TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 459.6 | Formula: C28H29NO3S
H donors: 1 H acceptors: 3 LogP: 5.67 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N[C@@H](C(=O)S[C@H](Cc1ccc(cc1)c1ccccc1)C)C)CCC(=O)c1ccccc1
InChi: 1S/C28H29NO3S/c1-20(19-22-13-15-24(16-14-22)23-9-5-3-6-10-23)33-28(32)21(2)29-27(31)18-17-26(30)25-11-7-4-8-12-25/h3-16,20-21H,17-19H2,1-2H3,(H,29,31)/t20-,21+/m0/s1
InChiKey: FUWPWXJBAXLAPV-LEWJYISDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Pseudomonas aeruginosa	Beta-lactamase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0015	0.0192	0.0526
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0208	0.057
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0501	0.5
Schistosoma mansoni	zinc phosphodiesterase	0.0019	0.0501	0.0894
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.153	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0501	0.5224
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0501	0.5
Trichomonas vaginalis	beta lactamase domain, putative	0.0019	0.0501	0.5
Trypanosoma cruzi	glyoxalase II	0.0019	0.0501	0.2309
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0208	0.057
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3649	1
Plasmodium vivax	unspecified product	0.0019	0.0501	0.2309
Echinococcus multilocularis	musashi	0.0026	0.1003	0.2748
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0208	0.0208
Schistosoma mansoni	lamin	0.0026	0.1003	0.2346
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0208	0.0047
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0208	0.057
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0019	0.0501	0.2309
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3649	1
Leishmania major	metallo-beta-lactamase family-like protein	0.0019	0.0501	0.2309
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0769	0.0673
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0103	0.0103
Brugia malayi	jmjC domain containing protein	0.0057	0.3291	0.3222
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0208	0.057
Trichomonas vaginalis	beta lactamase domain, putative	0.0019	0.0501	0.5
Brugia malayi	jmjC domain containing protein	0.0057	0.3291	0.3222
Echinococcus granulosus	tar DNA binding protein	0.0062	0.3649	1
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.153	1
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0192	0.0526
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0769	1
Mycobacterium ulcerans	glyoxalase II, GloB	0.0019	0.0501	0.3784
Giardia lamblia	Metallo-beta-lactamase superfamily protein	0.0019	0.0501	0.5
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0769	1
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0019	0.0501	0.0501
Trichomonas vaginalis	beta lactamase domain, putative	0.0019	0.0501	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0338	0.0338
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.3649	1
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0019	0.0501	0.3784
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0769	1
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0019	0.0501	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0501	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0338	0.0338
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0769	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.1003	0.2346
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0192	0.0526
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0338	0.2316
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0501	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.3291	0.3291
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0338	0.1091
Trichomonas vaginalis	A-type flavoprotein	0.0019	0.0501	0.5
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0019	0.0501	0.2309
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0501	0.0501
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0769	1
Mycobacterium ulcerans	hydrolase	0.0019	0.0501	0.3784
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0769	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0501	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0019	0.0501	0.5224
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0019	0.0501	0.2309
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0501	0.3784
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0033	0.153	0.4193
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0192	0.0192
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0192	0.0526
Mycobacterium tuberculosis	Conserved protein	0.0019	0.0501	0.5224
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.153	1
Trypanosoma brucei	glyoxalase II	0.0019	0.0501	0.2309
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0192	0.0526
Trichomonas vaginalis	beta lactamase domain, putative	0.0019	0.0501	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.1003	0.0909
Brugia malayi	RNA binding protein	0.0062	0.3649	0.3583
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.3291	0.8966
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.153	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.3649	0.3583
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0208	0.0121
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0769	1
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0019	0.0501	0.1373
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0019	0.0501	0.1373
Schistosoma mansoni	zinc phosphodiesterase	0.0019	0.0501	0.0894
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0769	0.0673
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0769	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0769	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0208	0.0121
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0019	0.0501	0.1373
Brugia malayi	hypothetical protein	0.0019	0.0501	0.0402
Plasmodium falciparum	cytosolic glyoxalase II	0.0019	0.0501	0.2309
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0019	0.0501	0.2309
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0208	0.0121
Mycobacterium tuberculosis	Beta lactamase like protein	0.0019	0.0501	0.5224
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0338	0.1091
Brugia malayi	Augmenter of liver regeneration	0.0033	0.153	0.1442
Mycobacterium ulcerans	hydrolase	0.0019	0.0501	0.3784
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0192	0.0192
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0769	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0208	0.0121
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.153	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0501	0.0501
Echinococcus multilocularis	ETHE1 protein	0.0019	0.0501	0.1373
Onchocerca volvulus		0.0147	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0192	0.0192
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0019	0.0501	0.2309
Loa Loa (eye worm)	hepatopoietin HPO2	0.0033	0.153	0.153
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.3291	0.8966
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0501	0.5224
Mycobacterium tuberculosis	Possible hydrolase	0.0019	0.0501	0.5224
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0208	0.0121
Echinococcus multilocularis	lamin dm0	0.0026	0.1003	0.2748
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0501	0.3784
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0019	0.0501	0.1373
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0019	0.0501	0.2309
Brugia malayi	jmjC domain containing protein	0.0015	0.0192	0.009
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0268	0.1075
Brugia malayi	intermediate filament protein	0.0026	0.1003	0.0909
Mycobacterium ulcerans	beta lactamase-like protein	0.0019	0.0501	0.3784
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0033	0.153	0.4193
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0019	0.0501	0.5
Leishmania major	hypothetical protein, conserved	0.0019	0.0501	0.2309
Echinococcus multilocularis	zinc phosphodiesterase	0.0019	0.0501	0.1373
Brugia malayi	jmjC domain containing protein	0.0015	0.0192	0.009
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.3291	0.9021
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0501	0.5
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.3291	0.8966
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0192	0.0526
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0769	0.431
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0019	0.0501	0.2309
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0208	0.057
Trypanosoma cruzi	glyoxalase II	0.0019	0.0501	0.2309
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0192	0.0526
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0019	0.0501	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0769	0.0769
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.1003	0.1003
Schistosoma mansoni	hypothetical protein	0.0019	0.0501	0.0894
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0019	0.0501	0.2309
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3649	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0268	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0147	1	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0208	0.0121
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0769	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0501	0.0894
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0019	0.0501	0.0402
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0208	0.0121
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.1003	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0501	0.0501
Echinococcus multilocularis	lamin	0.0026	0.1003	0.2748
Loa Loa (eye worm)	RNA binding protein	0.0062	0.3649	0.3649
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.3291	0.9021
Brugia malayi	jmjC domain containing protein	0.0015	0.0192	0.009
Onchocerca volvulus		0.0023	0.0769	0.0282
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0769	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.153	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.3649	0.3649
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0769	0.431
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0268	0.1075
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0501	0.3784
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0501	0.0501
Mycobacterium tuberculosis	Possible hydrolase	0.0019	0.0501	0.5224
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.3291	0.9021
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0019	0.0501	0.2309
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0019	0.0501	0.2309
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0192	0.0192
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.3649	0.3649
Echinococcus granulosus	intermediate filament protein	0.0026	0.1003	0.2748
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0208	0.0106
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0019	0.0501	0.0402
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0208	0.0121
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0501	0.5224
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1003	0.1003
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0208	0.057
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0019	0.0501	0.5
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.3291	0.9021
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.153	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0268	0.1075
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0208	0.0106
Brugia malayi	ethe1-prov protein	0.0019	0.0501	0.0402
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.153	1
Echinococcus granulosus	zinc phosphodiesterase	0.0019	0.0501	0.1373
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0019	0.0501	0.1373
Mycobacterium ulcerans	hydrolase	0.0019	0.0501	0.3784
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3649	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0019	0.0501	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0967	0.0967
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0192	0.0192
Leishmania major	cleavage and polyadenylation specificity factor, putative	0.0019	0.0501	0.2309
Brugia malayi	TAR-binding protein	0.0062	0.3649	0.3583
Onchocerca volvulus		0.0026	0.1003	0.0528
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0015	0.0192	0.0526
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3649	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0769	0.0769
Echinococcus granulosus	lamin dm0	0.0026	0.1003	0.2748
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0769	0.431
Leishmania major	metallo-beta-lactamase family protein-like protein	0.0019	0.0501	0.2309
Chlamydia trachomatis	ribonuclease Z	0.0019	0.0501	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0769	0.0769
Echinococcus granulosus	lamin	0.0026	0.1003	0.2748
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0501	0.5
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0019	0.0501	0.0501
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0019	0.0501	0.2309
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0019	0.0501	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0338	0.0338
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0769	1
Onchocerca volvulus		0.0026	0.1003	0.0528
Brugia malayi	jmjC domain containing protein	0.0015	0.0192	0.009
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0769	1
Schistosoma mansoni	lamin	0.0026	0.1003	0.2346
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0019	0.0501	0.2309
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0019	0.0501	0.1373
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0208	0.0121
Leishmania major	hypothetical protein, conserved	0.0033	0.153	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0019	0.0501	0.5
Mycobacterium tuberculosis	Conserved protein	0.0019	0.0501	0.5224
Treponema pallidum	ribonuclease Z	0.0019	0.0501	0.5
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0019	0.0501	0.5
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0019	0.0501	0.0501
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0769	1
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0019	0.0501	0.2309
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0192	0.0526
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0501	0.3784
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0338	0.0338
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0192	0.0526
Trypanosoma cruzi	glyoxalase II	0.0019	0.0501	0.2309
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0769	0.0673
Echinococcus granulosus	ETHE1 protein	0.0019	0.0501	0.1373
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0019	0.0501	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.602	Inhibition of Pseudomonas aeruginosa IMP1 metallo-beta-lactamase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2283134

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1802610