TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 336.899 | Formula: C19H29ClN2O
H donors: 1 H acceptors: 1 LogP: 4.2 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NCCCN1CCCCC1)CCCCc1ccc(cc1)Cl
InChi: 1S/C19H29ClN2O/c20-18-11-9-17(10-12-18)7-2-3-8-19(23)21-13-6-16-22-14-4-1-5-15-22/h9-12H,1-8,13-16H2,(H,21,23)
InChiKey: UPDWSMDMTBILPY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide FF receptor 2	0.0032	0.0107	0.0107
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0107	0.0107
Toxoplasma gondii	phosphoglycerate mutase	0.0035	0.0124	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Plasmodium vivax	phosphoglucomutase-2, putative	0.0035	0.0124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0032	0.0107	0.0107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.019	0.019
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Giardia lamblia	Hypothetical protein	0.1233	0.5883	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0032	0.0107	0.0107
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0035	0.0124	0.5
Schistosoma mansoni	hypothetical protein	0.0035	0.0124	0.0124
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.001	0.001
Echinococcus multilocularis	somatostatin receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0124	0.0124
Brugia malayi	larval opioid receptor	0.0032	0.0107	0.1206
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.001	0.0113
Onchocerca volvulus	Protein UBASH3A homolog	0.0035	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0035	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0035	0.0124	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.001	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.001	0.0113
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	myosin xvIII	0.0032	0.0107	0.0107
Brugia malayi	Serotonin receptor	0.0032	0.0107	0.1206
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0032	0.0107	0.0107
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0035	0.0124	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.001	0.001
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0035	0.0124	0.0124
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.001	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0035	0.0124	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0035	0.0124	0.0124
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0032	0.0107	0.0107
Brugia malayi	ORL1-like opioid receptor	0.0032	0.0107	0.1206
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.019	0.019
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0124	0.0124
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0035	0.0124	0.0124
Echinococcus multilocularis	phosphoglycerate mutase	0.0035	0.0124	0.0124
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0032	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	melatonin receptor type 1A	0.0032	0.0107	0.0107
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.001	0.001
Echinococcus multilocularis	sex peptide receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	growth hormone secretagogue receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.001	0.0113
Echinococcus granulosus	dro:myosuppressin receptor	0.0032	0.0107	0.0107
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0035	0.0124	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.001	0.0113
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.001	0.001
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.001	0.0113
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0107	0.0107
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0035	0.0124	0.5
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0035	0.0124	0.0124
Onchocerca volvulus		0.0012	0.001	0.001
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0032	0.0107	0.0107
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.001	0.001
Echinococcus multilocularis	neuropeptides capa receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	neuropeptide receptor A26	0.0032	0.0107	0.0107
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0035	0.0124	0.5
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.1233	0.5883	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Brugia malayi	N-terminal motif family protein	0.0194	0.0886	1
Brugia malayi	putative neuropeptide receptor	0.0032	0.0107	0.1206
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0032	0.0107	0.1206
Brugia malayi	nuclear hormone receptor	0.0012	0.001	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus multilocularis	serotonin receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	phosphoglycerate mutase	0.0035	0.0124	0.0124
Onchocerca volvulus		0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Brugia malayi	Dopamine receptor	0.0032	0.0107	0.1206
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.001	0.001
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.001	0.001
Echinococcus granulosus	sex peptide receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.019	0.019
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0032	0.0107	0.0107
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0032	0.0107	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Schistosoma mansoni	phosphoglycerate mutase	0.0035	0.0124	0.0124
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0124	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2088	1	1
Brugia malayi	Dopamine receptor protein 1	0.0032	0.0107	0.1206
Schistosoma mansoni	neuropeptide f receptor 76f	0.0032	0.0107	0.0107
Echinococcus granulosus	neuropeptide s receptor	0.0032	0.0107	0.0107
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0035	0.0124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.001	0.001
Brugia malayi	follicle stimulating hormone receptor	0.0032	0.0107	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0035	0.0124	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.001	0.0113
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.001	0.001
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0124	0.0124
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	putative neuropeptide receptor NPR1	0.0032	0.0107	0.1206
Schistosoma mansoni	opsin-like receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0032	0.0107	0.0107
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2053	0.983	0.9828
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0124	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0107	0.0107
Brugia malayi	G protein-coupled receptor	0.0032	0.0107	0.1206
Echinococcus granulosus	G protein coupled receptor 139	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	G-protein coupled receptor	0.0032	0.0107	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.001	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.001	0.001
Brugia malayi	AKH receptor	0.0032	0.0107	0.1206
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Echinococcus granulosus	allatostatin A receptor	0.0032	0.0107	0.0107
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0032	0.0107	0.0107
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	amine GPCR	0.0032	0.0107	0.0107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.019	0.019
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	phosphoglycerate mutase	0.0035	0.0124	0.0124
Echinococcus multilocularis	phosphoglycerate mutase	0.0035	0.0124	0.0124
Echinococcus multilocularis	neuropeptide receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	neuropeptide F receptor	0.0032	0.0107	0.1206
Brugia malayi	Melatonin receptor type 1A	0.0032	0.0107	0.1206
Schistosoma mansoni	histamine h1 receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Loa Loa (eye worm)	TYRA-2 protein	0.0032	0.0107	0.0107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.019	0.019
Mycobacterium leprae	probable isochorismate synthase EntC	0.0035	0.0124	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.001	0.0113
Echinococcus multilocularis	neuropeptide Y receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0032	0.0107	0.0107
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0035	0.0124	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.001	0.001
Echinococcus multilocularis	orexin receptor type 2	0.0032	0.0107	0.0107
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.001	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0035	0.0124	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Brugia malayi	Serotonin receptor	0.0032	0.0107	0.1206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.001	0.001
Echinococcus multilocularis	allatostatin A receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0124	0.5
Onchocerca volvulus		0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.001	0.0113
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2088	1	1
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0035	0.0124	0.0124
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0032	0.0107	0.0107
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0035	0.0124	1
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0107	0.0107
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2088	1	1
Schistosoma mansoni	amine GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0107	0.0107
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0032	0.0107	0.1206
Loa Loa (eye worm)	hypothetical protein	0.1197	0.5713	0.5713
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0107	0.0107
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.001	0.001
Echinococcus granulosus	g-protein coupled receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	phosphoglycerate mutase	0.0035	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.001	0.0113
Brugia malayi	nuclear receptor NHR-88	0.0012	0.001	0.0113
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.001	0.001
Schistosoma mansoni	amine GPCR	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Giardia lamblia	Hypothetical protein	0.1233	0.5883	0.5
Plasmodium falciparum	phosphoglucomutase-2	0.0035	0.0124	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0891	0.4241	0.4169
Treponema pallidum	phosphoglyceromutase	0.0035	0.0124	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.001	0.001
Brugia malayi	steroid hormone receptor	0.0012	0.001	0.0113
Onchocerca volvulus	Protein UBASH3A homolog	0.0035	0.0124	0.0124
Echinococcus multilocularis	geminin	0.0182	0.0829	0.0829
Brugia malayi	neuropeptide F receptor	0.0032	0.0107	0.1206
Echinococcus granulosus	7TM GPCR rhodopsin	0.0032	0.0107	0.0107
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0032	0.0107	0.0107
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.001	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus multilocularis	dro:myosuppressin receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	opsin-like receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0032	0.0107	0.0107
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.2053	0.983	0.983
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0035	0.0124	0.5
Brugia malayi	phosphoglycerate mutase family protein	0.0035	0.0124	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.001	0.001
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0035	0.0124	0.5
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0035	0.0124	0.5
Echinococcus multilocularis	serotonin receptor	0.0032	0.0107	0.0107
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0124	0.5
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.001	0.0113
Onchocerca volvulus		0.0032	0.0107	0.0107
Brugia malayi	GnHR receptor homolog	0.0032	0.0107	0.1206
Brugia malayi	phosphoglycerate mutase family protein	0.0035	0.0124	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0035	0.0124	0.0124
Echinococcus multilocularis	phosphoglycerate mutase	0.0035	0.0124	0.0124
Brugia malayi	ecdysteroid receptor	0.0012	0.001	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.001	0.0113
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0032	0.0107	0.0107
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0891	0.4241	0.4169
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0035	0.0124	0.0124
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.1233	0.5883	1
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.2088	1	1
Onchocerca volvulus		0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0032	0.0107	0.0107
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.2053	0.983	0.9828
Onchocerca volvulus	Protein UBASH3A homolog	0.0035	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0032	0.0107	0.1206
Loa Loa (eye worm)	phosphoglycerate mutase	0.0035	0.0124	0.0124
Onchocerca volvulus		0.0032	0.0107	0.0107
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0107	0.0107
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0035	0.0124	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus multilocularis	neuropeptide receptor A26	0.0032	0.0107	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0032	0.0107	0.0107
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.019	0.2147
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0107	0.0107
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0124	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0107	0.0107
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.001	0.0113
Echinococcus multilocularis	neuropeptide receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0107	0.0107
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0886	0.0886
Brugia malayi	G protein-coupled receptor F59B2.13	0.0032	0.0107	0.1206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0107	0.0107
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0124	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0032	0.0107	0.0107
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0035	0.0124	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0035	0.0124	1
Echinococcus granulosus	phosphoglycerate mutase	0.0035	0.0124	0.0124
Brugia malayi	sulfakinin receptor protein	0.0032	0.0107	0.1206
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0032	0.0107	0.0107
Schistosoma mansoni	opsin-like receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus multilocularis	G protein coupled receptor 139	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.001	0.001
Onchocerca volvulus		0.2088	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.001	0.001
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.001	0.001
Echinococcus granulosus	phosphoglycerate mutase	0.0035	0.0124	0.0124
Schistosoma mansoni	amine GPCR	0.0032	0.0107	0.0107
Echinococcus granulosus	geminin	0.0182	0.0829	0.0829
Plasmodium vivax	phosphoglycerate mutase, putative	0.0035	0.0124	0.5
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0032	0.0107	0.0107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0032	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0182	0.0829	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0032	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.001	0.0113
Echinococcus granulosus	orexin receptor type 2	0.0032	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0035	0.0124	0.0124
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0035	0.0124	0.5
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0194	0.0886	0.0886
Brugia malayi	UBASH3A protein homolog	0.0035	0.0124	0.1397
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	RE15519p	0.0032	0.0107	0.1206
Echinococcus granulosus	phosphoglycerate mutase	0.0035	0.0124	0.0124
Echinococcus multilocularis	fmrfamide receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	fmrfamide receptor	0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2053	0.983	0.9828
Schistosoma mansoni	hypothetical protein	0.0182	0.0829	0.0829
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.001	0.0113
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0035	0.0124	0.5
Onchocerca volvulus		0.0032	0.0107	0.0107
Echinococcus multilocularis	neuropeptide Y receptor	0.0032	0.0107	0.0107
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.0891	0.4241	0.4169
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.001	0.0113
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.001	0.001
Echinococcus granulosus	somatostatin receptor	0.0032	0.0107	0.0107
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0032	0.0107	0.0107
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.019	0.019
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.001	0.001
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0032	0.0107	0.1206
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.2088	1	1
Onchocerca volvulus		0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.019	0.019
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0032	0.0107	0.1206
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0891	0.4241	0.4169
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Schistosoma mansoni	phosphoglycerate mutase	0.0035	0.0124	0.0124
Brugia malayi	Dopamine receptor protein 2	0.0032	0.0107	0.1206
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.019	0.019
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2053	0.983	0.9828
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0035	0.0124	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.001	0.001
Onchocerca volvulus		0.0032	0.0107	0.0107
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0035	0.0124	0.0124
Echinococcus granulosus	phosphoglycerate mutase	0.0035	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0035	0.0124	0.0124
Schistosoma mansoni	adenoreceptor	0.0032	0.0107	0.0107
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2088	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.001	0.001
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.001	0.001
Echinococcus granulosus	serotonin receptor	0.0032	0.0107	0.0107
Onchocerca volvulus	Protein UBASH3A homolog	0.0035	0.0124	0.0124
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0035	0.0124	0.5
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0124	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Echinococcus granulosus	hypothetical protein	0.0032	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0032	0.0107	0.1206
Schistosoma mansoni	amine GPCR	0.0032	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0107
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0035	0.0124	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0107	0.0107
Onchocerca volvulus		0.0035	0.0124	0.0124
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0032	0.0107	0.0107
Echinococcus granulosus	fmrfamide receptor	0.0032	0.0107	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0107	0.0107
Mycobacterium ulcerans	hypothetical protein	0.1233	0.5883	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0035	0.0124	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0032	0.0107	0.0107
Brugia malayi	G-protein coupled receptor	0.0032	0.0107	0.1206
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0032	0.0107	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.001	0.001
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.001	0.001
Schistosoma mansoni	6-phosphofructokinase	0.2088	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0107	0.0107
Schistosoma mansoni	coup transcription factor	0.0012	0.001	0.001
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0035	0.0124	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3040755

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1799786