Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.1302 | 0.1302 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.853 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0011 | 0.0953 | 0.0953 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.1934 | 0.1934 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.1302 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.1302 | 0.1302 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0634 | 0.0634 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0892 | 0.0892 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.853 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0892 | 0.0892 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0017 | 0.1934 | 0.1934 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0011 | 0.0953 | 0.0953 |
Entamoeba histolytica | ABC transporter, putative | 0.0011 | 0.0953 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0062 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | phd/f-box containing protein | 0.0017 | 0.1934 | 0.1934 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.853 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.853 | 1 |
Brugia malayi | ABC transporter family protein | 0.0009 | 0.0656 | 0.0656 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.853 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.853 | 0.853 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.853 | 0.853 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0892 | 0.0892 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0892 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.853 | 0.853 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0892 | 0.0892 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.1934 | 0.1934 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.1302 | 0.1302 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0892 | 0.0892 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | jumonji domain containing protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0017 | 0.1934 | 0.1934 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0017 | 0.1934 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.853 | 0.853 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0892 | 0.0892 |
Leishmania major | hypothetical protein, conserved | 0.0017 | 0.1934 | 0.1295 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0892 | 0.0892 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.853 | 1 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0017 | 0.1934 | 0.1934 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.853 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Echinococcus multilocularis | phd:f box containing protein | 0.0017 | 0.1934 | 0.1934 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0.1302 | 0.046 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.1302 | 0.1302 |
Loa Loa (eye worm) | ABC transporter | 0.0009 | 0.0656 | 0.0656 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.1302 | 0.1302 |
Plasmodium vivax | JmjC domain containing protein | 0.0017 | 0.1934 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0017 | 0.1934 | 0.1934 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.1302 | 0.046 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.853 | 0.853 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.064 | 0.064 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.853 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 1 | 1 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0017 | 0.1934 | 0.1295 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0892 | 0.0892 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0011 | 0.0953 | 0.0953 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0892 | 0.0892 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0892 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0011 | 0.0953 | 0.0953 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0892 | 0.0892 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0017 | 0.1934 | 0.1295 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | phd:f box containing protein | 0.0017 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0017 | 0.1934 | 0.1934 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0011 | 0.0953 | 0.0953 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0892 | 0.0892 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0017 | 0.1934 | 0.1295 |
Brugia malayi | jmjC domain containing protein | 0.0017 | 0.1934 | 0.1934 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0017 | 0.1934 | 0.1934 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.853 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0062 | 1 | 1 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0017 | 0.1934 | 0.1295 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0011 | 0.0953 | 0.0953 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0017 | 0.1934 | 0.1295 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | jumonji domain containing protein | 0.0017 | 0.1934 | 0.1934 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.1302 | 0.046 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0892 | 0.0892 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.853 | 0.853 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0892 | 0.0892 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.853 | 0.853 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0892 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0892 | 0.0892 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.853 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.853 | 1 |
Schistosoma mansoni | ABC transporter | 0.0009 | 0.0656 | 0.0656 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1934 | 0.1934 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0892 | 0.0892 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.853 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0892 | 0.0892 |
Onchocerca volvulus | 0.0011 | 0.0892 | 0.5 | |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0009 | 0.0634 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.853 | 1 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0011 | 0.0953 | 0.0953 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.1302 | 0.046 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0017 | 0.1934 | 0.1934 |
Schistosoma mansoni | protein phosphatase 2C | 0.0017 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0892 | 0.0892 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.