Detailed information for compound 1803835

Basic information

Technical information
  • TDR Targets ID: 1803835
  • Name: oxolan-3-ylmethanol
  • MW: 102.132 | Formula: C5H10O2
  • H donors: 1 H acceptors: 1 LogP: -0.22 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1COCC1
  • InChi: 1S/C5H10O2/c6-3-5-1-2-7-4-5/h5-6H,1-4H2
  • InChiKey: PCPUMGYALMOCHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • tetrahydrofuran-3-ylmethanol
  • 3-tetrahydrofuranylmethanol
  • 15833-61-1
  • .+/-.-Tetrahydro-3-furanmethanol
  • (+-)-Tetrahydro-3-furanmethanol
  • 340588_ALDRICH
  • Tetrahydro-3-furanmethanol
  • Tetrahydro-3-furanylmethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0029 0.0933 0.0933
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.8712 0.8712
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.8712 0.8712
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0059 1 1
Schistosoma mansoni thyroid hormone receptor 0.0055 0.8712 0.8712
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0028 0.0787 0.0787
Echinococcus multilocularis nervana 2 0.0028 0.0787 0.0787
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0028 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Schistosoma mansoni thyroid hormone receptor 0.0055 0.8712 0.8712
Schistosoma mansoni nuclear hormone receptor 0.0055 0.8712 0.8712
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0029 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Echinococcus multilocularis Glutaredoxin protein 5 0.0028 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.1028 0.1028
Brugia malayi hypothetical protein 0.0029 0.0933 0.0933
Leishmania major protein kinase, putative 0.0059 1 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0933 0.0933
Trypanosoma brucei aurora B kinase 0.0059 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0933 0.0933
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.8712 0.8712
Trichomonas vaginalis AGC family protein kinase 0.0059 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0029 0.1028 0.1028
Echinococcus granulosus nervana 2 0.0028 0.0787 0.0787
Onchocerca volvulus 0.0055 0.8712 1
Entamoeba histolytica protein kinase, putative 0.0044 0.5398 0.4871
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0933 0.0933
Toxoplasma gondii aurora kinase 0.0059 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.8712 0.8712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.8712 0.8712
Brugia malayi serine/threonine kinase 12 0.0059 1 1
Brugia malayi nuclear receptor NHR-88 0.0055 0.8712 0.8712
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0059 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0059 1 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0059 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 1 1
Entamoeba histolytica protein kinase, putative 0.0044 0.5398 0.4871
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.8712 0.8712
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.8712 0.8712
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.8712 0.8712
Brugia malayi nuclear receptor RXR 0.0029 0.0933 0.0933
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.8712 0.8712
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.8712 0.8712
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.8712 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.8712 0.8712
Loa Loa (eye worm) hypothetical protein 0.0029 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0029 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0029 0.0933 0.0933
Entamoeba histolytica protein kinase, putative 0.0059 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0933 0.0933
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0059 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.8712 0.8712
Giardia lamblia Aurora kinase 0.0059 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.8712 0.8712
Trichomonas vaginalis AGC family protein kinase 0.0059 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.8712 0.8712
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0933 0.0933
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.8712 0.8712
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.8712 0.8712
Brugia malayi p70 ribosomal S6 kinase beta 0.0044 0.5398 0.5398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.8712 0.8712
Loa Loa (eye worm) AUR protein kinase 0.0059 1 1
Echinococcus granulosus nervana 2 0.0028 0.0787 0.0787
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.8712 0.8712
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.8712 1
Schistosoma mansoni protein kinase 0.0059 1 1
Brugia malayi ecdysteroid receptor 0.0055 0.8712 0.8712
Trichomonas vaginalis AGC family protein kinase 0.0059 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.8712 0.8712
Entamoeba histolytica protein kinase, putative 0.0059 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.8712 0.8712
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.8712 0.8712
Echinococcus granulosus FTZ F1 alpha 0.0055 0.8712 0.8712
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.8712 0.8712
Brugia malayi steroid hormone receptor 0.0055 0.8712 0.8712
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.8712 0.8712
Brugia malayi nuclear hormone receptor 0.0055 0.8712 0.8712
Schistosoma mansoni coup transcription factor 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0933 0.0933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.8712 0.8712
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.8712 0.8712
Trichomonas vaginalis AGC family protein kinase 0.0059 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.8712 0.8712
Echinococcus multilocularis rac serine:threonine kinase 0.0029 0.1028 0.1028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.8712 0.8712
Loa Loa (eye worm) AGC/AKT protein kinase 0.0044 0.5398 0.5398
Echinococcus granulosus serine/threonine protein kinase 0.0029 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.8712 0.8712
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0044 0.5398 0.5398
Brugia malayi Protein kinase domain containing protein 0.0044 0.5398 0.5398
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.8712 0.8712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.8712 0.8712
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.8712 0.8712
Loa Loa (eye worm) hypothetical protein 0.0029 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.8712 0.8712
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.8712 0.8712
Loa Loa (eye worm) AUR protein kinase 0.0059 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.8712 0.8712
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.8712 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.8712 0.8712
Trypanosoma cruzi aurora B kinase, putative 0.0059 1 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0059 1 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0059 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.8712 0.8712
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.8712 0.8712
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.8712 0.8712
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.8712 0.8712
Echinococcus multilocularis nervana 2 0.0028 0.0787 0.0787
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0059 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.8712 0.8712
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.8712 0.8712
Echinococcus granulosus serine threonine protein kinase nrc 0.0029 0.1028 0.1028
Echinococcus multilocularis aurora kinase A 0.0059 1 1
Entamoeba histolytica protein kinase , putative 0.0059 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.8712 0.8712
Loa Loa (eye worm) hypothetical protein 0.0055 0.8712 0.8712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.8712 0.8712
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.8712 0.8712
Loa Loa (eye worm) AUR protein kinase 0.0059 1 1
Entamoeba histolytica protein kinase, putative 0.0044 0.5398 0.4871
Echinococcus granulosus aurora kinase A 0.0059 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.8712 0.8712
Brugia malayi serine/threonine-protein kinase 6 0.0059 1 1
Echinococcus granulosus Glutaredoxin protein 5 0.0028 0.0787 0.0787

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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