | conserved hypothetical protein | 0.0047 | 0.003 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.0227 | 0.0198 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0053 | 0.0088 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2771 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0047 | 0.003 | 0.5 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0047 | 0.003 | 0.003 |
Brugia malayi | UBASH3A protein homolog | 0.0047 | 0.003 | 0.0049 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1707 | 0.6104 | 0.6104 |
Leishmania major | hypothetical protein, unknown function | 0.0047 | 0.003 | 0.003 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0047 | 0.003 | 1 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1183 | 0.4186 | 0.4186 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0047 | 0.003 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0053 | 0.0053 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0053 | 0.0053 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1636 | 0.5844 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0047 | 0.003 | 0.5 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0047 | 0.003 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0047 | 0.003 | 0.0051 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0047 | 0.003 | 0.003 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0174 | 0.0496 | 0.0496 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0047 | 0.003 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2725 | 0.9829 | 0.9829 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0053 | 0.0053 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Onchocerca volvulus | 0.2771 | 1 | 1 | |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0174 | 0.0496 | 0.0496 |
Giardia lamblia | Hypothetical protein | 0.1636 | 0.5844 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0047 | 0.003 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.015 | 0.0407 | 0.0407 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1636 | 0.5844 | 1 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2771 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0047 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0047 | 0.003 | 0.5 |
Leishmania major | glycerolphosphate mutase, putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma brucei | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0047 | 0.003 | 0.003 |
Mycobacterium ulcerans | hypothetical protein | 0.1636 | 0.5844 | 1 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0047 | 0.003 | 0.5 |
Treponema pallidum | phosphoglyceromutase | 0.0047 | 0.003 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0047 | 0.003 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1636 | 0.5844 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1183 | 0.4186 | 0.4186 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2725 | 0.9829 | 0.9829 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0047 | 0.003 | 0.5 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0047 | 0.003 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0053 | 0.0053 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0047 | 0.003 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.1679 | 0.6004 | 0.6004 |
Loa Loa (eye worm) | hypothetical protein | 0.2725 | 0.9829 | 0.9829 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.015 | 0.0407 | 0.0407 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1679 | 0.6004 | 0.6004 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0047 | 0.003 | 0.5 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0047 | 0.003 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2771 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0047 | 0.003 | 0.003 |
Leishmania major | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 0.003 |
Leishmania major | phosphoglycerate mutase family member 5, putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2771 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0047 | 0.003 | 0.003 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0047 | 0.003 | 0.003 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0047 | 0.003 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0174 | 0.0496 | 0.0496 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0047 | 0.003 | 0.5 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0047 | 0.003 | 0.5 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0047 | 0.003 | 0.003 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.003 | 0.003 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0941 | 0.3304 | 0.3304 |
Trypanosoma brucei | phosphoglycerate mutase protein, putative | 0.0047 | 0.003 | 0.003 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2771 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0053 | 0.0053 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0047 | 0.003 | 0.003 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2725 | 0.9829 | 0.9829 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.003 | 1 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0047 | 0.003 | 0.003 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0053 | 0.0053 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0047 | 0.003 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0174 | 0.0496 | 0.0496 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0047 | 0.003 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 1 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.1679 | 0.6004 | 0.6004 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2725 | 0.9829 | 0.9829 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0047 | 0.003 | 0.003 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0047 | 0.003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1679 | 0.6004 | 0.6004 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.003 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.003 | 1 |
Trypanosoma brucei | glycerolphosphate mutase, putative | 0.0047 | 0.003 | 0.003 |
Entamoeba histolytica | phosphoglycerate mutase family protein. putative | 0.0047 | 0.003 | 0.0051 |
Mycobacterium tuberculosis | Conserved protein | 0.0047 | 0.003 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.