Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0124 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0435 | 0.512 | 0.512 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0139 | 0.0253 | 0.0253 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0124 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0124 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0732 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0435 | 0.512 | 0.512 |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0234 | 0.181 | 0.181 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0732 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0234 | 0.181 | 0.181 |
Echinococcus multilocularis | acetylcholinesterase | 0.0732 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0732 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0732 | 1 | 1 |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0732 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0231 | 0.177 | 0.177 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0139 | 0.0253 | 0.0253 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0139 | 0.0253 | 0.0253 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0732 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0139 | 0.0253 | 0.0253 |
Echinococcus granulosus | acetylcholinesterase | 0.0732 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0124 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0234 | 0.181 | 0.181 |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0234 | 0.181 | 0.181 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0435 | 0.512 | 0.512 |
Echinococcus multilocularis | insulin receptor | 0.0139 | 0.0253 | 0.0253 |
Echinococcus granulosus | insulin receptor | 0.0139 | 0.0253 | 0.0253 |
Echinococcus granulosus | carboxylesterase 5A | 0.0732 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0234 | 0.181 | 0.181 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0124 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0139 | 0.0253 | 0.0253 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0124 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0231 | 0.177 | 0.177 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0435 | 0.512 | 0.512 |
Echinococcus granulosus | acetylcholinesterase | 0.0732 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0139 | 0.0253 | 0.0253 |
Schistosoma mansoni | tyrosine kinase | 0.0231 | 0.177 | 0.177 |
Echinococcus multilocularis | 0.0135 | 0.0181 | 0.0181 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0435 | 0.512 | 0.512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.