Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0092 | 1 | 0.5 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 | |
Leishmania major | prostaglandin f synthase, putative | 0.0092 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0092 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0092 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0092 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0092 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0092 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase | 0.0092 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0092 | 1 | 0.5 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 | |
Schistosoma mansoni | pol-related | 0.0092 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0092 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0092 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0092 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0092 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0092 | 1 | 1 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0092 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0092 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0092 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0092 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0092 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0092 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0092 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0092 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0092 | 1 | 1 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 28.7 % | Inhibition of PTP1B in Rattus norvegicus (rat) L6 cells assessed as increase in 2-deoxy-D-[U-14C]-glucose uptake at 50 uM after 18 hr relative to control | ChEMBL. | No reference |
Inhibition (binding) | = 56.2 % | Inhibition of Homo sapiens (human) recombinant PTP1B assessed as decrease in free phosphate release at 10 uM by malachite staining relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.