TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.835 | Formula: C19H21ClN2O3
H donors: 1 H acceptors: 1 LogP: 3.51 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(c1ccccc1CO/N=C(/c1ccccc1Cl)\C)C(=O)NC
InChi: 1S/C19H21ClN2O3/c1-13(15-9-6-7-11-17(15)20)22-25-12-14-8-4-5-10-16(14)18(24-3)19(23)21-2/h4-11,18H,12H2,1-3H3,(H,21,23)/b22-13+
InChiKey: XCJBWBZKQVFJMG-LPYMAVHISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0595
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0217	0.023
Brugia malayi	Dopamine receptor	0.0051	0.0345	0.0653
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0051	0.0345	0.0653
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	amine GPCR	0.0051	0.0345	0.0366
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0051	0.0345	0.0366
Toxoplasma gondii	exonuclease III APE	0.004	0.0199	0.6462
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0345	0.0366
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0068	0.0562	1
Onchocerca volvulus		0.003	0.0074	0.0274
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0051	0.0345	0.0345
Schistosoma mansoni	ap endonuclease	0.004	0.0199	0.0211
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0051	0.0345	0.1279
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	hypothetical protein	0.0032	0.0107	0.0113
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0217	0.3869
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Onchocerca volvulus		0.0051	0.0345	0.1279
Onchocerca volvulus		0.0051	0.0345	0.1279
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0051	0.0345	0.0653
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0345	0.0345
Schistosoma mansoni	opsin-like receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0051	0.0345	0.0653
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0051	0.0345	0.0653
Echinococcus granulosus	integrin alpha ps	0.0068	0.0553	0.0586
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0048	0.0309	0.0998
Echinococcus granulosus	allatostatin A receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0051	0.0345	0.1279
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.1498	0.1588
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Brugia malayi	Serotonin receptor	0.0051	0.0345	0.0653
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0085	0.0777	0.2511
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0051	0.0345	0.0653
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0345	0.0653
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Schistosoma mansoni	neuropeptide f receptor 76f	0.0051	0.0345	0.0366
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0199	0.0377
Echinococcus multilocularis	orexin receptor type 2	0.0051	0.0345	0.0345
Echinococcus granulosus	neuropeptide receptor A26	0.0051	0.0345	0.0366
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0051	0.0345	0.0366
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0074	0.0079
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0068	0.0562	0.0562
Echinococcus multilocularis	integrin alpha 3	0.0116	0.1162	0.1162
Brugia malayi	Serotonin receptor	0.0051	0.0345	0.0653
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Echinococcus granulosus	serotonin receptor	0.0051	0.0345	0.0366
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0257	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1142	0.2162
Brugia malayi	Integrin alpha pat-2 precursor	0.0151	0.1608	0.3043
Brugia malayi	neuroendocrine convertase 1 precursor	0.0278	0.3208	0.607
Echinococcus granulosus	somatostatin receptor	0.0051	0.0345	0.0366
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.27	0.8731
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0085	0.0777	0.2511
Onchocerca volvulus		0.0068	0.0562	0.208
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Onchocerca volvulus		0.0151	0.16	0.5925
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0068	0.0562	0.1816
Echinococcus multilocularis	dro:myosuppressin receptor	0.0051	0.0345	0.0345
Brugia malayi	putative neuropeptide receptor NPR1	0.0051	0.0345	0.0653
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0068	0.0562	1
Onchocerca volvulus		0.0051	0.0345	0.1279
Brugia malayi	neuropeptide F receptor	0.0051	0.0345	0.0653
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	g-protein coupled receptor	0.0051	0.0345	0.0345
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0199	0.3551
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0345	0.0366
Echinococcus multilocularis	neuropeptide s receptor	0.0051	0.0345	0.0345
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Plasmodium falciparum	plasmepsin IV	0.0048	0.0309	1
Brugia malayi	neuropeptide F receptor	0.0051	0.0345	0.0653
Schistosoma mansoni	integrin alpha-ps	0.0035	0.0142	0.015
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0345	0.0345
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	integrin alpha pat-2	0.0233	0.2644	0.5003
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.009	0.1611
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0048	0.0309	0.0584
Brugia malayi	larval opioid receptor	0.0051	0.0345	0.0653
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0048	0.0309	0.0327
Plasmodium vivax	plasmepsin IV, putative	0.0048	0.0309	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0051	0.0345	0.0366
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0199	0.0377
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0104	0.1016	0.3284
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0104	0.1016	0.1076
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0595
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0199	0.0211
Loa Loa (eye worm)	TYRA-2 protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus granulosus	neuroendocrine convertase 2	0.0278	0.3208	0.34
Brugia malayi	Melatonin receptor type 1A	0.0051	0.0345	0.0653
Schistosoma mansoni	histamine h1 receptor	0.0051	0.0345	0.0366
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0199	0.3551
Trypanosoma brucei	unspecified product	0.0035	0.0133	0.2376
Brugia malayi	Pre-SET motif family protein	0.0209	0.2335	0.4419
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.0217	0.0703
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0345	0.0345
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0345	0.0345
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Onchocerca volvulus		0.0051	0.0345	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0085	0.0777	0.2511
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0199	0.5
Onchocerca volvulus		0.0051	0.0345	0.1279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0345	0.0366
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0562
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0051	0.0345	0.1279
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0345	0.0345
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	7TM GPCR rhodopsin	0.0051	0.0345	0.0366
Schistosoma mansoni	growth hormone secretagogue receptor	0.0051	0.0345	0.0366
Plasmodium falciparum	plasmepsin I	0.0048	0.0309	1
Brugia malayi	GnHR receptor homolog	0.0051	0.0345	0.0653
Echinococcus granulosus	neuropeptide FF receptor 2	0.0051	0.0345	0.0366
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0199	0.3551
Brugia malayi	Peptidase family M1 containing protein	0.0151	0.16	0.3027
Echinococcus granulosus	orexin receptor type 2	0.0051	0.0345	0.0366
Brugia malayi	G protein-coupled receptor	0.0051	0.0345	0.0653
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	amine GPCR	0.0051	0.0345	0.0366
Plasmodium falciparum	plasmepsin II	0.0048	0.0309	1
Loa Loa (eye worm)	proprotein convertase 2	0.0104	0.1016	0.1922
Echinococcus granulosus	neuropeptide s receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	integrin alpha-ps	0.0068	0.0553	0.0586
Echinococcus multilocularis	G protein coupled receptor 139	0.0251	0.2866	0.2866
Brugia malayi	G-protein coupled receptor	0.0051	0.0345	0.0653
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0092	0.0854	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0051	0.0345	0.0653
Trypanosoma cruzi	aminopeptidase, putative	0.0068	0.0562	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0595
Schistosoma mansoni	neuropeptide receptor	0.0251	0.2866	0.3038
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0051	0.0345	0.0653
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0074	0.0079
Brugia malayi	hypothetical protein	0.0237	0.2695	0.5099
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0345	0.0345
Giardia lamblia	High cysteine membrane protein Group 2	0.0164	0.1772	1
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0199	0.0645
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.0217	0.0703
Echinococcus granulosus	Furin 1	0.0104	0.1016	0.1076
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0074	0.0079
Echinococcus granulosus	7tm_1 domain containing protein	0.0051	0.0345	0.0366
Brugia malayi	hypothetical protein	0.0068	0.0562	0.1063
Echinococcus granulosus	G protein coupled receptor 139	0.0051	0.0345	0.0366
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0199	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	hypothetical protein	0.0051	0.0345	0.0366
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0133	0.2376
Echinococcus granulosus	hypothetical protein	0.0051	0.0345	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0051	0.0345	0.0653
Brugia malayi	celfurPC protein	0.0356	0.4204	0.7954
Plasmodium vivax	aspartyl proteinase, putative	0.0048	0.0309	1
Echinococcus multilocularis	somatostatin receptor	0.0051	0.0345	0.0345
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	furin	0.0442	0.5285	0.5601
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Brugia malayi	polk-prov protein	0.0031	0.009	0.0171
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0199	0.0645
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0442	0.5285	0.5601
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0051	0.0345	0.0345
Echinococcus granulosus	sex peptide receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0854	0.0905
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0345	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	amine GPCR	0.0051	0.0345	0.0366
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0345	0.0366
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Loa Loa (eye worm)	hypothetical protein	0.003	0.0074	0.014
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0751	0.1421
Schistosoma mansoni	hypothetical protein	0.0048	0.0307	0.0326
Echinococcus multilocularis	sex peptide receptor	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0269
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.1498	0.1588
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0074	0.0079
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	opsin-like receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.2335	0.4419
Loa Loa (eye worm)	melatonin receptor type 1A	0.0051	0.0345	0.0653
Echinococcus granulosus	integrin alpha 3	0.0116	0.1162	0.1231
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0051	0.0345	0.0653
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0106	0.1038	0.1964
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0051	0.0345	0.0366
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0074	0.0079
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0199	0.0199
Schistosoma mansoni	hypothetical protein	0.0085	0.0777	0.0823
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2695	0.2856
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2695	0.2695
Brugia malayi	follicle stimulating hormone receptor	0.0051	0.0345	0.0653
Brugia malayi	sulfakinin receptor protein	0.0051	0.0345	0.0653
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0092	0.0854	0.0905
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.009	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Echinococcus granulosus	integrin alpha ps	0.0032	0.0107	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0051	0.0345	0.0345
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0269	0.3093	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0199	0.6462
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0068	0.0562	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0345	0.0653
Loa Loa (eye worm)	aminopeptidase N	0.0068	0.0562	0.1063
Echinococcus granulosus	dro:myosuppressin receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	serotonin receptor	0.0051	0.0345	0.0345
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0345	0.0366
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0104	0.1016	0.3284
Schistosoma mansoni	hypothetical protein	0.0051	0.0345	0.0366
Schistosoma mansoni	opsin-like receptor	0.0051	0.0345	0.0366
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0104	0.1016	0.3284
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0114	0.1142	0.2162
Onchocerca volvulus		0.0051	0.0345	0.1279
Trypanosoma brucei	Aminopeptidase M1, putative	0.0068	0.0562	1
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0269	0.3093	0.3277
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0562
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0126	0.1295	0.1295
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Trypanosoma brucei	Aminopeptidase M1, putative	0.0068	0.0562	1
Brugia malayi	Dopamine receptor protein 1	0.0051	0.0345	0.0653
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0269	0.3093	0.3093
Brugia malayi	Pre-SET motif family protein	0.003	0.0074	0.014
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0051	0.0345	0.0345
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0074	0.0637	0.0675
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0217	0.3869
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0217	0.3869
Loa Loa (eye worm)	endoprotease bli-4	0.0442	0.5285	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0051	0.0345	0.1279
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0051	0.0345	0.0345
Brugia malayi	RE15519p	0.0051	0.0345	0.0653
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0345	0.0345
Echinococcus multilocularis	neuroendocrine convertase 2	0.0278	0.3208	0.3208
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Brugia malayi	ORL1-like opioid receptor	0.0051	0.0345	0.0653
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0854	0.0905
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	adenoreceptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1197	0.2266
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.077	0.9436	1
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0.0199	0.5
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0068	0.0562	1
Schistosoma mansoni	amine GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0048	0.0309	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0307	0.0581
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0104	0.1016	0.3284
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0074	0.0074
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0044	0.0257	0.4578
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	neuropeptide receptor A26	0.0051	0.0345	0.0345
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0082	0.0734	0.0734
Echinococcus multilocularis	integrin alpha ps	0.0068	0.0553	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0734	0.1388
Brugia malayi	proprotein convertase 2	0.0278	0.3208	0.607
Schistosoma mansoni	ap endonuclease	0.004	0.0199	0.0211
Schistosoma mansoni	furin-1 (S08 family)	0.0192	0.2127	0.2254
Echinococcus granulosus	fmrfamide receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	cathepsin D (A01 family)	0.0143	0.1503	0.1593
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0199	0.3551
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0345	0.0366
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0104	0.1016	0.3284
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0345	0.0345
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0309	0.0584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Echinococcus granulosus	aminopeptidase N	0.0151	0.16	0.1696
Toxoplasma gondii	aspartyl protease ASP1	0.0048	0.0309	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0126	0.1295	0.1373
Echinococcus multilocularis	Furin 1	0.0104	0.1016	0.1016
Schistosoma mansoni	amine GPCR	0.0051	0.0345	0.0366
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0048	0.0307	0.1138
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0051	0.0345	0.0366
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0345	0.0653
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.077	0.9436	0.9436
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1888	0.3572
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0345	0.0366
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0199	0.5
Mycobacterium ulcerans	aminopeptidase N PepN	0.0068	0.0562	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0345	0.0345
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0082	0.0734	0.0778
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0345	0.0366
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Brugia malayi	endoprotease bli-4 precursor	0.0442	0.5285	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0143	0.1503	0.1593
Giardia lamblia	Furin precursor putative serine protease	0.0085	0.0777	0.3669
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	hypothetical protein	0.0051	0.0345	0.0366
Echinococcus multilocularis	integrin alpha ps	0.0032	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Brugia malayi	G-protein coupled receptor	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2695	0.5099
Brugia malayi	Dopamine receptor protein 2	0.0051	0.0345	0.0653
Plasmodium vivax	SET domain protein, putative	0.003	0.0074	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0345	0.0366
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Onchocerca volvulus		0.0051	0.0345	0.1279
Echinococcus multilocularis	allatostatin A receptor	0.0051	0.0345	0.0345
Brugia malayi	G protein-coupled receptor F59B2.13	0.0051	0.0345	0.0653
Entamoeba histolytica	aminopeptidase, putative	0.0068	0.0562	1
Onchocerca volvulus		0.0051	0.0345	0.1279
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0345	0.0366
Echinococcus multilocularis	integrin alpha ps	0.0068	0.0553	0.0553
Brugia malayi	Peptidase family M1 containing protein	0.0068	0.0562	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0238	0.27	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0345	0.0345
Plasmodium falciparum	plasmepsin VI	0.0048	0.0309	1
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0345	0.0345
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0048	0.0309	0.0309
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	hypothetical protein	0.0126	0.1295	0.1373
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0044	0.0257	0.0272
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.077	0.9436	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Trichomonas vaginalis	hypothetical protein	0.0085	0.0777	0.2511
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0217	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0562
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0051	0.0345	0.1279
Onchocerca volvulus		0.0051	0.0345	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0257	0.0486
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1295	0.2451
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0562
Onchocerca volvulus		0.0051	0.0345	0.1279
Onchocerca volvulus		0.0051	0.0345	0.1279
Brugia malayi	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0345	0.0653
Schistosoma mansoni	integrin alpha	0.0151	0.1608	0.1705
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0345	0.0345
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0051	0.0345	0.1279
Brugia malayi	putative neuropeptide receptor	0.0051	0.0345	0.0653
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0074	0.0074
Echinococcus multilocularis	aminopeptidase N	0.0151	0.16	0.16
Echinococcus granulosus	neuropeptide receptor	0.0251	0.2866	0.3038
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0068	0.0562	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0309	0.0327
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0217	0.0217
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0068	0.0562	0.0595
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0074	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0202
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0562
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Echinococcus multilocularis		0.0356	0.4204	0.4204
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0269	0.3093	1
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0307	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0044	0.0257	0.0257
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0051	0.0345	0.0345
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0092	0.0854	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.1498	0.1498
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0777	0.2511
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0345	0.0366
Schistosoma mansoni	myosin xvIII	0.0051	0.0345	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0345	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Brugia malayi	AKH receptor	0.0051	0.0345	0.0653
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0068	0.0562	0.1816
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0051	0.0345	0.0345
Echinococcus multilocularis	neuropeptide receptor	0.0251	0.2866	0.2866
Echinococcus granulosus	g-protein coupled receptor	0.0051	0.0345	0.0366
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0104	0.1016	0.3284
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653
Schistosoma mansoni	hypothetical protein	0.0051	0.0345	0.0366
Onchocerca volvulus		0.0051	0.0345	0.1279
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0199	0.6462
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0345	0.0345
Echinococcus multilocularis	serotonin receptor	0.0051	0.0345	0.0345
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0345	0.0366
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.006	0.0064
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0345	0.0345
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0068	0.0562	0.0595
Onchocerca volvulus		0.0051	0.0345	0.1279
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0217	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0345	0.0653

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2271958

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1798911