Detailed information for compound 1799941

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 516.517 | Formula: C29H25FN2O6
  • H donors: 0 H acceptors: 3 LogP: 5.25 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO/C=C(\c1ccccc1COc1cc(nn1C)c1ccccc1OC(=O)c1ccc(cc1)F)/C(=O)OC
  • InChi: 1S/C29H25FN2O6/c1-32-27(37-17-20-8-4-5-9-22(20)24(18-35-2)29(34)36-3)16-25(31-32)23-10-6-7-11-26(23)38-28(33)19-12-14-21(30)15-13-19/h4-16,18H,17H2,1-3H3/b24-18+
  • InChiKey: BQBCQLNHNZUJJG-HKOYGPOVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Cytochrome b Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii Cytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Toxoplasma gondii apocytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium yoelii Cytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Babesia bovis cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Echinococcus granulosus cytochrome B Get druggable targets OG5_128504 All targets in OG5_128504
Toxoplasma gondii apocytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Theileria parva cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium berghei cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Toxoplasma gondii cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrB Get druggable targets OG5_128504 All targets in OG5_128504
Schistosoma mansoni cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Schistosoma japonicum ko:K00412 ubiquinol-cytochrome c reductase cytochrome b subunit, putative Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium knowlesi cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Onchocerca volvulus Get druggable targets OG5_128504 All targets in OG5_128504
Mycobacterium leprae Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium yoelii Cytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Mycobacterium tuberculosis Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium falciparum cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium vivax cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex Get druggable targets OG5_128504 All targets in OG5_128504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Leishmania major hypothetical protein, conserved 0.0017 0.0101 0.0235
Loa Loa (eye worm) hypothetical protein 0.004 0.0414 0.1
Echinococcus multilocularis chromobox protein 2 0.0012 0.0039 0.0037
Echinococcus multilocularis cpg binding protein 0.0033 0.0317 0.0315
Brugia malayi steroid hormone receptor 0.0021 0.0162 0.0416
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0497 0.0495
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0095 0.0245
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0414 0.0412
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.1019 0.208
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0624 0.1421
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0058 0.0666 0.0664
Echinococcus granulosus tar DNA binding protein 0.0069 0.0813 0.0811
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1745
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0083 0.1001 0.9696
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Toxoplasma gondii cytochrome b 0.0083 0.1001 0.9814
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0384 0.1454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0134 0.0248
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0759 0.0757
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.077 0.1028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0199
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0414 0.0406
Brugia malayi Nuclear hormone receptor E75 0.001 0.0008 0.0021
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0384 0.3976
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.077 0.9072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0162 0.0416
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.084 0.0839
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Schistosoma mansoni cpg binding protein 0.0031 0.0293 0.0285
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0384 0.4314
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0414 0.4367
Loa Loa (eye worm) hypothetical protein 0.0189 0.2455 0.5951
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0162 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0765 0.0758
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0413 0.4675
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0101 0.0242
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0083 0.0115
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0813 0.0811
Brugia malayi nuclear receptor NHR-67 0.001 0.0008 0.0021
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0432 0.043
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4811
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0162 0.0153
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0894 0.2224
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Schistosoma mansoni DNA polymerase eta 0.0016 0.0084 0.0076
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0497 0.4709
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.1999 0.1997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0162 0.0388
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrB 0.0293 0.3883 0.9999
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1624 0.3934
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0162 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0619 0.0611
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0162 0.0416
Onchocerca volvulus 0.0189 0.2455 0.6314
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0039 0.0027
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0813 0.1967
Schistosoma mansoni inositol monophosphatase 0.004 0.0413 0.0406
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0162 0.0388
Leishmania major DNA polymerase kappa, putative 0.0023 0.0181 0.128
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0084 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0095 0.0094
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0039 0.0067
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0039 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1205 0.1204
Trypanosoma brucei unspecified product 0.0037 0.0377 0.437
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0164 0.1784
Echinococcus granulosus transcription factor btf3 0.0038 0.0384 0.0383
Schistosoma mansoni hypothetical protein 0.0189 0.2455 0.2449
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0008 0.0016
Brugia malayi chromobox protein homolog 3 0.0042 0.0444 0.1145
Plasmodium vivax cytochrome b 0.0083 0.1001 0.3998
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 0.4074
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0162 0.016
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0164 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0384 0.0899
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0063 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0162 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0162 0.0416
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Echinococcus multilocularis dna polymerase eta 0.0016 0.0084 0.0082
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0414 0.0406
Echinococcus multilocularis tumor protein p63 0.0363 0.4831 0.483
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.084 0.2163
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0762 0.0755
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0813 0.1967
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0762 0.1787
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0734 0.0733
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Brugia malayi beta-NAC-like protein 0.0038 0.0384 0.099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0162 0.0416
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0162 0.016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0722 0.699
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0101 0.0703
Schistosoma mansoni hypothetical protein 0.0012 0.0039 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0162 0.016
Schistosoma mansoni cytochrome b 0.0083 0.1001 0.0993
Brugia malayi Inositol-1 0.004 0.0413 0.1064
Echinococcus multilocularis RUN 0.0189 0.2455 0.2454
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0413 0.0975
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0414 0.4367
Leishmania major basic transcription factor 3a, putative 0.0038 0.0384 0.3976
Echinococcus granulosus Chromobox protein 3 0.0012 0.0039 0.0037
Schistosoma mansoni hypothetical protein 0.0058 0.0666 0.0658
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.077 0.0768
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0008 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0619 0.0618
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0025 0.0016
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0008 0.0007
Echinococcus multilocularis macrophage expressed protein 0.0106 0.1325 0.1324
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0039 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Echinococcus multilocularis Polycystic kidney disease protein 0.0189 0.2455 0.2454
Brugia malayi RNA binding protein 0.0069 0.0813 0.2092
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0162 0.0416
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0762 0.1006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0162 0.016
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0034 0.002
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0253 0.0914
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0762 0.0761
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0488 0.1169
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0162 0.0153
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0729 0.9846 0.9846
Giardia lamblia DINP protein human, muc B family 0.0023 0.0181 0.0353
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0894 0.2224
Brugia malayi Muscleblind-like protein 0.0162 0.2091 0.5384
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0734 0.0733
Schistosoma mansoni lipoxygenase 0.0729 0.9846 0.9846
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0579 0.1491
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0095 0.0094
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0039 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0355 0.0915
Mycobacterium ulcerans glutaminase 0.0293 0.3884 1
Schistosoma mansoni importin beta-1 0.0029 0.027 0.0262
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0008 0.0007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0164 0.0163
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0162 0.016
Schistosoma mansoni ran 0.0021 0.0164 0.0156
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0181 0.0255
Schistosoma mansoni chromobox protein 0.0075 0.0894 0.0886
Schistosoma mansoni transcription factor btf3 0.0038 0.0384 0.0377
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0384 0.4459
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0162 0.0416
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0162 0.0416
Brugia malayi RNA, U transporter 1 0.0083 0.1004 0.2586
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0162 0.0416
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.084 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0084 0.0562
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0058 0.0666 0.1714
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0619 0.7078
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0162 0.0416
Echinococcus granulosus chromobox protein 1 0.0075 0.0894 0.0892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0162 0.0388
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0762 0.0761
Echinococcus multilocularis chromobox protein 1 0.0075 0.0894 0.0892
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.084 0.2034
Brugia malayi hypothetical protein 0.0011 0.0025 0.0063
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0497 0.1918
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0619 0.0618
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0384 0.3976
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0579 0.1401
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0162 0.0396
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Toxoplasma gondii hypothetical protein 0.0029 0.0267 0.2377
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0162 0.0388
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0414 0.0412
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0497 0.1192
Schistosoma mansoni hypothetical protein 0.0439 0.5875 0.5871
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0101 0.0235
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0101 0.0242
Echinococcus granulosus snurportin 1 0.0311 0.4124 0.4123
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.077 0.1806
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1745
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0414 0.5489
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0063 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0474 0.1132
Onchocerca volvulus 0.0012 0.0039 0.0079
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0058 0.0666 0.1714
Brugia malayi Flap endonuclease-1 0.0028 0.0253 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Plasmodium falciparum flap endonuclease 1 0.0028 0.0253 0.0914
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Schistosoma mansoni hypothetical protein 0.0106 0.1325 0.1318
Echinococcus granulosus inhibitor of apoptosis protein 0.0058 0.0666 0.0664
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0619 0.7313
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0025 0.0023
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0734 0.0733
Brugia malayi nuclear receptor RXR 0.001 0.0008 0.0021
Schistosoma mansoni rab6-interacting 0.0189 0.2455 0.2449
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0253 0.2866
Brugia malayi nuclear receptor NHR-88 0.0021 0.0162 0.0416
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0063 0.0148
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0253 0.2243
Onchocerca volvulus 0.0293 0.3883 1
Entamoeba histolytica hypothetical protein 0.0024 0.0194 0.1942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1205 0.1204
Echinococcus multilocularis geminin 0.0182 0.2358 0.2357
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.027 0.3063
Onchocerca volvulus 0.0189 0.2455 0.6314
Loa Loa (eye worm) acetyltransferase 0.0156 0.1999 0.4844
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.077 0.0768
Echinococcus granulosus phd:f box containing protein 0.0017 0.0101 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0474 0.5548
Schistosoma mansoni inositol monophosphatase 0.004 0.0413 0.0406
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0084 0.0216
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0624 0.0622
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0021
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0101 0.1018
Brugia malayi hypothetical protein 0.0189 0.2455 0.6321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0162 0.0388
Loa Loa (eye worm) inositol-1 0.004 0.0413 0.0999
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0432 0.043
Echinococcus multilocularis importin subunit beta 1 0.0029 0.027 0.0268
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.084 0.0839
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0125 0.0124
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0162 0.0153
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0039 0.0027
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0084 0.0082
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0039 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0162 0.0388
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0413 0.0975
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Echinococcus granulosus dna polymerase kappa 0.0044 0.0474 0.0472
Toxoplasma gondii apocytochrome b, putative 0.0083 0.1001 0.9814
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0084 0.0076
Brugia malayi hypothetical protein 0.0189 0.2455 0.6321
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0162 0.0153
Echinococcus multilocularis transcription factor btf3 0.0038 0.0384 0.0383
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0474 0.5548
Entamoeba histolytica Ran family GTPase 0.0021 0.0164 0.157
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0619 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0384 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0253 0.0611
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.009 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0162 0.0416
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0162 0.016
Entamoeba histolytica hypothetical protein 0.0038 0.0384 0.4314
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.027 0.2407
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0039 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0181 0.1979
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0445 0.1703
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0497 0.4709
Loa Loa (eye worm) hypothetical protein 0.0053 0.0597 0.1444
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0084 0.0082
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0164 0.0163
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0734 0.0727
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0101 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Echinococcus granulosus muscleblind protein 0.0162 0.2091 0.209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0321 0.0774
Schistosoma mansoni rab6-interacting 0.0189 0.2455 0.2449
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1205 0.3104
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1018
Brugia malayi hypothetical protein 0.0011 0.0025 0.0063
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0162 0.0153
Echinococcus multilocularis microtubule associated protein 2 0.0741 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1205 0.1204
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0414 0.1066
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0181 0.128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0762 0.1006
Schistosoma mansoni chromobox protein 0.0075 0.0894 0.0886
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0327 0.3766
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0894 0.2164
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0445 0.6164
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0039 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0162 0.0416
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1624 0.3934
Brugia malayi SET domain containing protein 0.0013 0.0048 0.0123
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0084 0.0216
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0413 0.0412
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0101 0.0703
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Schistosoma mansoni hypothetical protein 0.0182 0.2358 0.2352
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0162 0.0396
Loa Loa (eye worm) hypothetical protein 0.0162 0.2091 0.5068
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0384 0.0899
Echinococcus granulosus flap endonuclease 1 0.0028 0.0253 0.0252
Echinococcus multilocularis lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1205 0.1198
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Brugia malayi polk-prov protein 0.0033 0.0327 0.0843
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0444 0.1056
Echinococcus granulosus Polycystic kidney disease protein 0.0189 0.2455 0.2454
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0357 0.0718
Loa Loa (eye worm) glutaminase 0.0293 0.3884 0.9416
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0384 0.357
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0008 0.0007
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0008 0.0016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.077 0.1028
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0162 0.0153
Schistosoma mansoni cpg binding protein 0.0033 0.0317 0.0309
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0039 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0444 0.1074
Echinococcus granulosus geminin 0.0182 0.2358 0.2357
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0039 0.0099
Brugia malayi MAP kinase sur-1 0.0055 0.0619 0.1594
Plasmodium falciparum cytochrome b 0.0083 0.1001 0.3998
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0619 0.5948
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0164 0.1068
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0759 0.1836
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.1019 0.1012
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Echinococcus granulosus lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Echinococcus multilocularis muscleblind protein 0.0162 0.2091 0.209
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0474 0.0472
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0619 0.7078
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0474 0.0175
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1205 0.292
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0058 0.0666 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0162 0.0416
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0327 0.3766
Brugia malayi jmjC domain containing protein 0.0065 0.0759 0.1953
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0619 0.0618
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0008 0.0021
Schistosoma mansoni cytochrome b 0.005 0.0561 0.0553
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0164 0.0547
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0619 0.7078
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0084 0.0802
Brugia malayi conserved hypotetical protein 0.001 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0162 0.2091 0.5068
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0162 0.016
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.084 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0444 0.1126
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0162 0.0396
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0759 0.0751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0162 0.0388
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0039 0.0037
Echinococcus granulosus lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0413 0.3863
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.084 0.0833
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0194 0.0405
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0253 0.2244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Loa Loa (eye worm) hypothetical protein 0.0058 0.0666 0.1611
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0025 0.0023
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0762 0.74
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0813 0.2092
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0357 0.0248
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0101 0.0093
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0164 0.1342
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.027 0.3063
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0597 0.0589
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0039 0.0027
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0194 0.0405
Schistosoma mansoni microtubule-associated protein tau 0.0741 1 1
Schistosoma mansoni chromobox protein 0.0012 0.0039 0.003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0414 0.0976
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Brugia malayi nuclear hormone receptor 0.0021 0.0162 0.0416
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0162 0.0153
Trichomonas vaginalis ran, putative 0.0021 0.0164 0.0327
Brugia malayi cytochrome b 0.005 0.0561 0.1445
Echinococcus multilocularis lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0162 0.0416
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0413 0.0975
Onchocerca volvulus 0.0031 0.0293 0.0734
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0762 0.8973
Brugia malayi hypothetical protein 0.001 0.0008 0.0021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0474 0.1132
Brugia malayi hypothetical protein 0.0012 0.0039 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.009 0.0133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0162 0.0153
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4358
Schistosoma mansoni chromobox protein 0.0012 0.0039 0.003
Brugia malayi Protein cec-1. 0.0012 0.0039 0.0099
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.084 1
Echinococcus granulosus chromobox protein 2 0.0012 0.0039 0.0037
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0414 0.0412
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0253 0.0559
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0377 0.437
Loa Loa (eye worm) RNA binding protein 0.0069 0.0813 0.1967
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Echinococcus granulosus GPCR family 2 0.0016 0.0095 0.0094
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0497 0.1192
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0101 0.0093
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0101 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0384 0.0928
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0008 0.0021
Echinococcus granulosus importin subunit beta 1 0.0029 0.027 0.0268
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0101 0.0286
Schistosoma mansoni polycystin 1-related 0.0189 0.2455 0.2449
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0414 0.4818
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0039 0.0099
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0162 0.016
Loa Loa (eye worm) cytochrome b 0.005 0.0561 0.1357
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0058 0.0666 0.0658
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0115 0.1177
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0253 0.0252
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0488 0.1238
Schistosoma mansoni loxhd1 0.0189 0.2455 0.2449
Brugia malayi ecdysteroid receptor 0.0021 0.0162 0.0416
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0619 0.7078
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Echinococcus multilocularis inhibitor of apoptosis protein 0.0058 0.0666 0.0664
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0384 0.1454
Echinococcus granulosus cytochrome B 0.0083 0.1001 0.0999
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0657 0.1589
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0101 0.01
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0039 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0162 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Echinococcus granulosus macrophage expressed protein 0.0106 0.1325 0.1324
Loa Loa (eye worm) helicase 0.0012 0.0039 0.009
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0008 0.0021
Schistosoma mansoni flap endonuclease-1 0.0025 0.0217 0.0209
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0162 0.0153
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0414 0.0976
Brugia malayi Importin beta-1 subunit 0.0029 0.027 0.0694
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0084 0.0199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0162 0.0416
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0008 0.0007
Brugia malayi CXXC zinc finger family protein 0.0031 0.0293 0.0754
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.077 0.1983
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0414 0.0412
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0579 0.1401
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.1939 0.1938
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0162 0.0416
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0101 0.01
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0101 0.0093
Trichomonas vaginalis glutaminase, putative 0.0293 0.3884 1
Onchocerca volvulus 0.0053 0.0597 0.152
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0162 0.016
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0619 0.0618
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4358
Plasmodium vivax multidomain scavenger receptor, putative 0.0189 0.2455 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0293 0.0706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1205 0.1198
Mycobacterium tuberculosis Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.0293 0.3883 1
Schistosoma mansoni hypothetical protein 0.0311 0.4124 0.412
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0619 0.7078
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0063 0.0061
Loa Loa (eye worm) DR-78 0.001 0.0008 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0579 0.1491
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0194 0.0405
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0162 0.016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4358
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0162 0.016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1018
Echinococcus multilocularis chromobox protein 1 0.0075 0.0894 0.0892
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0095 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.0063
Toxoplasma gondii apocytochrome b, putative 0.0032 0.0311 0.2825
Schistosoma mansoni coup transcription factor 0.0021 0.0162 0.0153
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0253 0.1958
Plasmodium vivax JmjC domain containing protein 0.0017 0.0101 0.0286
Schistosoma mansoni hypothetical protein 0.0035 0.0355 0.0347
Loa Loa (eye worm) hypothetical protein 0.0084 0.1019 0.2468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0414 0.4684
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Mycobacterium leprae Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.0293 0.3883 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0058 0.0666 0.1611
Brugia malayi hypothetical protein 0.001 0.0008 0.0021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0162 0.016
Loa Loa (eye worm) hypothetical protein 0.0189 0.2455 0.5951
Brugia malayi MH2 domain containing protein 0.0128 0.1624 0.4181
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.084 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0039 0.0067
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0008 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.0063
Echinococcus multilocularis muscleblind protein 1 0.0162 0.2091 0.209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1205 0.1204
Echinococcus granulosus tumor protein p63 0.0363 0.4831 0.483
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Echinococcus granulosus cpg binding protein 0.0033 0.0317 0.0315
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0021
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.1999 0.1992
Schistosoma mansoni inhibitor of apoptosis protein 0.0058 0.0666 0.0658
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0125 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0277 0.062
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0488 0.1169
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0474 0.0175
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.079
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0101 0.01
Trypanosoma brucei protein kinase, putative 0.0055 0.0619 0.7313
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0101 0.0242
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0413 0.0412
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1019 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0624 0.1421
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0048 0.004
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.084 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0759 0.0751
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0619 0.1498
Leishmania major GTP-binding protein, putative 0.0021 0.0164 0.1068
Echinococcus multilocularis Chromo domain 0.0012 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.5875 0.5874
Brugia malayi tailless protein 0.001 0.0008 0.0021
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0624 0.0622
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0624 0.0987
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0414 0.0412
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0025 0.0056
Plasmodium falciparum LCCL domain-containing protein 0.0189 0.2455 1
Brugia malayi Doublecortin family protein 0.0189 0.2455 0.6321
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0445 0.5067
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0101 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0162 0.0416
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1019 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0164 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0115 0.1177
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0095 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Plasmodium falciparum importin beta, putative 0.0029 0.027 0.0981
Schistosoma mansoni hypothetical protein 0.0182 0.2358 0.2352
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.065
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.1999 0.5146
Leishmania major importin beta-1 subunit, putative 0.0024 0.0194 0.1462
Plasmodium vivax importin-beta 2, putative 0.0029 0.027 0.0981
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Brugia malayi Probable ClpP-like protease 0.0084 0.1019 0.2624
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0762 0.1006
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0101 0.0093
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0414 0.4367
Brugia malayi glutaminase DH11.1 0.0293 0.3884 1
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0101 0.01
Schistosoma mansoni lipoxygenase 0.0389 0.5195 0.5191
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0095 0.0245
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0039 0.0027
Brugia malayi nuclear receptor RXR 0.0011 0.0025 0.0063
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0164 0.0547
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0025 0.0016
Loa Loa (eye worm) glutaminase 2 0.0293 0.3884 0.9416
Onchocerca volvulus Deterin homolog 0.0058 0.0666 0.1697
Brugia malayi Heterochromatin protein 1 0.0075 0.0894 0.2302
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0134 0.0248
Schistosoma mansoni cpg binding protein 0.0033 0.0317 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0242
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0253 0.2681
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0277 0.062
Echinococcus multilocularis GPCR, family 2 0.0016 0.0095 0.0094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0095 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0164 0.0424
Loa Loa (eye worm) doublecortin family protein 0.0189 0.2455 0.5951
Brugia malayi ecdysone receptor 0.001 0.0008 0.0021
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0414 0.0412
Onchocerca volvulus 0.0012 0.0039 0.0079
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0762 0.0755
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0267 0.0969
Echinococcus granulosus RUN 0.0189 0.2455 0.2454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0729 0.9846 0.9846
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.1019 0.4074
Schistosoma mansoni glutaminase 0.0293 0.3884 0.3879
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0039 0.0027
Echinococcus multilocularis snurportin 1 0.0311 0.4124 0.4123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0162 0.016
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0267 0.0969
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0253 0.2244
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1205 0.1198
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0039 0.003
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0355 0.0857
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0008 0.0016
Onchocerca volvulus 0.0058 0.0666 0.1697
Onchocerca volvulus 0.0013 0.0048 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0414 0.0976
Echinococcus granulosus Chromo domain 0.0012 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Brugia malayi TAR-binding protein 0.0069 0.0813 0.2092
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.4124 1
Onchocerca volvulus 0.0021 0.0162 0.0396
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0619 0.7078
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0115 0.1177
Brugia malayi jmjC domain containing protein 0.0063 0.0734 0.1891
Echinococcus granulosus chromobox protein 1 0.0075 0.0894 0.0892
Echinococcus granulosus dnaJ subfamily B 0.0439 0.5875 0.5874
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0008 0.0007
Schistosoma mansoni ran 0.0021 0.0164 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0444 0.1056
Onchocerca volvulus 0.0033 0.0321 0.0806
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.077 0.0762
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0162 0.0153
Brugia malayi CHD4 protein 0.0014 0.0063 0.0161
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0194 0.1462
Echinococcus granulosus dna polymerase eta 0.0016 0.0084 0.0082

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 97.7 nM Inhibition of Sus scrofa (pig) heart cytochrome bc1 complex using DBH2 as substrate by spectrophotometric analysis ChEMBL. 19928849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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