TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.397 | Formula: C20H21N3O7
H donors: 2 H acceptors: 4 LogP: 3.35 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(C(=O)O)c(cc1OC)Nc1ncnc2c1c(OC)c(c(c2)OC)OC
InChi: 1S/C20H21N3O7/c1-26-13-6-10(20(24)25)11(7-14(13)27-2)23-19-16-12(21-9-22-19)8-15(28-3)17(29-4)18(16)30-5/h6-9H,1-5H3,(H,24,25)(H,21,22,23)
InChiKey: BXJQPCPRZFIJHX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Treponema pallidum	phosphoglyceromutase	0.0039	0.0086	1
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.2282	0.983	0.983
Mycobacterium ulcerans	hypothetical protein	0.137	0.5867	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.0157
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0086	0.0133
Plasmodium vivax	phosphoglycerate mutase, putative	0.0039	0.0086	0.6394
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Onchocerca volvulus		0.0041	0.0093	0.0007
Leishmania major	hypothetical protein, unknown function	0.0039	0.0086	0.0078
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0093	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Plasmodium falciparum	phosphoglucomutase-2	0.0039	0.0086	0.8356
Brugia malayi	Bromodomain containing protein	0.0089	0.0302	0.1125
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0039	0.0086	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0086	0.0298
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0093	0.0145
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0622	0.2617	0.2553
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0083	0.0286
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Schistosoma mansoni	ap endonuclease	0.0021	0.0009	0.0009
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0039	0.0086	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.013	0.013
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.0078
Leishmania major	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	geminin	0.0191	0.0747	0.0747
Onchocerca volvulus		0.2321	1	1
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Leishmania major	hypothetical protein, conserved	0.0041	0.0093	0.0085
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0154	0.0585	0.0585
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0093	0.0085
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.013	1
Giardia lamblia	Hypothetical protein	0.137	0.5867	1
Loa Loa (eye worm)	hypothetical protein	0.2282	0.983	0.983
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0009	0.0009
Brugia malayi	beta-lactamase family protein	0.0041	0.0093	0.0325
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0227	0.0227
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0093	0.0093
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0093	0.0325
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0093	0.0145
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0093	0.0814
Plasmodium vivax	phosphoglucomutase-2, putative	0.0039	0.0086	0.6394
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Onchocerca volvulus		0.0041	0.0093	0.0007
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0093	0.0085
Loa Loa (eye worm)	hypothetical protein	0.2321	1	1
Brugia malayi	beta-lactamase	0.0041	0.0093	0.0325
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0102	0.0159
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.099	0.4219	0.4214
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0086	0.0746
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2282	0.983	0.983
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0622	0.2617	0.2617
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0039	0.0086	0.8356
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Schistosoma mansoni	phosphoglycerate mutase	0.0039	0.0086	0.0086
Toxoplasma gondii	phosphoglycerate mutase	0.0039	0.0086	0.6394
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.0648	0.0648
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.0157
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	survival motor neuron protein 1	0.0267	0.1075	0.1075
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2282	0.983	0.983
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0093	0.6974
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.016	0.016
Leishmania major	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Brugia malayi	hypothetical protein	0.0267	0.1075	0.409
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0093	0.0814
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0157	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.2321	1	1
Brugia malayi	phosphoglycerate mutase family protein	0.0039	0.0086	0.0298
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0039	0.0086	0.5
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Mycobacterium ulcerans	acid phosphatase	0.0039	0.0086	0.0133
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0018	0.0018
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0039	0.0086	0.0078
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0093	1
Trichomonas vaginalis	CAMK family protein kinase	0.0622	0.2617	1
Brugia malayi	Muscleblind-like protein	0.0169	0.0648	0.2453
Echinococcus granulosus	muscleblind protein	0.0169	0.0648	0.0648
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0251	0.1007	0.3826
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.013	0.0465
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0093	0.0093
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0093	0.0093
Brugia malayi	beta-lactamase family protein	0.0041	0.0093	0.0325
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0039	0.0086	0.0133
Schistosoma mansoni	hypothetical protein	0.0191	0.0747	0.0747
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0039	0.0086	0.0746
Brugia malayi	phosphoglycerate mutase family protein	0.0039	0.0086	0.0298
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0102	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0093	0.0085
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0093	0.0093
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.013	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Loa Loa (eye worm)	phosphoglycerate mutase	0.0039	0.0086	0.0086
Brugia malayi	PHD-finger family protein	0.0032	0.0056	0.018
Giardia lamblia	Kinase, TTK	0.0622	0.2617	0.4452
Schistosoma mansoni	zinc finger protein	0.0026	0.0029	0.0029
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0622	0.2617	0.2617
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0648	0.0648
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0093	0.0814
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0261	0.1049	1
Leishmania major	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0086	0.0133
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0086	0.0746
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0027	0.0027
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0093	0.0325
Loa Loa (eye worm)	hypothetical protein	0.1331	0.5697	0.5697
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0093	0.0093
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0153	0.0552
Onchocerca volvulus		0.0041	0.0093	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0083	0.0083
Mycobacterium ulcerans	lipase LipD	0.0041	0.0093	0.0145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.0157
Onchocerca volvulus		0.0343	0.1405	0.133
Loa Loa (eye worm)	hypothetical protein	0.0056	0.016	0.016
Schistosoma mansoni	hypothetical protein	0.0191	0.0747	0.0747
Onchocerca volvulus		0.0054	0.0153	0.0067
Schistosoma mansoni	hypothetical protein	0.0054	0.0153	0.0153
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0093	0.0814
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0157	0.0157
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0039	0.0086	0.0133
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.137	0.5867	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0039	0.0086	0.0746
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.0078
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0093	0.0814
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0153	0.0153
Brugia malayi	hypothetical protein	0.0343	0.1405	0.5352
Loa Loa (eye worm)	hypothetical protein	0.008	0.0264	0.0264
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.2282	0.983	0.983
Echinococcus multilocularis	muscleblind protein	0.0169	0.0648	0.0648
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0093	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0093	0.0093
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0039	0.0086	0.0078
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0027	0.0027
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0039	0.0086	0.0078
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0093	1
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	phosphoglycerate mutase	0.0039	0.0086	0.0086
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0093	0.0093
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0039	0.0086	0.0133
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.099	0.4219	0.4214
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1075	0.1075
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.013	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0093	0.0814
Brugia malayi	acetyltransferase, GNAT family protein	0.0161	0.0616	0.2328
Echinococcus multilocularis	zinc finger protein	0.0026	0.0029	0.0029
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0093	0.0325
Leishmania major	hypothetical protein, conserved	0.0039	0.0086	0.0078
Schistosoma mansoni	6-phosphofructokinase	0.2321	1	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.099	0.4219	0.4214
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0093	0.0814
Echinococcus multilocularis	phosphoglycerate mutase	0.0039	0.0086	0.0086
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0039	0.0086	0.0078
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0244	0.0244
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0086	0.0298
Mycobacterium ulcerans	phosphoglycerate mutase	0.0039	0.0086	0.0133
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.013	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1007	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0086	0.0086
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0039	0.0086	0.0746
Echinococcus granulosus	phosphoglycerate mutase	0.0039	0.0086	0.0086
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0093	0.0814
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0622	0.2617	0.2617
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0161	0.0616	0.0616
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0039	0.0086	0.0746
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Echinococcus granulosus	geminin	0.0191	0.0747	0.0747
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0039	0.0086	0.0078
Trichomonas vaginalis	esterase, putative	0.0041	0.0093	0.0325
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0039	0.0086	0.0746
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Loa Loa (eye worm)	acetyltransferase	0.0161	0.0616	0.0616
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0157	0.0157
Mycobacterium ulcerans	lipoprotein LpqD	0.0039	0.0086	0.0133
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.099	0.4219	0.4214
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0157	0.0157
Loa Loa (eye worm)	TTK protein kinase	0.0622	0.2617	0.2617
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0157	0.0157
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0086	0.0078
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0039	0.0086	0.0086
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Giardia lamblia	Hypothetical protein	0.137	0.5867	1
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0039	0.0086	0.0746
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0009	0.0009
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0648	0.0648
Brugia malayi	UBASH3A protein homolog	0.0039	0.0086	0.0298
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0009	0.0009
Mycobacterium ulcerans	phosphoglyceromutase	0.0039	0.0086	0.0133
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0023	0.0018	0.0018
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0227	0.0227
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0039	0.0086	0.0078
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0093	0.0145
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0093	0.0814
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0039	0.0086	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0622	0.2617	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0009	0.5
Mycobacterium ulcerans	phosphoglycerate mutase	0.0039	0.0086	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0143	0.0143
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.016	0.0582
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0102	0.0159
Echinococcus granulosus	survival motor neuron protein 1	0.0267	0.1075	0.1075
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0093	0.0325
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0039	0.0086	0.6394
Trichomonas vaginalis	conserved hypothetical protein	0.0244	0.0977	0.3712
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0105	0.0105
Toxoplasma gondii	ABC1 family protein	0.0041	0.0093	0.6974
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0039	0.0086	0.0133
Schistosoma mansoni	hypothetical protein	0.0038	0.0083	0.0083
Schistosoma mansoni	ap endonuclease	0.0021	0.0009	0.0009
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0039	0.0086	0.0078
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0093	0.0325
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0039	0.0086	0.6394
Echinococcus granulosus	zinc finger protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	bromodomain containing protein	0.0024	0.002	0.002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.016	0.0582
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0093	0.0814
Schistosoma mansoni	hypothetical protein	0.0039	0.0086	0.0086
Trichomonas vaginalis	CAMK family protein kinase	0.0622	0.2617	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0086	0.0078
Brugia malayi	Bromodomain containing protein	0.0047	0.0121	0.0433
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.2321	1	1
Loa Loa (eye worm)	hypothetical protein	0.0343	0.1405	0.1405
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.137	0.5867	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0039	0.0086	0.0078
Mycobacterium ulcerans	hydrolase MutT1	0.0039	0.0086	0.0133
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0161	0.0616	0.0616
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0039	0.0086	0.0298
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0086	0.0746
Loa Loa (eye worm)	hypothetical protein	0.005	0.0133	0.0133

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3040066

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1800008