Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.0052 | 0.0529 | 0.0284 |
Mycobacterium tuberculosis | Toxin MazF6 | 0.0154 | 0.4049 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0529 | 0.0284 |
Echinococcus multilocularis | acetylcholinesterase | 0.0258 | 0.7638 | 0.7577 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0327 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5481 | 0.5364 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0327 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0258 | 0.7638 | 0.7577 |
Echinococcus granulosus | geminin | 0.0195 | 0.5481 | 0.5364 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0044 | 0.0252 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0258 | 0.7638 | 0.7577 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0258 | 0.7638 | 0.7577 |
Echinococcus granulosus | dna polymerase eta | 0.0052 | 0.0529 | 0.0284 |
Onchocerca volvulus | 0.0044 | 0.0252 | 0.5 | |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0258 | 0.7638 | 0.7577 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.7638 | 0.7577 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0052 | 0.0529 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0052 | 0.0529 | 0.0284 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0052 | 0.0529 | 0.0284 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0258 | 0.7638 | 0.7577 |
Onchocerca volvulus | 0.0044 | 0.0252 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0044 | 0.0252 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0258 | 0.7638 | 0.7577 |
Leishmania major | DNA polymerase eta, putative | 0.0052 | 0.0529 | 1 |
Mycobacterium tuberculosis | Possible toxin MazF1 | 0.0154 | 0.4049 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.4049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.7638 | 0.7577 |
Mycobacterium tuberculosis | Toxin MazF9 | 0.0154 | 0.4049 | 1 |
Onchocerca volvulus | 0.0044 | 0.0252 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0258 | 0.7638 | 0.7577 |
Mycobacterium tuberculosis | Possible toxin MazF5 | 0.0154 | 0.4049 | 1 |
Onchocerca volvulus | 0.0044 | 0.0252 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5481 | 0.5364 |
Echinococcus granulosus | acetylcholinesterase | 0.0258 | 0.7638 | 0.7577 |
Mycobacterium tuberculosis | Toxin MazF2 | 0.0154 | 0.4049 | 1 |
Mycobacterium tuberculosis | Possible toxin MazF7 | 0.0154 | 0.4049 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0258 | 0.7638 | 0.7577 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5481 | 0.5364 |
Mycobacterium tuberculosis | Conserved protein | 0.0154 | 0.4049 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0052 | 0.0529 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0258 | 0.7638 | 0.7577 |
Onchocerca volvulus | 0.0044 | 0.0252 | 0.5 | |
Mycobacterium tuberculosis | Toxin MazF3 | 0.0154 | 0.4049 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0327 | 1 | 1 |
Mycobacterium tuberculosis | Possible toxin MazF4 | 0.0154 | 0.4049 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.