Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0062 | 0.0507 | 0.086 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.0507 | 0.094 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.0507 | 0.086 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0046 | 0.026 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0033 | 0.0054 | 0.0092 |
Brugia malayi | nuclear receptor RXR | 0.0033 | 0.0054 | 0.0057 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0062 | 0.0507 | 0.0534 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.0507 | 0.086 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0062 | 0.0507 | 0.086 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0062 | 0.0507 | 0.086 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.0507 | 0.086 |
Brugia malayi | nuclear receptor NHR-88 | 0.0062 | 0.0507 | 0.0534 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0062 | 0.0507 | 0.086 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0046 | 0.026 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0645 | 0.9493 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0062 | 0.0507 | 0.086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | ecdysteroid receptor | 0.0062 | 0.0507 | 0.0534 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.0507 | 0.094 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0033 | 0.0054 | 0.0057 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.0507 | 0.094 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0048 | 0.0291 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0062 | 0.0507 | 0.086 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0057 | 0.0426 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | nuclear hormone receptor | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0062 | 0.0507 | 0.0534 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0033 | 0.0054 | 0.0092 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.0507 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0078 | 0.0754 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0754 | 0.0795 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0379 | 0.5387 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0411 | 0.5894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.0507 | 0.0534 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0062 | 0.0507 | 0.086 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.0054 | 0.0092 |
Brugia malayi | steroid hormone receptor | 0.0062 | 0.0507 | 0.0534 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0062 | 0.0507 | 0.094 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0062 | 0.0507 | 0.094 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0062 | 0.0507 | 0.0534 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.0507 | 0.094 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0062 | 0.0507 | 0.0534 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.0507 | 0.086 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.0507 | 0.094 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.0507 | 0.0534 |
Echinococcus granulosus | FTZ F1 alpha | 0.0062 | 0.0507 | 0.086 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0057 | 0.0426 | 0.0722 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.0507 | 0.0534 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0062 | 0.0507 | 0.094 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.0507 | 0.0534 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.0507 | 0.086 |
Schistosoma mansoni | nuclear hormone receptor | 0.0062 | 0.0507 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0054 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0054 | 0.0057 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.0507 | 0.0534 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0062 | 0.0507 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.0507 | 0.086 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0057 | 0.0426 | 0.079 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0062 | 0.0507 | 0.0534 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0062 | 0.0507 | 0.0534 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0062 | 0.0507 | 0.086 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.0507 | 0.086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0062 | 0.0507 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0033 | 0.0054 | 0.0101 |
Onchocerca volvulus | 0.0062 | 0.0507 | 0.0507 | |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.9041 | 0.9523 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0062 | 0.0507 | 0.0534 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0062 | 0.0507 | 0.0507 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0062 | 0.0507 | 0.094 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0046 | 0.026 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0062 | 0.0507 | 0.086 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0411 | 0.5894 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.0507 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | nuclear hormone receptor | 0.0645 | 0.9493 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0054 | 0.0057 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0062 | 0.0507 | 0.0534 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0062 | 0.0507 | 0.0534 |
Schistosoma mansoni | coup transcription factor | 0.0062 | 0.0507 | 0.086 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.