Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0015 | 0.037 | 0.1279 |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0038 | 0.1444 | 0.1444 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.037 | 0.256 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0008 | 0.0036 | 0.0247 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.0249 | 0.0256 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0155 | 0.6917 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0015 | 0.037 | 0.256 |
Echinococcus granulosus | activin receptor type | 0.0008 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0071 | 0.0103 |
Entamoeba histolytica | protein kinase, putative | 0.0008 | 0.0028 | 0.0176 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0038 | 0.1444 | 0.9255 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2837 | 0.4102 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0008 | 0.0036 | 0.0036 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0008 | 0.0036 | 0.0124 |
Echinococcus multilocularis | activin receptor type | 0.0008 | 0.0036 | 0.0036 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0028 | 0.0176 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.003 | 0.103 | 0.356 |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus multilocularis | cyclin B3 1 | 0.0015 | 0.037 | 0.037 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.032 | 0.032 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0038 | 0.1444 | 0.4994 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.032 | 0.0463 |
Entamoeba histolytica | cyclin, putative | 0.0015 | 0.037 | 0.2369 |
Echinococcus multilocularis | Immunoglobulin | 0.0009 | 0.0071 | 0.0071 |
Giardia lamblia | Kinase, CMGC CDK | 0.0038 | 0.1444 | 0.9255 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0015 | 0.037 | 0.0535 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0068 | 0.2837 | 0.981 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.1444 | 0.2088 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0145 | 0.6459 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0287 | 0.0296 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0038 | 0.1444 | 0.9255 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.1444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0071 | 0.0103 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0069 | 0.2892 | 0.2892 |
Trichomonas vaginalis | cyclin A, putative | 0.0015 | 0.037 | 0.256 |
Echinococcus granulosus | Immunoglobulin | 0.0009 | 0.0071 | 0.0071 |
Plasmodium falciparum | protein kinase, putative | 0.0008 | 0.0036 | 0.0247 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0038 | 0.1444 | 1 |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Schistosoma mansoni | cyclin B | 0.0015 | 0.037 | 0.0381 |
Trichomonas vaginalis | cyclin B, putative | 0.0015 | 0.037 | 0.256 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0008 | 0.0036 | 0.0229 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0069 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0071 | 0.0103 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0038 | 0.1444 | 0.4994 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0038 | 0.1444 | 0.4994 |
Echinococcus multilocularis | cyclin B | 0.0015 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.037 | 0.0535 |
Onchocerca volvulus | 0.0135 | 0.5993 | 0.9279 | |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.001 | 0.0109 | 0.0109 |
Giardia lamblia | Hypothetical protein | 0.0041 | 0.1561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0071 | 0.0103 |
Giardia lamblia | Hypothetical protein | 0.0041 | 0.1561 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.1444 | 0.2088 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0069 | 0.2892 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0015 | 0.037 | 0.256 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0009 | 0.0071 | 0.0074 |
Giardia lamblia | Cyclin A | 0.0015 | 0.037 | 0.2369 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0015 | 0.037 | 0.1279 |
Echinococcus granulosus | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0221 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0038 | 0.1444 | 0.1487 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0068 | 0.2837 | 0.981 |
Entamoeba histolytica | cyclin, putative | 0.0015 | 0.037 | 0.2369 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0211 | 0.0217 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0038 | 0.1444 | 0.4994 |
Schistosoma mansoni | cyclins | 0.0015 | 0.037 | 0.0381 |
Echinococcus granulosus | cyclins | 0.0015 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0099 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0211 | 0.0305 |
Schistosoma mansoni | vesicular amine transporter | 0.0009 | 0.0071 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1409 | 0.2036 |
Echinococcus granulosus | cyclin dependent kinase | 0.0038 | 0.1444 | 0.1444 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0008 | 0.0036 | 0.0124 |
Trypanosoma cruzi | cyclin, putative | 0.0015 | 0.037 | 0.1279 |
Trypanosoma cruzi | cyclin 6, putative | 0.0015 | 0.037 | 0.1279 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0068 | 0.2837 | 0.981 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0211 | 0.0211 |
Echinococcus multilocularis | neuroglian | 0.0011 | 0.0181 | 0.0181 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0216 | 0.0216 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.003 | 0.103 | 0.356 |
Trichomonas vaginalis | cyclin B, putative | 0.0015 | 0.037 | 0.256 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.003 | 0.103 | 0.356 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0015 | 0.037 | 0.0535 |
Plasmodium falciparum | cyclin | 0.0015 | 0.037 | 0.256 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0028 | 0.0176 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0009 | 0.0071 | 0.0103 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0015 | 0.037 | 0.1279 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.1444 | 1 |
Schistosoma mansoni | protein kinase | 0.0008 | 0.0036 | 0.0037 |
Trichomonas vaginalis | cyclin B3, putative | 0.0015 | 0.037 | 0.256 |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0038 | 0.1444 | 0.2088 |
Echinococcus granulosus | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0008 | 0.0036 | 0.0036 |
Entamoeba histolytica | cyclin family protein | 0.0015 | 0.037 | 0.2369 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0038 | 0.1444 | 0.1444 |
Brugia malayi | Protein kinase domain containing protein | 0.0038 | 0.1444 | 0.2088 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0015 | 0.037 | 0.037 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0069 | 0.2892 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0015 | 0.037 | 0.0381 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.1561 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Leishmania major | cyclin | 0.0015 | 0.037 | 0.1279 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0009 | 0.0071 | 0.0074 |
Onchocerca volvulus | 0.0069 | 0.2892 | 0.4478 | |
Toxoplasma gondii | hypothetical protein | 0.0012 | 0.0194 | 0.1346 |
Echinococcus granulosus | defective proboscis extension response | 0.0009 | 0.0071 | 0.0071 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0038 | 0.1444 | 0.1444 |
Entamoeba histolytica | cyclin family protein | 0.0015 | 0.037 | 0.2369 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0038 | 0.1444 | 0.4994 |
Entamoeba histolytica | leucine-rich repeat domain-containing protein | 0.0008 | 0.0028 | 0.0176 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0041 | 0.1561 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1506 | 0.2177 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0068 | 0.2837 | 0.981 |
Trypanosoma brucei | protein kinase, putative | 0.0008 | 0.0036 | 0.0124 |
Trichomonas vaginalis | cyclins, putative | 0.0015 | 0.037 | 0.256 |
Trichomonas vaginalis | cyclins, putative | 0.0015 | 0.037 | 0.256 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.001 | 0.0109 | 0.0158 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0038 | 0.1444 | 0.4994 |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus multilocularis | Immunoglobulin | 0.0009 | 0.0071 | 0.0071 |
Schistosoma mansoni | nephrin | 0.0011 | 0.0181 | 0.0186 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0008 | 0.0036 | 0.0124 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0069 | 0.2892 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0015 | 0.037 | 0.037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0214 | 0.9713 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0038 | 0.1444 | 0.1444 |
Leishmania major | protein kinase, putative | 0.0008 | 0.0036 | 0.0124 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0038 | 0.1444 | 0.4994 |
Trichomonas vaginalis | cyclins, putative | 0.0015 | 0.037 | 0.256 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0071 | 0.0103 |
Brugia malayi | cell division control protein 2 homolog | 0.0038 | 0.1444 | 0.2088 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0041 | 0.1561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2892 | 0.4181 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0015 | 0.037 | 0.0535 |
Echinococcus granulosus | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0009 | 0.0071 | 0.0071 |
Plasmodium falciparum | protein kinase 5 | 0.0038 | 0.1444 | 1 |
Schistosoma mansoni | protein kinase | 0.0008 | 0.0036 | 0.0037 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.1444 | 1 |
Giardia lamblia | Hypothetical protein | 0.0015 | 0.037 | 0.2369 |
Loa Loa (eye worm) | TK protein kinase | 0.001 | 0.0109 | 0.0158 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0038 | 0.1444 | 0.1444 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.032 | 0.0463 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0038 | 0.1444 | 0.1487 |
Trichomonas vaginalis | cyclin D, putative | 0.0015 | 0.037 | 0.256 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0028 | 0.0176 |
Trypanosoma cruzi | cyclin, putative | 0.0015 | 0.037 | 0.1279 |
Echinococcus multilocularis | cyclin b3 | 0.0015 | 0.037 | 0.037 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0008 | 0.0036 | 0.0036 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.003 | 0.103 | 0.356 |
Echinococcus granulosus | cyclin b3 | 0.0015 | 0.037 | 0.037 |
Echinococcus granulosus | cyclin B | 0.0015 | 0.037 | 0.037 |
Schistosoma mansoni | protein kinase | 0.0008 | 0.0036 | 0.0037 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0015 | 0.037 | 0.2369 |
Echinococcus granulosus | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.001 | 0.0109 | 0.0109 |
Echinococcus granulosus | neuroglian | 0.0011 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.001 | 0.0109 | 0.0158 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0009 | 0.0071 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0071 | 0.0103 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0015 | 0.037 | 0.037 |
Giardia lamblia | Kinase, CMGC CDK | 0.0038 | 0.1444 | 0.9255 |
Trichomonas vaginalis | cyclin B, putative | 0.0015 | 0.037 | 0.256 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0069 | 0.2892 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0038 | 0.1444 | 0.4994 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.037 | 0.0535 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0069 | 0.2892 | 0.2978 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0038 | 0.1444 | 0.1444 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0155 | 0.6917 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0038 | 0.1444 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0015 | 0.037 | 0.256 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0015 | 0.037 | 0.0535 |
Onchocerca volvulus | 0.0015 | 0.037 | 0.0572 | |
Echinococcus multilocularis | cyclins | 0.0015 | 0.037 | 0.037 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0038 | 0.1444 | 0.1444 |
Trichomonas vaginalis | cyclins, putative | 0.0015 | 0.037 | 0.256 |
Trichomonas vaginalis | cyclins, putative | 0.0015 | 0.037 | 0.256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.