Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Botryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytiscinerea) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cytochrome b-c1 complex subunit Rieske, mitochondrial | 227 aa | 203 aa | 44.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.283 | 0.2787 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.1743 | 0.1743 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.1743 | 0.1547 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.1743 | 0.1693 |
Onchocerca volvulus | 0.0028 | 0.1743 | 0.5 | |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0046 | 0.3794 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.283 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.006 | 0.006 |
Echinococcus granulosus | lamin | 0.0028 | 0.1743 | 0.1693 |
Echinococcus multilocularis | lamin | 0.0028 | 0.1743 | 0.1693 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.283 | 0.1316 |
Echinococcus granulosus | ubiquinol cytochrome c reductase Rieske | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.1743 | 0.1743 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.283 | 0.5 |
Echinococcus multilocularis | musashi | 0.0028 | 0.1743 | 0.1693 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.283 | 0.2787 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.283 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.1743 | 0.1693 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.283 | 0.5 |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0046 | 0.3794 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.1743 | 0.5 | |
Leishmania major | reiske iron-sulfur protein precursor, putative | 0.0046 | 0.3794 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.1743 | 0.1693 |
Trypanosoma brucei | rieske iron-sulfur protein, mitochondrial precursor | 0.0046 | 0.3794 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Rieske Fe-S protein | 0.0046 | 0.3794 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1743 | 0.1743 |
Brugia malayi | hypothetical protein | 0.0037 | 0.283 | 0.2659 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1683 | 0.1683 |
Echinococcus multilocularis | ubiquinol cytochrome c reductase, Rieske | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | ubiquinol-cytochrome c reductase | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0232 | 0.0232 |
Plasmodium falciparum | cytochrome b-c1 complex subunit Rieske, putative | 0.0046 | 0.3794 | 0.5 |
Plasmodium vivax | ubiquinol cytochrome c oxidoreductase, putative | 0.0046 | 0.3794 | 0.5 |
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0099 | 1 | 1 |
Toxoplasma gondii | ubiquinol cytochrome c oxidoreductase, putative | 0.0046 | 0.3794 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.1743 | 0.1547 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.283 | 0.5 |
Schistosoma mansoni | ubiquinol--cytochrome C reductase | 0.0099 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.18 | Inhibition of Botryotinia fuckeliana succinate dehydrogenase by DCPIP-based spectrophotometric assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.