Detailed information for compound 1800221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.22 | Formula: C15H16Cl2N4O
  • H donors: 1 H acceptors: 3 LogP: 3.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/C(=O)NCC(c1ccc(cc1Cl)Cl)Cn1cncn1
  • InChi: 1S/C15H16Cl2N4O/c1-2-3-15(22)19-7-11(8-21-10-18-9-20-21)13-5-4-12(16)6-14(13)17/h2-6,9-11H,7-8H2,1H3,(H,19,22)/b3-2+
  • InChiKey: KBOWITCTENYGGW-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0021 0.0127 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1186 0.1753
Brugia malayi glutathione reductase 0.0231 0.3017 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1249 0.4141
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.008 0.0937 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0021 0.0127 0.0316
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0021 0.0127 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1186 0.1186
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0021 0.0127 0.0187
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0586 0.7905 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.008 0.0937 0.1385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2866 0.9499
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0127 0.0127
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0127 0.0316
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0403 0.1226
Trypanosoma brucei polo-like protein kinase 0.0103 0.1249 0.2779
Loa Loa (eye worm) hypothetical protein 0.0073 0.0843 0.2795
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0021 0.0127 0.0173
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.047 0.097
Schistosoma mansoni disulfide oxidoreductase 0.0021 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0041 0.0403 0.1335
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1684 0.5583
Schistosoma mansoni chromobox protein 0.0074 0.0849 0.0849
Trypanosoma cruzi trypanothione reductase, putative 0.0231 0.3017 0.6884
Leishmania major NADH dehydrogenase, putative 0.0021 0.0127 0.0173
Echinococcus granulosus thioredoxin glutathione reductase 0.0232 0.3032 0.4483
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0127 0.0173
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0077 0.0077
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.008 0.0937 0.3875
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.008 0.0937 0.3105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1186 0.1753
Toxoplasma gondii hypothetical protein 0.0053 0.0564 0.1869
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0237 0.0591
Leishmania major hypothetical protein, conserved 0.0021 0.0127 0.0173
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.2217 0.2688
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0021 0.0127 0.0316
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0527 0.7095 0.8958
Loa Loa (eye worm) hypothetical protein 0.0021 0.0127 0.042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.047 0.097
Schistosoma mansoni glutamate synthase 0.0021 0.0127 0.0127
Brugia malayi Pre-SET motif family protein 0.022 0.2866 0.9499
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0059 0.0644 0.2135
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0021 0.0127 0.042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0686 0.1014
Echinococcus multilocularis chromobox protein 1 0.0074 0.0849 0.1255
Mycobacterium ulcerans flavoprotein disulfide reductase 0.008 0.0937 0.3875
Echinococcus granulosus neuropeptide receptor A26 0.0503 0.6763 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0373 0.0551
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0021 0.0127 0.0187
Loa Loa (eye worm) hypothetical protein 0.0044 0.0443 0.1467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1186 0.1186
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0127 0.0316
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0446 0.1358
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.4006 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0021 0.0127 0.0316
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0192 0.2476 0.7539
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0021 0.0127 0.0187
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0127 0.0187
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0021 0.0127 0.0316
Plasmodium falciparum thioredoxin reductase 0.0231 0.3017 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Trypanosoma brucei NADH dehydrogenase 0.0021 0.0127 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0512 0.0757
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0021 0.0127 0.0316
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1872 0.2243
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0527 0.7095 0.8958
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.0931
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0127 0.0173
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0021 0.0127 0.0316
Schistosoma mansoni hypothetical protein 0.0039 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0021 0.0128 0.0128
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.4006 1
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.0931
Plasmodium falciparum thioredoxin reductase 0.008 0.0937 0.3105
Echinococcus multilocularis thioredoxin glutathione reductase 0.0232 0.3032 0.4483
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0403 0.1006
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0127 0.0173
Giardia lamblia NADH oxidase lateral transfer candidate 0.008 0.0937 0.2089
Loa Loa (eye worm) hypothetical protein 0.0042 0.0415 0.1377
Brugia malayi CHD4 protein 0.0014 0.0027 0.009
Schistosoma mansoni chromobox protein 0.0074 0.0849 0.0849
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0077 0.0114
Brugia malayi MH2 domain containing protein 0.0134 0.1684 0.5583
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.4006 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.008 0.0937 0.2054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.008 0.0937 0.3875
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Onchocerca volvulus 0.0032 0.028 0.0852
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0086 0.0285
Trypanosoma cruzi NADH dehydrogenase, putative 0.0021 0.0127 0.0173
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0021 0.0127 0.042
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0021 0.0127 0.0187
Echinococcus multilocularis zinc finger protein 0.002 0.0113 0.0168
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.008 0.0937 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.008 0.0937 0.2054
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0373 0.0373
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0077 0.0114
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0127 0.0173
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0849 0.2119
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0021 0.0127 0.042
Leishmania major hypothetical protein, conserved 0.0021 0.0127 0.0173
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0586 0.7905 1
Plasmodium falciparum glutathione reductase 0.008 0.0937 0.3105
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0156 0.0156
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0021 0.0127 0.0173
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.4359 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0512 0.1698
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0127 0.042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0527 0.7095 0.8958
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.047 0.097
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1249 0.3119
Brugia malayi Pre-SET motif family protein 0.0032 0.0269 0.0891
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0347 0.0513
Echinococcus granulosus neuropeptide s receptor 0.0503 0.6763 1
Brugia malayi N-terminal motif family protein 0.0192 0.2476 0.8208
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0156 0.023
Brugia malayi glutamate synthase 0.0021 0.0127 0.042
Mycobacterium tuberculosis Probable reductase 0.0527 0.7095 0.8958
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Echinococcus multilocularis chromobox protein 1 0.0074 0.0849 0.1255
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.0928
Leishmania major dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.008 0.0937 0.2054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1186 0.1753
Entamoeba histolytica thioredoxin reductase, putative 0.0021 0.0127 0.0316
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0059 0.0644 0.2135
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.047 0.097
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0021 0.0127 0.0316
Plasmodium falciparum ferrodoxin reductase-like protein 0.0021 0.0127 0.042
Leishmania major acetoin dehydrogenase e3 component-like protein 0.008 0.0937 0.2054
Schistosoma mansoni hypothetical protein 0.0021 0.0127 0.0127
Leishmania major trypanothione reductase 0.0231 0.3017 0.6884
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.008 0.0937 0.3105
Trichomonas vaginalis set domain proteins, putative 0.025 0.3285 0.8201
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0127 0.0316
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1249 0.2779
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1684 0.5583
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0021 0.0127 0.0316
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1249 0.2779
Trichomonas vaginalis mercuric reductase, putative 0.008 0.0937 0.2339
Trichomonas vaginalis glutamate synthase, putative 0.0021 0.0127 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.008 0.0937 0.2054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0027 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0347 0.0513
Loa Loa (eye worm) hypothetical protein 0.004 0.0382 0.1265
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0127 0.0127
Brugia malayi hypothetical protein 0.0039 0.0373 0.1236
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0435 0.0435
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.008 0.0937 0.1042
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.008 0.0937 0.0937
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0586 0.7905 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0403 0.1006
Brugia malayi Bromodomain containing protein 0.004 0.0381 0.1261
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1249 0.1847
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0446 0.1114
Toxoplasma gondii thioredoxin reductase 0.0231 0.3017 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0021 0.0127 0.042
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1249 0.4141
Toxoplasma gondii NADPH-glutathione reductase 0.008 0.0937 0.3105
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1249 0.3803
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0127 0.042
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0127 0.0173
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0127 0.0316
Echinococcus granulosus glutamate synthase 0.0021 0.0127 0.0187
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0527 0.7095 0.8958
Loa Loa (eye worm) thioredoxin reductase 0.0231 0.3017 1
Schistosoma mansoni kinase 0.0052 0.0553 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0535 0.1334
Treponema pallidum NADH oxidase 0.008 0.0937 0.2089
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0527 0.7095 0.8958
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0156 0.023
Echinococcus granulosus zinc finger protein 0.002 0.0113 0.0168
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.0931
Echinococcus granulosus chromobox protein 1 0.0074 0.0849 0.1255
Schistosoma mansoni glutamate synthase 0.0021 0.0127 0.0127
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0269 0.0891
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0127 0.0187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.008 0.0937 0.3105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0021 0.0127 0.0187
Echinococcus granulosus chromobox protein 1 0.0074 0.0849 0.1255
Leishmania major hypothetical protein, conserved 0.0021 0.0127 0.0173
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.0937 0.2054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1186 0.393
Schistosoma mansoni glutamate synthase 0.0021 0.0127 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0127 0.0187
Trichomonas vaginalis glutathione reductase, putative 0.008 0.0937 0.2339
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1976 0.4466
Brugia malayi chromobox protein homolog 3 0.0041 0.0403 0.1335
Loa Loa (eye worm) hypothetical protein 0.0192 0.2476 0.8208
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1976 0.4466
Mycobacterium tuberculosis Probable oxidoreductase 0.0586 0.7905 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0021 0.0127 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1186 0.1753
Onchocerca volvulus 0.0021 0.0127 0.0386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0373 0.0551
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0849 0.2814
Loa Loa (eye worm) programmed cell death 8 0.0021 0.0127 0.042
Trypanosoma brucei trypanothione reductase 0.0231 0.3017 0.6884
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1249 0.1847
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.4359 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0021 0.0127 0.0173
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1249 0.2779
Brugia malayi SET domain containing protein 0.0013 0.0016 0.0053
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.4006 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0021 0.0127 0.042
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0127 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0535 0.1334
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0021 0.0127 0.0316
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0021 0.0127 0.042
Echinococcus granulosus Chromobox protein 3 0.0012 0.000000018216 0.000000026936
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0128 0.0426
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.008 0.0937 0.1385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.008 0.0937 1
Echinococcus multilocularis neuropeptide receptor A26 0.0503 0.6763 1
Brugia malayi PHD-finger family protein 0.0026 0.0189 0.0628
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0849 0.2119
Giardia lamblia Kinase, PLK 0.0103 0.1249 0.2894
Plasmodium vivax glutathione reductase, putative 0.0231 0.3017 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1249 0.3119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1186 0.1186
Schistosoma mansoni zinc finger protein 0.002 0.0113 0.0113
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.008 0.0937 0.2054
Plasmodium vivax ferrodoxin reductase, putative 0.0021 0.0127 0.042
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0027 0.004
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0021 0.0127 0.042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.008 0.0937 0.3105
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0686 0.1014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0269 0.0269
Brugia malayi Heterochromatin protein 1 0.0074 0.0849 0.2814
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0127 0.0173
Brugia malayi Bromodomain containing protein 0.0078 0.0904 0.2998
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1872 0.8346
Trichomonas vaginalis glutamate synthase, putative 0.0021 0.0127 0.0316
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0512 0.0757
Entamoeba histolytica hypothetical protein 0.0039 0.0373 0.0931
Plasmodium vivax thioredoxin reductase, putative 0.0231 0.3017 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0127 0.042
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0127 0.0316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Loa Loa (eye worm) glutathione reductase 0.0231 0.3017 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0127 0.042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.008 0.0937 0.2054
Echinococcus multilocularis Chromobox protein 3 0.0012 0.000000018216 0.000000026936
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.008 0.0937 0.3105
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0231 0.3017 0.3716
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0127 0.042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0253 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4006 1
Toxoplasma gondii selenide, water dikinase 0.0021 0.0127 0.042
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.008 0.0937 0.3105
Onchocerca volvulus 0.0012 0.000000018216 0.000000055456
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0609 0.1294
Echinococcus multilocularis glutamate synthase 0.0021 0.0127 0.0187
Mycobacterium ulcerans hypothetical protein 0.0173 0.2217 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0021 0.0127 0.0173
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1186 0.393
Trypanosoma cruzi NADH dehydrogenase, putative 0.0021 0.0127 0.0173
Entamoeba histolytica disulphide oxidoreductase, putative 0.0021 0.0127 0.0316
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0021 0.0127 0.0187
Onchocerca volvulus 0.0044 0.0435 0.1324
Plasmodium vivax SET domain protein, putative 0.0032 0.0269 0.0891
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0269 0.0397
Onchocerca volvulus 0.025 0.3285 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0127 0.0316
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0527 0.7095 0.8958
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.4359 1
Brugia malayi Thioredoxin reductase 0.0231 0.3017 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0237 0.0591
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0512 0.0512
Echinococcus multilocularis neuropeptide s receptor 0.0503 0.6763 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0021 0.0127 0.0173
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0027 0.004
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0021 0.0127 0.0187
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1872 0.2243
Schistosoma mansoni bromodomain containing protein 0.0066 0.0737 0.0737
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.008 0.0937 0.2054
Plasmodium falciparum glutathione reductase 0.0231 0.3017 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.4359 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0021 0.0127 0.0187
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0446 0.1114
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0127 0.0187
Leishmania major dihydrolipoamide dehydrogenase, putative 0.008 0.0937 0.2054
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.1976 0.4466
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1249 0.1249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0512 0.0512
Schistosoma mansoni zinc finger protein 0.0016 0.0052 0.0052
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0021 0.0127 0.0173

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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