Detailed information for compound 1802891

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.389 | Formula: C8H13NO3S3
  • H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CSc1scc(n1)OS(=O)(=O)C)C
  • InChi: 1S/C8H13NO3S3/c1-6(2)4-13-8-9-7(5-14-8)12-15(3,10)11/h5-6H,4H2,1-3H3
  • InChiKey: VUKQRTDWIZJXSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.0036 0.1176 0.421
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0048 0.0124
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.3137 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.179 0.5693
Trypanosoma brucei unspecified product 0.0072 0.2535 0.9113
Loa Loa (eye worm) Smad1 0.0008 0.0115 0.0106
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.029 0.1013
Schistosoma mansoni dep domain containing protein 0.0009 0.0143 0.0134
Brugia malayi MH2 domain containing protein 0.0008 0.0115 0.0106
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0782 0.3816
Mycobacterium ulcerans glutaminase 0.0271 1 1
Leishmania major DNA polymerase kappa, putative 0.0059 0.2036 0.7423
Trypanosoma cruzi hypothetical protein 0.0006 0.0048 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1422 0.5097
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.041 0.2978
Echinococcus multilocularis Smad4 0.0008 0.0115 0.0328
Brugia malayi acetyltransferase, GNAT family protein 0.0091 0.3233 0.3227
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0598 0.7614
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.2781 0.2774
Giardia lamblia Histone acetyltransferase GCN5 0.0025 0.0734 0.3578
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0115 0.0328
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0181 0.0534
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.2781 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0143 0.0415
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.029 0.1013
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0143 0.0134
Schistosoma mansoni smad 0.0008 0.0115 0.0106
Brugia malayi N-terminal motif family protein 0.0179 0.654 0.6537
Brugia malayi Flap endonuclease-1 0.0026 0.0782 0.0774
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0181 0.055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0181 0.1317
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.2739 0.985
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.4261 0.4256
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0009 0.0066
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0048 0.0039
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.1375 0.4928
Echinococcus granulosus flap endonuclease 1 0.0026 0.0782 0.2472
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0048 0.014
Echinococcus multilocularis dna polymerase eta 0.0078 0.2739 0.8468
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.179 0.5523
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.2095 0.2088
Brugia malayi hypothetical protein 0.0009 0.0143 0.0134
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.2036 1
Leishmania major DNA damage repair protein, putative 0.0016 0.0426 0.1526
Trypanosoma brucei unspecified product 0.0036 0.1176 0.421
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0782 0.0774
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0706 0.0698
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0048 0.0039
Leishmania major DNA polymerase kappa, putative 0.0016 0.0426 0.1526
Entamoeba histolytica acetyltransferase, GNAT family 0.0025 0.0734 0.4102
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0048 0.012
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0426 0.0417
Loa Loa (eye worm) hypothetical protein 0.0025 0.0751 0.0743
Echinococcus granulosus Smad4 0.0008 0.0115 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0143 0.0415
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0143 0.0428
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0143 0.0134
Brugia malayi RasGEF domain containing protein 0.0006 0.0048 0.0039
Entamoeba histolytica exonuclease, putative 0.0005 0.0009 0.005
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.0048 0.0039
Brugia malayi RasGEF domain containing protein 0.0006 0.0048 0.0039
Plasmodium falciparum flap endonuclease 1 0.0026 0.0782 1
Schistosoma mansoni hypothetical protein 0.0061 0.2095 0.2088
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0048 0.012
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0181 0.0849
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0751 0.2678
Brugia malayi Smad1 0.0008 0.0115 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.2781 1
Echinococcus granulosus Protein son of sevenless 0.0006 0.0048 0.0124
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0181 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1422 0.5097
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.2036 0.7423
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0751 0.9597
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0143 0.0134
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0091 0.3233 0.3227
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.2739 0.985
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0426 0.1503
Entamoeba histolytica recQ family helicase, putative 0.0013 0.029 0.1619
Giardia lamblia DINP protein human, muc B family 0.0059 0.2036 1
Entamoeba histolytica DNA-repair protein, putative 0.0005 0.0009 0.005
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0048 0.0039
Echinococcus granulosus dna polymerase eta 0.0078 0.2739 0.8728
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0115 0.0106
Schistosoma mansoni DNA helicase recq1 0.001 0.0181 0.0172
Brugia malayi MH2 domain containing protein 0.0118 0.4261 0.4256
Loa Loa (eye worm) glutaminase 0.0271 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0115 0.0106
Schistosoma mansoni Smad4 0.0008 0.0115 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.179 0.8757
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0036 0.0027
Brugia malayi hypothetical protein 0.0016 0.0418 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0426 0.1503
Schistosoma mansoni smad1 5 8 and 0.0008 0.0115 0.0106
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0233 0.0695
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0706 0.0698
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Leishmania major hypothetical protein, conserved 0.0025 0.0751 0.2719
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0782 0.4371
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1417 0.5079
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.2781 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0426 0.5388
Loa Loa (eye worm) RecQ helicase 0.0024 0.0706 0.0698
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0072 0.2535 0.9113
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0672 0.4884
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0009 0.0066
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0048 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.2739 0.2733
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0143 0.0428
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0181 0.2225
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0782 0.2833
Brugia malayi DIX domain containing protein 0.0009 0.0143 0.0134
Echinococcus multilocularis smad 0.0008 0.0115 0.0328
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0143 0.0428
Plasmodium falciparum histone acetyltransferase GCN5 0.0025 0.0734 0.9376
Loa Loa (eye worm) acetyltransferase 0.0091 0.3233 0.3227
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0426 0.1503
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0233 0.0716
Echinococcus granulosus son of sevenless 1 0.0006 0.0048 0.0124
Schistosoma mansoni hypothetical protein 0.0011 0.0233 0.0224
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.2095 0.6469
Loa Loa (eye worm) hypothetical protein 0.001 0.0181 0.0172
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0115 0.0328
Loa Loa (eye worm) hypothetical protein 0.0179 0.654 0.6537
Echinococcus granulosus dna polymerase kappa 0.0079 0.2781 0.8861
Entamoeba histolytica exonuclease, putative 0.0005 0.0009 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.2036 0.7312
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0143 0.0428
Loa Loa (eye worm) hypothetical protein 0.012 0.4315 0.431
Loa Loa (eye worm) hypothetical protein 0.0043 0.1417 0.1409
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.179 0.1782
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0115 0.0339
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0181 0.0172
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0818 0.081
Brugia malayi RasGEF domain containing protein 0.0006 0.0048 0.0039
Leishmania major DNA polymerase eta, putative 0.0078 0.2739 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0706 0.2163
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Echinococcus granulosus smad 0.0008 0.0115 0.0339
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0039
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.2095 0.2088
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.2781 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0143 0.0134
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0048 0.0039
Brugia malayi DnaJ domain containing protein 0.0061 0.2095 0.2088
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0417 0.504
Loa Loa (eye worm) glutaminase 2 0.0271 1 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0115 0.0106
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0782 0.956
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0009 0.0066
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0782 0.279
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.179 1
Schistosoma mansoni DNA polymerase eta 0.0078 0.2739 0.2733
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0027 0.0818 0.5948
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0048 0.0039
Brugia malayi N-terminal motif family protein 0.0006 0.0048 0.0039
Schistosoma mansoni smad1 5 8 and 0.0008 0.0115 0.0106
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0181 0.0534
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0027 0.0818 0.081
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0751 0.2678
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0782 0.279
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0048 0.012
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.2781 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.029 0.0281
Brugia malayi N-terminal motif family protein 0.0006 0.0048 0.0039
Loa Loa (eye worm) hypothetical protein 0.0078 0.2739 0.2733
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.179 0.1782
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0143 0.0415
Brugia malayi hypothetical protein 0.0009 0.0143 0.0134
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0048 0.0039
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.029 0.1028
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.1375 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0143 0.0146
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0181 0.1317
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0181 0.0172
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0782 0.5689
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0751 0.5463
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0782 0.0774
Schistosoma mansoni dishevelled 0.0009 0.0143 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0426 0.1503
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.654 1
Brugia malayi polk-prov protein 0.0043 0.1417 0.1409
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0048 0.012
Brugia malayi MH1 domain containing protein 0.0008 0.0115 0.0106
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.2095 0.6668
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0091 0.3233 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0143 0.0415
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0115 0.0339
Leishmania major DNA polymerase eta, putative 0.0042 0.1375 0.5004
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0181 0.055
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.4261 0.4256
Echinococcus multilocularis dna polymerase kappa 0.0079 0.2781 0.8597
Echinococcus multilocularis son of sevenless 1 0.0006 0.0048 0.012
Schistosoma mansoni DNA helicase recq5 0.001 0.0181 0.0172
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.2781 0.246
Loa Loa (eye worm) hypothetical protein 0.0009 0.0143 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1422 0.5097
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0143 0.0134
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0143 0.0134
Schistosoma mansoni glutaminase 0.0271 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0426 0.3096
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0782 0.2399
Loa Loa (eye worm) hypothetical protein 0.0009 0.0143 0.0134
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0143 0.0428
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0143 0.0134
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0143 0.0134
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.2781 0.2774
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0518 0.051
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0426 0.1503
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0426 0.1503
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0027 0.0818 0.5948
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.179 0.1782
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0027 0.0818 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0027 0.0818 0.2586
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0426 0.1503
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Entamoeba histolytica hypothetical protein 0.0006 0.0048 0.0267
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0751 0.9597
Trypanosoma cruzi hypothetical protein 0.0006 0.0048 0.014
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.179 0.1782
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1417 0.5079
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0426 0.1503
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0143 0.0134
Brugia malayi hypothetical protein 0.0025 0.0751 0.0743
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0048 0.0039
Toxoplasma gondii hypothetical protein 0.0009 0.0143 0.1039
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0706 0.0698
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0143 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0039
Schistosoma mansoni dishevelled 0.0009 0.0143 0.0134
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0005 0.0009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.2781 0.246
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0048 0.0124
Echinococcus granulosus bloom syndrome protein 0.0024 0.0706 0.223
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0048 0.0124
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0115 0.0106
Trichomonas vaginalis glutaminase, putative 0.0271 1 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0048 0.0039
Giardia lamblia DNA damage repair protein 0.0016 0.0426 0.2056
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0267
Onchocerca volvulus 0.0009 0.0143 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0751 0.9175
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0426 0.5151
Brugia malayi MH1 domain containing protein 0.0008 0.0115 0.0106
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0048 0.0039
Brugia malayi MH2 domain containing protein 0.0008 0.0115 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.2781 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0751 0.2678
Schistosoma mansoni flap endonuclease-1 0.0023 0.0689 0.0681
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0426 0.1503
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.2781 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.2 10'-3M Inhibition of Musca domestica (house fly) NAIDM head acetylcholinesterase ChEMBL. No reference
IC50 (binding) = 3.1 10'-5M Inhibition of Bos taurus (bovine) erythrocytes acetylcholinesterase ChEMBL. No reference
IC50 (binding) = 5.8 10'-5M Inhibition of drug-susceptible Nephotettix cincticeps Ageo (green rice leafhopper) acetylcholinesterase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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