Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.2253 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.7367 | 0.8116 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.7367 | 0.8116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.2253 | 0.2482 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0972 | 0.1071 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.2253 | 0.2482 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.2253 | 0.2253 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0018 | 0.008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.9077 | 0.9077 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0668 | 0.0736 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.9077 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0062 | 0.8871 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.9077 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.4413 | 0.4862 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.9077 | 0.9077 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.7367 | 0.8116 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.4697 | 0.5175 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0972 | 0.1071 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.7367 | 0.8116 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.9077 | 0.9077 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.9077 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0559 | 0.2482 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0952 | 0.1049 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0668 | 0.0736 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.2253 | 0.2482 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.7367 | 0.7367 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.9077 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.2253 | 1 |
Schistosoma mansoni | myst-related protein | 0.0004 | 0.0018 | 0.0018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.7367 | 0.8116 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.2253 | 1 |
Onchocerca volvulus | 0.0033 | 0.4413 | 1 | |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0036 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0018 | 0.008 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.2253 | 0.5 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0668 | 0.0736 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4697 | 0.4697 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0145 | 0.0145 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.4697 | 0.5175 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.2253 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.2253 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.9077 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.9077 | 0.9077 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.7367 | 0.7367 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.2253 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0668 | 0.0736 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.2253 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.4413 | 0.4862 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.9077 | 0.9077 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.2253 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.9077 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.2253 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.9077 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4697 | 0.4697 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.2253 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.2253 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0036 | 0.016 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0668 | 0.0668 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.2253 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0972 | 0.1071 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.7367 | 0.7367 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0036 | 0.016 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.9077 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.2253 | 0.2482 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.2253 | 0.2539 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.2253 | 0.2253 |
Schistosoma mansoni | myst-related protein | 0.0004 | 0.0018 | 0.0018 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0559 | 0.2482 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.7367 | 0.8116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0559 | 0.2482 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.2253 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4413 | 0.4413 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.