Detailed information for compound 1804911

Basic information

Technical information
  • TDR Targets ID: 1804911
  • Name: 2,6-dichloro-N-[5-(4-chlorophenyl)-1,3,4-thia diazol-2-yl]benzamide
  • MW: 384.668 | Formula: C15H8Cl3N3OS
  • H donors: 1 H acceptors: 3 LogP: 5.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(Cl)cccc1Cl)Nc1nnc(s1)c1ccc(cc1)Cl
  • InChi: 1S/C15H8Cl3N3OS/c16-9-6-4-8(5-7-9)14-20-21-15(23-14)19-13(22)12-10(17)2-1-3-11(12)18/h1-7H,(H,19,21,22)
  • InChiKey: CPRPLWKGHKHUOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MAP kinase sur-1 0.0216 0.3752 0.3664
Trichomonas vaginalis CMGC family protein kinase 0.0256 0.4602 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0256 0.4602 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0763 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.3752 0.7765
Loa Loa (eye worm) hypothetical protein 0.0077 0.08 0.08
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.08 0.1738
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0725 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.08 0.1738
Echinococcus granulosus lamin 0.0086 0.0989 0.215
Onchocerca volvulus 0.0086 0.0989 0.6375
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0216 0.3752 0.8154
Loa Loa (eye worm) CYP4Cod1 0.0074 0.0725 0.0725
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0082 0.0179
Schistosoma mansoni intermediate filament proteins 0.0086 0.0989 0.0499
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.4138 0.4138
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0216 0.3752 0.8154
Echinococcus granulosus lamin dm0 0.0086 0.0989 0.215
Loa Loa (eye worm) hypothetical protein 0.0085 0.0956 0.0956
Echinococcus multilocularis musashi 0.0086 0.0989 0.215
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0256 0.4602 0.4602
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Brugia malayi Cytochrome P450 family protein 0.0074 0.0725 0.0593
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0216 0.3752 0.7808
Brugia malayi PAS domain containing protein 0.0152 0.2391 0.2283
Echinococcus granulosus intermediate filament protein 0.0086 0.0989 0.215
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.08 0.1738
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0043 0.0093
Echinococcus multilocularis mitogen activated protein kinase 3 0.0216 0.3752 0.8154
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0043 0.0082 0.0179
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0216 0.3752 0.8154
Leishmania major protein kinase, putative 0.0256 0.4602 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0082 0.0179
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.08 0.1738
Loa Loa (eye worm) hypothetical protein 0.0511 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.08 0.0193
Leishmania major protein kinase, putative 0.0043 0.0082 0.0179
Brugia malayi bHLH-PAS transcription factor 0.0113 0.1552 0.1432
Plasmodium falciparum protein serine/threonine kinase-1 0.0256 0.4602 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0216 0.3752 0.3752
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0989 0.0989
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0043 0.0093
Schistosoma mansoni aryl hydrocarbon receptor 0.0152 0.2391 0.4186
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.3752 0.8154
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.08 0.1738
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0725 0.0725
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.3752 0.8154
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.004 0 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0471 0.916 0.916
Loa Loa (eye worm) hypothetical protein 0.0086 0.0989 0.0989
Giardia lamblia Kinase, CMGC CLK 0.0256 0.4602 1
Brugia malayi Cytochrome P450 family protein 0.0075 0.0763 0.0631
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.08 0.1738
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.08 0.1738
Schistosoma mansoni single-minded 0.0152 0.2391 0.4186
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0256 0.4602 1
Echinococcus granulosus single minded 2 0.0113 0.1552 0.3372
Mycobacterium ulcerans putative regulatory protein 0.0113 0.1552 1
Echinococcus multilocularis 0.0252 0.452 0.9821
Loa Loa (eye worm) hypothetical protein 0.0252 0.452 0.452
Echinococcus multilocularis transfer RNA-Lys 0.0113 0.1552 0.3372
Brugia malayi Protein kinase domain containing protein 0.0256 0.4602 0.4525
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.08 0.1738
Leishmania major protein kinase, putative 0.0043 0.0082 0.0179
Leishmania major protein kinase, putative 0.0256 0.4602 1
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.4602 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0216 0.3752 0.8154
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0256 0.4602 1
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0725 0.1575
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.08 0.1738
Echinococcus multilocularis mitogen activated protein kinase 0.0216 0.3752 0.8154
Schistosoma mansoni lamin 0.0086 0.0989 0.0499
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0725 0.1575
Mycobacterium leprae Possible regulatory protein 0.004 0 0.5
Leishmania major cytochrome p450-like protein 0.0074 0.0725 0.1575
Trypanosoma brucei protein kinase, putative 0.0216 0.3752 0.7808
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0256 0.4602 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.014 0.014
Onchocerca volvulus 0.0113 0.1552 1
Echinococcus multilocularis lamin dm0 0.0086 0.0989 0.215
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.08 0.1738
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.08 0.1738
Echinococcus multilocularis lamin 0.0086 0.0989 0.215
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.3752 0.8154
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0216 0.3752 0.8154
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.4602 1
Echinococcus granulosus mitogen activated protein kinase 0.0216 0.3752 0.8154
Trichomonas vaginalis CMGC family protein kinase 0.0216 0.3752 0.8154
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0256 0.4602 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0256 0.4602 1
Giardia lamblia Kinase, CMGC MAPK 0.0216 0.3752 0.7765
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.08 0.0669
Brugia malayi follicle stimulating hormone receptor 0.0234 0.4138 0.4055
Echinococcus granulosus hypothetical protein 0.0252 0.452 0.9821
Schistosoma mansoni lamin 0.0086 0.0989 0.0499
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0216 0.3752 0.8154
Onchocerca volvulus 0.0086 0.0989 0.6375
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0043 0.0082 0.0179
Brugia malayi intermediate filament protein 0.0086 0.0989 0.0861
Brugia malayi Cytochrome P450 family protein 0.0074 0.0725 0.0593
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0989 0.0861
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0256 0.4602 1
Brugia malayi hypoxia-induced factor 1 0.0471 0.916 0.9148
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.08 0.1738
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0989 0.0989
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.08 0.5
Echinococcus multilocularis dual specificity protein kinase clk2 0.0256 0.4602 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0043
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0216 0.3752 0.8154
Echinococcus granulosus dual specificity protein kinase clk2 0.0256 0.4602 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0256 0.4602 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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