Detailed information for compound 1803675

Basic information

Technical information
  • TDR Targets ID: 1803675
  • Name: 1-[(6-chloropyridin-3-yl)methyl]-3-cyano-1,2- dimethylguanidine
  • MW: 237.689 | Formula: C10H12ClN5
  • H donors: 1 H acceptors: 2 LogP: 1.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/N=C(/N(Cc1ccc(nc1)Cl)C)\NC
  • InChi: 1S/C10H12ClN5/c1-13-10(15-7-12)16(2)6-8-3-4-9(11)14-5-8/h3-5H,6H2,1-2H3,(H,13,15)
  • InChiKey: XWFQEFWALTZDKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(6-chloro-3-pyridyl)methyl]-3-cyano-1,2-dimethyl-guanidine
  • 1-[(6-chloro-3-pyridyl)methyl]-3-cyano-1,2-dimethylguanidine
  • 1-[(6-chloropyridin-3-yl)methyl]-3-cyano-1,2-dimethyl-guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum LCCL domain-containing protein 0.0049 0.0016 0.0132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Plasmodium falciparum subtilisin-like protease 2 0.0218 0.0355 1
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0049 0.0016 0.0005
Schistosoma mansoni hypothetical protein 0.0067 0.0052 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni protein kinase 0.0125 0.0168 0.0158
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0057 0.1609
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1207 0.234 0.2332
Toxoplasma gondii PA14 domain-containing protein 0.0049 0.0016 0.0437
Toxoplasma gondii subtilisin SUB7 0.0218 0.0355 1
Trypanosoma brucei subtilisin peptidase 0.0218 0.0355 0.8094
Loa Loa (eye worm) hypothetical protein 0.0059 0.0036 0.0033
Echinococcus multilocularis membrane bound transcription factor site 1 0.0218 0.0355 0.043
Schistosoma mansoni integrin alpha-ps 0.0073 0.0063 0.0053
Loa Loa (eye worm) apoptosis regulator protein 0.0059 0.0036 0.0033
Plasmodium vivax hypothetical protein, conserved 0.007 0.0057 0.1341
Schistosoma mansoni septate junction protein 0.0058 0.0033 0.0022
Echinococcus multilocularis protein arginine methyltransferase 0.0061 0.0038 0.0034
Toxoplasma gondii subtilisin SUB4 0.0218 0.0355 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0034 0.0958
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus granulosus adam 0.0358 0.0635 0.0625
Brugia malayi hypothetical protein 0.0394 0.0708 0.0698
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0005
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0218 0.0355 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0094 0.0106 0.0119
Loa Loa (eye worm) WD40 repeat protein 0.0068 0.0054 0.005
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.011 0.0137 0.0134
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0016 0.0437
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0218 0.0355 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3063 0.6067 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0057 0.1108
Echinococcus multilocularis glutamate receptor 2 0.005 0.0018 0.0009
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0095 0.0107 0.2381
Plasmodium vivax subtilisin-like protease 1 0.0218 0.0355 1
Toxoplasma gondii subtilisin SUB12 0.0218 0.0355 1
Echinococcus multilocularis fibrillin 1 0.006 0.0038 0.0034
Schistosoma mansoni dock 0.0049 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0011 0.0008
Echinococcus multilocularis Furin 1 0.1207 0.234 0.291
Brugia malayi celfurPC protein 0.4034 0.8015 0.8013
Echinococcus granulosus integrin alpha ps 0.0067 0.0052 0.0041
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0016 0.0006
Echinococcus granulosus c-Jun N-terminal kinases 0.0245 0.0408 0.0397
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0153 0.0223 0.0213
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0064 0.0046 0.1026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0018 0.0009
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0088 0.2252
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0084 0.0086 0.2194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Plasmodium vivax plasmepsin V, putative 0.0127 0.0172 0.4681
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0084 0.0086 0.2076
Schistosoma mansoni amine oxidase 0.007 0.0057 0.0046
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0057 0.1146
Plasmodium vivax LCCL domain-containing protein 0.0049 0.0016 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Loa Loa (eye worm) subtilase 0.0218 0.0355 0.0352
Echinococcus multilocularis discoidin domain receptor 0.0049 0.0016 0.0006
Brugia malayi Stress-activated protein kinase jnk-1 0.0245 0.0408 0.0397
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0094 0.0106 0.0095
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0063 0.0043 0.0032
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0018 0.0007
Mycobacterium ulcerans polyketide synthase 0.0084 0.0086 0.197
Leishmania major subtilisin-like serine peptidase 0.0218 0.0355 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0068 0.0054 0.1265
Schistosoma mansoni discoidin domain receptor 0.0049 0.0016 0.0005
Brugia malayi Protein kinase domain containing protein 0.0094 0.0105 0.0094
Mycobacterium leprae Polyketide synthase Pks13 0.012 0.0157 0.4174
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Loa Loa (eye worm) hypothetical protein 0.0133 0.0184 0.0181
Plasmodium vivax subtilisin-like serine protease, putative 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0188 0.0185
Schistosoma mansoni integrin alpha-ps 0.014 0.0199 0.0188
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0057 0.1341
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0057 0.1609
Brugia malayi hypothetical protein 0.0095 0.0107 0.0096
Echinococcus multilocularis MAM 0.0094 0.0105 0.0117
Echinococcus granulosus fibrillin 1 0.006 0.0038 0.0027
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0245 0.0408 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Echinococcus multilocularis integrin alpha 3 0.024 0.0399 0.0484
Leishmania major UDP-galactopyranose mutase 0.007 0.0057 0.1341
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0057 0.1355
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0103
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0057 0.1108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0018 0.0009
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0057 0.0046
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0059 0.0036 0.0031
Toxoplasma gondii hypothetical protein 0.006 0.0037 0.1029
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0125 0.0168 0.0197
Schistosoma mansoni amine oxidase 0.007 0.0057 0.0046
Onchocerca volvulus 0.0094 0.0105 0.1427
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0745 0.1413 0.1751
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0057 0.1108
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0218 0.0355 1
Echinococcus granulosus integrin alpha 3 0.024 0.0399 0.0388
Schistosoma mansoni hypothetical protein 0.0094 0.0105 0.0094
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0016 0.0005
Loa Loa (eye worm) TK/EGFR protein kinase 0.0194 0.0307 0.0304
Mycobacterium ulcerans polyketide synthase 0.0079 0.0076 0.1665
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0018 0.0007
Mycobacterium tuberculosis Polyketide synthase Pks2 0.008 0.0076 0.1915
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0063 0.0044 0.0827
Loa Loa (eye worm) integrin alpha pat-2 0.0483 0.0886 0.0883
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3063 0.6067 0.6062
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0248 0.0414 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0038 0.0027
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0248 0.0414 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni glutamate receptor NMDA 0.0281 0.048 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0134 0.0196
Mycobacterium ulcerans monoamine oxidase 0.007 0.0057 0.1108
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1247 0.242 0.2411
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.0408 0.0397
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0134 0.3051
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0084 0.0086 0.2194
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0218 0.0355 0.043
Brugia malayi Integrin alpha pat-2 precursor 0.0313 0.0545 0.0535
Brugia malayi Will die slowly protein 0.0068 0.0054 0.0043
Echinococcus granulosus protein arginine N methyltransferase 8 0.0061 0.0038 0.0027
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0125 0.0168 0.0158
Mycobacterium leprae Probable polyketide synthase Pks1 0.0084 0.0086 0.2076
Trichomonas vaginalis hypothetical protein 0.006 0.0037 0.0035
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0218 0.0355 0.0345
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0134 1
Onchocerca volvulus 0.0049 0.0016 0.0069
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0218 0.0355 1
Loa Loa (eye worm) reprolysin 0.0228 0.0374 0.0371
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0745 0.1413 0.1403
Toxoplasma gondii subtilisin SUB11 0.0218 0.0355 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0086 0.2194
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0423 0.0766 0.0763
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0088 0.203
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0054
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0989 0.1902 0.3117
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0218 0.0355 1
Echinococcus granulosus Furin 1 0.1207 0.234 0.2332
Echinococcus granulosus discoidin domain receptor 0.0049 0.0016 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0018 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0071 0.006
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0076 0.1897
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0298 0.0515 0.0505
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.008 0.0076 0.1915
Echinococcus granulosus adam 17 protease 0.0094 0.0106 0.0095
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0218 0.0355 0.0345
Toxoplasma gondii subtilisin SUB5 0.0218 0.0355 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0018 0.0007
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0344 0.0608 0.0598
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0245 0.0408 0.0405
Plasmodium vivax subtilisin-like protease 2, putative 0.0218 0.0355 1
Loa Loa (eye worm) integrin beta-2 0.2569 0.5075 0.5073
Schistosoma mansoni hypothetical protein 0.0094 0.0105 0.0094
Giardia lamblia Hypothetical protein 0.0108 0.0134 0.027
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0025
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0057 0.1146
Loa Loa (eye worm) metalloprotease 0.0063 0.0043 0.004
Echinococcus granulosus integrin alpha ps 0.014 0.0199 0.0188
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0043 0.004
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.0088 0.5
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0038 0.0038
Echinococcus multilocularis 0.007 0.0057 0.0058
Schistosoma mansoni hypothetical protein 0.0049 0.0016 0.0005
Loa Loa (eye worm) angiogenesis inhibito 0.0063 0.0043 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0057 0.1341
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Mycobacterium ulcerans dehydrogenase 0.007 0.0057 0.1108
Echinococcus multilocularis integrin beta 2 0.1897 0.3725 0.4641
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0059 0.0036 0.0025
Echinococcus granulosus disintegrin and metalloproteinase 0.0094 0.0106 0.0095
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0038 0.0027
Loa Loa (eye worm) hypothetical protein 0.0373 0.0666 0.0663
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0137 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Toxoplasma gondii subtilisin SUB1 0.0218 0.0355 1
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0307 0.0296
Echinococcus granulosus lysine specific histone demethylase 1A 0.0344 0.0608 0.0598
Toxoplasma gondii aspartyl protease ASP5 0.0116 0.0149 0.4207
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Schistosoma mansoni integrin beta subunit 0.1503 0.2934 0.2927
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0079 0.0076 0.1775
Onchocerca volvulus 0.0049 0.0016 0.0069
Schistosoma mansoni hypothetical protein 0.0989 0.1902 0.1893
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0012
Schistosoma mansoni btb and poz domain-containing protein 0.0049 0.0016 0.0005
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0218 0.0355 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0079 0.0076 0.1897
Brugia malayi SWIRM domain containing protein 0.0373 0.0666 0.0656
Echinococcus granulosus protein arginine methyltransferase 0.0061 0.0038 0.0027
Schistosoma mansoni hypothetical protein 0.0068 0.0054 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Loa Loa (eye worm) TK/ROR protein kinase 0.0047 0.0011 0.0008
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0038 0.0038
Mycobacterium leprae Possible secreted protease 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0052 0.0048
Brugia malayi proprotein convertase 2 0.3167 0.6274 0.627
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0018 0.0009
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0049 0.0016 0.0006
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0134 0.3051
Echinococcus granulosus furin 0.5023 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0108 0.0134 0.0123
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0057 0.1225
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.0038 0.0038
Echinococcus multilocularis fibrillin 2 0.006 0.0037 0.0032
Echinococcus multilocularis 0.4034 0.8015 1
Schistosoma mansoni apoptosis regulator bax 0.0059 0.0036 0.0025
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus granulosus fibrillin 2 0.006 0.0037 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0119 0.0155 0.018
Loa Loa (eye worm) hypothetical protein 0.0344 0.0608 0.0605
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0012
Onchocerca volvulus 0.0068 0.0054 0.065
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0053 0.0024 0.0665
Toxoplasma gondii subtilisin SUB8 0.0218 0.0355 1
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0228 0.0374 0.0363
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0374 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0344 0.0608 0.0746
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0016 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3063 0.6067 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Mycobacterium ulcerans thioesterase TesA 0.0068 0.0054 0.1015
Schistosoma mansoni discoidin domain receptor 0.0049 0.0016 0.0005
Mycobacterium ulcerans thioesterase 0.0068 0.0054 0.1015
Loa Loa (eye worm) fatty acid synthase 0.0081 0.0079 0.0076
Giardia lamblia Furin precursor putative serine protease 0.0989 0.1902 0.5172
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0079 0.0076 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Loa Loa (eye worm) hypothetical protein 0.0099 0.0116 0.0112
Brugia malayi hypothetical protein 0.007 0.0057 0.0046
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0025
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0061 0.0038 0.0795
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0076 0.1665
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5023 1 1
Echinococcus multilocularis nmda type glutamate receptor 0.0119 0.0155 0.018
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0063 0.0044 0.0705
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Onchocerca volvulus 0.0373 0.0666 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0079 0.0076 0.1775
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0076 0.1665
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0059 0.0036 0.0025
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0049 0.0016 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis chromatin regulatory protein sir2 0.0108 0.0134 0.0154
Leishmania major arginine N-methyltransferase-like protein 0.0061 0.0038 0.0795
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.007 0.0058 0.0047
Echinococcus granulosus nmda type glutamate receptor 0.0119 0.0155 0.0144
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0134 0.0131
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0228 0.0374 0.0371
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0077 0.0071 0.1748
Toxoplasma gondii subtilisin SUB10 0.0218 0.0355 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0218 0.0355 0.0345
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0016 0.0437
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0057 0.1341
Schistosoma mansoni site-1 peptidase (S08 family) 0.0218 0.0355 0.0345
Plasmodium vivax hypothetical protein, conserved 0.007 0.0057 0.1341
Echinococcus multilocularis adam 0.0358 0.0635 0.078
Brugia malayi metalloprotease 0.0063 0.0043 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.0355 0.0562
Loa Loa (eye worm) hypothetical protein 0.1959 0.385 0.3848
Echinococcus granulosus membrane bound transcription factor site 1 0.0218 0.0355 0.0345
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0084 0.0086 0.2076
Loa Loa (eye worm) hypothetical protein 0.0394 0.0708 0.0705
Brugia malayi Kelch motif family protein 0.0423 0.0766 0.0756
Brugia malayi Reprolysin 0.0133 0.0184 0.0174
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0057 0.0058
Brugia malayi Integrin beta pat-3 precursor 0.2569 0.5075 0.5069
Echinococcus multilocularis neuropeptides capa receptor 0.0218 0.0354 0.0429
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0989 0.1902 0.3117
Chlamydia trachomatis glutamine binding protein 0.0085 0.0088 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis neuroendocrine convertase 2 0.3167 0.6274 0.7824
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0061 0.0038 0.0034
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0068 0.0054 0.1134
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0228 0.0374 0.0454
Loa Loa (eye worm) hypothetical protein 0.0095 0.0107 0.0104
Plasmodium vivax LCCL domain-containing protein 0.0049 0.0016 0.0132
Plasmodium falciparum LCCL domain-containing protein 0.0049 0.0016 0.0132
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0016 0.0005
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0057 0.1341
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Onchocerca volvulus 0.0143 0.0204 0.2939
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0061 0.0038 0.0795
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0077 0.0071 0.0067
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0307 0.037
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0095 0.0107 0.2381
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3063 0.6067 0.7566
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.0088 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0063 0.006
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0076 0.1665
Brugia malayi hypothetical protein 0.0298 0.0515 0.0505
Echinococcus granulosus glutamate NMDA receptor subunit 0.0281 0.048 0.047
Brugia malayi ADAM-TS Spacer 1 family protein 0.0133 0.0184 0.0173
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.012 0.0157 0.426
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0016 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Loa Loa (eye worm) hypothetical protein 0.006 0.0037 0.0033
Loa Loa (eye worm) endoprotease bli-4 0.5023 1 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0108 0.0134 0.088
Echinococcus multilocularis disintegrin and metalloproteinase 0.0094 0.0106 0.0119
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0057 0.1355
Trichomonas vaginalis hypothetical protein 0.0989 0.1902 0.3117
Trichomonas vaginalis WD repeat domain, putative 0.0068 0.0054 0.0063
Echinococcus multilocularis integrin alpha ps 0.014 0.0199 0.0234
Onchocerca volvulus 0.0077 0.0071 0.0911
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Echinococcus multilocularis integrin alpha ps 0.014 0.0199 0.0234
Loa Loa (eye worm) hypothetical protein 0.0133 0.0184 0.0181
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0049 0.0016 0.0149
Echinococcus granulosus protein will die slowly 0.0068 0.0054 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Echinococcus granulosus integrin beta 2 0.1897 0.3725 0.3718
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.0035 0.0716
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.006 0.0037 0.0035
Onchocerca volvulus 0.0218 0.0355 0.5254
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0374 0.0363
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0237 0.0392 0.0382
Schistosoma mansoni furin-1 (S08 family) 0.2178 0.4289 0.4282
Echinococcus granulosus neuroendocrine convertase 2 0.3167 0.6274 0.627
Loa Loa (eye worm) hypothetical protein 0.0218 0.0355 0.0352
Loa Loa (eye worm) hypothetical protein 0.0173 0.0264 0.026
Mycobacterium tuberculosis Polyketide synthase Pks13 0.012 0.0157 0.426
Onchocerca volvulus 0.0053 0.0023 0.0181
Trypanosoma cruzi subtilisin peptidase 0.0218 0.0355 0.8548
Loa Loa (eye worm) hypothetical protein 0.0246 0.041 0.0407
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0059 0.0036 0.0025
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0281 0.048 0.0587
Brugia malayi hypothetical protein 0.0094 0.0105 0.0094
Schistosoma mansoni integrin alpha 0.0313 0.0545 0.0535
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0218 0.0355 1
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Echinococcus multilocularis protein jagged 2 0.006 0.0037 0.0032
Giardia lamblia High cysteine membrane protein Group 2 0.1856 0.3643 1
Loa Loa (eye worm) hypothetical protein 0.0344 0.0608 0.0605
Brugia malayi Furin-like cysteine rich region family protein 0.0194 0.0307 0.0296
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0134 1
Echinococcus granulosus MAM 0.0094 0.0105 0.0094
Toxoplasma gondii kringle domain-containing protein 0.0047 0.0011 0.0309
Brugia malayi angiogenesis inhibito 0.0133 0.0184 0.0173
Brugia malayi Disintegrin family protein 0.0094 0.0106 0.0095
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0134 0.0196
Onchocerca volvulus 0.0094 0.0105 0.1427
Echinococcus multilocularis protein will die slowly 0.0068 0.0054 0.0053
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0218 0.0355 0.0345
Mycobacterium ulcerans oxidoreductase 0.007 0.0057 0.1108
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0227 0.0372 0.0361
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0061 0.0038 0.108
Schistosoma mansoni tyrosine kinase 0.0194 0.0307 0.0296
Toxoplasma gondii subtilisin SUB2 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0105 0.0101
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0016 0.0437
Loa Loa (eye worm) TK/ALK protein kinase 0.0094 0.0105 0.0101
Echinococcus granulosus neuropeptides capa receptor 0.0218 0.0354 0.0343
Onchocerca volvulus Fatty acid synthase homolog 0.0148 0.0214 0.3095
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0086 0.197
Toxoplasma gondii type I fatty acid synthase, putative 0.0084 0.0086 0.2422
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0989 0.1902 0.3117
Brugia malayi neuroendocrine convertase 1 precursor 0.3167 0.6274 0.627
Loa Loa (eye worm) hypothetical protein 0.0237 0.0392 0.0389
Echinococcus multilocularis integrin alpha ps 0.0067 0.0052 0.0051
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0134 0.0123
Loa Loa (eye worm) proprotein convertase 2 0.1207 0.234 0.2338
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0057 0.1341
Plasmodium falciparum subtilisin-like protease 1 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0058 0.0054
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0108 0.0134 0.0154
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0063 0.0044 0.0705
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0218 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0074 0.0071
Schistosoma mansoni site-1 peptidase (S08 family) 0.0218 0.0355 0.0345
Schistosoma mansoni protein kinase 0.0125 0.0168 0.0158
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0076 0.1665
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0057 0.0046
Schistosoma mansoni protein kinase 0.0125 0.0168 0.0158
Loa Loa (eye worm) hypothetical protein 0.0094 0.0105 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1207 0.234 0.3842
Toxoplasma gondii subtilisin SUB6 0.0218 0.0355 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0086 0.197
Schistosoma mansoni dihydroceramide desaturase 0.0094 0.0106 0.0095
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0079 0.0076 0.1897
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0355 0.0562
Loa Loa (eye worm) hypothetical protein 0.007 0.0057 0.0054
Mycobacterium ulcerans polyketide synthase Pks13 0.012 0.0157 0.4096
Brugia malayi Subtilase family protein 0.0218 0.0355 0.0345
Loa Loa (eye worm) hypothetical protein 0.0094 0.0105 0.0101
Onchocerca volvulus 0.006 0.0037 0.039
Brugia malayi amine oxidase, flavin-containing family protein 0.0099 0.0116 0.0105
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.0088 0.5
Plasmodium falciparum subtilisin-like protease 3 0.0218 0.0355 1
Brugia malayi EGF-like domain containing protein 0.006 0.0037 0.0026
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0248 0.0414 1
Toxoplasma gondii subtilisin SUB9 0.0218 0.0355 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0016 0.0005
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0018 0.0007
Brugia malayi ADAMTS-like protease 0.0133 0.0184 0.0173
Plasmodium falciparum plasmepsin V 0.0127 0.0172 0.4681
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0218 0.0355 0.0345
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0051 0.002 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Loa Loa (eye worm) hypothetical protein 0.5023 1 1
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0218 0.0355 0.8548
Leishmania major silent information regulator 2, putative 0.0108 0.0134 0.357
Echinococcus granulosus chromatin regulatory protein sir2 0.0108 0.0134 0.0123
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0061 0.0038 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1902 0.3117
Echinococcus granulosus glutamate receptor 2 0.005 0.0018 0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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