Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0143 | 0.8271 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0062 | 0.0611 | 0.5 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0124 | 0.6428 | 0.5338 |
Brugia malayi | hypothetical protein | 0.0124 | 0.6428 | 0.6428 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0143 | 0.8271 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.01 | 0.4183 | 0.4183 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0162 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0081 | 0.2455 | 0.0151 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0062 | 0.0611 | 0.5 |
Treponema pallidum | flavodoxin | 0.0062 | 0.0611 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0094 | 0.3686 | 0.3276 |
Leishmania major | cytochrome P450 reductase, putative | 0.0143 | 0.8271 | 0.8159 |
Chlamydia trachomatis | sulfite reductase | 0.01 | 0.4183 | 0.5 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0094 | 0.3686 | 0.1759 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0162 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0062 | 0.0611 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0143 | 0.8271 | 0.8159 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0162 | 1 | 1 |
Echinococcus granulosus | adam | 0.0124 | 0.6428 | 0.4343 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0062 | 0.0611 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.01 | 0.4183 | 0.3805 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0162 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0162 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0062 | 0.0611 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.008 | 0.2339 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0162 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.01 | 0.4183 | 0.0787 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.008 | 0.2339 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0162 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0162 | 1 | 0.5 |
Echinococcus multilocularis | adam | 0.0124 | 0.6428 | 0.4343 |
Trypanosoma cruzi | p450 reductase, putative | 0.0162 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0143 | 0.8271 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0162 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.01 | 0.4183 | 0.0787 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0162 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0062 | 0.0611 | 0.0611 |
Brugia malayi | FAD binding domain containing protein | 0.0162 | 1 | 1 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0094 | 0.3686 | 0.1759 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0162 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0162 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0162 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0162 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.01 | 0.4183 | 0.2407 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3686 | 0.3276 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 ug ml-1 | Anticancer activity against Homo sapiens (human) MCF-7 cells assessed as inhibition of cell survival after 24 hr by MTT assay | ChEMBL. | No reference |
Survival (functional) | = 71.4 % | Anticancer activity against Homo sapiens (human) MCF-7 cells assessed as cell survival at 100 ug/ml after 24 hr by MTT assay (Rvb = 100%) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.