Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0043 | 0.0043 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0043 | 0.0043 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0043 | 0.0043 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0043 | 0.0043 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.1695 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.042 | 0.1187 |
Onchocerca volvulus | 0.003 | 0.0609 | 0.4741 | |
Onchocerca volvulus | 0.0023 | 0.042 | 0.3162 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0043 | 0.0061 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0609 | 0.0609 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.042 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | RNA binding protein | 0.0194 | 0.5398 | 0.7633 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1236 | 0.1236 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0252 | 0.7072 | 0.7072 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0043 | 0.0043 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0043 | 0.0061 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.5398 | 0.5398 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1695 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0899 | 0.0899 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.042 | 0.1187 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.042 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.016 | 0.0226 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0043 | 0.0061 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0609 | 0.0609 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.5398 | 0.5398 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0043 | 0.0043 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0899 | 0.0899 |
Onchocerca volvulus | 0.003 | 0.0609 | 0.4741 | |
Schistosoma mansoni | lamin | 0.003 | 0.0609 | 0.0609 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.042 | 0.1187 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0248 | 0.0351 |
Brugia malayi | hypothetical protein | 0.0252 | 0.7072 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0043 | 0.0043 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.5398 | 0.5398 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1695 | 1 |
Brugia malayi | TAR-binding protein | 0.0194 | 0.5398 | 0.7633 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0043 | 0.0061 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.042 | 0.1187 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1695 | 0.1695 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.3547 | 0.5015 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0043 | 0.0043 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.1695 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0043 | 0.0043 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0144 | 0.0203 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0206 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.5398 | 0.5398 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.1695 | 0.1695 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0043 | 0.0043 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0043 | 0.0043 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0899 | 0.0899 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0043 | 0.0043 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1236 | 0.1748 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0194 | 0.5398 | 0.7633 |
Echinococcus multilocularis | geminin | 0.0352 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0609 | 0.0861 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0043 | 0.0043 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1236 | 0.1236 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0043 | 0.0061 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1695 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0043 | 0.0043 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.042 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0248 | 0.0351 |
Schistosoma mansoni | lamin | 0.003 | 0.0609 | 0.0609 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.042 | 0.1187 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.042 | 0.0594 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0043 | 0.0061 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0043 | 0.0043 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0043 | 0.0061 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0043 | 0.0043 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0899 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0043 | 0.0043 |
Echinococcus multilocularis | lamin | 0.003 | 0.0609 | 0.0609 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.1695 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1695 | 0.1695 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.042 | 0.1187 |
Echinococcus granulosus | tar DNA binding protein | 0.0194 | 0.5398 | 0.5398 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.042 | 0.0594 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0899 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0609 | 0.0861 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0043 | 0.0043 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0194 | 0.5398 | 0.7633 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.3547 | 0.5015 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0248 | 0.0351 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0043 | 0.0061 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0043 | 0.0043 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0609 | 0.0609 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0248 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0043 | 0.0043 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0609 | 0.0609 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.3547 | 0.5015 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0252 | 0.7072 | 0.7072 |
Echinococcus multilocularis | musashi | 0.003 | 0.0609 | 0.0609 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.042 | 0.1187 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0248 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0194 | 0.5398 | 0.7633 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | RNA binding protein | 0.0194 | 0.5398 | 0.7633 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0609 | 0.0861 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0043 | 0.0043 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.042 | 0.1353 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0593 | 0.0838 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0043 | 0.0061 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.042 | 0.1187 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0043 | 0.0043 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0043 | 0.0061 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0609 | 0.0861 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0609 | 0.0861 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0043 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0248 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0043 | 0.0061 |
Onchocerca volvulus | 0.0051 | 0.1236 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0144 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.042 | 0.0594 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0043 | 0.0061 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0899 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0043 | 0.0061 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0248 | 0.0188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.5398 | 0.5398 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.7072 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0899 | 0.1271 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0899 | 0.0899 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.042 | 0.1353 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.016 | 0.016 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0899 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.042 | 0.0594 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.016 | 0.016 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0248 | 0.0351 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0043 | 0.0061 |
Echinococcus granulosus | lamin | 0.003 | 0.0609 | 0.0609 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0043 | 0.0043 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0043 | 0.0043 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0043 | 0.0043 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.1695 | 0.1695 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0206 | 0.0291 |
Echinococcus multilocularis | tar DNA binding protein | 0.0194 | 0.5398 | 0.5398 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 59.24 uM | Cytotoxicity against human HepG2 cells after 72 hrs by XTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.