Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0888 | 0.4155 | 0.4149 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0083 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 0.0079 | 0.0069 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2046 | 0.9828 | 0.9828 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2081 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0079 | 0.0079 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.2046 | 0.9828 | 0.9828 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0081 | 0.0081 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.0101 | 0.009 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0066 | 0.0066 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.019 | 0.5625 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0037 | 0.0831 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0011 | 0.0318 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0011 | 0.0011 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0108 | 0.0333 | 0.0333 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.1531 | 0.1522 |
Echinococcus granulosus | geminin | 0.0191 | 0.0742 | 0.0742 |
Brugia malayi | Heterochromatin protein 1 | 0.0079 | 0.019 | 0.5712 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.005 | 0.0048 | 0.0037 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0079 | 0.0079 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0021 | 0.0021 |
Trypanosoma brucei | polo-like protein kinase | 0.0107 | 0.033 | 0.0319 |
Onchocerca volvulus | 0.2081 | 1 | 1 | |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0107 | 0.033 | 0.9904 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0107 | 0.033 | 0.033 |
Brugia malayi | jmjC domain containing protein | 0.0108 | 0.0333 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1228 | 0.5822 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0021 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2046 | 0.9828 | 0.9828 |
Giardia lamblia | Hypothetical protein | 0.1228 | 0.5822 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Mycobacterium ulcerans | hypothetical protein | 0.0186 | 0.0714 | 0.1211 |
Schistosoma mansoni | jumonji domain containing protein | 0.0086 | 0.0224 | 0.0224 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0079 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.2081 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.112 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2046 | 0.9828 | 0.9828 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.0079 | 0.0069 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.019 | 0.019 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.0138 | 0.0138 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0107 | 0.033 | 0.033 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.1193 | 0.565 | 0.565 |
Echinococcus multilocularis | geminin | 0.0191 | 0.0742 | 0.0742 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 0.1531 | 0.1522 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0108 | 0.0333 | 0.0333 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2046 | 0.9828 | 0.9828 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 0.0079 | 0.0069 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0011 | 0.0011 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0622 | 0.0612 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0107 | 0.033 | 0.033 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0011 | 0.0011 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0021 | 0.0626 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2081 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0742 | 0.0742 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0011 | 0.0322 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 0.0079 | 0.0069 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0037 | 0.0831 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0011 | 0.0322 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0048 | 0.0037 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0011 | 0.0011 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0107 | 0.033 | 0.0319 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 0.0079 | 0.0069 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1228 | 0.5822 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0079 | 0.019 | 0.019 |
Giardia lamblia | Hypothetical protein | 0.1228 | 0.5822 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0167 | 0.0622 | 0.0612 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.033 | 0.033 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.0079 | 0.9446 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0079 | 0.0079 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0011 | 0.0011 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Schistosoma mansoni | kinase | 0.0055 | 0.0073 | 0.0073 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.0079 | 0.0069 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0079 | 0.0079 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0037 | 0.0027 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0029 | 0.0029 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0066 | 0.173 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0066 | 0.0066 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0066 | 0.0066 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0079 | 0.2384 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.019 | 0.5625 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.019 | 0.019 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0066 | 0.1995 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2081 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0352 | 0.1531 | 0.1522 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0011 | 0.0322 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0079 | 0.2152 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0066 | 0.0066 |
Giardia lamblia | Kinase, PLK | 0.0107 | 0.033 | 0.0436 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0066 | 0.0066 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0021 | 0.0317 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0066 | 0.173 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 0.1531 | 0.1522 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0167 | 0.0622 | 0.0612 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0107 | 0.033 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.033 | 0.0319 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0021 | 0.0317 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0011 | 0.0322 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0011 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0079 | 0.0069 |
Mycobacterium ulcerans | hypothetical protein | 0.1228 | 0.5822 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0186 | 0.0714 | 0.6344 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0011 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0011 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0742 | 0.0742 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.033 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0888 | 0.4155 | 0.4149 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0011 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.