Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 1 | 1 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 1 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor-related protein, putative | 0.0005 | 0 | 0.5 |
Echinococcus granulosus | ferritin | 0.001 | 1 | 1 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Loa Loa (eye worm) | low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 1 | 0.5 |
Brugia malayi | enteropeptidase precursor | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.001 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 1 | 1 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 1 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.001 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Brugia malayi | basement membrane proteoglycan precursor | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | Terribly reduced optic lobes homolog | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 1 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0005 | 0 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.001 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Brugia malayi | CUB domain containing protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 1 | 1 |
Echinococcus multilocularis | ferritin | 0.001 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | calcium binding EGF domain-containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0005 | 0 | 0.5 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor domain class A containing protein | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0 | 0.5 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.9 mM | Inhibition of Musca domestica (house fly) acetylcholinesterase | ChEMBL. | No reference |
Ki (binding) | = 226 uM | Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.