Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0631 | 1 | 1 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0631 | 1 | 1 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0631 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0107 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0107 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0631 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0631 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0631 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0631 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0631 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0107 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0107 | 0 | 0.5 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0631 | 1 | 1 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0631 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0631 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0631 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0107 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.