Detailed information for compound 1802505

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 240.216 | Formula: C9H12N4O4
  • H donors: 2 H acceptors: 3 LogP: 0.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1(CO)CC(=NO1)NC(=O)/C(=N/OC)/C#N
  • InChi: 1S/C9H12N4O4/c1-9(5-14)3-7(13-17-9)11-8(15)6(4-10)12-16-2/h14H,3,5H2,1-2H3,(H,11,13,15)/b12-6+
  • InChiKey: JTHJSNSNCSTQBH-WUXMJOGZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.095 0.095
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1331 0.3978
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0044 0.0235 0.048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0289 0.0397
Loa Loa (eye worm) hypothetical protein 0.0044 0.0235 0.048
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0194 0.0194
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.2347 0.4797
Entamoeba histolytica chitinase, putative 0.0302 0.2886 1
Schistosoma mansoni hypothetical protein 0.0184 0.1674 0.23
Brugia malayi endochitinase 0.0302 0.2886 0.5896
Echinococcus granulosus neuropeptide receptor A26 0.0992 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0239 0.0176
Plasmodium vivax hypothetical protein, conserved 0.0114 0.095 0.1683
Leishmania major hypothetical protein, conserved 0.0114 0.095 0.2651
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1331 0.3978
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0715 0.0744
Echinococcus multilocularis mitogen activated protein kinase 3 0.0155 0.1374 0.1374
Mycobacterium ulcerans chitinase/cellulase 0.0257 0.2428 1
Leishmania major chitinase 0.0302 0.2886 0.9391
Echinococcus granulosus survival motor neuron protein 1 0.0497 0.4894 0.4894
Brugia malayi hypothetical protein 0.0044 0.0235 0.048
Loa Loa (eye worm) hypothetical protein 0.0178 0.1606 0.3282
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0239 0.0176
Loa Loa (eye worm) beta-lactamase 0.0114 0.095 0.194
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1606 0.3282
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0155 0.1374 0.413
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0056 0.0114
Echinococcus multilocularis neuropeptide s receptor 0.0992 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.1722 0.678
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0289 0.0591
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0322 0.0297
Echinococcus granulosus mitogen activated protein kinase 3 0.0155 0.1374 0.1374
Onchocerca volvulus 0.0036 0.0152 0.0322
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1331 0.3978
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0727 0.7269 1
Loa Loa (eye worm) hypothetical protein 0.0479 0.4712 0.9629
Onchocerca volvulus 0.0036 0.0152 0.0322
Brugia malayi RNA binding protein 0.0069 0.0486 0.0994
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0486 0.0668
Brugia malayi Glycosyl hydrolases family 18 protein 0.0044 0.0235 0.048
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0322 0.0297
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.1722 0.2365
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.1722 0.1722
Echinococcus granulosus intermediate filament protein 0.0027 0.0056 0.0056
Onchocerca volvulus 0.0114 0.095 0.2015
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0479 0.4712 0.4712
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.095 0.1075
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.095 0.6273
Mycobacterium ulcerans chitinase/cellulase 0.0257 0.2428 1
Echinococcus granulosus lamin 0.0027 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0114 0.095 0.194
Toxoplasma gondii hypothetical protein 0.0479 0.4712 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.095 0.095
Brugia malayi beta-lactamase 0.0114 0.095 0.194
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.095 0.1075
Echinococcus granulosus geminin 0.0184 0.1674 0.1674
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0624 0.0624
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.0036 0.0152 0.031
Echinococcus multilocularis GPCR, family 2 0.0082 0.0624 0.0624
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0486 0.0994
Echinococcus granulosus tar DNA binding protein 0.0069 0.0486 0.0486
Mycobacterium ulcerans hypothetical protein 0.0114 0.095 0.326
Onchocerca volvulus 0.0036 0.0152 0.0322
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.2453 0.5012
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.1374 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.082 0.0892
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0036 0.0152 0.031
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0155 0.1374 0.2622
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.095 0.1305
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0715 0.0744
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Brugia malayi Glycosyl hydrolases family 18 protein 0.0044 0.0235 0.048
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0036 0.0152 0.031
Brugia malayi hypothetical protein 0.0034 0.0129 0.0264
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0322 0.0297
Loa Loa (eye worm) hypothetical protein 0.0044 0.0235 0.048
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0486 0.0668
Echinococcus multilocularis geminin 0.0184 0.1674 0.1674
Loa Loa (eye worm) hypothetical protein 0.0479 0.4712 0.9629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0289 0.0289
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.095 0.6273
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0486 0.0668
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0479 0.4712 0.4712
Loa Loa (eye worm) hypothetical protein 0.0497 0.4894 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0155 0.1374 0.413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.095 0.1305
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.1374 1
Brugia malayi TAR-binding protein 0.0069 0.0486 0.0994
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0322 0.0467
Loa Loa (eye worm) RNA binding protein 0.0069 0.0486 0.0994
Onchocerca volvulus 0.0114 0.095 0.2015
Leishmania major hypothetical protein, conserved 0.0053 0.0322 0.0467
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.2453 0.5012
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0036 0.0152 0.031
Schistosoma mansoni chitinase 0.0044 0.0235 0.0323
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.095 0.2651
Plasmodium falciparum conserved protein, unknown function 0.0479 0.4712 1
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.095 0.2651
Onchocerca volvulus Putative endochitinase 0.0302 0.2886 0.6124
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0624 0.1274
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0044 0.0235 0.0235
Echinococcus multilocularis neuropeptide receptor A26 0.0992 1 1
Brugia malayi follicle stimulating hormone receptor 0.0249 0.2347 0.4797
Loa Loa (eye worm) hypothetical protein 0.0053 0.0322 0.0659
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0322 0.0297
Brugia malayi beta-lactamase family protein 0.0114 0.095 0.194
Brugia malayi beta-lactamase family protein 0.0114 0.095 0.194
Trypanosoma brucei protein kinase, putative 0.0155 0.1374 0.413
Loa Loa (eye worm) hypothetical protein 0.0257 0.2428 0.4961
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0044 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0114 0.095 0.194
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0056 0.0114
Onchocerca volvulus Putative endochitinase 0.0338 0.326 0.6919
Echinococcus granulosus lamin dm0 0.0027 0.0056 0.0056
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.095 0.194
Loa Loa (eye worm) hypothetical protein 0.0114 0.095 0.194
Mycobacterium ulcerans beta-lactamase 0.0114 0.095 0.326
Schistosoma mansoni lamin 0.0027 0.0056 0.0077
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0188 0.0385
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.0036 0.0152 0.031
Onchocerca volvulus 0.0101 0.0821 0.1742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0289 0.0397
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.095 0.1075
Onchocerca volvulus Putative chitinase 0.0044 0.0235 0.0498
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Toxoplasma gondii hypothetical protein 0.0051 0.0307 0.0262
Onchocerca volvulus 0.0114 0.095 0.2015
Onchocerca volvulus Putative endochitinase 0.0044 0.0235 0.0498
Brugia malayi MAP kinase sur-1 0.0155 0.1374 0.2808
Echinococcus multilocularis survival motor neuron protein 1 0.0497 0.4894 0.4894
Loa Loa (eye worm) hypothetical protein 0.026 0.2453 0.5012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0022 0.0022
Onchocerca volvulus 0.0027 0.0056 0.0119
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.095 0.1075
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.306 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.306 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0082 0.0624 0.0857
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.0036 0.0152 0.031
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0322 0.0467
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.095 0.194
Echinococcus multilocularis lamin dm0 0.0027 0.0056 0.0056
Schistosoma mansoni lamin 0.0027 0.0056 0.0077
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0486 0.0486
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.1374 1
Echinococcus multilocularis microtubule associated protein 2 0.0728 0.7279 0.7279
Plasmodium falciparum chitinase 0.0044 0.0235 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Onchocerca volvulus 0.0479 0.4712 1
Schistosoma mansoni hypothetical protein 0.0101 0.0821 0.1127
Echinococcus granulosus GPCR family 2 0.0082 0.0624 0.0624
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.1722 0.678
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.082 0.4464
Schistosoma mansoni hypothetical protein 0.0184 0.1674 0.23
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.095 0.6273
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.095 0.6273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0082 0.0624 0.1274
Loa Loa (eye worm) hypothetical protein 0.0114 0.095 0.194
Mycobacterium tuberculosis Probable reductase 0.0091 0.0715 0.0744
Schistosoma mansoni hypothetical protein 0.0082 0.0624 0.0857
Schistosoma mansoni hypothetical protein 0.0082 0.0624 0.0857
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.306 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0155 0.1374 0.413
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0155 0.1374 0.413
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.1722 0.5339
Onchocerca volvulus Putative endochitinase 0.0302 0.2886 0.6124
Schistosoma mansoni hypothetical protein 0.0479 0.4712 0.6473
Loa Loa (eye worm) hypothetical protein 0.0114 0.095 0.194
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0155 0.1374 0.413
Toxoplasma gondii ABC1 family protein 0.0114 0.095 0.1683
Onchocerca volvulus Putative endochitinase 0.0338 0.326 0.6919
Brugia malayi Thioredoxin reductase 0.004 0.0188 0.0385
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.095 0.326
Loa Loa (eye worm) chitinase I 0.0302 0.2886 0.5896
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0155 0.1374 0.2808
Trichomonas vaginalis esterase, putative 0.0114 0.095 0.6273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0289 0.0397
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.095 0.1075
Onchocerca volvulus 0.0036 0.0152 0.0322
Echinococcus granulosus mitogen activated protein kinase 0.0155 0.1374 0.1374
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.2453 0.5012
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0155 0.1374 0.413
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0486 0.0994
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.082 0.0892
Echinococcus multilocularis mitogen activated protein kinase 0.0155 0.1374 0.1374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.1722 0.678
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.095 0.1075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.034 0.0527
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0322 0.0467
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0624 0.0624
Onchocerca volvulus 0.0036 0.0152 0.0322
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Mycobacterium leprae Probable lipase LipE 0.0114 0.095 1
Mycobacterium tuberculosis Conserved protein 0.0114 0.095 0.1075
Echinococcus multilocularis musashi 0.0027 0.0056 0.0056
Brugia malayi hypothetical protein 0.0053 0.0322 0.0659
Loa Loa (eye worm) hypothetical protein 0.0114 0.095 0.194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Schistosoma mansoni hypothetical protein 0.0082 0.0624 0.0857
Brugia malayi intermediate filament protein 0.0027 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.1374 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0486 0.0994
Giardia lamblia Kinase, CMGC MAPK 0.0155 0.1374 0.5
Brugia malayi Endochitinase 0.0044 0.0235 0.048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0104
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0479 0.4712 0.9629
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.031
Brugia malayi endochitinase 0.0338 0.326 0.6662
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1374 0.1888
Brugia malayi Endochitinase 0.0338 0.326 0.6662
Schistosoma mansoni hypothetical protein 0.0178 0.1606 0.2206
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0715 0.0744
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.095 0.326
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.306 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.082 0.0892
Mycobacterium tuberculosis Possible chitinase 0.0257 0.2428 0.3163
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0056 0.0114
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.1722 0.2166
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0022 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0715 0.0744
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.1722 0.339
Schistosoma mansoni hypothetical protein 0.0024 0.0022 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0289 0.0591
Brugia malayi hypothetical protein 0.0044 0.0235 0.048
Mycobacterium ulcerans hypothetical protein 0.0168 0.1506 0.5799
Echinococcus multilocularis lamin 0.0027 0.0056 0.0056
Loa Loa (eye worm) glutathione reductase 0.004 0.0188 0.0385
Schistosoma mansoni survival motor neuron protein 0.0101 0.0821 0.1127
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0155 0.1374 0.413
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0821 0.1677
Plasmodium vivax chitinase 0.0044 0.0235 0.0103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0624 0.1274
Brugia malayi hypothetical protein 0.0497 0.4894 1
Mycobacterium tuberculosis Conserved protein 0.0114 0.095 0.1075
Mycobacterium leprae conserved hypothetical protein 0.0114 0.095 1
Schistosoma mansoni microtubule-associated protein tau 0.0728 0.7279 1
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0194 0.0194
Echinococcus granulosus microtubule associated protein 2 0.0728 0.7279 0.7279
Brugia malayi glutathione reductase 0.004 0.0188 0.0385
Loa Loa (eye worm) cuticular endochitinase 0.0302 0.2886 0.5896
Mycobacterium tuberculosis Conserved protein 0.0114 0.095 0.1075
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.1722 0.2365
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0715 0.0744
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.1722 0.1722
Onchocerca volvulus 0.0027 0.0056 0.0119
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.095 0.6273
Plasmodium vivax hypothetical protein, conserved 0.0479 0.4712 1
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.095 0.2651
Onchocerca volvulus 0.0479 0.4712 1
Mycobacterium ulcerans lipase LipD 0.0114 0.095 0.326
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0239 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1506 0.1862
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.095 0.1075
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0486 0.0668
Onchocerca volvulus Putative endochitinase 0.0338 0.326 0.6919
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0239 0.0176
Schistosoma mansoni intermediate filament proteins 0.0027 0.0056 0.0077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0624 0.1274
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0486 0.0668
Loa Loa (eye worm) microfilarial chitinase 0.0294 0.2803 0.5727

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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