TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 404.755 | Formula: C18H11ClF2N4O3
H donors: 0 H acceptors: 3 LogP: 3.23 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1n1nc(n(c1=O)C(F)F)C)N1C(=O)c2c(C1=O)cccc2
InChi: 1S/C18H11ClF2N4O3/c1-9-22-25(18(28)23(9)17(20)21)14-8-10(6-7-13(14)19)24-15(26)11-4-2-3-5-12(11)16(24)27/h2-8,17H,1H3
InChiKey: IFHYXMIDWSQYHG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Protein UBASH3A homolog	0.0065	0.0116	0.0098
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0018	0.0179
Entamoeba histolytica	hypothetical protein	0.0027	0.0017	0.0022
Leishmania major	hypothetical protein, unknown function	0.0065	0.0116	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0116	0.0116
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0005	0.0005
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0018	0.0179
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0111	0.0239	0.0234
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0065	0.0116	0.8854
Schistosoma mansoni	phosphoglycerate mutase	0.0065	0.0116	0.0111
Onchocerca volvulus	Protein UBASH3A homolog	0.0065	0.0116	0.0098
Schistosoma mansoni	hypothetical protein	0.0065	0.0116	0.0111
Echinococcus multilocularis	phosphoglycerate mutase	0.0065	0.0116	0.0111
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0065	0.0116	0.3726
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0131	0.0223
Trichomonas vaginalis	glutaminase, putative	0.0317	0.0778	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0111	0.0239	0.0234
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0018	0.0587
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0022	0.0004	0.0004
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0022	0.0004	0.0004
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0065	0.0116	0.1441
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0111	0.0239	0.0234
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0111	0.0239	0.0234
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0125	0.0274	0.8753
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.0131	1
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0027	0.0017	0.0555
Plasmodium vivax	glutathione reductase, putative	0.0055	0.009	0.7766
Loa Loa (eye worm)	glutaminase	0.0317	0.0778	0.0778
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0018	0.0179
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0023	0.0007	0.0007
Mycobacterium ulcerans	hypothetical protein	0.2261	0.588	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0131	0.0223
Mycobacterium leprae	conserved hypothetical protein	0.0065	0.0116	0.3358
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0065	0.0116	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0065	0.0116	0.1441
Echinococcus granulosus	phosphoglycerate mutase	0.0065	0.0116	0.0111
Echinococcus granulosus	phosphoglycerate mutase	0.0065	0.0116	0.0111
Brugia malayi	UBASH3A protein homolog	0.0065	0.0116	0.1441
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0065	0.0116	0.019
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0111	0.0239	0.0234
Mycobacterium ulcerans	acid phosphatase	0.0065	0.0116	0.0197
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0111	0.0239	0.0234
Brugia malayi	Thioredoxin reductase	0.0055	0.009	0.1106
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0018	0.0034
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Schistosoma mansoni	microtubule-associated protein tau	0.08	0.2045	0.2042
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0199	0.0199
Mycobacterium ulcerans	hydrolase MutT1	0.0065	0.0116	0.0197
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0065	0.0116	0.1441
Giardia lamblia	Hypothetical protein	0.2261	0.588	1
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0065	0.0116	0.0111
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0065	0.0116	0.0111
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0125	0.0274	0.8822
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0116	0.1441
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0065	0.0116	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0000062628	0.0000062628
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.009	0.009
Toxoplasma gondii	phosphoglycerate mutase	0.0065	0.0116	0.8854
Echinococcus granulosus	voltage dependent calcium channel	0.0023	0.0007	0.0003
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0027	0.0017	0.0029
Mycobacterium tuberculosis	Probable reductase	0.0125	0.0274	0.8822
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.0131	0.0126
Leishmania major	hypothetical protein, conserved	0.0065	0.0116	0.0111
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0065	0.0116	0.0111
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0005	0.0008
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0065	0.0116	0.0111
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0018	0.0031
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0005	0.0008
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0065	0.0116	0.0111
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0065	0.0116	0.8854
Plasmodium falciparum	glutathione reductase	0.0055	0.009	0.7766
Schistosoma mansoni	hypothetical protein	0.0065	0.0116	0.0111
Onchocerca volvulus		0.0065	0.0116	0.0098
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0065	0.0116	0.8854
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0065	0.0116	0.0197
Loa Loa (eye worm)	RGS-3 protein	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.3766	0.983	0.983
Mycobacterium ulcerans	lipoprotein LpqD	0.0065	0.0116	0.0197
Leishmania major	phosphoglycerate mutase protein, putative	0.0065	0.0116	0.0111
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0065	0.0116	0.0111
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0065	0.0116	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.009	0.0086
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0065	0.0116	0.0111
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0018	0.0034
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0027	0.0017	0.1489
Echinococcus multilocularis	amyloid beta A4 protein	0.008	0.0155	0.0151
Loa Loa (eye worm)	hypothetical protein	0.383	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0131	0.0126
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0005	0.0001
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0065	0.0116	0.8854
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0000062628	0.0000062628
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0139	0.0311	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Brugia malayi	glutathione reductase	0.0055	0.009	0.1106
Echinococcus granulosus	voltage dependent calcium channel	0.0111	0.0239	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0065	0.0116	0.0111
Schistosoma mansoni	phosphoglycerate mutase	0.0065	0.0116	0.0111
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0018	0.0024
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.0131	0.4209
Toxoplasma gondii	transporter, cation channel family protein	0.0023	0.0007	0.0564
Echinococcus granulosus	amyloid beta A4 protein	0.008	0.0155	0.0151
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0047	0.007	0.0066
Mycobacterium tuberculosis	Probable dehydrogenase	0.0125	0.0274	0.8822
Mycobacterium tuberculosis	Probable oxidoreductase	0.0139	0.0311	1
Plasmodium vivax	phosphoglucomutase-2, putative	0.0065	0.0116	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0116	0.0116
Plasmodium vivax	phosphoglycerate mutase, putative	0.0065	0.0116	1
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0065	0.0116	0.0111
Brugia malayi	phosphoglycerate mutase family protein	0.0065	0.0116	0.1441
Onchocerca volvulus	Protein UBASH3A homolog	0.0065	0.0116	0.0098
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0065	0.0116	0.3726
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Schistosoma mansoni	amyloid beta A4 protein related	0.008	0.0155	0.0151
Echinococcus multilocularis	sodium channel protein	0.0047	0.007	0.0066
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.383	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0065	0.0116	0.019
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0017	0.0012
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0111	0.0239	0.3026
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0065	0.0116	0.0111
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.383	1	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0065	0.0116	0.0111
Echinococcus granulosus	phosphoglycerate mutase	0.0065	0.0116	0.0111
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0125	0.0274	0.8822
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0017	0.1489
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0027	0.0017	0.0029
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0139	0.0311	1
Schistosoma mansoni	regulator of G protein signaling	0.0025	0.0013	0.0008
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0022	0.0004	0.0004
Leishmania major	hypothetical protein, conserved	0.0065	0.0116	0.0111
Leishmania major	glycerolphosphate mutase, putative	0.0065	0.0116	0.0111
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0065	0.0116	0.0111
Toxoplasma gondii	thioredoxin reductase	0.0055	0.009	0.6877
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0065	0.0116	0.3358
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3766	0.983	0.983
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0065	0.0116	0.0197
Mycobacterium leprae	probable isochorismate synthase EntC	0.0065	0.0116	0.3358
Trypanosoma cruzi	trypanothione reductase, putative	0.0055	0.009	0.0085
Leishmania major	hypothetical protein, conserved	0.0065	0.0116	0.0111
Schistosoma mansoni	hypothetical protein	0.0065	0.0116	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0000062628	0.0000062628
Echinococcus multilocularis	phosphoglycerate mutase	0.0065	0.0116	0.0111
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0065	0.0116	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0116	0.0116
Mycobacterium ulcerans	phosphoglycerate mutase	0.0065	0.0116	0.0197
Echinococcus granulosus	phosphoglycerate mutase	0.0065	0.0116	0.0111
Echinococcus multilocularis	phosphoglycerate mutase	0.0065	0.0116	0.0111
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.009	0.7766
Onchocerca volvulus		0.0065	0.0116	0.0098
Plasmodium falciparum	phosphoglucomutase-2	0.0065	0.0116	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0000062628	0.0000062628
Loa Loa (eye worm)	glutathione reductase	0.0055	0.009	0.009
Trypanosoma brucei	trypanothione reductase	0.0055	0.009	0.0085
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0027	0.0017	0.5
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0065	0.0116	0.0111
Loa Loa (eye worm)	phosphoglycerate mutase	0.0065	0.0116	0.0116
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.2196	0.571	0.571
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.009	0.0086
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0096	0.0199	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0116	0.0116
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.2261	0.588	1
Plasmodium falciparum	thioredoxin reductase	0.0055	0.009	0.7766
Mycobacterium tuberculosis	Conserved protein	0.0065	0.0116	0.3726
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0005	0.0155
Loa Loa (eye worm)	glutaminase 2	0.0317	0.0778	0.0778
Loa Loa (eye worm)	X11 protein	0.008	0.0155	0.0155
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0065	0.0116	0.0111
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1634	0.4236	0.4233
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0065	0.0116	0.0111
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0027	0.0017	0.1322
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0018	0.0587
Onchocerca volvulus		0.0096	0.0199	0.0181
Leishmania major	phosphoglycerate mutase, putative	0.0065	0.0116	0.0111
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0065	0.0116	0.8854
Mycobacterium leprae	conserved hypothetical protein	0.0065	0.0116	0.3358
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0111	0.0239	0.0234
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0018	0.0013
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0139	0.0311	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0018	0.0031
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0018	0.0031
Leishmania major	phosphopantetheinyl transferase-like protein	0.0027	0.0017	0.0012
Schistosoma mansoni	hypothetical protein	0.0065	0.0116	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0131	0.0223
Echinococcus multilocularis	microtubule associated protein 2	0.08	0.2045	0.2042
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1634	0.4236	0.4233
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0005	0.0005
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0116	0.1441
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0096	0.0199	0.0195
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0125	0.0274	0.8822
Mycobacterium ulcerans	phosphoglyceromutase	0.0065	0.0116	0.0197
Echinococcus multilocularis	phosphoglycerate mutase	0.0065	0.0116	0.0111
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0005	0.0005
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.383	1	1
Leishmania major	trypanothione reductase	0.0055	0.009	0.0085
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0111	0.0239	0.0234
Giardia lamblia	Hypothetical protein	0.2261	0.588	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0065	0.0116	0.0197
Echinococcus granulosus	phosphoglycerate mutase	0.0065	0.0116	0.0111
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0071	0.0133	0.1663
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3766	0.983	0.983
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0018	0.0013
Loa Loa (eye worm)	calcium channel	0.0111	0.0239	0.0239
Echinococcus multilocularis	voltage dependent calcium channel	0.0111	0.0239	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0131	0.0126
Schistosoma mansoni	hypothetical protein	0.0065	0.0116	0.0111
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0018	0.0031
Mycobacterium tuberculosis	Conserved protein	0.0065	0.0116	0.3726
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0005	0.0155
Echinococcus granulosus	microtubule associated protein 2	0.08	0.2045	0.2042
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0065	0.0116	0.0111
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.3766	0.983	0.983
Echinococcus granulosus	expressed protein	0.0433	0.1082	0.1078
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0017	0.1489
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1634	0.4236	0.4233
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0065	0.0116	0.3358
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0065	0.0116	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0147	0.0147
Mycobacterium leprae	conserved hypothetical protein	0.0065	0.0116	0.3358
Mycobacterium ulcerans	phosphoglycerate mutase	0.0065	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0239	0.0239
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0065	0.0116	0.3726
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0111	0.0239	0.0234
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0065	0.0116	0.3358
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0096	0.0199	0.2517
Schistosoma mansoni	6-phosphofructokinase	0.383	1	1
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0065	0.0116	0.3358
Echinococcus multilocularis	phosphoglycerate mutase	0.0065	0.0116	0.0111
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0065	0.0116	0.3726
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0007	0.0007
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0000062628	0.0000062628
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0065	0.0116	0.3726
Schistosoma mansoni	voltage-gated cation channel	0.0111	0.0239	0.0234
Brugia malayi	glutaminase DH11.1	0.0317	0.0778	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0018	0.0024
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0068	0.0124	0.0119
Echinococcus multilocularis	expressed protein	0.0433	0.1082	0.1078
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0005	0.0005
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0018	0.0031
Mycobacterium ulcerans	hypothetical protein	0.0065	0.0116	0.0197
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0065	0.0116	0.019
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0065	0.0116	0.3726
Onchocerca volvulus		0.383	1	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.0131	0.0126
Brugia malayi	hypothetical protein	0.0076	0.0147	0.1842
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0005	0.0005
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0065	0.0116	0.0111
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0065	0.0116	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0004	0.0004
Echinococcus multilocularis	phosphoglycerate mutase	0.0065	0.0116	0.0111
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0065	0.0116	0.1441
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.2261	0.588	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0116	0.0111
Onchocerca volvulus		0.0065	0.0116	0.0098
Treponema pallidum	phosphoglyceromutase	0.0065	0.0116	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0027	0.0017	0.1322
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0065	0.0116	0.0111
Onchocerca volvulus	Protein UBASH3A homolog	0.0065	0.0116	0.0098
Echinococcus granulosus	L aminoadipate semialdehyde	0.0096	0.0199	0.0195
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0018	0.0031
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.383	1	1
Brugia malayi	phosphoglycerate mutase family protein	0.0065	0.0116	0.1441
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0018	0.0024
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0125	0.0274	0.8822
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0055	0.009	0.2894
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0018
Loa Loa (eye worm)	PXA domain-containing protein	0.0022	0.0004	0.0004
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0065	0.0116	0.0111
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0065	0.0116	0.3726
Mycobacterium ulcerans	glutaminase	0.0317	0.0778	0.1323
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.383	1	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0068	0.0124	0.0119
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0065	0.0116	0.0111
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0018	0.0013
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1634	0.4236	0.4233
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0111	0.0239	0.0234
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3766	0.983	0.983
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.0131	0.0126
Schistosoma mansoni	glutaminase	0.0317	0.0778	0.0774

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2252789

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1798861