Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldo-keto reductase | 0.0073 | 0.883 | 0.883 |
Mycobacterium ulcerans | oxidoreductase | 0.0073 | 0.883 | 1 |
Onchocerca volvulus | 0.008 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0073 | 0.883 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.008 | 1 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0225 | 0.0255 |
Echinococcus granulosus | hypothetical protein | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Leishmania major | aldo-keto reductase-like protein | 0.0073 | 0.883 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0073 | 0.883 | 0.883 |
Echinococcus granulosus | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0073 | 0.883 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0073 | 0.883 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0073 | 0.883 | 0.883 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0225 | 0.0255 |
Onchocerca volvulus | 0.0073 | 0.883 | 0.883 | |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0225 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.008 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0225 | 0.0255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Schistosoma mansoni | pol-related | 0.0073 | 0.883 | 0.883 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Onchocerca volvulus | 0.0073 | 0.883 | 0.883 | |
Toxoplasma gondii | aldose reductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0052 | 0.5229 | 0.5229 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Loa Loa (eye worm) | oxidoreductase | 0.0073 | 0.883 | 0.883 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Loa Loa (eye worm) | oxidoreductase | 0.0073 | 0.883 | 0.883 |
Onchocerca volvulus | 0.0073 | 0.883 | 0.883 | |
Echinococcus granulosus | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Onchocerca volvulus | 0.0073 | 0.883 | 0.883 | |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0225 | 0.0255 |
Echinococcus multilocularis | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Onchocerca volvulus | 0.0073 | 0.883 | 0.883 | |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0225 | 0.0255 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Schistosoma mansoni | aldo-keto reductase | 0.0073 | 0.883 | 0.883 |
Loa Loa (eye worm) | oxidoreductase | 0.0073 | 0.883 | 0.883 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.883 | 0.883 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.008 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0073 | 0.883 | 1 |
Giardia lamblia | Aldose reductase | 0.0073 | 0.883 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0052 | 0.5229 | 0.5922 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0073 | 0.883 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0225 | 0.0255 |
Echinococcus multilocularis | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Loa Loa (eye worm) | oxidoreductase | 0.0073 | 0.883 | 0.883 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0073 | 0.883 | 0.883 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0225 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Entamoeba histolytica | aldose reductase, putative | 0.0073 | 0.883 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0225 | 0.0255 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Trypanosoma brucei | prostaglandin f synthase | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0073 | 0.883 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0073 | 0.883 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.883 | 1 |
Onchocerca volvulus | 0.0073 | 0.883 | 0.883 | |
Echinococcus granulosus | aldo keto reductase | 0.0073 | 0.883 | 0.883 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0073 | 0.883 | 0.883 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0073 | 0.883 | 0.883 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0073 | 0.883 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0225 | 0.0255 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0073 | 0.883 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0052 | 0.5229 | 0.5229 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0225 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0225 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0225 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0073 | 0.883 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0225 | 0.0255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Saccharomyces cerevisiae MTCC 36 at 100 ug after 48 hr by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antimicrobial activity against Candida albicans MTCC 227 at 100 ug after 48 hr by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antimicrobial activity against Saccharomyces cerevisiae MTCC 36 at 150 ug after 48 hr by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antimicrobial activity against Candida albicans MTCC 227 at 150 ug after 48 hr by agar well diffusion method | ChEMBL. | No reference | |
IC50 (functional) | = 278.14 uM | Cytotoxicity against Homo sapiens (human) A549 cell by MTT assay | ChEMBL. | No reference |
MIC (functional) | = 150 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.