Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | phosphoglycerate mutase protein, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | phosphoglycerate mutase | 0.0029 | 0.0039 | 0.0067 |
Giardia lamblia | Hypothetical protein | 0.1012 | 0.5848 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1685 | 0.9829 | 0.9829 |
Mycobacterium ulcerans | hypothetical protein | 0.1012 | 0.5848 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0059 | 0.0216 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0029 | 0.0039 | 0.0039 |
Leishmania major | fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein | 0.0029 | 0.0039 | 0.0039 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0029 | 0.0039 | 0.0327 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1685 | 0.9829 | 0.9829 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1714 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.0216 | 0.0177 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0029 | 0.0039 | 0.5 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0059 | 0.0216 | 0.0177 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0029 | 0.0039 | 0.5 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0059 | 0.0216 | 0.0177 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0029 | 0.0039 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | phosphoglyceromutase | 0.0029 | 0.0039 | 0.0067 |
Onchocerca volvulus | 0.1714 | 1 | 1 | |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0.0039 | 0.0067 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0059 | 0.0216 | 1 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Leishmania major | protein kinase, putative | 0.0059 | 0.0216 | 0.0216 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0029 | 0.0039 | 0.5 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1714 | 1 | 1 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0029 | 0.0039 | 0.0039 |
Echinococcus granulosus | hypothetical protein | 0.0058 | 0.0213 | 0.0175 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0029 | 0.0039 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0.0039 | 0.5 |
Trypanosoma brucei | phosphoglycerate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0059 | 0.0216 | 0.0216 |
Trypanosoma brucei | phosphoglycerate mutase protein, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0029 | 0.0039 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0059 | 0.0216 | 0.0216 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0059 | 0.0216 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.1685 | 0.9829 | 0.9829 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0731 | 0.4191 | 0.4191 |
Mycobacterium ulcerans | phosphoglycerate mutase | 0.0029 | 0.0039 | 0.0067 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0059 | 0.0216 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0039 | 0.0039 |
Leishmania major | glycerolphosphate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | hydrolase MutT1 | 0.0029 | 0.0039 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0039 | 0.0039 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.0216 | 0.1799 |
Loa Loa (eye worm) | hypothetical protein | 0.0983 | 0.5677 | 0.5677 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0029 | 0.0039 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0059 | 0.0494 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Leishmania major | phosphoglycerate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.12 | 0.12 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0.0039 | 0.0067 |
Mycobacterium ulcerans | phosphohistidine phosphatase SixA | 0.0029 | 0.0039 | 0.0067 |
Giardia lamblia | Hypothetical protein | 0.1012 | 0.5848 | 1 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0029 | 0.0039 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0029 | 0.0039 | 0.5 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0059 | 0.0216 | 0.0216 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.0216 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0029 | 0.0039 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.0216 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0029 | 0.0039 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0039 | 0.0039 |
Brugia malayi | UBASH3A protein homolog | 0.0029 | 0.0039 | 0.0327 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Conserved protein | 0.0029 | 0.0039 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0029 | 0.0039 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1685 | 0.9829 | 0.9829 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0059 | 0.0059 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0029 | 0.0039 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0.0039 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0059 | 0.0216 | 0.0216 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0731 | 0.4191 | 0.4191 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1714 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1714 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1714 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1714 | 1 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1685 | 0.9829 | 0.9829 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0029 | 0.0039 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0029 | 0.0039 | 0.5 |
Treponema pallidum | phosphoglyceromutase | 0.0029 | 0.0039 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0059 | 0.0216 | 0.0216 |
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.12 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0.0039 | 0.5 |
Leishmania major | phosphoglycerate mutase family member 5, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0029 | 0.0039 | 0.0039 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0029 | 0.0039 | 0.5 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | glycerolphosphate mutase, putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | acid phosphatase | 0.0029 | 0.0039 | 0.0067 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0731 | 0.4191 | 0.4191 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1012 | 0.5848 | 1 |
Mycobacterium ulcerans | lipoprotein LpqD | 0.0029 | 0.0039 | 0.0067 |
Mycobacterium ulcerans | bifunctional RNase H/acid phosphatase | 0.0029 | 0.0039 | 0.0067 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1012 | 0.5848 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0029 | 0.0039 | 0.0039 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0029 | 0.0039 | 0.0039 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1714 | 1 | 1 |
Echinococcus multilocularis | 0.0058 | 0.0213 | 0.0175 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0731 | 0.4191 | 0.4191 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0059 | 0.0216 | 1 |
Leishmania major | protein kinase, putative | 0.0059 | 0.0216 | 0.0216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.