Detailed information for compound 1803673

Basic information

Technical information
  • TDR Targets ID: 1803673
  • Name: 2-[(6-chloropyridin-3-yl)methyl]-3-cyano-1,1- dimethylguanidine
  • MW: 237.689 | Formula: C10H12ClN5
  • H donors: 1 H acceptors: 2 LogP: 1.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/N=C(\N(C)C)/NCc1ccc(nc1)Cl
  • InChi: 1S/C10H12ClN5/c1-16(2)10(15-7-12)14-6-8-3-4-9(11)13-5-8/h3-5H,6H2,1-2H3,(H,14,15)
  • InChiKey: ZOYIAGJETAJZNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(6-chloro-3-pyridyl)methyl]-3-cyano-1,1-dimethyl-guanidine
  • 2-[(6-chloro-3-pyridyl)methyl]-3-cyano-1,1-dimethylguanidine
  • 2-[(6-chloropyridin-3-yl)methyl]-3-cyano-1,1-dimethyl-guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax subtilisin-like protease 1 0.0218 0.0355 1
Toxoplasma gondii subtilisin SUB12 0.0218 0.0355 1
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0095 0.0107 0.2381
Echinococcus multilocularis glutamate receptor 2 0.005 0.0018 0.0009
Schistosoma mansoni dock 0.0049 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0011 0.0008
Echinococcus multilocularis Furin 1 0.1207 0.234 0.291
Echinococcus multilocularis fibrillin 1 0.006 0.0038 0.0034
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0153 0.0223 0.0213
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0064 0.0046 0.1026
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0088 0.2252
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0084 0.0086 0.2194
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0018 0.0009
Brugia malayi celfurPC protein 0.4034 0.8015 0.8013
Echinococcus granulosus c-Jun N-terminal kinases 0.0245 0.0408 0.0397
Echinococcus granulosus integrin alpha ps 0.0067 0.0052 0.0041
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0016 0.0006
Plasmodium vivax plasmepsin V, putative 0.0127 0.0172 0.4681
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0094 0.0106 0.0119
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.011 0.0137 0.0134
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0016 0.0437
Loa Loa (eye worm) WD40 repeat protein 0.0068 0.0054 0.005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3063 0.6067 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0057 0.1108
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0218 0.0355 1
Echinococcus multilocularis protein arginine methyltransferase 0.0061 0.0038 0.0034
Plasmodium vivax hypothetical protein, conserved 0.007 0.0057 0.1341
Schistosoma mansoni septate junction protein 0.0058 0.0033 0.0022
Loa Loa (eye worm) apoptosis regulator protein 0.0059 0.0036 0.0033
Toxoplasma gondii subtilisin SUB4 0.0218 0.0355 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0034 0.0958
Echinococcus granulosus adam 0.0358 0.0635 0.0625
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0218 0.0355 1
Brugia malayi hypothetical protein 0.0394 0.0708 0.0698
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0005
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0049 0.0016 0.0005
Plasmodium falciparum subtilisin-like protease 2 0.0218 0.0355 1
Schistosoma mansoni hypothetical protein 0.0067 0.0052 0.0041
Plasmodium falciparum LCCL domain-containing protein 0.0049 0.0016 0.0132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni protein kinase 0.0125 0.0168 0.0158
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0057 0.1609
Toxoplasma gondii PA14 domain-containing protein 0.0049 0.0016 0.0437
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1207 0.234 0.2332
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Trypanosoma brucei subtilisin peptidase 0.0218 0.0355 0.8094
Toxoplasma gondii subtilisin SUB7 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0036 0.0033
Schistosoma mansoni integrin alpha-ps 0.0073 0.0063 0.0053
Echinococcus multilocularis membrane bound transcription factor site 1 0.0218 0.0355 0.043
Mycobacterium tuberculosis Polyketide synthase Pks2 0.008 0.0076 0.1915
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0018 0.0007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0063 0.0044 0.0827
Loa Loa (eye worm) integrin alpha pat-2 0.0483 0.0886 0.0883
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3063 0.6067 0.6062
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Mycobacterium ulcerans polyketide synthase 0.0079 0.0076 0.1665
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0248 0.0414 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0248 0.0414 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0038 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0134 0.0196
Mycobacterium ulcerans monoamine oxidase 0.007 0.0057 0.1108
Schistosoma mansoni glutamate receptor NMDA 0.0281 0.048 0.047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1247 0.242 0.2411
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.0408 0.0397
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0057 0.1355
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0057 0.1108
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0245 0.0408 0.0496
Leishmania major UDP-galactopyranose mutase 0.007 0.0057 0.1341
Echinococcus multilocularis integrin alpha 3 0.024 0.0399 0.0484
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0018 0.0009
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0057 0.0046
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0059 0.0036 0.0031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0125 0.0168 0.0197
Toxoplasma gondii hypothetical protein 0.006 0.0037 0.1029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0745 0.1413 0.1751
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0057 0.1108
Onchocerca volvulus 0.0094 0.0105 0.1427
Schistosoma mansoni amine oxidase 0.007 0.0057 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Loa Loa (eye worm) TK/EGFR protein kinase 0.0194 0.0307 0.0304
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0016 0.0005
Echinococcus granulosus integrin alpha 3 0.024 0.0399 0.0388
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0218 0.0355 1
Schistosoma mansoni hypothetical protein 0.0094 0.0105 0.0094
Schistosoma mansoni integrin alpha-ps 0.014 0.0199 0.0188
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0057 0.1341
Plasmodium vivax subtilisin-like serine protease, putative 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0188 0.0185
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0057 0.1609
Brugia malayi hypothetical protein 0.0095 0.0107 0.0096
Echinococcus granulosus fibrillin 1 0.006 0.0038 0.0027
Echinococcus multilocularis MAM 0.0094 0.0105 0.0117
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0057 0.1146
Plasmodium vivax LCCL domain-containing protein 0.0049 0.0016 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Schistosoma mansoni amine oxidase 0.007 0.0057 0.0046
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0084 0.0086 0.2076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0018 0.0007
Loa Loa (eye worm) subtilase 0.0218 0.0355 0.0352
Echinococcus multilocularis discoidin domain receptor 0.0049 0.0016 0.0006
Brugia malayi Stress-activated protein kinase jnk-1 0.0245 0.0408 0.0397
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0063 0.0043 0.0032
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0094 0.0106 0.0095
Loa Loa (eye worm) hypothetical protein 0.0133 0.0184 0.0181
Leishmania major subtilisin-like serine peptidase 0.0218 0.0355 1
Schistosoma mansoni discoidin domain receptor 0.0049 0.0016 0.0005
Mycobacterium tuberculosis Probable thioesterase TesA 0.0068 0.0054 0.1265
Brugia malayi Protein kinase domain containing protein 0.0094 0.0105 0.0094
Mycobacterium ulcerans polyketide synthase 0.0084 0.0086 0.197
Mycobacterium leprae Polyketide synthase Pks13 0.012 0.0157 0.4174
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0245 0.0408 0.0405
Plasmodium vivax subtilisin-like protease 2, putative 0.0218 0.0355 1
Loa Loa (eye worm) integrin beta-2 0.2569 0.5075 0.5073
Giardia lamblia Hypothetical protein 0.0108 0.0134 0.027
Schistosoma mansoni hypothetical protein 0.0094 0.0105 0.0094
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0076 0.1897
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0071 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.008 0.0076 0.1915
Echinococcus granulosus adam 17 protease 0.0094 0.0106 0.0095
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0298 0.0515 0.0505
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0018 0.0007
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0218 0.0355 0.0345
Toxoplasma gondii subtilisin SUB5 0.0218 0.0355 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0344 0.0608 0.0598
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0423 0.0766 0.0763
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0745 0.1413 0.1403
Toxoplasma gondii subtilisin SUB11 0.0218 0.0355 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0086 0.2194
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0218 0.0355 1
Echinococcus granulosus Furin 1 0.1207 0.234 0.2332
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0054
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0989 0.1902 0.3117
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0088 0.203
Echinococcus granulosus discoidin domain receptor 0.0049 0.0016 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0018 0.0009
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0134 0.3051
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0218 0.0355 0.043
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0084 0.0086 0.2194
Mycobacterium leprae Probable polyketide synthase Pks1 0.0084 0.0086 0.2076
Brugia malayi Will die slowly protein 0.0068 0.0054 0.0043
Brugia malayi Integrin alpha pat-2 precursor 0.0313 0.0545 0.0535
Echinococcus granulosus protein arginine N methyltransferase 8 0.0061 0.0038 0.0027
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0125 0.0168 0.0158
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Trichomonas vaginalis hypothetical protein 0.006 0.0037 0.0035
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0218 0.0355 0.0345
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0134 1
Loa Loa (eye worm) reprolysin 0.0228 0.0374 0.0371
Onchocerca volvulus 0.0049 0.0016 0.0069
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0218 0.0355 1
Mycobacterium leprae Possible secreted protease 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0052 0.0048
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0038 0.0038
Brugia malayi proprotein convertase 2 0.3167 0.6274 0.627
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Loa Loa (eye worm) TK/ROR protein kinase 0.0047 0.0011 0.0008
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0018 0.0009
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0049 0.0016 0.0006
Echinococcus granulosus furin 0.5023 1 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0134 0.3051
Echinococcus multilocularis 0.4034 0.8015 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0108 0.0134 0.0123
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0038 0.0038
Echinococcus multilocularis fibrillin 2 0.006 0.0037 0.0032
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0057 0.1225
Onchocerca volvulus 0.0049 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0012
Schistosoma mansoni hypothetical protein 0.0989 0.1902 0.1893
Schistosoma mansoni btb and poz domain-containing protein 0.0049 0.0016 0.0005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0079 0.0076 0.1897
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0218 0.0355 1
Echinococcus granulosus protein arginine methyltransferase 0.0061 0.0038 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni hypothetical protein 0.0068 0.0054 0.0043
Brugia malayi SWIRM domain containing protein 0.0373 0.0666 0.0656
Echinococcus multilocularis integrin beta 2 0.1897 0.3725 0.4641
Mycobacterium ulcerans dehydrogenase 0.007 0.0057 0.1108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Loa Loa (eye worm) hypothetical protein 0.0373 0.0666 0.0663
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0038 0.0027
Echinococcus granulosus disintegrin and metalloproteinase 0.0094 0.0106 0.0095
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0059 0.0036 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Toxoplasma gondii subtilisin SUB1 0.0218 0.0355 1
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0307 0.0296
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0137 0.0126
Toxoplasma gondii aspartyl protease ASP5 0.0116 0.0149 0.4207
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni integrin beta subunit 0.1503 0.2934 0.2927
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0079 0.0076 0.1775
Echinococcus granulosus lysine specific histone demethylase 1A 0.0344 0.0608 0.0598
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0057 0.1146
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0025
Loa Loa (eye worm) metalloprotease 0.0063 0.0043 0.004
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.004
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.0088 0.5
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0038 0.0038
Echinococcus granulosus integrin alpha ps 0.014 0.0199 0.0188
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0218 0.0355 1
Echinococcus multilocularis 0.007 0.0057 0.0058
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0057 0.1341
Schistosoma mansoni hypothetical protein 0.0049 0.0016 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Loa Loa (eye worm) angiogenesis inhibito 0.0063 0.0043 0.004
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0049 0.0016 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.007 0.0058 0.0047
Echinococcus granulosus nmda type glutamate receptor 0.0119 0.0155 0.0144
Echinococcus multilocularis chromatin regulatory protein sir2 0.0108 0.0134 0.0154
Leishmania major arginine N-methyltransferase-like protein 0.0061 0.0038 0.0795
Loa Loa (eye worm) hypothetical protein 0.0228 0.0374 0.0371
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0077 0.0071 0.1748
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0134 0.0131
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0018 0.0007
Giardia lamblia Furin precursor putative serine protease 0.0989 0.1902 0.5172
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0079 0.0076 0.0065
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Loa Loa (eye worm) fatty acid synthase 0.0081 0.0079 0.0076
Brugia malayi hypothetical protein 0.007 0.0057 0.0046
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0025
Loa Loa (eye worm) hypothetical protein 0.0099 0.0116 0.0112
Echinococcus multilocularis nmda type glutamate receptor 0.0119 0.0155 0.018
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5023 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0063 0.0044 0.0705
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0061 0.0038 0.0795
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0076 0.1665
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0059 0.0036 0.0025
Onchocerca volvulus 0.0373 0.0666 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0079 0.0076 0.1775
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0076 0.1665
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0374 0.0363
Toxoplasma gondii subtilisin SUB8 0.0218 0.0355 1
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0228 0.0374 0.0363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0344 0.0608 0.0746
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Schistosoma mansoni discoidin domain receptor 0.0049 0.0016 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Mycobacterium ulcerans thioesterase TesA 0.0068 0.0054 0.1015
Mycobacterium ulcerans thioesterase 0.0068 0.0054 0.1015
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0016 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3063 0.6067 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0025
Schistosoma mansoni apoptosis regulator bax 0.0059 0.0036 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus granulosus fibrillin 2 0.006 0.0037 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0119 0.0155 0.018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0012
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0053 0.0024 0.0665
Onchocerca volvulus 0.0068 0.0054 0.065
Loa Loa (eye worm) hypothetical protein 0.0344 0.0608 0.0605
Loa Loa (eye worm) hypothetical protein 0.0073 0.0063 0.006
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.0088 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0076 0.1665
Brugia malayi hypothetical protein 0.0298 0.0515 0.0505
Brugia malayi ADAM-TS Spacer 1 family protein 0.0133 0.0184 0.0173
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0016 0.0006
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.012 0.0157 0.426
Echinococcus granulosus glutamate NMDA receptor subunit 0.0281 0.048 0.047
Loa Loa (eye worm) endoprotease bli-4 0.5023 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0068 0.0054 0.1134
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0061 0.0038 0.0034
Echinococcus multilocularis neuroendocrine convertase 2 0.3167 0.6274 0.7824
Plasmodium falciparum LCCL domain-containing protein 0.0049 0.0016 0.0132
Loa Loa (eye worm) hypothetical protein 0.0095 0.0107 0.0104
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0228 0.0374 0.0454
Plasmodium vivax LCCL domain-containing protein 0.0049 0.0016 0.0132
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0057 0.1341
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0016 0.0005
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0095 0.0107 0.2381
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3063 0.6067 0.7566
Onchocerca volvulus 0.0143 0.0204 0.2939
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0061 0.0038 0.0795
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0077 0.0071 0.0067
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0307 0.037
Loa Loa (eye worm) hypothetical protein 0.1959 0.385 0.3848
Echinococcus granulosus membrane bound transcription factor site 1 0.0218 0.0355 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Brugia malayi Kelch motif family protein 0.0423 0.0766 0.0756
Loa Loa (eye worm) hypothetical protein 0.0394 0.0708 0.0705
Brugia malayi Reprolysin 0.0133 0.0184 0.0174
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0084 0.0086 0.2076
Echinococcus multilocularis neuropeptides capa receptor 0.0218 0.0354 0.0429
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0057 0.0058
Brugia malayi Integrin beta pat-3 precursor 0.2569 0.5075 0.5069
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0989 0.1902 0.3117
Chlamydia trachomatis glutamine binding protein 0.0085 0.0088 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0218 0.0355 0.0345
Toxoplasma gondii subtilisin SUB10 0.0218 0.0355 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0016 0.0437
Echinococcus multilocularis adam 0.0358 0.0635 0.078
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0057 0.1341
Schistosoma mansoni site-1 peptidase (S08 family) 0.0218 0.0355 0.0345
Plasmodium vivax hypothetical protein, conserved 0.007 0.0057 0.1341
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Brugia malayi metalloprotease 0.0063 0.0043 0.0032
Schistosoma mansoni tyrosine kinase 0.0194 0.0307 0.0296
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0061 0.0038 0.108
Loa Loa (eye worm) hypothetical protein 0.0094 0.0105 0.0101
Toxoplasma gondii subtilisin SUB2 0.0218 0.0355 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0094 0.0105 0.0101
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0016 0.0437
Onchocerca volvulus Fatty acid synthase homolog 0.0148 0.0214 0.3095
Echinococcus granulosus neuropeptides capa receptor 0.0218 0.0354 0.0343
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0281 0.048 0.0587
Brugia malayi hypothetical protein 0.0094 0.0105 0.0094
Schistosoma mansoni integrin alpha 0.0313 0.0545 0.0535
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0218 0.0355 1
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0134 1
Echinococcus granulosus MAM 0.0094 0.0105 0.0094
Brugia malayi angiogenesis inhibito 0.0133 0.0184 0.0173
Toxoplasma gondii kringle domain-containing protein 0.0047 0.0011 0.0309
Giardia lamblia High cysteine membrane protein Group 2 0.1856 0.3643 1
Brugia malayi Furin-like cysteine rich region family protein 0.0194 0.0307 0.0296
Loa Loa (eye worm) hypothetical protein 0.0344 0.0608 0.0605
Echinococcus multilocularis protein jagged 2 0.006 0.0037 0.0032
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0218 0.0355 0.0345
Mycobacterium ulcerans oxidoreductase 0.007 0.0057 0.1108
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0227 0.0372 0.0361
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0134 0.0196
Echinococcus multilocularis protein will die slowly 0.0068 0.0054 0.0053
Onchocerca volvulus 0.0094 0.0105 0.1427
Brugia malayi Disintegrin family protein 0.0094 0.0106 0.0095
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0237 0.0392 0.0382
Echinococcus granulosus neuroendocrine convertase 2 0.3167 0.6274 0.627
Schistosoma mansoni furin-1 (S08 family) 0.2178 0.4289 0.4282
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0374 0.0363
Loa Loa (eye worm) hypothetical protein 0.0218 0.0355 0.0352
Loa Loa (eye worm) hypothetical protein 0.0173 0.0264 0.026
Mycobacterium tuberculosis Polyketide synthase Pks13 0.012 0.0157 0.426
Trypanosoma cruzi subtilisin peptidase 0.0218 0.0355 0.8548
Onchocerca volvulus 0.0053 0.0023 0.0181
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0059 0.0036 0.0025
Loa Loa (eye worm) hypothetical protein 0.0246 0.041 0.0407
Trichomonas vaginalis WD repeat domain, putative 0.0068 0.0054 0.0063
Onchocerca volvulus 0.0077 0.0071 0.0911
Echinococcus multilocularis integrin alpha ps 0.014 0.0199 0.0234
Echinococcus multilocularis disintegrin and metalloproteinase 0.0094 0.0106 0.0119
Trichomonas vaginalis hypothetical protein 0.0989 0.1902 0.3117
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0108 0.0134 0.088
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0057 0.1355
Loa Loa (eye worm) hypothetical protein 0.0133 0.0184 0.0181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis integrin alpha ps 0.014 0.0199 0.0234
Echinococcus granulosus protein will die slowly 0.0068 0.0054 0.0043
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0049 0.0016 0.0149
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.0035 0.0716
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.006 0.0037 0.0035
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Onchocerca volvulus 0.0218 0.0355 0.5254
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Echinococcus granulosus integrin beta 2 0.1897 0.3725 0.3718
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0016 0.0005
Toxoplasma gondii subtilisin SUB9 0.0218 0.0355 1
Brugia malayi ADAMTS-like protease 0.0133 0.0184 0.0173
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0218 0.0355 0.0345
Plasmodium falciparum plasmepsin V 0.0127 0.0172 0.4681
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0018 0.0007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0248 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.5023 1 1
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0218 0.0355 0.8548
Leishmania major silent information regulator 2, putative 0.0108 0.0134 0.357
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0051 0.002 0.0132
Echinococcus granulosus chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Echinococcus granulosus glutamate receptor 2 0.005 0.0018 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0038 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Toxoplasma gondii subtilisin SUB6 0.0218 0.0355 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0086 0.197
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni dihydroceramide desaturase 0.0094 0.0106 0.0095
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0079 0.0076 0.1897
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0054
Mycobacterium ulcerans polyketide synthase Pks13 0.012 0.0157 0.4096
Brugia malayi amine oxidase, flavin-containing family protein 0.0099 0.0116 0.0105
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.0088 0.5
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Plasmodium falciparum subtilisin-like protease 3 0.0218 0.0355 1
Brugia malayi Subtilase family protein 0.0218 0.0355 0.0345
Onchocerca volvulus 0.006 0.0037 0.039
Loa Loa (eye worm) hypothetical protein 0.0094 0.0105 0.0101
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0108 0.0134 0.0154
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0063 0.0044 0.0705
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0074 0.0071
Schistosoma mansoni site-1 peptidase (S08 family) 0.0218 0.0355 0.0345
Schistosoma mansoni protein kinase 0.0125 0.0168 0.0158
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0094 0.0105 0.0101
Schistosoma mansoni protein kinase 0.0125 0.0168 0.0158
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0076 0.1665
Toxoplasma gondii type I fatty acid synthase, putative 0.0084 0.0086 0.2422
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0086 0.197
Loa Loa (eye worm) hypothetical protein 0.0237 0.0392 0.0389
Echinococcus multilocularis integrin alpha ps 0.0067 0.0052 0.0051
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0134 0.0123
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0989 0.1902 0.3117
Brugia malayi neuroendocrine convertase 1 precursor 0.3167 0.6274 0.627
Loa Loa (eye worm) hypothetical protein 0.007 0.0058 0.0054
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0057 0.1341
Plasmodium falciparum subtilisin-like protease 1 0.0218 0.0355 1
Loa Loa (eye worm) proprotein convertase 2 0.1207 0.234 0.2338

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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