TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 443.453 | Formula: C21H25N5O6
H donors: 4 H acceptors: 6 LogP: 0.76 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1Cc2c(C1)cc(c(c2)OC)OC
InChi: 1S/C21H25N5O6/c1-30-13-5-10-3-12(4-11(10)6-14(13)31-2)25-19-16-20(23-8-22-19)26(9-24-16)21-18(29)17(28)15(7-27)32-21/h5-6,8-9,12,15,17-18,21,27-29H,3-4,7H2,1-2H3,(H,22,23,25)/t15-,17-,18-,21-/m1/s1
InChiKey: PILRJYSWCIRUKA-QTQZEZTPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Adenosine A1 receptor	Starlite/ChEMBL	References
Rattus norvegicus	Adenosine A2 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Echinococcus granulosus	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Adenosine A1 receptor	326 aa	295 aa	28.1 %
Schistosoma mansoni	dro/myosuppressin receptor	Adenosine A1 receptor	326 aa	326 aa	22.1 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Adenosine A2 receptor	410 aa	340 aa	27.9 %
Brugia malayi	hypothetical protein	Adenosine A1 receptor	326 aa	305 aa	21.0 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	304 aa	21.1 %
Loa Loa (eye worm)	neuropeptide F receptor	Adenosine A1 receptor	326 aa	316 aa	19.9 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Adenosine A2 receptor	410 aa	366 aa	25.4 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	311 aa	21.2 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	317 aa	24.6 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	315 aa	21.6 %
Echinococcus multilocularis	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Onchocerca volvulus		Adenosine A2 receptor	410 aa	337 aa	23.1 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Adenosine A1 receptor	326 aa	286 aa	26.9 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	306 aa	21.2 %
Loa Loa (eye worm)	hypothetical protein	Adenosine A1 receptor	326 aa	300 aa	24.3 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Adenosine A1 receptor	326 aa	327 aa	24.8 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	274 aa	22.6 %
Onchocerca volvulus		Adenosine A2 receptor	410 aa	356 aa	23.9 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	323 aa	20.7 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Adenosine A2 receptor	410 aa	346 aa	28.3 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	23.1 %
Echinococcus multilocularis	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Adenosine A2 receptor	410 aa	399 aa	28.1 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Adenosine A1 receptor	326 aa	286 aa	22.7 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	22.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Echinococcus multilocularis	protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK/INSR protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosin kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1353	0.1661	0.1661
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Onchocerca volvulus		0.1353	0.1661	0.1661
Echinococcus granulosus	ephrin type A receptor 4 A	0.0084	0.0061	0.0061
Loa Loa (eye worm)	phosphatidylinositol 3	0.0167	0.0166	0.0166
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	serine/threonine protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	protein kinase atn1, putative	0.0084	0.0061	0.4839
Echinococcus granulosus	activated cdc42 kinase 1	0.0084	0.0061	0.0061
Leishmania major	protein kinase, putative	0.0084	0.0061	0.5
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.1353	0.1661	0.1661
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.01	0.0081	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	serotonin transporter	0.797	1	1
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Onchocerca volvulus		0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/RYK protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	protein tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/ABL protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0084	0.0061	0.0061
Toxoplasma gondii	hypothetical protein	0.1353	0.1661	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.01	0.0081	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0084	0.0061	0.0061
Echinococcus multilocularis	integrin linked protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	serine/threonine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0084	0.0061	0.0061
Echinococcus multilocularis	protein tyrosine kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0084	0.0061	0.5
Onchocerca volvulus		0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FAK protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Brugia malayi	C-terminal src kinase protein 1	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK/ROR protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.5154	0.6451	0.6451
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Brugia malayi	SRC-1	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0084	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium/chloride dependent transporter	0.1353	0.1661	0.1661
Echinococcus granulosus	integrin linked protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Echinococcus multilocularis	activated cdc42 kinase 1	0.0084	0.0061	0.0061
Plasmodium falciparum	amino acid transporter, putative	0.1353	0.1661	1
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0065	0.0037	0.0037
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.1353	0.1661	0.1661
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	serine/threonine kinase, putative	0.0084	0.0061	0.7096
Giardia lamblia	Kinase	0.0084	0.0061	1
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	hypothetical protein	0.5154	0.6451	0.6451
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	activin receptor type	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium/chloride dependent transporter	0.797	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	raf serine:threonine protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	CAMK family protein kinase	0.0084	0.0061	0.4839
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	protein-tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.797	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	serine/threonine kinase, putative	0.0084	0.0061	0.7096
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Giardia lamblia	Kinase, NEK	0.0084	0.0061	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0084	0.0061	0.0061
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.01	0.0081	1
Echinococcus granulosus	epidermal growth factor receptor	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Brugia malayi	SH2 domain containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/EPH protein kinase	0.0084	0.0061	0.0061
Plasmodium vivax	amine transporter, putative	0.1353	0.1661	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0187	0.0192	0.0192
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0084	0.0061	0.0061
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0088	0.0066	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK/DDR protein kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	hypothetical protein	0.797	1	1
Onchocerca volvulus		0.797	1	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0084	0.0061	0.0061
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	0.1661
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0187	0.0192	0.0192
Echinococcus granulosus	tyrosine kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0084	0.0061	0.0061
Echinococcus granulosus	natriuretic peptide receptor 1	0.0084	0.0061	0.0061
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	tyrosine protein kinase shark	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	tyrosin kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	epidermal growth factor receptor	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0037	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.0061	0.0061
Brugia malayi	ephrin receptor 1 precursor	0.0084	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Echinococcus granulosus	protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0084	0.0061	0.4839
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0084	0.0061	0.0061
Echinococcus multilocularis	epidermal growth factor receptor	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Onchocerca volvulus		0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosin kinase, putative	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/CSK protein kinase	0.0084	0.0061	0.0061
Onchocerca volvulus		0.0084	0.0061	0.0061
Leishmania major	hypothetical protein, conserved	0.0084	0.0061	0.5
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Onchocerca volvulus	Tyrosine kinase homolog	0.0084	0.0061	0.0061
Trypanosoma brucei	Pseudokinase, putative	0.0084	0.0061	0.5
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.1353	0.1661	0.1661
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0084	0.0061	0.7096
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase pr2	0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0084	0.0061	0.0061
Leishmania major	protein kinase, putative	0.0084	0.0061	0.5
Onchocerca volvulus		0.1353	0.1661	0.1661
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trypanosoma brucei	protein kinase, putative	0.0084	0.0061	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Plasmodium falciparum	transporter, putative	0.1353	0.1661	1
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.5154	0.6451	0.6451
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0084	0.0061	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Echinococcus granulosus	sodium and chloride dependent glycine	0.1353	0.1661	0.1661
Onchocerca volvulus		0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.797	1	1
Trichomonas vaginalis	TK family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Echinococcus granulosus	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0084	0.0061	0.7096
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	sodium and chloride dependent glycine	0.1353	0.1661	0.1661
Echinococcus granulosus	insulin receptor	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	0.1661
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosin kinase, putative	0.0084	0.0061	0.7096
Onchocerca volvulus		0.0084	0.0061	0.0061
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	0.1661
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0097	0.0078	0.9468
Giardia lamblia	Kinase, NEK	0.0084	0.0061	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0084	0.0061	0.0061
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0061	0.4839
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	0.1661
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0084	0.0061	0.0061
Loa Loa (eye worm)	SRC-1	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0084	0.0061	0.0061
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0084	0.0061	0.4839
Echinococcus multilocularis	protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Brugia malayi	SH2 domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	serotonin transporter b	0.797	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0079	0.0056	0.633
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Onchocerca volvulus		0.0084	0.0061	0.0061
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.5154	0.6451	0.6451
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Onchocerca volvulus		0.0084	0.0061	0.0061
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	Tyrosine-protein kinase PR2	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Blk	0.0084	0.0061	0.0061
Echinococcus granulosus	activin receptor type	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Loa Loa (eye worm)	norepinephrine transporter	0.797	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.01	0.0081	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	ephrin receptor	0.0084	0.0061	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Onchocerca volvulus		0.0084	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	1
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	hypothetical protein	0.797	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0084	0.0061	0.0061
Brugia malayi	hypothetical protein	0.1353	0.1661	0.1661
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0084	0.0061	0.0061
Schistosoma mansoni	serine/threonine protein kinase	0.5237	0.6556	0.6556
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	serine/threonine RGC	0.0084	0.0061	0.0061
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0084	0.0061	0.0061
Schistosoma mansoni	protein tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	hypothetical protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Schistosoma mansoni	ephrin receptor	0.0084	0.0061	0.0061
Entamoeba histolytica	receptor protein kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	serine/threonine kinase, putative	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Trichomonas vaginalis	STE family protein kinase	0.0084	0.0061	0.4839
Onchocerca volvulus		0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Echinococcus multilocularis	insulin receptor	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0084	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	solute carrier family 6 member 4	0.797	1	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0084	0.0061	0.0061
Echinococcus multilocularis	FL cytokine receptor	0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.5154	0.6451	0.6451
Echinococcus multilocularis	tyrosine protein kinase csk	0.0084	0.0061	0.0061
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0187	0.0192	0.0192
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.1353	0.1661	0.1661
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Toxoplasma gondii	hypothetical protein	0.1353	0.1661	1
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.1353	0.1661	0.1661
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	serine/threonine kinase, putative	0.0084	0.0061	0.7096
Onchocerca volvulus		0.0084	0.0061	0.0061
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	ankyrin repeat protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.1353	0.1661	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0084	0.0061	0.4839
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.01	0.0081	1
Echinococcus multilocularis	serotonin transporter	0.797	1	1
Schistosoma mansoni	tyrosine protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Onchocerca volvulus		0.1353	0.1661	0.1661
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/Met protein kinase	0.0084	0.0061	0.0061
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	tyrosine protein kinase HCK	0.0084	0.0061	0.0061
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	ankyrin repeat protein	0.0084	0.0061	0.7096
Echinococcus granulosus	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0065	0.0037	0.0037
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Onchocerca volvulus		0.0084	0.0061	0.0061
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Onchocerca volvulus		0.0084	0.0061	0.0061
Brugia malayi	Tyrosine-protein kinase abl-1	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Treponema pallidum	sodium- and chloride- dependent transporter	0.797	1	0.5
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0.0061	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0084	0.0061	0.0061
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0065	0.0037	0.0037
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0084	0.0061	0.0061
Echinococcus granulosus	epidermal growth factor receptor	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0084	0.0061	0.0061
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0084	0.0061	0.7096
Brugia malayi	integrin-linked kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	c src tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	1
Entamoeba histolytica	receptor protein kinase, putative	0.0084	0.0061	0.7096
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Guanylyl cyclase protein 23	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium-dependent amino acid transporter	0.1353	0.1661	0.1661
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0084	0.0061	0.4839
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	tyrosine protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/ACK protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Brugia malayi	Furin-like cysteine rich region family protein	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Plasmodium vivax	hypothetical protein, conserved	0.1353	0.1661	1
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Entamoeba histolytica	cysteine surface protein, putative	0.0084	0.0061	0.7096
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1353	0.1661	0.1661
Echinococcus granulosus	activated cdc42 kinase 1	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus multilocularis	c src tyrosine kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0084	0.0061	0.0061
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.1353	0.1661	0.1661
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0084	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.0084	0.0061	0.7096
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0061	0.4839
Entamoeba histolytica	protein kinase, putative	0.0084	0.0061	0.7096
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Brugia malayi	hypothetical protein	0.0084	0.0061	0.0061
Echinococcus multilocularis	transfer RNA-Thr	0.0084	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Brugia malayi	Receptor family ligand binding region containing protein	0.0084	0.0061	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.1353	0.1661	0.1661
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium/chloride dependent transporter	0.1353	0.1661	0.1661
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Onchocerca volvulus		0.0084	0.0061	0.0061
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0084	0.0061	0.0061
Echinococcus multilocularis	sodium and chloride dependent glycine	0.1353	0.1661	0.1661
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.5154	0.6451	0.6451
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	sodium and chloride dependent glycine	0.1353	0.1661	0.1661
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.01	0.0081	0.0081
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0084	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0084	0.0061	0.0061
Entamoeba histolytica	hypothetical protein, conserved	0.0084	0.0061	0.7096
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Giardia lamblia	Protein 21.1	0.0084	0.0061	1
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0061	0.7096
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0084	0.0061	0.0061
Echinococcus multilocularis	heat shock protein 70	0.0084	0.0061	0.0061
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Brugia malayi	Raf kinase	0.0084	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase shark	0.0084	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.1353	0.1661	0.1661
Schistosoma mansoni	protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0061	0.0061
Loa Loa (eye worm)	TK/FER protein kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Echinococcus granulosus	tyrosine protein kinase Srms	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0084	0.0061	0.0061
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1353	0.1661	0.1661
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0084	0.0061	0.7096
Onchocerca volvulus		0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0084	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	serine/threonine kinase, putative	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	hypothetical protein	0.0079	0.0056	0.633
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0084	0.0061	0.0061
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.01	0.0081	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Entamoeba histolytica	tyrosine kinase, putative	0.0084	0.0061	0.7096
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0084	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0084	0.0061	0.4839
Brugia malayi	hypothetical protein	0.0084	0.0061	0.0061

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4.98 nM	Binding affinity towards adenosine A1 receptor	ChEMBL.	2002448
Ki (binding)	= 1383 nM	Binding affinity of the compound towards adenosine A2 receptor	ChEMBL.	2002448

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2235605

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1800189