TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 332.664 | Formula: C14H19BrClNO
H donors: 1 H acceptors: 1 LogP: 4.62 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)Cl)NC(=O)C(C(C)(C)C)Br
InChi: 1S/C14H19BrClNO/c1-9(10-5-7-11(16)8-6-10)17-13(18)12(15)14(2,3)4/h5-9,12H,1-4H3,(H,17,18)
InChiKey: LOGHWBBZMUTRQJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	multidrug resistance protein 1	0.0008	0.007	0.007
Echinococcus granulosus	geminin	0.0183	0.4074	0.4074
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Loa Loa (eye worm)	hypothetical protein	0.0135	0.296	0.5866
Trichomonas vaginalis	abcb9, putative	0.0012	0.0148	0.0184
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0014	0.0014
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0148	0.0148
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0773	0.0773
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.1143	0.3536
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0773	0.1277
Trypanosoma brucei	aldo-keto reductase, putative	0.0135	0.296	1
Onchocerca volvulus		0.0135	0.296	0.5141
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0062	0.1301	0.2125
Echinococcus granulosus	aldo keto reductase	0.0135	0.296	0.296
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0132	0.0262
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0148	0.0148
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0132	0.0262
Echinococcus multilocularis	aldehyde reductase	0.0096	0.2068	0.2068
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0011	0.014	0.014
Toxoplasma gondii	aldo-keto reductase	0.0039	0.0774	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0132	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0725	0.1437
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0132	0.0132
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0148	0.0294
Schistosoma mansoni	potassium channel beta	0.0039	0.0774	0.0774
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0129	0.0129
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0773	0.1603
Brugia malayi	nuclear receptor RXR	0.0006	0.0014	0.0028
Echinococcus granulosus	aldehyde reductase	0.0096	0.2068	0.2068
Echinococcus granulosus	aldo keto reductase	0.0135	0.296	0.296
Schistosoma mansoni	hypothetical protein	0.0017	0.0272	0.0272
Loa Loa (eye worm)	multidrug resistance protein 3	0.0012	0.0148	0.0294
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0132	0.0262
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0272	0.0272
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0132	0.0132
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0774	0.1153
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.5757	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0135	0.296	0.5105
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0132	0.0262
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0636	0.0636
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0148	0.0184
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0129	0.0256
Schistosoma mansoni	hypothetical protein	0.0017	0.0272	0.0272
Schistosoma mansoni	smdr2	0.0012	0.0148	0.0148
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0132	0.0262
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0135	0.296	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Echinococcus multilocularis	ATP binding cassette sub family G	0.0021	0.0355	0.0355
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1449	0.1449
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0148	0.0184
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1143	0.1924
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0132	0.0229
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.0017	0.0275	0.0234
Echinococcus granulosus	aldo keto reductase	0.0135	0.296	0.296
Onchocerca volvulus		0.0135	0.296	0.5141
Brugia malayi	beta-lactamase family protein	0.0039	0.0773	0.1531
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0062	0.1301	0.3632
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0135	0.296	0.5105
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.1449	0.2872
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0132	0.0132
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0132	0.0132
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0148	0.0148
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0773	0.1531
Leishmania major	aldo-keto reductase-like protein	0.0135	0.296	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0028
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.1449	0.2872
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.1143	0.3045
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.1143	0.3536
Schistosoma mansoni	coup transcription factor	0.0011	0.0132	0.0132
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Echinococcus multilocularis	dnaJ subfamily B	0.0442	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Mycobacterium leprae	Possible oxidoreductase	0.0039	0.0774	0.0004
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0008	0.007	0.0047
Brugia malayi	beta-lactamase family protein	0.0039	0.0773	0.1531
Schistosoma mansoni	hypothetical protein	0.0017	0.0272	0.0272
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0148	0.0294
Echinococcus multilocularis	ATP binding cassette sub family G	0.0021	0.0355	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0011	0.014	0.0278
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0773	0.1603
Schistosoma mansoni	hypothetical protein	0.0037	0.0725	0.0725
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0773	0.1531
Schistosoma mansoni	cpg binding protein	0.0033	0.0633	0.0633
Mycobacterium ulcerans	oxidoreductase	0.0135	0.296	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0086	0.0086
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0148	0.0148
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0135	0.296	0.5866
Brugia malayi	Pre-SET motif family protein	0.0033	0.0636	0.126
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0086	0.0086
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0132	0.0132
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.5046	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0132	0.0262
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0132	0.0132
Trichomonas vaginalis	esterase, putative	0.0039	0.0773	0.1277
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.1449	0.2872
Trichomonas vaginalis	aldo-keto reductase, putative	0.0039	0.0774	0.1279
Brugia malayi	beta-lactamase	0.0039	0.0773	0.1531
Echinococcus granulosus	hypothetical protein	0.0135	0.296	0.296
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Echinococcus multilocularis	geminin	0.0183	0.4074	0.4074
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0135	0.296	0.5105
Echinococcus multilocularis	aldo keto reductase	0.0135	0.296	0.296
Echinococcus granulosus	tar DNA binding protein	0.0068	0.1449	0.1449
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0132	0.0262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0132	0.0262
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0132	0.0132
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.1143	0.3536
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.1143	0.3023
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0773	0.1603
Trypanosoma brucei	aldo/keto reductase, putative	0.0039	0.0774	0.1607
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Plasmodium vivax	aldehyde reductase, putative	0.0039	0.0774	1
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0148	0.0148
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0636	0.0636
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0773	0.1531
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0148	0.0148
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0062	0.1301	0.3632
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0773	0.1603
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0132	0.0262
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0636	0.0636
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0773	0.1277
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0592	0.1174
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0132	0.0132
Trichomonas vaginalis	aldo-keto reductase, putative	0.0039	0.0774	0.1279
Echinococcus granulosus	ATP binding cassette sub family G	0.0021	0.0355	0.0355
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0773	0.1151
Echinococcus granulosus	cpg binding protein	0.0033	0.0633	0.0633
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0039	0.0774	0.2224
Mycobacterium leprae	Conserved hypothetical protein	0.0096	0.2068	0.5924
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0148	0.0184
Leishmania major	prostaglandin f synthase, putative	0.0135	0.296	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0132	0.0132
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0135	0.296	0.5866
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0773	0.1531
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0773	0.9986
Entamoeba histolytica	ABC transporter, putative	0.0021	0.0355	0.0735
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0014	0.0014
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0039	0.0774	0.2224
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Loa Loa (eye worm)	oxidoreductase	0.0135	0.296	0.5866
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1115	0.221
Onchocerca volvulus		0.0135	0.296	0.5141
Onchocerca volvulus		0.0031	0.0592	0.1029
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0272	0.054
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0148	0.0184
Echinococcus multilocularis	cpg binding protein	0.0033	0.0633	0.0633
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0773	0.1531
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1449	0.1449
Onchocerca volvulus		0.0012	0.0148	0.0258
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0773	0.1603
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.1143	0.1143
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0132	0.0132
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0773	0.1151
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.1143	0.3023
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Schistosoma mansoni	hypothetical protein	0.0183	0.4074	0.4074
Toxoplasma gondii	aldose reductase, putative	0.0135	0.296	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Brugia malayi	nuclear hormone receptor	0.0011	0.0132	0.0262
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0773	0.0773
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0272	0.0272
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0272	0.0272
Onchocerca volvulus		0.0135	0.296	0.5141
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0132	0.0132
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0132	0.0132
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0773	0.1151
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0135	0.296	0.5105
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0132	0.0262
Schistosoma mansoni	hypothetical protein	0.0442	1	1
Toxoplasma gondii	ABC1 family protein	0.0039	0.0773	0.222
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0773	0.1151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1143	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0132	0.0132
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0039	0.0774	0.1533
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.1143	0.3023
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0039	0.0774	0.2224
Onchocerca volvulus		0.0039	0.0773	0.1342
Onchocerca volvulus		0.0033	0.0636	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Plasmodium falciparum	ABC transporter G family member 2	0.0021	0.0355	0.3305
Schistosoma mansoni	cpg binding protein	0.0033	0.0633	0.0633
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0132	0.0132
Trypanosoma brucei	protein kinase, putative	0.0055	0.1143	0.3023
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0148	0.0184
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0773	0.0773
Echinococcus granulosus	ATP binding cassette sub family G	0.0021	0.0355	0.0355
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0062	0.1301	0.1301
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0148	0.0148
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.1449	0.1449
Loa Loa (eye worm)	ABC transporter	0.0018	0.0284	0.0562
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.1143	0.1143
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Onchocerca volvulus		0.0135	0.296	0.5141
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0014	0.0028
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.1115	0.221
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1449	0.1449
Onchocerca volvulus		0.0135	0.296	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0773	0.1531
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0132	0.0262
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0132	0.0262
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0132	0.0132
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0039	0.0774	0.1533
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0773	0.1531
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0132	0.0262
Onchocerca volvulus		0.0039	0.0773	0.1342
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0012	0.0148	0.0294
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0132	0.0132
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0132	0.0132
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0039	0.0774	0.0774
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1449	0.1449
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Brugia malayi	steroid hormone receptor	0.0011	0.0132	0.0262
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.1143	0.3023
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0773	0.1151
Brugia malayi	hypothetical protein	0.0006	0.0014	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0132	0.0262
Trypanosoma cruzi	aldo/keto reductase, putative	0.0039	0.0774	0.1607
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0249	0.5572	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0028
Trichomonas vaginalis	aldo-keto reductase, putative	0.0039	0.0774	0.1279
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0132	0.0132
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0272	0.0272
Plasmodium vivax	ABC transporter G family member 2, putative	0.0021	0.0355	0.3305
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0062	0.1301	0.2579
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0132	0.0262
Brugia malayi	ecdysteroid receptor	0.0011	0.0132	0.0262
Echinococcus granulosus	multidrug resistance protein 1	0.0008	0.007	0.007
Loa Loa (eye worm)	oxidoreductase	0.0135	0.296	0.5866
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0636	0.0636
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0132	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0774	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0773	0.1531
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.1143	0.1143
Entamoeba histolytica	aldose reductase, putative	0.0135	0.296	1
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0148	0.0184
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0039	0.0774	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0008	0.007	0.007
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0593	0.0593
Plasmodium vivax	SET domain protein, putative	0.0033	0.0636	0.78
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0636	0.126
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0132	0.0132
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0773	0.1151
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0774	0.1607
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0773	0.1531
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0148	0.0184
Brugia malayi	NADH-dependent xylose reductase	0.0039	0.0774	0.1533
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0773	0.1277
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0272	0.054
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0592	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0028
Brugia malayi	TAR-binding protein	0.0068	0.1449	0.2872
Leishmania major	hypothetical protein, conserved	0.0039	0.0773	0.222
Giardia lamblia	Aldose reductase	0.0135	0.296	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0014	0.0028
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0039	0.0774	0.1279
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0129	0.0129
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.0021	0.0355	0.0735
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0132	0.0132
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0148	0.0148
Schistosoma mansoni	ABC transporter	0.0018	0.0284	0.0284
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.1301	0.1301
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0148	0.0184
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0086	0.0086
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1143	0.1924
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.1143	0.3023
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Entamoeba histolytica	aldose reductase, putative	0.0135	0.296	1
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1449	0.1449
Trichomonas vaginalis	aldo/keto reductase, putative	0.0135	0.296	0.5105
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0636	0.1734
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0062	0.1301	0.41
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0132	0.0132
Entamoeba histolytica	aldose reductase, putative	0.0135	0.296	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0275	0.0275
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.1143	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0272	0.054
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0132	0.0262
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0132	0.0132
Schistosoma mansoni	aldo-keto reductase	0.0135	0.296	0.296
Schistosoma mansoni	aldo-keto reductase	0.0135	0.296	0.296
Giardia lamblia	Aldose reductase	0.0135	0.296	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0773	0.1277
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.0021	0.0355	0.0735
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0773	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0028
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.0021	0.0355	0.0355
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0012	0.0148	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.1255	0.3936
Schistosoma mansoni	pol-related	0.0135	0.296	0.296
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0058	0.1206	0.2389
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0132	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Trichomonas vaginalis	taga, putative	0.0012	0.0148	0.0184
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0773	0.1603
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0132	0.0262
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0135	0.296	0.5866
Loa Loa (eye worm)	oxidoreductase	0.0135	0.296	0.5866
Echinococcus multilocularis	aldo keto reductase	0.0135	0.296	0.296
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0148	0.0148
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0636	0.0636
Trichomonas vaginalis	abcb9, putative	0.0012	0.0148	0.0184
Brugia malayi	ABC transporter family protein	0.0012	0.0148	0.0294
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0132	0.0132
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0011	0.0011
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0135	0.296	0.5866
Brugia malayi	ABC transporter family protein	0.0018	0.0284	0.0562
Trichomonas vaginalis	abcb9, putative	0.0012	0.0148	0.0184
Echinococcus multilocularis	aldo keto reductase	0.0135	0.296	0.296
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.1115	0.221
Loa Loa (eye worm)	oxidoreductase	0.0135	0.296	0.5866
Onchocerca volvulus		0.0039	0.0774	0.1344
Schistosoma mansoni	hypothetical protein	0.0017	0.0272	0.0272
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0135	0.296	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0132	0.0132
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0086	0.0086
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0039	0.0774	0.2224
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0039	0.0774	0.0774
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0132	0.0262
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0773	0.1151
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0132	0.0132
Mycobacterium tuberculosis	Probable oxidoreductase	0.0135	0.296	0.5184
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0148	0.0184
Plasmodium falciparum	aldo-keto reductase, putative	0.0039	0.0774	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0039	0.0774	0.2224
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0272	0.054
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.1115	0.221
Echinococcus granulosus	GPCR family 2	0.0017	0.0272	0.0272
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0636	0.0636
Echinococcus granulosus	ATP binding cassette sub family G	0.0021	0.0355	0.0355
Echinococcus granulosus	voltage gated potassium channel subunit	0.0039	0.0774	0.0774
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0773	0.1151
Trichomonas vaginalis	aldo/keto reductase, putative	0.0135	0.296	0.5105
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Trypanosoma brucei	prostaglandin f synthase	0.0135	0.296	1
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.1143	0.1143
Plasmodium falciparum	aldehyde reductase, putative	0.0039	0.0774	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0126	0.025
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0135	0.296	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Schistosoma mansoni	cpg binding protein	0.0031	0.0592	0.0592
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0272	0.0272
Brugia malayi	multidrug resistance protein 3	0.0012	0.0148	0.0294
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0148	0.0148
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0135	0.296	0.296
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0773	0.1151
Brugia malayi	RNA binding protein	0.0068	0.1449	0.2872
Echinococcus multilocularis	aldo keto reductase	0.0135	0.296	0.296
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.1416	0.1416
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0148	0.0148
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0773	0.1151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0135	0.296	0.296
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0773	0.1277
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.1143	0.2264
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0262
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.0021	0.0355	0.0735
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0132	0.0229
Trypanosoma cruzi	aldo/keto reductase, putative	0.0135	0.296	1
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0148	0.0184
Loa Loa (eye worm)	RNA binding protein	0.0068	0.1449	0.2872
Loa Loa (eye worm)	oxidoreductase	0.0135	0.296	0.5866
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0014	0.0028
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Echinococcus multilocularis	ATP binding cassette sub family B	0.0011	0.014	0.014
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0148	0.0184
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Mycobacterium ulcerans	lipase LipD	0.0039	0.0773	0.1603
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0773	0.0773
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0132	0.0262
Echinococcus multilocularis	ATP binding cassette sub family G	0.0021	0.0355	0.0355
Onchocerca volvulus		0.0011	0.0132	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0132	0.0262
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0148	0.0184
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0132	0.0262
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0636	0.0636
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0148	0.0184
Brugia malayi	Pre-SET motif family protein	0.0226	0.5046	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0132	0.0132
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0132	0.0132
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0014	0.0014
Onchocerca volvulus		0.0257	0.5757	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0725	0.1437
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0132	0.0262
Brugia malayi	MAP kinase sur-1	0.0055	0.1143	0.2264
Brugia malayi	hypothetical protein	0.0006	0.0014	0.0028
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0132	0.0132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0132	0.0132
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.1143	0.1143
Schistosoma mansoni	hypothetical protein	0.0183	0.4074	0.4074
Trypanosoma cruzi	aldo-keto reductase	0.0135	0.296	1
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0132	0.0229
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0148	0.0148
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.1301	0.1301
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0014	0.0014
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0148	0.0148
Onchocerca volvulus		0.0039	0.0773	0.1342
Trichomonas vaginalis	aldo-keto reductase, putative	0.0135	0.296	0.5105
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0028
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0086	0.0086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2287172

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1801689