Detailed information for compound 1802664

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 382.906 | Formula: C21H19ClN2OS
  • H donors: 0 H acceptors: 2 LogP: 4.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1C1=C(C)CN(C1=O)C(c1nc2c(s1)cccc2)(C)C
  • InChi: 1S/C21H19ClN2OS/c1-13-12-24(19(25)18(13)14-8-4-5-9-15(14)22)21(2,3)20-23-16-10-6-7-11-17(16)26-20/h4-11H,12H2,1-3H3
  • InChiKey: BUQOFQPMQFUOOM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Brugia malayi cytokine inducible SH2-containing protein 5 0.0022 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0028
Echinococcus granulosus tyrosine protein kinase HCK 0.0178 0.7292 0.7959
Trichomonas vaginalis flap endonuclease-1, putative 0.0023 0.0675 0.0507
Brugia malayi Protein kinase domain containing protein 0.0028 0.0906 0.0906
Brugia malayi Tensin 0.0022 0.064 0.064
Loa Loa (eye worm) guanylate kinase 0.0022 0.0616 0.0616
Schistosoma mansoni vav2 0.0022 0.064 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1317 0.4524
Echinococcus multilocularis tyrosine protein kinase HCK 0.0178 0.7292 0.7959
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0616 0.0616
Echinococcus multilocularis SH2 motif 0.0022 0.064 0.0698
Echinococcus multilocularis SH2 motif 0.0022 0.064 0.0698
Echinococcus multilocularis NCK adaptor protein 0.0044 0.1563 0.1706
Echinococcus multilocularis Spectrin alpha actinin 0.0022 0.0616 0.0673
Echinococcus multilocularis dna polymerase kappa 0.007 0.2697 0.2944
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Brugia malayi Variant SH3 domain containing protein 0.0044 0.1563 0.1563
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0644 0.1852
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0598 0.0653
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0028 0.0031
Brugia malayi SH3 domain containing protein 0.0022 0.0616 0.0616
Schistosoma mansoni hypothetical protein 0.0022 0.064 0.064
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0053 0.1943 0.7128
Echinococcus granulosus dna polymerase eta 0.0069 0.2655 0.2898
Schistosoma mansoni dreadlocks/dock 0.0022 0.0616 0.0616
Brugia malayi Variant SH3 domain containing protein 0.0022 0.064 0.064
Schistosoma mansoni apoptosis stimulating of P53 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.1694 0.1849
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0298 0.2164
Echinococcus granulosus tyrosine protein kinase ABL1 0.0028 0.0906 0.0989
Echinococcus granulosus intersectin 2 0.0022 0.0616 0.0673
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0028 0.0906 0.0989
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.2697 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0644 0.9482
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0022 0.0616 0.0673
Loa Loa (eye worm) protein-tyrosine kinase 0.0022 0.0616 0.0616
Echinococcus granulosus SH2 domain containing adapter protein F 0.0022 0.064 0.0698
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Echinococcus granulosus growth factor receptor bound protein 2 0.0044 0.1563 0.1706
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0022 0.064 0.0698
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.2697 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.1275 0.4357
Echinococcus granulosus tyrosine protein kinase shark 0.0028 0.0906 0.0989
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0067 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Onchocerca volvulus 0.0028 0.0906 0.1356
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0222 0.9162 1
Brugia malayi N-terminal motif family protein 0.016 0.65 0.65
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0222 0.9162 1
Trichomonas vaginalis glutaminase, putative 0.0242 1 1
Brugia malayi hypothetical protein 0.0014 0.0307 0.0307
Onchocerca volvulus 0.0022 0.064 0.0945
Entamoeba histolytica unconventional myosin IB 0.0022 0.0616 0.0618
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Schistosoma mansoni signal transduction protein lnk-related 0.0022 0.064 0.064
Schistosoma mansoni DNA polymerase IV / kappa 0.0015 0.0314 0.0314
Echinococcus granulosus nostrin 0.0022 0.0616 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.1694 0.1694
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.2655 0.2655
Schistosoma mansoni tensin 0.0022 0.064 0.064
Loa Loa (eye worm) SH2 domain-containing protein 0.0022 0.064 0.064
Onchocerca volvulus 0.0028 0.0906 0.1356
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.016 0.65 1
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0022 0.0616 0.0673
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Schistosoma mansoni tyrosine kinase 0.0028 0.0906 0.0906
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0222 0.9162 1
Schistosoma mansoni cell polarity protein 0.0022 0.0616 0.0616
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0022 0.064 0.064
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0616 0.0616
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0028 0.0906 0.0989
Echinococcus granulosus dna polymerase kappa 0.007 0.2697 0.2944
Onchocerca volvulus 0.0022 0.064 0.0945
Echinococcus multilocularis SH2 motif 0.0022 0.064 0.0698
Giardia lamblia DINP protein human, muc B family 0.0053 0.1943 1
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Schistosoma mansoni tensin 0.0022 0.064 0.064
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0314 0.0546
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Echinococcus granulosus tyrosine protein kinase Fyn 0.0222 0.9162 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0644 0.9482
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0616 0.1744
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.1694 0.1694
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0022 0.064 0.064
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0022 0.064 0.0945
Echinococcus granulosus hypothetical protein 0.0022 0.064 0.0698
Echinococcus multilocularis tyrosine protein kinase Srms 0.02 0.8239 0.8992
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0022 0.0616 0.0673
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Onchocerca volvulus 0.0022 0.0616 0.0909
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Brugia malayi DIX domain containing protein 0.0008 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0314 0.0546
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Echinococcus granulosus NCK adaptor protein 0.0044 0.1563 0.1706
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0022 0.064 0.0698
Trypanosoma brucei DNA polymerase kappa, putative 0.0053 0.1943 0.7009
Trypanosoma cruzi DNA damage repair protein, putative 0.0015 0.0314 0.0546
Entamoeba histolytica SH2 domain containing protein 0.0022 0.064 0.0651
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.1694 0.2133
Echinococcus granulosus expressed protein 0.0022 0.0616 0.0673
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0022 0.0616 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1322 0.4544
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.1694 0.1694
Onchocerca volvulus 0.0022 0.064 0.0945
Brugia malayi Src substrate cortactin 0.0022 0.0616 0.0616
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Schistosoma mansoni dishevelled 0.0008 0.0028 0.0028
Brugia malayi Flap endonuclease-1 0.0023 0.0675 0.0675
Trypanosoma cruzi DNA damage repair protein, putative 0.0015 0.0314 0.0546
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.007 0.2697 0.2565
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.012 0.0131
Schistosoma mansoni suppressor of cytokine signaling 0.0022 0.064 0.064
Trypanosoma brucei unspecified product 0.0065 0.2448 0.9013
Brugia malayi polk-prov protein 0.0038 0.1317 0.1317
Plasmodium falciparum DNA repair protein REV1, putative 0.0015 0.0314 0.4068
Echinococcus multilocularis intersectin 2 0.0022 0.0616 0.0673
Echinococcus multilocularis expressed protein 0.0022 0.0616 0.0673
Schistosoma mansoni shc transforming protein 0.0022 0.064 0.064
Brugia malayi MH2 domain containing protein 0.0106 0.4195 0.4195
Schistosoma mansoni tyrosine kinase 0.0222 0.9162 0.9162
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0022 0.064 0.0698
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0022 0.0616 0.0673
Loa Loa (eye worm) hypothetical protein 0.0022 0.0644 0.0644
Loa Loa (eye worm) hypothetical protein 0.0107 0.4249 0.4249
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.2655 0.9833
Brugia malayi Tyrosine-protein kinase abl-1 0.005 0.1829 0.1829
Echinococcus granulosus SH2 domain containing protein 7 0.0022 0.064 0.0698
Echinococcus multilocularis SHC transforming protein 3 0.0022 0.064 0.0698
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0644 0.9148
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.012 0.0131
Giardia lamblia DNA damage repair protein 0.0015 0.0314 0.1319
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0023 0.0675 0.2011
Schistosoma mansoni hypothetical protein 0.0022 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0022 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0028 0.0906 0.0906
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0616 0.1744
Brugia malayi Protein kinase domain containing protein 0.0028 0.0906 0.0906
Brugia malayi Protein kinase domain containing protein 0.0028 0.0906 0.0906
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) SRC-1 0.0222 0.9162 0.9162
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.005 0.1829 0.1829
Brugia malayi hypothetical protein 0.0008 0.0028 0.0028
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0067 0.0073
Schistosoma mansoni suppressor of cytokine signaling 0.0022 0.064 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Echinococcus granulosus suppressor of cytokine signaling 7 0.0022 0.064 0.0698
Leishmania major hypothetical protein, conserved 0.0022 0.0616 0.1774
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0022 0.064 0.0698
Echinococcus granulosus SHC transforming protein 3 0.0022 0.064 0.0698
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) SH2 domain-containing protein 0.0022 0.064 0.064
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0028 0.0906 0.0989
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0022 0.0616 0.0616
Onchocerca volvulus 0.0022 0.064 0.0945
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0022 0.064 0.0698
Brugia malayi Myosin tail family protein 0.0022 0.0616 0.0616
Entamoeba histolytica BAR/SH3 domain containing protein 0.0022 0.0616 0.0618
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0222 0.9162 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0022 0.064 0.0698
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0616 0.1744
Echinococcus multilocularis dna polymerase eta 0.0069 0.2655 0.2898
Loa Loa (eye worm) TK protein kinase 0.0178 0.7292 0.7292
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0028 0.0028
Schistosoma mansoni tensin-related 0.0022 0.064 0.064
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0598 0.0598
Brugia malayi protein-tyrosine kinase 0.0022 0.0616 0.0616
Schistosoma mansoni growth factor receptor-bound protein 0.0044 0.1563 0.1563
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0644 0.4937
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0044 0.1563 0.1563
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0067 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0028
Echinococcus granulosus tyrosine protein kinase Fyn 0.0222 0.9162 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0408 0.0408
Echinococcus granulosus tyrosine kinase 0.0028 0.0906 0.0989
Echinococcus granulosus tyrosine protein kinase Src64B 0.0222 0.9162 1
Onchocerca volvulus 0.0022 0.0616 0.0909
Trichomonas vaginalis DNA polymerase eta, putative 0.007 0.2697 0.2565
Onchocerca volvulus 0.0022 0.0616 0.0909
Loa Loa (eye worm) glutaminase 0.0242 1 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0008 0.0028 0.0031
Schistosoma mansoni tyrosine kinase 0.005 0.1829 0.1829
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0022 0.0616 0.0447
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0022 0.0616 0.0673
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0022 0.064 0.0698
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0028 0.0028
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0028 0.0031
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0314 0.0546
Plasmodium vivax DNA repair protein REV1, putative 0.0015 0.0314 0.0245
Echinococcus granulosus tyrosine protein kinase Fyn 0.0222 0.9162 1
Echinococcus granulosus N chimaerin 0.0022 0.064 0.0698
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0022 0.064 0.0698
Schistosoma mansoni hypothetical protein 0.0054 0.2003 0.2003
Brugia malayi tRNA modification GTPase TrmE family protein 0.0022 0.064 0.064
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0022 0.064 0.064
Onchocerca volvulus 0.0022 0.0616 0.0909
Echinococcus granulosus tyrosine protein kinase Srms 0.0028 0.0906 0.0989
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0022 0.0616 0.0673
Schistosoma mansoni sorting nexin 0.0022 0.0616 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Loa Loa (eye worm) transcription factor SMAD2 0.0106 0.4195 0.4195
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Onchocerca volvulus Putative cortactin 0.0022 0.0616 0.0909
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.064 0.064
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Schistosoma mansoni run and tbc1 domain containing 0.0022 0.0616 0.0616
Schistosoma mansoni dishevelled 0.0008 0.0028 0.0028
Trypanosoma brucei DNA damage repair protein, putative 0.0015 0.0314 0.0546
Trypanosoma brucei unspecified product 0.0032 0.1073 0.3557
Loa Loa (eye worm) TK protein kinase 0.02 0.8239 0.8239
Loa Loa (eye worm) hypothetical protein 0.0044 0.1563 0.1563
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0044 0.1563 0.1563
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0222 0.9162 1
Loa Loa (eye worm) STAT protein 0.0022 0.064 0.064
Brugia malayi Variant SH3 domain containing protein 0.0022 0.064 0.064
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0008 0.0028 0.0028
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0067 0.0073
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0598 0.0429
Echinococcus granulosus fch and double sh3 domains protein 2 0.0022 0.0616 0.0673
Echinococcus granulosus expressed conserved protein 0.0022 0.064 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Mycobacterium ulcerans glutaminase 0.0242 1 1
Echinococcus multilocularis transfer RNA-Ala 0.0022 0.0616 0.0673
Brugia malayi Sex muscle abnormal protein 5 0.0044 0.1563 0.1563
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0644 0.1852
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Brugia malayi Fes/CIP4 homology domain containing protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0222 0.9162 1
Trypanosoma brucei unspecified product 0.0032 0.1073 0.3557
Schistosoma mansoni dynamin-associated protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) DIX domain-containing protein 0.0008 0.0028 0.0028
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0022 0.0616 0.0673
Schistosoma mansoni tensin-related 0.0022 0.064 0.064
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0044 0.1563 0.1563
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0067 0.0067
Loa Loa (eye worm) SH2 domain-containing protein 0.0022 0.064 0.064
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0616 0.0616
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Brugia malayi Variant SH3 domain containing protein 0.0044 0.1563 0.1563
Echinococcus granulosus flap endonuclease 1 0.0023 0.0675 0.0737
Brugia malayi protein-tyrosine kinase 0.02 0.8239 0.8239
Brugia malayi hypothetical protein 0.0008 0.0028 0.0028
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0022 0.064 0.0698
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0022 0.0616 0.0616
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0023 0.0675 0.519
Echinococcus multilocularis tyrosine protein kinase Fyn 0.02 0.8239 0.8992
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0028 0.0031
Echinococcus multilocularis flap endonuclease 1 0.0023 0.0675 0.0737
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0028 0.0031
Loa Loa (eye worm) TK/ABL protein kinase 0.0028 0.0906 0.0906
Leishmania major DNA polymerase eta, putative 0.0069 0.2655 1
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0616 0.0618
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.2697 1
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0022 0.0616 0.0673
Brugia malayi STAT protein, DNA binding domain containing protein 0.0022 0.064 0.064
Echinococcus multilocularis SH2 domain containing protein 7 0.0022 0.064 0.0698
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0067 0.0067
Schistosoma mansoni nck2/grb4 0.0044 0.1563 0.1563
Schistosoma mansoni hypothetical protein 0.0022 0.0616 0.0616
Echinococcus multilocularis tyrosine protein kinase shark 0.0028 0.0906 0.0989
Schistosoma mansoni DNA helicase recq5 0.0009 0.0067 0.0067
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0067 0.0067
Trichomonas vaginalis protein kinase inhibitor, putative 0.0054 0.2003 0.1859
Echinococcus multilocularis endophilin A3 0.0022 0.0616 0.0673
Mycobacterium ulcerans DNA polymerase IV 0.007 0.2697 0.246
Loa Loa (eye worm) DnaJ domain-containing protein 0.0054 0.2003 0.2003
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1317 0.4524
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1322 0.4544
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.1275 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.02 0.8239 0.8992
Schistosoma mansoni C-fyn 0.0022 0.0616 0.0616
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0022 0.0616 0.0673
Schistosoma mansoni flap endonuclease-1 0.0021 0.0581 0.0581
Onchocerca volvulus 0.0022 0.0616 0.0909
Schistosoma mansoni growth factor receptor-bound protein 0.0044 0.1563 0.1563
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1322 0.4544
Echinococcus granulosus tyrosine kinase 0.02 0.8239 0.8992
Echinococcus granulosus tyrosine protein kinase Src42A 0.0194 0.7973 0.8702
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0022 0.064 0.064
Loa Loa (eye worm) p53BP2 0.0022 0.0616 0.0616
Brugia malayi DnaJ domain containing protein 0.0054 0.2003 0.2003
Brugia malayi Guanylate kinase family protein 0.0022 0.0616 0.0616
Echinococcus granulosus tyrosine protein kinase Btk29A 0.005 0.1829 0.1996
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0067 0.0073
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0028 0.0031
Leishmania major DNA polymerase eta, putative 0.0037 0.1275 0.4431
Loa Loa (eye worm) glutaminase 2 0.0242 1 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0023 0.0675 0.1977
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0022 0.0616 0.1744
Echinococcus granulosus Spectrin alpha actinin 0.0022 0.0616 0.0673
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.2697 1
Loa Loa (eye worm) flap endonuclease-1 0.0023 0.0675 0.0675
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0022 0.0616 0.0673
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0023 0.0675 0.1977
Schistosoma mansoni GTPase activating protein 0.0022 0.064 0.064
Entamoeba histolytica Flap nuclease, putative 0.0023 0.0675 0.07
Echinococcus multilocularis tyrosine kinase 0.0028 0.0906 0.0989
Schistosoma mansoni SH2A 0.0022 0.064 0.064
Schistosoma mansoni eps8-related protein 0.0022 0.0616 0.0616
Entamoeba histolytica hypothetical protein 0.0022 0.0616 0.0618
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0222 0.9162 1
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Echinococcus multilocularis nostrin 0.0022 0.0616 0.0673
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Schistosoma mansoni DNA polymerase eta 0.0069 0.2655 0.2655
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0222 0.9162 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0008 0.0028 0.0031
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0022 0.064 0.0651
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.0314 0.2295
Onchocerca volvulus 0.0028 0.0906 0.1356
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0022 0.064 0.0698
Brugia malayi SRC-1 0.0222 0.9162 0.9162
Schistosoma mansoni DNA helicase recq1 0.0009 0.0067 0.0067
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0222 0.9162 1
Echinococcus granulosus tyrosine protein kinase Blk 0.02 0.8239 0.8992
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0022 0.064 0.064
Trypanosoma brucei DNA polymerase eta, putative 0.0069 0.2655 0.9833
Onchocerca volvulus 0.0028 0.0906 0.1356
Echinococcus multilocularis 0.0022 0.064 0.0698
Schistosoma mansoni tyrosine kinase 0.0028 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0067
Onchocerca volvulus 0.0028 0.0906 0.1356
Echinococcus multilocularis signal transduction protein lnk realted 0.0022 0.064 0.0698
Schistosoma mansoni adapter molecule crk 0.0044 0.1563 0.1563
Echinococcus multilocularis tyrosine protein kinase Abl 0.005 0.1829 0.1996
Echinococcus granulosus c src tyrosine kinase 0.005 0.1829 0.1996
Schistosoma mansoni sorbin 0.0022 0.0616 0.0616
Trypanosoma brucei DNA damage repair protein, putative 0.0015 0.0314 0.0546
Leishmania major DNA polymerase kappa, putative 0.0015 0.0314 0.0555
Schistosoma mansoni z-protein (S1r protein) 0.0008 0.0028 0.0028
Echinococcus multilocularis N chimaerin 0.0022 0.064 0.0698
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0022 0.064 0.064
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0028 0.0028
Brugia malayi SH2 domain containing protein 0.0028 0.0906 0.0906
Echinococcus granulosus SH2 motif 0.0022 0.064 0.0698
Brugia malayi hypothetical protein 0.0028 0.0906 0.0906
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0028 0.0031
Schistosoma mansoni regulator of G protein signaling 0.0008 0.0028 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.007 0.2697 1
Brugia malayi hypothetical protein 0.0022 0.0644 0.0644
Giardia lamblia Flap structure-specific endonuclease 0.0023 0.0675 0.3242
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.2448 0.9013
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Echinococcus granulosus src region 0.0022 0.0616 0.0673
Leishmania major DNA polymerase kappa, putative 0.0053 0.1943 0.7128
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.1694 0.1849
Leishmania major hypothetical protein, conserved 0.0022 0.0644 0.1884
Brugia malayi SH2 domain containing protein 0.0028 0.0906 0.0906
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0563 0.429
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0022 0.064 0.0698
Leishmania major DNA damage repair protein, putative 0.0015 0.0314 0.0555
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0022 0.064 0.0945
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0022 0.064 0.0698
Entamoeba histolytica protein kinase, putative 0.0178 0.7292 1
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Onchocerca volvulus 0.0022 0.064 0.0945
Echinococcus granulosus bloom syndrome protein 0.0021 0.0598 0.0653
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0194 0.7973 0.8702
Brugia malayi Peripheral plasma membrane protein CASK 0.0022 0.0616 0.0616
Echinococcus multilocularis c src tyrosine kinase 0.005 0.1829 0.1996
Loa Loa (eye worm) RecQ helicase 0.0021 0.0598 0.0598
Trypanosoma brucei chrX additional, unordered contigs 0.0015 0.0314 0.0546
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0053 0.1943 1
Echinococcus granulosus endophilin A3 0.0022 0.0616 0.0673
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0022 0.064 0.064
Schistosoma mansoni glutaminase 0.0242 1 1
Onchocerca volvulus 0.0022 0.064 0.0945
Echinococcus multilocularis dnaJ subfamily C 6 0.0054 0.2003 0.2186
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0022 0.064 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Loa Loa (eye worm) hypothetical protein 0.016 0.65 0.65
Echinococcus granulosus signal transduction protein lnk realted 0.0022 0.064 0.0698
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0022 0.064 0.0698
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.005 0.1829 0.1996
Echinococcus multilocularis tensin 0.0022 0.064 0.0698
Schistosoma mansoni hypothetical protein 0.001 0.012 0.012
Echinococcus multilocularis tyrosine protein kinase Blk 0.02 0.8239 0.8992
Entamoeba histolytica protein kinase, putative 0.0022 0.0616 0.0618
Loa Loa (eye worm) hypothetical protein 0.0038 0.1317 0.1317
Entamoeba histolytica BAR/SH3 domain containing protein 0.0022 0.0616 0.0618
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0644 0.1852
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.2697 1
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Brugia malayi regulator of G-protein signaling egl-10 0.0008 0.0028 0.0028
Schistosoma mansoni tensin 0.0022 0.064 0.064
Echinococcus granulosus SH2 motif 0.0022 0.064 0.0698
Echinococcus granulosus suppressor of cytokine signaling 6 0.0022 0.064 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Schistosoma mansoni dep domain containing protein 0.0008 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.4195 0.4195
Echinococcus multilocularis growth factor receptor bound protein 2 0.0044 0.1563 0.1706
Echinococcus multilocularis tensin 0.0022 0.064 0.0698
Brugia malayi SH2 domain containing protein 0.0022 0.064 0.064
Onchocerca volvulus 0.0028 0.0906 0.1356
Brugia malayi hypothetical protein 0.0022 0.064 0.064
Brugia malayi Spectrin alpha chain 0.0022 0.0616 0.0616
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0222 0.9162 1
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0022 0.0616 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0488 0.6931
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0616 0.0618
Mycobacterium ulcerans DNA polymerase IV 0.007 0.2697 0.246
Schistosoma mansoni tyrosine kinase 0.0222 0.9162 0.9162
Loa Loa (eye worm) hypothetical protein 0.0069 0.2655 0.2655
Plasmodium vivax flap endonuclease 1, putative 0.0023 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0616 0.0616
Brugia malayi RhoGAP domain containing protein 0.0022 0.064 0.064
Echinococcus granulosus dnaJ subfamily C 6 0.0054 0.2003 0.2186
Brugia malayi Protein kinase domain containing protein 0.0028 0.0906 0.0906
Entamoeba histolytica protein kinase, putative 0.0022 0.064 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0616 0.0447
Trypanosoma brucei conserved protein 0.0022 0.0616 0.1744
Schistosoma mansoni hypothetical protein 0.0022 0.0616 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0882 0.0882
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0028 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.2697 1
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0022 0.0616 0.0616
Schistosoma mansoni Dab2-interacting protein-like 0.0022 0.0616 0.0616
Echinococcus granulosus tyrosine protein kinase Lyn 0.0222 0.9162 1
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0314 0.0546
Echinococcus granulosus tyrosine protein kinase Src42A 0.0222 0.9162 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.0906 0.0906
Trichomonas vaginalis p67phox protein, putative 0.0022 0.0616 0.0447
Schistosoma mansoni formin binding protein and related proteins 0.0022 0.0616 0.0616
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0022 0.0616 0.0673
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0067 0.031
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0598 0.0429
Schistosoma mansoni tyrosine kinase 0.005 0.1829 0.1829
Loa Loa (eye worm) thyroid receptor interactor 0.0022 0.0616 0.0616
Echinococcus granulosus tensin 0.0022 0.064 0.0698
Echinococcus granulosus epidermal growth factor receptor kinase 0.0022 0.0616 0.0673
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0906 0.0906
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0028 0.0906 0.1024
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.1694 0.1694
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0222 0.9162 1
Plasmodium falciparum flap endonuclease 1 0.0023 0.0675 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0028 0.0031

Activities

Activity type Activity value Assay description Source Reference
MTD (ADMET) = 1.25 g/acre Phytotoxicity against two-leaf stage Oryza sativa cv. Nihonbare (rice) planted 1 cm depth measured after 20 to 25 weeks ChEMBL. No reference
MTD (ADMET) = 2.5 g/acre Phytotoxicity against two-leaf stage Oryza sativa cv. Nihonbare (rice) planted 3 cm depth measured after 20 to 25 weeks ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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