Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.024 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.024 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.024 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.024 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.024 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.024 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 10536 after 24 hr by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 8 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 21 days by broth microdilution method | ChEMBL. | No reference |
MIC (functional) | = 62.5 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 24 hr by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.