Detailed information for compound 180479

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 558.708 | Formula: C34H42N2O5
  • H donors: 4 H acceptors: 4 LogP: 5.23 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC(C)(C)C)N[C@H]([C@H](C[C@H](C(=O)N[C@@H]1[C@H](O)CCc2c1cccc2)Cc1ccccc1)O)Cc1ccccc1
  • InChi: 1S/C34H42N2O5/c1-34(2,3)41-33(40)35-28(21-24-14-8-5-9-15-24)30(38)22-26(20-23-12-6-4-7-13-23)32(39)36-31-27-17-11-10-16-25(27)18-19-29(31)37/h4-17,26,28-31,37-38H,18-22H2,1-3H3,(H,35,40)(H,36,39)/t26-,28+,29-,30+,31+/m1/s1
  • InChiKey: IMGCDQHXXAQTBJ-LUSCGSNMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0037 0.0032 0.0069
Trypanosoma cruzi calmodulin, putative 0.0037 0.0032 0.005
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0085 0.0178 0.0385
Leishmania major i/6 autoantigen-like protein 0.0037 0.0032 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0108 0.0255
Loa Loa (eye worm) calpain D 0.0061 0.0104 0.0245
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.4623 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Leishmania major calpain protease-like protein 0.0061 0.0104 0.0389
Schistosoma mansoni histone deacetylase 4 5 0.0792 0.2358 0.51
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Echinococcus multilocularis expressed conserved protein 0.0283 0.0788 0.0788
Echinococcus granulosus histone deacetylase 8 0.0278 0.0772 0.1814
Trypanosoma cruzi kinesin, putative 0.0141 0.0352 0.0897
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0085 0.0178 0.0868
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Onchocerca volvulus 0.0298 0.0835 0.8867
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0062
Loa Loa (eye worm) calpain family protein 1 0.0393 0.1129 0.2651
Echinococcus granulosus histone deacetylase 1 0.0648 0.1914 0.4497
Trypanosoma cruzi histone deacetylase 1, putative 0.0648 0.1914 0.5035
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0066 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0171 0.0444 0.1143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0136 0.0526
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0058
Echinococcus multilocularis integrin alpha ps 0.0032 0.0018 0.0018
Schistosoma mansoni mitochondrial solute carrier 0.0037 0.0032 0.0069
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0085 0.0178 0.0868
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Entamoeba histolytica hypothetical protein 0.004 0.004 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0085 0.0178 0.0868
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1257 0.3789 1
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.004 0.0141
Echinococcus multilocularis cathepsin b 0.1257 0.3789 0.3789
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0171 0.0444 0.1143
Leishmania major calmodulin, putative 0.0037 0.0032 0.008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0026 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0136 0.0526
Brugia malayi Cathepsin L-like precursor 0.0211 0.0569 0.1336
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0182
Plasmodium falciparum cysteine proteinase falcipain 3 0.0298 0.0835 0.3507
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Echinococcus multilocularis calpain A 0.0572 0.1679 0.1679
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.027 0.0633
Echinococcus multilocularis integrin alpha 3 0.0116 0.0274 0.0274
Leishmania major histone deacetylase, putative 0.0648 0.1914 0.8109
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0037 0.0032 0.0075
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0155
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0432
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.004 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.004 0.0114
Echinococcus multilocularis histone deacetylase 6 0.0792 0.2358 0.2358
Echinococcus granulosus EF HAND 1 calcium binding site 0.0037 0.0032 0.0075
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0085 0.0178 0.0418
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Toxoplasma gondii hypothetical protein 0.0061 0.0104 0.0389
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Giardia lamblia Histone deacetylase 0.0648 0.1914 1
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.0569 0.2923
Onchocerca volvulus 0.0082 0.0172 0.1822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Trypanosoma cruzi calmodulin, putative 0.0037 0.0032 0.005
Echinococcus granulosus calpain A 0.0572 0.1679 0.3946
Echinococcus multilocularis BRCA1 associated protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) histone deacetylase 7A 0.0792 0.2358 0.5539
Schistosoma mansoni cathepsin F (C01 family) 0.0211 0.0569 0.123
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0037 0.0032 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Loa Loa (eye worm) ctsf protein 0.0298 0.0835 0.1962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0444 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Schistosoma mansoni integrin beta subunit 0.0182 0.0479 0.1036
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0031 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0071 0.0136 1
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Loa Loa (eye worm) integrin alpha pat-2 0.0233 0.0635 0.1492
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.3481
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Echinococcus multilocularis centrin 2 0.0037 0.0032 0.0032
Trypanosoma cruzi caltractin, putative 0.0037 0.0032 0.005
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0043 0.0051 0.012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Trypanosoma brucei antigen, putative 0.0201 0.0538 0.2239
Schistosoma mansoni cathepsin F (C01 family) 0.0298 0.0835 0.1807
Loa Loa (eye worm) acetyltransferase 0.0143 0.0358 0.0841
Brugia malayi cathepsin L-like cysteine proteinase 0.0085 0.0178 0.0418
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Onchocerca volvulus Histone deacetylase 10 homolog 0.0278 0.0772 0.8199
Toxoplasma gondii EF hand domain-containing protein 0.0037 0.0032 0.008
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0038 0.0035 0.0075
Echinococcus multilocularis histone deacetylase 3 0.0648 0.1914 0.1914
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0136 0.0327
Leishmania major centrin, putative 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Schistosoma mansoni hypothetical protein 0.0287 0.0803 0.1736
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Echinococcus multilocularis integrin alpha ps 0.0068 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0155
Onchocerca volvulus 0.0287 0.0803 0.852
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0085 0.0178 0.0868
Toxoplasma gondii cathepsin CPC2 0.0085 0.0178 0.0704
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Trichomonas vaginalis calcineurin B subunit, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi histone deacetylase, putative 0.0792 0.2358 0.6209
Schistosoma mansoni histone deacetylase 4 5 0.0792 0.2358 0.51
Loa Loa (eye worm) calmodulin-like protein 0.0037 0.0032 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0028 0.006
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0061 0.0104 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0184 0.0432
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0037 0.0032 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.0569 0.2923
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Loa Loa (eye worm) histone deacetylase 3 0.0648 0.1914 0.4497
Entamoeba histolytica calpain large subunit domain III containing protein 0.0141 0.0352 0.1781
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0278 0.0653
Echinococcus granulosus cathepsin b 0.1257 0.3789 0.8902
Plasmodium falciparum serine repeat antigen 9 0.0085 0.0178 0.0704
Trypanosoma cruzi major cysteine proteinase, putative 0.0085 0.0178 0.0437
Brugia malayi hypothetical protein 0.004 0.004 0.0094
Trypanosoma brucei mitochondrial calcium uptake 1 0.0037 0.0032 0.008
Toxoplasma gondii preprocathepsin c precursor, putative 0.0085 0.0178 0.0704
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0037 0.0032 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0383 0.09
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0066 0.2718
Plasmodium vivax histone deacetylase, putative 0.0278 0.0772 0.3238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Toxoplasma gondii histone deacetylase HDAC5 0.0278 0.0772 0.3238
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Echinococcus granulosus Niemann Pick C1 protein 0.043 0.1242 0.2919
Trypanosoma brucei Calpain-like protein CALP1.3 0.0061 0.0104 0.0389
Trypanosoma brucei histone deacetylase 1 0.0648 0.1914 0.8109
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0571 0.1677 0.1677
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Loa Loa (eye worm) calpain 0.0201 0.0538 0.1264
Loa Loa (eye worm) hypothetical protein 0.0515 0.1503 0.3531
Schistosoma mansoni calmodulin related calcium binding protein 0.0037 0.0032 0.0069
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.004 0.0086
Echinococcus granulosus cathepsin b 0.1257 0.3789 0.8902
Echinococcus multilocularis histone deacetylase 6 0.0792 0.2358 0.2358
Onchocerca volvulus 0.0298 0.0835 0.8867
Trypanosoma cruzi cysteine protease, putative 0.0171 0.0444 0.1143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0066 0.0279
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0037 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Schistosoma mansoni hypothetical protein 0.0497 0.1447 0.313
Plasmodium vivax histone deacetylase 1, putative 0.0648 0.1914 0.8109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Echinococcus multilocularis cathepsin L cysteine protease 0.0298 0.0835 0.0835
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0136 1
Brugia malayi hypothetical protein 0.0047 0.0062 0.0147
Brugia malayi cathepsin L-like precursor 0.0211 0.0569 0.1336
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Echinococcus multilocularis histone deacetylase 6 0.0823 0.2453 0.2453
Leishmania major histone deacetylase, putative 0.0648 0.1914 0.8109
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.0514 0.1208
Schistosoma mansoni calpain C (C02 family) 0.0201 0.0538 0.1164
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Entamoeba histolytica cysteine proteinase, putative 0.0298 0.0835 0.4325
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Loa Loa (eye worm) hypothetical protein 0.0047 0.0062 0.0147
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0013 0.0031
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Entamoeba histolytica grainin 2 0.0037 0.0032 0.0099
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0648 0.1914 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0031 0.0013 0.0031
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0298 0.0835 0.1962
Trypanosoma brucei caltractin, putative 0.0037 0.0032 0.008
Plasmodium vivax calpain, putative 0.0201 0.0538 0.2239
Loa Loa (eye worm) hypothetical protein 0.0211 0.0569 0.1336
Trypanosoma brucei Component of motile flagella 41 0.0037 0.0032 0.008
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0571 0.1677 0.3627
Entamoeba histolytica protein kinase, putative 0.0141 0.0352 0.1781
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0178 0.0868
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.004 0.0094
Toxoplasma gondii histone deacetylase HDAC4 0.0278 0.0772 0.3238
Brugia malayi calpain D 0.0061 0.0104 0.0245
Brugia malayi calpain family protein 1 0.0534 0.1562 0.3671
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0226
Trypanosoma brucei histone deacetylase 4 0.0792 0.2358 1
Schistosoma mansoni hypothetical protein 0.0061 0.0104 0.0225
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0085 0.0178 0.0704
Schistosoma mansoni calpain (C02 family) 0.0201 0.0538 0.1164
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0031 0.0013 0.0028
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0052 0.0167
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0136 0.0649
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Loa Loa (eye worm) hypothetical protein 0.0534 0.1562 0.3671
Entamoeba histolytica hypothetical protein 0.0085 0.0178 0.0868
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0031 0.0013 0.0013
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0034 0.0113
Entamoeba histolytica cysteine proteinase 2 0.0171 0.0444 0.2269
Entamoeba histolytica histone deacetylase, putative 0.0648 0.1914 1
Trypanosoma cruzi histone deacetylase, putative 0.0278 0.0772 0.2011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Schistosoma mansoni cathepsin s 0.0087 0.0184 0.0398
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0085 0.0178 0.0704
Brugia malayi Calmodulin-like protein 0.0037 0.0032 0.0075
Brugia malayi Cathepsin L-like precursor 0.0087 0.0184 0.0432
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0136 0.0881
Onchocerca volvulus 0.0298 0.0835 0.8867
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0062 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0085 0.0178 0.0868
Brugia malayi programmed cell death protein 6 0.0037 0.0032 0.0075
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus granulosus neuronal calcium sensor 0.0037 0.0032 0.0075
Onchocerca volvulus 0.0071 0.0136 0.1447
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Plasmodium vivax histone deacetylase 2, putative 0.0792 0.2358 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0052 0.0206
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis calmodulin-2, putative 0.0037 0.0032 0.0099
Echinococcus granulosus calcium uptake protein 1 0.0038 0.0035 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0077 0.0182
Trypanosoma cruzi centrin, putative 0.0037 0.0032 0.005
Echinococcus granulosus integrin alpha ps 0.0032 0.0018 0.0041
Echinococcus granulosus cathepsin L cysteine protease 0.0171 0.0444 0.1044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Schistosoma mansoni hypothetical protein 0.0036 0.0028 0.006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Trypanosoma brucei centrin-3 0.0037 0.0032 0.008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0339 0.0796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0171 0.0444 0.184
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0037 0.0032 0.0032
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Echinococcus multilocularis neurocalcin 0.0037 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Echinococcus granulosus integrin alpha 3 0.0116 0.0274 0.0644
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1257 0.3789 0.8197
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Mycobacterium tuberculosis Conserved protein 0.0071 0.0136 0.0881
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0085 0.0178 0.0868
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Trypanosoma cruzi histone deacetylase, putative 0.0792 0.2358 0.6209
Trypanosoma brucei I/6 autoantigen 0.0037 0.0032 0.008
Leishmania major phospholipase c-like protein 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0031 0.0013 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Loa Loa (eye worm) TAR-binding protein 0.0194 0.0514 0.1208
Loa Loa (eye worm) hypothetical protein 0.0648 0.1914 0.4497
Brugia malayi calpain family protein 1 0.0534 0.1562 0.3671
Loa Loa (eye worm) beta-lactamase 0.0071 0.0136 0.032
Brugia malayi beta-lactamase 0.0071 0.0136 0.032
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Brugia malayi Cathepsin L-like precursor 0.0211 0.0569 0.1336
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0358 0.0841
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0134
Leishmania major calmodulin-like protein 0.0037 0.0032 0.008
Echinococcus granulosus cathepsin L cysteine proteinase 0.0298 0.0835 0.1962
Brugia malayi calpain 5 0.0141 0.0352 0.0826
Echinococcus multilocularis neuronal calcium sensor 0.0037 0.0032 0.0032
Schistosoma mansoni histone deacetylase 0.0648 0.1914 0.4141
Leishmania major calcineurin B subunit, putative 0.0037 0.0032 0.008
Plasmodium falciparum serine repeat antigen 7 0.0085 0.0178 0.0704
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0136 0.0881
Trypanosoma brucei cysteine peptidase, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0052 0.0206
Schistosoma mansoni cathepsin B (C01 family) 0.0085 0.0178 0.0385
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0029 0.0047
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0444 0.1044
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Brugia malayi DKFZp564C0469 protein 0.004 0.004 0.0094
Echinococcus multilocularis programmed cell death protein 0.0037 0.0032 0.0032
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Brugia malayi hypothetical protein 0.0146 0.0368 0.0864
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0171 0.0444 0.0962
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0136 0.0881
Mycobacterium tuberculosis Conserved protein 0.0071 0.0136 0.0881
Trypanosoma brucei histone deacetylase, putative 0.0792 0.2358 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0171 0.0444 0.184
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0085 0.0178 0.0704
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0041
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Brugia malayi topoisomerase 0.004 0.004 0.0094
Toxoplasma gondii centrin, putative 0.0037 0.0032 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Leishmania major calmodulin, putative 0.0037 0.0032 0.008
Trichomonas vaginalis calpain, putative 0.0061 0.0104 0.0479
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0085 0.0178 0.0704
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Schistosoma mansoni histone deacetylase hda2 0.0278 0.0772 0.1671
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0061 0.0106 0.0395
Echinococcus granulosus expressed conserved protein 0.0283 0.0788 0.1852
Trypanosoma cruzi histone deacetylase, putative 0.0792 0.2358 0.6209
Giardia lamblia Replication factor C, subunit 1 0.004 0.004 0.0141
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Schistosoma mansoni brca1-associated protein (brap2) 0.0031 0.0013 0.0028
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0031 0.0013 0.0013
Echinococcus granulosus calumenin 0.0038 0.0035 0.0081
Schistosoma mansoni brca1-associated protein (brap2) 0.0031 0.0013 0.0028
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0085 0.0178 0.0868
Echinococcus granulosus nibrin 0.004 0.004 0.0094
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Plasmodium falciparum serine repeat antigen 1 0.0085 0.0178 0.0704
Schistosoma mansoni topbp1 0.004 0.004 0.0086
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0298 0.0835 0.1962
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0052 0.0167
Loa Loa (eye worm) hypothetical protein 0.1409 0.4257 1
Schistosoma mansoni reticulocalbin 0.0038 0.0035 0.0075
Echinococcus granulosus geminin 0.0497 0.1447 0.3399
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0028 0.0028
Brugia malayi EF hand family protein 0.0037 0.0032 0.0075
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0534 0.1562 0.338
Echinococcus granulosus centrin 2 0.0037 0.0032 0.0075
Echinococcus multilocularis calpain 5 0.0201 0.0538 0.0538
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trypanosoma cruzi calmodulin, putative 0.0037 0.0032 0.005
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0301 0.0845 0.4374
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0085 0.0178 0.0704
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0306 0.0859 0.1858
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0104 0.0479
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0031 0.0013 0.0031
Giardia lamblia Hypothetical protein 0.0085 0.0178 0.0868
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trypanosoma brucei Calpain-like protein 1.2 0.0061 0.0104 0.0389
Echinococcus granulosus cathepsin l1 0.0211 0.0569 0.1336
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Leishmania major histone deacetylase, putative 0.0792 0.2358 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0136 0.0136
Giardia lamblia Cathepsin B precursor 0.0447 0.1295 0.6742
Echinococcus multilocularis survival motor neuron protein 1 0.1409 0.4257 0.4257
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.004 0.0114
Echinococcus granulosus BRCA1 associated protein 0.0031 0.0013 0.0031
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0085 0.0178 0.0704
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0066 0.3481
Echinococcus granulosus microtubule associated protein 2 0.1403 0.4239 0.9959
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0184 0.0453
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Onchocerca volvulus Cathepsin L homolog 0.0085 0.0178 0.189
Brugia malayi Histone deacetylase family protein 0.0792 0.2358 0.5539
Brugia malayi BRCA1-associated protein 2 containing protein 0.0031 0.0013 0.0031
Loa Loa (eye worm) cathepsin B 0.0447 0.1295 0.3042
Schistosoma mansoni reticulocalbin 0.0037 0.0032 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1257 0.3789 0.8197
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0032 0.0099
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0085 0.0178 0.0704
Brugia malayi Integrin beta pat-3 precursor 0.0309 0.0871 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Trypanosoma brucei calpain, putative 0.0061 0.0104 0.0389
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Mycobacterium ulcerans beta-lactamase 0.0071 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0368 0.0864
Echinococcus multilocularis cysteine protease 0.0298 0.0835 0.0835
Toxoplasma gondii EFHC1, putative 0.0037 0.0032 0.008
Loa Loa (eye worm) histone deacetylase 1 0.0648 0.1914 0.4497
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0278 0.0653
Loa Loa (eye worm) RNA binding protein 0.0194 0.0514 0.1208
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0172 0.0371
Trypanosoma brucei histone deacetylase 2 0.0278 0.0772 0.3238
Toxoplasma gondii histone deacetylase HDAC1 0.0792 0.2358 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0028 0.0065
Trypanosoma brucei hypothetical protein 0.0061 0.0104 0.0389
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0298 0.0835 0.3507
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0031 0.0013 0.0028
Brugia malayi cathepsin B-like cysteine proteinase 0.1257 0.3789 0.8902
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Echinococcus granulosus calpain 5 0.0201 0.0538 0.1264
Loa Loa (eye worm) histone deacetylase 11 0.0278 0.0772 0.1814
Trypanosoma brucei centrin, putative 0.0037 0.0032 0.008
Echinococcus granulosus cathepsin L 0.0085 0.0178 0.0418
Schistosoma mansoni calmodulin 0.0037 0.0032 0.0069
Echinococcus granulosus Niemann Pick C1 protein 0.0301 0.0845 0.1984
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0085 0.0178 0.0704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0085 0.0178 0.0868
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0054 0.0128
Echinococcus granulosus calpain 7 C02 family 0.0201 0.0538 0.1264
Echinococcus multilocularis EF hand domain containing family member A2 0.0037 0.0032 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Echinococcus granulosus survival motor neuron protein 1 0.1409 0.4257 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0201 0.0538 0.1164
Plasmodium vivax unspecified product 0.0085 0.0178 0.0704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0063
Brugia malayi PHD-finger family protein 0.0028 0.0003 0.0008
Toxoplasma gondii ATPase, AAA family protein 0.004 0.004 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0032 0.0099
Echinococcus granulosus Protein patched homolog 1 0.0129 0.0315 0.0741
Trichomonas vaginalis myosin light chain 1, putative 0.0037 0.0032 0.0099
Onchocerca volvulus Cathepsin L homolog 0.0298 0.0835 0.8867
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0172 0.0403
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.004 0.0141
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0035 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0136 0.0649
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0054 0.0054
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0066 0.3481
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0054 0.0118
Brugia malayi EF hand family protein 0.0038 0.0035 0.0081
Echinococcus multilocularis integrin alpha ps 0.0068 0.0126 0.0126
Onchocerca volvulus 0.0333 0.0942 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Toxoplasma gondii ABC1 family protein 0.0071 0.0136 0.0526
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0085 0.0178 0.0385
Echinococcus granulosus EF hand domain containing family member A2 0.0038 0.0035 0.0081
Mycobacterium ulcerans hypothetical protein 0.0048 0.0066 0.3481
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Brugia malayi Bromodomain containing protein 0.0077 0.0155 0.0363
Trypanosoma cruzi major cysteine proteinase, putative 0.0085 0.0178 0.0437
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0031 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0432
Leishmania major kinesin, putative 0.0141 0.0352 0.1444
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Plasmodium falciparum histone deacetylase 2 0.0792 0.2358 1
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Echinococcus granulosus tar DNA binding protein 0.0194 0.0514 0.1208
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0085 0.0178 0.0704
Echinococcus multilocularis replication factor c subunit 1 0.004 0.004 0.004
Trichomonas vaginalis esterase, putative 0.0071 0.0136 0.0649
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0315 0.159
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0037 0.0032 0.0099
Brugia malayi cathepsin F-like cysteine proteinase 0.0085 0.0178 0.0418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Toxoplasma gondii cathepsin CPC1 0.0085 0.0178 0.0704
Trypanosoma cruzi I/6 autoantigen, putative 0.0037 0.0032 0.005
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0037 0.0032 0.005
Onchocerca volvulus 0.004 0.004 0.0423
Trypanosoma brucei protein I/6 0.0037 0.0032 0.008
Echinococcus multilocularis cysteine protease 0.0298 0.0835 0.0835
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0077 0.0182
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.004 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Toxoplasma gondii calcium-dependent protein kinase 0.0038 0.0035 0.0092
Brugia malayi fibroinase precursor 0.0085 0.0178 0.0418
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0136 1
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0029 0.0066
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0031 0.0013 0.0031
Brugia malayi hypothetical protein 0.004 0.004 0.0094
Echinococcus multilocularis integrin beta 2 0.0229 0.0624 0.0624
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0031 0.0013 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0054 0.0054
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0085 0.0178 0.0704
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Schistosoma mansoni centrin-related 0.0037 0.0032 0.0069
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0155
Echinococcus multilocularis protein patched 0.0129 0.0315 0.0315
Schistosoma mansoni histone deacetylase 1 2 3 0.0278 0.0772 0.1671
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0184 0.0432
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0085 0.0178 0.0418
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Leishmania major hypothetical protein, conserved 0.0038 0.0035 0.0092
Plasmodium vivax serine-repeat antigen (SERA) 0.0085 0.0178 0.0704
Giardia lamblia Encystation-specific protease 0.0085 0.0178 0.0868
Leishmania major hypothetical protein, conserved 0.0037 0.0032 0.008
Loa Loa (eye worm) histone deacetylase 0.0792 0.2358 0.5539
Plasmodium vivax unspecified product 0.0171 0.0444 0.184
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0201 0.0538 0.2239
Plasmodium vivax serine-repeat antigen (SERA) 0.0085 0.0178 0.0704
Onchocerca volvulus Cathepsin L homolog 0.0298 0.0835 0.8867
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0077 0.0182
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0026 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Echinococcus multilocularis hypothetical protein 0.0201 0.0538 0.0538
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Plasmodium falciparum centrin-1 0.0037 0.0032 0.008
Schistosoma mansoni calpain-7 (C02 family) 0.0201 0.0538 0.1164
Toxoplasma gondii calmodulin CAM1 0.0038 0.0035 0.0092
Onchocerca volvulus 0.0298 0.0835 0.8867
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0298 0.0835 0.0835
Echinococcus multilocularis cathepsin L 0.0171 0.0444 0.0444
Leishmania major hypothetical protein, conserved 0.0071 0.0136 0.0526
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0648 0.1914 1
Echinococcus granulosus EF hand domain containing family member A2 0.0037 0.0032 0.0075
Brugia malayi cathepsin Z-like cysteine proteinase 0.0085 0.0178 0.0418
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0136 1
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Echinococcus multilocularis calpain family protein 1, d 0.0393 0.1129 0.1129
Brugia malayi RNA binding protein 0.0194 0.0514 0.1208
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Brugia malayi calpain 5 0.0061 0.0104 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Schistosoma mansoni calpain-2 (C02 family) 0.0061 0.0104 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus multilocularis nibrin 0.004 0.004 0.004
Trichomonas vaginalis calpain, putative 0.0061 0.0104 0.0479
Loa Loa (eye worm) hypothetical protein 0.0278 0.0772 0.1814
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Leishmania major calmodulin-like protein 0.0037 0.0032 0.008
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0085 0.0178 0.0704
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0054 0.0128
Trypanosoma brucei calmodulin, putative 0.0038 0.0035 0.0092
Schistosoma mansoni calpain-7 (C02 family) 0.0201 0.0538 0.1164
Chlamydia trachomatis DNA ligase 0.004 0.004 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0136 0.0327
Loa Loa (eye worm) hypothetical protein 0.0129 0.0315 0.0741
Trichomonas vaginalis calcineurin B subunit, putative 0.0038 0.0035 0.0114
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Echinococcus granulosus histone deacetylase 0.0792 0.2358 0.5539
Brugia malayi Niemann-Pick C1 protein precursor 0.0301 0.0845 0.1984
Echinococcus granulosus cathepsin l cysteine peptidase 0.0298 0.0835 0.1962
Leishmania major programmed cell death 6 protein-like protein 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0546 0.1598 0.3755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0054 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0226
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Giardia lamblia Cathepsin L-like protease 0.0085 0.0178 0.0868
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0037 0.0032 0.0099
Schistosoma mansoni hypothetical protein 0.0497 0.1447 0.313
Entamoeba histolytica calcium-binding protein, putative 0.0037 0.0032 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0085 0.0178 0.0385
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0066 0.3481
Trypanosoma brucei Calpain-like protein 2 0.0061 0.0104 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Loa Loa (eye worm) EF hand family protein 0.0037 0.0032 0.0075
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0136 0.0881
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0301 0.0845 0.1984
Schistosoma mansoni integrin alpha-ps 0.0068 0.0126 0.0273
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Entamoeba histolytica calpain family cysteine protease, putative 0.0061 0.0104 0.0479
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0136 0.032
Leishmania major calpain family cysteine protease-like protein 0.0061 0.0104 0.0389
Echinococcus multilocularis calpain 0.0201 0.0538 0.0538
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi cysteine proteinase, putative 0.0171 0.0444 0.1143
Plasmodium falciparum serine repeat antigen 8 0.0085 0.0178 0.0704
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Loa Loa (eye worm) hypothetical protein 0.0082 0.0172 0.0403
Trypanosoma cruzi cysteine proteinase, putative 0.0171 0.0444 0.1143
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0037 0.0032 0.0099
Onchocerca volvulus 0.0048 0.0066 0.0701
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Mycobacterium leprae Probable lipase LipE 0.0071 0.0136 1
Plasmodium vivax centrin-1, putative 0.0037 0.0032 0.008
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0571 0.1677 0.3939
Brugia malayi calcium-binding protein 0.0037 0.0032 0.0075
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1257 0.3789 0.8197
Loa Loa (eye worm) cysteine protease 0.0298 0.0835 0.1962
Loa Loa (eye worm) hypothetical protein 0.0211 0.0569 0.1336
Trichomonas vaginalis calcium binding proteins, putative 0.0037 0.0032 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Echinococcus granulosus cathepsin L 0.0171 0.0444 0.1044
Echinococcus granulosus integrin beta 2 0.0229 0.0624 0.1465
Echinococcus multilocularis calmodulin 0.0037 0.0032 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0184 0.0432
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0054 0.0118
Plasmodium vivax vivapain-3 0.0171 0.0444 0.184
Echinococcus multilocularis sterol regulatory element binding protein 0.0129 0.0315 0.0315
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0066 0.0279
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0773 0.1672
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0648 0.1914 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0432
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0358 0.0774
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0029 0.0066
Echinococcus multilocularis cathepsin b 0.1257 0.3789 0.3789
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0136 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.0569 0.2923
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0447 0.1295 0.5467
Echinococcus multilocularis Niemann Pick C1 protein 0.043 0.1242 0.1242
Trypanosoma cruzi I/6 autoantigen, putative 0.0037 0.0032 0.005
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.1315 1
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Brugia malayi TAR-binding protein 0.0194 0.0514 0.1208
Echinococcus multilocularis cathepsin L 0.0085 0.0178 0.0178
Schistosoma mansoni bromodomain containing protein 0.0065 0.0119 0.0258
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0108 0.0108
Schistosoma mansoni integrin alpha-ps 0.0035 0.0026 0.0057
Plasmodium vivax unspecified product 0.0087 0.0184 0.073
Entamoeba histolytica calcium binding family protein 0.0037 0.0032 0.0099
Brugia malayi CHE-14 protein 0.0129 0.0315 0.0741
Schistosoma mansoni microtubule-associated protein tau 0.1403 0.4239 0.917
Mycobacterium tuberculosis Conserved protein 0.0071 0.0136 0.0881
Echinococcus multilocularis Niemann Pick C1 protein 0.0301 0.0845 0.0845
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0333 0.0942 0.2213
Schistosoma mansoni DNA ligase IV 0.004 0.004 0.0086
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0035 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Plasmodium falciparum serine repeat antigen 5 0.0085 0.0178 0.0704
Trypanosoma cruzi histone deacetylase, putative 0.0278 0.0772 0.2011
Echinococcus multilocularis calumenin 0.0038 0.0035 0.0035
Onchocerca volvulus 0.0298 0.0835 0.8867
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0054 0.0128
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0013 0.0031
Trichomonas vaginalis calmodulin, putative 0.0038 0.0035 0.0114
Brugia malayi hypothetical protein 0.1409 0.4257 1
Leishmania major centrin, putative 0.0037 0.0032 0.008
Onchocerca volvulus 0.0298 0.0835 0.8867
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0136 0.0295
Echinococcus multilocularis geminin 0.0497 0.1447 0.1447
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0136 0.0649
Brugia malayi calpain 7 0.0201 0.0538 0.1264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Schistosoma mansoni patched 1 0.0129 0.0315 0.0682
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.0514 0.1208
Plasmodium vivax vivapain-2 0.0298 0.0835 0.3507
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.3481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0444 0.2269
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0076 0.0165
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Schistosoma mansoni histone deacetylase 0.0648 0.1914 0.4141
Plasmodium vivax histone deacetylase, putative 0.0792 0.2358 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0211 0.0569 0.1472
Schistosoma mansoni cathepsin F (C01 family) 0.0298 0.0835 0.1807
Echinococcus granulosus calmodulin 0.0037 0.0032 0.0075
Trypanosoma brucei Calpain-like protein 1.1 0.0061 0.0104 0.0389
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0136 0.032
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.004 0.0094
Schistosoma mansoni histone deacetylase hda2 0.0823 0.2453 0.5307
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0447 0.1295 0.5467
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0172 0.0172
Plasmodium falciparum serine repeat antigen 6 0.0085 0.0178 0.0704
Leishmania major centrin, putative,caltractin, putative 0.0037 0.0032 0.008
Echinococcus granulosus programmed cell death protein 0.0037 0.0032 0.0075
Echinococcus multilocularis programmed cell death protein 0.0037 0.0032 0.0032
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0034 0.0091
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Treponema pallidum DNA ligase (lig) 0.004 0.004 0.5
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.004 0.0141
Echinococcus multilocularis microtubule associated protein 2 0.1403 0.4239 0.4239
Trichomonas vaginalis centrin, putative 0.0037 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0158 0.0405 0.0951
Echinococcus granulosus calbindin 32 0.0038 0.0035 0.0081
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0178 0.0868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Brugia malayi beta-lactamase family protein 0.0071 0.0136 0.032
Entamoeba histolytica cysteine protease, putative 0.0298 0.0835 0.4325
Onchocerca volvulus 0.0071 0.0136 0.1447
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0184 0.0453
Giardia lamblia Cathepsin B precursor 0.0447 0.1295 0.6742
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0032 0.008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Trypanosoma brucei histone deacetylase 3 0.0792 0.2358 1
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0037 0.0032 0.005
Brugia malayi Bromodomain containing protein 0.0041 0.0044 0.0103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0066 0.2718
Loa Loa (eye worm) calpain family protein 1 0.0534 0.1562 0.3671
Onchocerca volvulus 0.0146 0.0368 0.3906
Schistosoma mansoni rab 0.0037 0.0032 0.0069
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0298 0.0835 0.0835
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0136 0.0881
Echinococcus multilocularis calmodulin 0.0037 0.0032 0.0032
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0211 0.0569 0.1336
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0136 0.0881
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0129 0.0315 0.0741
Schistosoma mansoni integrin alpha 0.0151 0.0383 0.0828
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Mycobacterium ulcerans lipase LipD 0.0071 0.0136 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Echinococcus multilocularis histone deacetylase 0.0792 0.2358 0.2358
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0034 0.0113
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Echinococcus granulosus histone deacetylase 3 0.0648 0.1914 0.4497
Echinococcus granulosus histone deacetylase 7 0.0792 0.2358 0.5539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.004 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Giardia lamblia Cathepsin B precursor 0.0447 0.1295 0.6742
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1257 0.3789 0.8197
Onchocerca volvulus 0.0298 0.0835 0.8867
Schistosoma mansoni hypothetical protein 0.0032 0.0018 0.0038
Brugia malayi histone deacetylase 3 (HD3) 0.0648 0.1914 0.4497
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Brugia malayi histone deacetylase 1 (HD1) 0.0648 0.1914 0.4497
Loa Loa (eye worm) hypothetical protein 0.0061 0.0104 0.0245
Plasmodium falciparum serine repeat antigen 2 0.0085 0.0178 0.0704
Echinococcus multilocularis tar DNA binding protein 0.0194 0.0514 0.0514
Brugia malayi Cathepsin L-like cysteine proteinase 0.0211 0.0569 0.1336
Trypanosoma cruzi kinesin, putative 0.0141 0.0352 0.0897
Loa Loa (eye worm) programmed cell death protein 6 0.0038 0.0035 0.0081
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0031 0.0013 0.0031
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0447 0.1295 0.3395
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus granulosus tumor protein p63 0.0352 0.1001 0.2352
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Leishmania major histone deacetylase, putative 0.0792 0.2358 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0136 0.0881
Echinococcus granulosus sterol regulatory element binding protein 0.0129 0.0315 0.0741
Echinococcus granulosus calpain A 0.0201 0.0538 0.1264
Brugia malayi Papain family cysteine protease containing protein 0.0298 0.0835 0.1962
Loa Loa (eye worm) integrin beta-2 0.0309 0.0871 0.2046
Echinococcus multilocularis protein dispatched 1 0.0147 0.0372 0.0372
Entamoeba histolytica cysteine proteinase 1, putative 0.0171 0.0444 0.2269
Leishmania major hypothetical protein, unknown function 0.0061 0.0104 0.0389
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0393 0.1129 0.2651
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0171 0.0444 0.0962
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0037 0.0032 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0066 0.0337
Onchocerca volvulus Cathepsin F homolog 0.0298 0.0835 0.8867
Loa Loa (eye worm) hypothetical protein 0.0474 0.1376 0.3233
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Trypanosoma brucei calmodulin, putative 0.0037 0.0032 0.008
Echinococcus granulosus histone deacetylase 6 0.0823 0.2453 0.5763
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0298 0.0835 0.3507
Leishmania major hypothetical protein, conserved 0.0061 0.0104 0.0389
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.3481
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0052 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus granulosus neurocalcin 0.0037 0.0032 0.0075
Trypanosoma cruzi cruzipain precursor, putative 0.0298 0.0835 0.2178
Entamoeba histolytica grainin, putative 0.0038 0.0035 0.0114
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0066 0.0279
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Giardia lamblia Hypothetical protein 0.0038 0.0035 0.0114
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0389
Leishmania major protein kinase, putative 0.0037 0.0032 0.008
Trichomonas vaginalis hypothetical protein 0.0061 0.0104 0.0479
Loa Loa (eye worm) hypothetical protein 0.0083 0.0174 0.041
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0171 0.0444 0.0962
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0075
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0085 0.0178 0.0704
Plasmodium falciparum serine repeat antigen 3 0.0085 0.0178 0.0704
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0037 0.0032 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0447 0.1295 0.6742
Toxoplasma gondii centrin 0.0037 0.0032 0.008
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Schistosoma mansoni ef hand domain family member A2 0.0037 0.0032 0.0069
Toxoplasma gondii cathepsin CPL 0.0298 0.0835 0.3507
Brugia malayi Histone deacetylase family protein 0.0792 0.2358 0.5539
Giardia lamblia Cathepsin L-like protease 0.0085 0.0178 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0171 0.0444 0.184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0054 0.0128
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Toxoplasma gondii cathepsin B 0.0447 0.1295 0.5467
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0136 0.032
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0571 0.1677 0.3627
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0447 0.1295 0.2801
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0287 0.0803 0.1886
Onchocerca volvulus 0.0085 0.0178 0.189
Echinococcus multilocularis histone deacetylase 7 0.0792 0.2358 0.2358
Onchocerca volvulus 0.0211 0.0569 0.6039
Trypanosoma cruzi histone deacetylase 1, putative 0.0648 0.1914 0.5035
Echinococcus multilocularis EF hand domain containing family member A2 0.0038 0.0035 0.0035
Plasmodium falciparum histone deacetylase 1 0.0648 0.1914 0.8109
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0038 0.0035 0.0057
Trypanosoma brucei kinesin, putative 0.0141 0.0352 0.1444
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Trypanosoma brucei centrin, putative 0.0037 0.0032 0.008
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.004 0.0114
Loa Loa (eye worm) hypothetical protein 0.0298 0.0835 0.1962
Brugia malayi MH2 domain containing protein 0.0117 0.0278 0.0653
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0179
Trichomonas vaginalis calpain, putative 0.0061 0.0104 0.0479
Brugia malayi cathepsin L precursor 0.0085 0.0178 0.0418
Toxoplasma gondii troponin c, isotype gamma, putative 0.0037 0.0032 0.008
Echinococcus multilocularis calbindin 32 0.0038 0.0035 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0027 0.0063
Echinococcus multilocularis tumor protein p63 0.0352 0.1001 0.1001
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0075
Echinococcus granulosus histone deacetylase 6 0.0792 0.2358 0.5539
Trypanosoma cruzi centrin, putative 0.0037 0.0032 0.005
Plasmodium falciparum serine repeat antigen 4 0.0085 0.0178 0.0704
Echinococcus multilocularis calcium uptake protein 1 0.0038 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Giardia lamblia Hypothetical protein 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0119 0.0283 0.0665
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0031 0.0013 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Schistosoma mansoni calmodulin 0.0037 0.0032 0.0069
Plasmodium vivax vivapain-2 0.0298 0.0835 0.3507
Echinococcus multilocularis histone deacetylase 1 0.0648 0.1914 0.1914
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0136 0.0649
Trypanosoma brucei calpain, putative 0.0061 0.0104 0.0389
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0155
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Trichomonas vaginalis centrin, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0104 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Entamoeba histolytica calmodulin, putative 0.0037 0.0032 0.0099
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0066 0.3481
Trypanosoma cruzi conserved protein 0.0061 0.0104 0.0241
Echinococcus granulosus integrin alpha ps 0.0068 0.0126 0.0297
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.004 0.0071
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0037 0.0032 0.005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0013 0.0031
Onchocerca volvulus 0.0037 0.0032 0.0338
Echinococcus granulosus calpain 0.0201 0.0538 0.1264
Loa Loa (eye worm) hypothetical protein 0.1257 0.3789 0.8902
Loa Loa (eye worm) fibroinase 0.0298 0.0835 0.1962
Onchocerca volvulus 0.0071 0.0136 0.1447
Brugia malayi Kelch motif family protein 0.0047 0.0062 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus granulosus histone deacetylase 6 0.0792 0.2358 0.5539
Brugia malayi Histone deacetylase 1 0.0648 0.1914 0.4497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0172 0.0403
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0031 0.0013 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0136 0.0295
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0085 0.0178 0.0385
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0085 0.0178 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.0071
Plasmodium falciparum calpain 0.0061 0.0104 0.0389
Plasmodium vivax vivapain-1 0.0171 0.0444 0.184
Plasmodium falciparum histone deacetylase, putative 0.0792 0.2358 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0201 0.0538 0.139
Echinococcus granulosus replication factor c subunit 1 0.004 0.004 0.0094
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0085 0.0178 0.0868
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Loa Loa (eye worm) calpain 5 0.0141 0.0352 0.0826
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0052 0.0167
Brugia malayi cathepsin Z-like cysteine proteinase 0.0085 0.0178 0.0418
Brugia malayi beta-lactamase family protein 0.0071 0.0136 0.032
Onchocerca volvulus 0.0038 0.0035 0.0368
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Echinococcus multilocularis histone deacetylase 8 0.0278 0.0772 0.0772
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0444 0.1044
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.004 0.0114
Loa Loa (eye worm) hypothetical protein 0.0069 0.0131 0.0308
Brugia malayi histone deacetylase 11 0.0278 0.0772 0.1814
Echinococcus granulosus cathepsin l1 0.0298 0.0835 0.1962
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.004 0.0141
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Onchocerca volvulus 0.0052 0.0076 0.0809
Schistosoma mansoni hypothetical protein 0.0037 0.0032 0.0069
Trypanosoma cruzi centrin-3 0.0037 0.0032 0.005
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.004 0.0071
Schistosoma mansoni survival motor neuron protein 0.0287 0.0803 0.1736
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.004 0.1049
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0241
Toxoplasma gondii histone deacetylase HDAC2 0.0648 0.1914 0.8109
Echinococcus granulosus cysteine protease 0.0171 0.0444 0.1044
Toxoplasma gondii histone deacetylase HDAC3 0.0648 0.1914 0.8109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Loa Loa (eye worm) hypothetical protein 0.0114 0.027 0.0633
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Leishmania major cysteine peptidase A (CPA) 0.0298 0.0835 0.3507
Onchocerca volvulus 0.0037 0.0032 0.0338
Schistosoma mansoni cathepsin S (C01 family) 0.0085 0.0178 0.0385
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0358 0.0358
Schistosoma mansoni centrin 0.0037 0.0032 0.0069
Entamoeba histolytica cysteine proteinase, putative 0.0298 0.0835 0.4325
Brugia malayi hypothetical protein 0.0036 0.0028 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0085 0.0178 0.0868
Entamoeba histolytica calmodulin, putative 0.0037 0.0032 0.0099
Echinococcus multilocularis cathepsin L cysteine protease 0.0298 0.0835 0.0835
Schistosoma mansoni cathepsin C 0.0085 0.0178 0.0385
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0085 0.0178 0.0868
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus multilocularis calpain 7 (C02 family) 0.0201 0.0538 0.0538
Schistosoma mansoni topbp1 0.004 0.004 0.0086
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0037 0.0032 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0226

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -9.16 Inhibitory activity against HIV-1 protease. ChEMBL. 9526559
IC50 (binding) = 0.7 nM In vitro inhibition of HIV-1 protease ChEMBL. 7830273
IC50 (binding) = 0.7 nM In vitro inhibition of HIV-1 protease ChEMBL. 7830273
Log IC50 (binding) = 9.16 Inhibitory activity against HIV-1 protease. ChEMBL. 9526559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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